共查询到20条相似文献,搜索用时 11 毫秒
1.
You‐Min Ying Xiao‐Sa Liu Cui‐Ping Tong Jian‐Wei Wang Zha‐Jun Zhan Wei‐Guang Shan 《Helvetica chimica acta》2014,97(10):1433-1439
Three new lycopodium alkaloids, huperserramines A–C ( 1 – 3 , resp.), along with 15 known ones, lycopodine‐6α,11α‐diol ( 4 ), lycoposerramine H ( 5 ), lycoposerramine I ( 6 ), lycopodine‐6α‐ol ( 7 ), lycoposerramine M ( 8 ), diphaladine A ( 9 ), lycoposerramine K ( 10 ), lycoposerramine W ( 11 ), huperzine M ( 12 ), luciduline ( 13 ), phlegmariuine N ( 14 ), huperzine A ( 15 ), huperzine B ( 16 ), lycodine ( 17 ), and lycoposerramine R ( 18 ), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α‐glucosidase. As a result, lycopodine‐6α,11α‐diol ( 4 ) exhibited more potent α‐glucosidase inhibitory activity (IC50 148±5.5 μM ) than the positive control acarbose (IC50 376.3±2.7 μM ). 相似文献
2.
Two new nitrone alkaloids were isolated from the whole plant of Huperzia serrata (Thunb .) Trev . They are both phlegmarine‐type lycopodium alkaloids with a nitrone moiety. Their structures were elucidated on the basis of spectral evidences, and their configurations were established on the basis of optical rotation, CD, and NOESY‐NMR data. 相似文献
3.
Heng‐Bin Wang Chang‐Heng Tan Jun‐Jie Tan Ming‐Yao Gao Yi‐Ming Li Shan‐Hao Jiang Da‐Yuan Zhu 《Helvetica chimica acta》2007,90(1):153-157
Three new Lycopodium alkaloids, 2‐chlorohuperzine E ( 1 ), huperzines E′ ( 2 ), and F′ ( 3 ), along with two known compounds, huperzines E and F, were isolated from Huperzia serrata (Thunb .) Trev . Their structures were elucidated by spectroscopic methods. 相似文献
4.
Huperzine V, A New Lycopodium Alkaloid from Huperzia serrata 总被引:1,自引:0,他引:1
HuiQingLIU ChangHengTAN ShanHaoJIANG DaYuanZHU 《中国化学快报》2004,15(3):303-304
Huperzine V, a new Lycopodium alkaloid, was isolated from the whole plant of Huperzia serrata, and the absolute stereochemistry was determined by X-ray crystallographic analysis. 相似文献
5.
Wei‐Guang Shan You‐Min Ying Hai‐Ning Yu Wen‐Hong Liu Zha‐Jun Zhan 《Helvetica chimica acta》2010,93(4):772-776
Cultivation of the fungus Penicillium spp. HS‐3, an endophytic fungus from the stems of Huperzia serrata, led to the isolation of a new diketopiperazine alkaloid, named as tryhistatin ( 1 ), together with three known ones, 2 – 4 , all of which share a similar backbone. The structure of 1 was established by detailed interpretation of the 1D‐ and 2D‐NMR spectra, and HR‐ESI‐MS data. Furthermore, 1D‐ and 2D‐NMR experiments were employed to elucidate the structure of 2 which was deduced previously only on the basis of the LC/MS method. In this article, we confirmed the correctness of the previously reported structure and made a complete assignment of the NMR signals of 2 for the first time. 相似文献
6.
Ji‐Chun Wu Qiu‐Yue Wang Ying‐Jiang Tao Jin‐He Jiang Ying Liu Guo‐Li Huang Rui Zhan Bo Liu Ye‐Gao Chen 《Helvetica chimica acta》2014,97(12):1719-1722
Two new lycodine alkaloids, 11β‐methoxyhuperzine B ( 1 ) and 16‐oxohuperzinine ( 2 ), together with seven known ones, huperzinine N‐oxide, huperzine D, casuarinine A, huperzine B, casuarinine B, huperzinine, and N‐methyllycodine, were isolated from whole plants of Lycopodiastrum casuarinoides. Their structures were elucidated by spectroscopic methods, including NMR and MS experiments. 相似文献
7.
Xiang‐Hai Cai Chun‐Xia Zeng Tao Feng Yan Li Xiao‐Dong Luo 《Helvetica chimica acta》2010,93(10):2037-2044
Three new monoterpenoid indole alkaloids, (14α,15α)‐14,15‐epoxyaspidofractinine ( 1 ) and maireines A and B ( 2 and 3 , resp.), together with 19 known alkaloids, were isolated from the leaves and twigs of Alstonia mairei. The structures of the new compounds were elucidated by 1D‐ and 2D‐NMR spectroscopic methods in combination with MS experiments. 相似文献
8.
Du‐Qiang Luo Wen‐Liang Zhu Xiao‐Long Yang Shu‐Juan Liang Zhi‐Ran Cao 《Helvetica chimica acta》2010,93(6):1209-1215
Two new daphniphyllum alkaloids named 2‐hydroxyyunnandaphnine D ( 1 ) and methyl 7‐hydroxyhomodaphniphyllate ( 2 ), together with eight known alkaloids, daphnioldhanin D, calyciphylline F, calyciphylline B, deoxycalyciphylline B, daphnicyclidin H, macropodumine C, 9,10‐epoxycalycine A, and yunnandaphnine A, were isolated from the stems and leaves of Daphniphyllum calycinum. Their structures and relative configurations were established on the basis of spectral evidence (including 2D‐NMR) and subsequently confirmed by a single‐crystal X‐ray crystallographic diffraction analysis. 相似文献
9.
Yue Cong William Jia Jing Chen Shuang Song Jin‐Hui Wang Yu‐Hui Yang 《Helvetica chimica acta》2007,90(5):1038-1042
Two new steroidal alkaloids, neoverapatuline ( 1 ) and (1β,3α,5β)‐1,3‐dihydroxyjervanin‐12‐en‐11‐one ( 2 ), together with the four known compounds, veratramine ( 3 ), rubijervine ( 4 ), veratrosine ( 5 ), and veratroylzygadenine ( 6 ), were isolated from the roots and rhizomes of Veratrum nigrum L. Their structures were established through combined analyses of physicochemical properties and spectroscopic evidence. All compounds 1 – 6 were tested for their cytotoxicities in vitro against the human glioma cell line SF188. 相似文献
10.
Xanthones with α‐Glucosidase Inhibitory Activities from Aspergillus versicolor,a Fungal Endophyte of Huperzia serrata 下载免费PDF全文
Tian‐Tian Ma Wei‐Guang Shan You‐Min Ying Lie‐Feng Ma Wen‐Hong Liu Zha‐Jun Zhan 《Helvetica chimica acta》2015,98(1):148-152
Three new xanthones, namely huperxanthones A–C ( 1 – 3 , resp.), were obtained from the cultures of Aspergillus versicolor, a fungal endophyte of Huperzia serrata, together with 1,7‐dihydroxy‐8‐(methoxycarbonyl)xanthone‐3‐carboxylic acid ( 4 ), β‐diversonolic acid methyl ester ( 5 ), 4‐hydroxyvertixanthone ( 6 ), and sydowinin B ( 7 ). The structures of the new compounds were established by detailed NMR and MS analysis, especially by 2D‐NMR experiments. All xanthones were evaluated for their effects on α‐glucosidase. Compound 4 exhibited a potent inhibitory activity against α‐glucosidase with an IC50 value of 0.24 mM (vs. 0.38 mM for acarbose). The rest of the compounds showed weak or no activity against α‐glucosidase. 相似文献
11.
Bin Wang Wei‐Dong Zhang Yun‐Heng Shen Jian Tang Chuan Zhang Run‐hui Liu Min Lin Hui‐Liang Li 《Helvetica chimica acta》2008,91(2):244-248
Phytochemical studies on Veratrum nigrum L., collected in Shanxi, P. R. China, resulted in the isolation of two new steroidal alkaloids, 23‐methoxycyclopamine ( 1 ) and 15‐O‐(2‐methylbutanoyl)‐3‐O‐veratroylprotoverine ( 2 ). The structures of the two new compounds were established by means of extensive NMR spectroscopic studies. 相似文献
12.
Two new Lycopodium alkaloids, (+)‐cermizine D N‐oxide ( 1 ) and (8β)‐8‐(acetyloxy)obscurumine A ( 2 ), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All of these alkaloids were tested in an assay for acetylcholine esterase (AChE) inhibitory activity. 相似文献
13.
14.
Two new 5‐methoxyfuran‐3(2H)‐one derivatives, huaspenone A ( 1 ) and B ( 2 ), together with four known ones, i.e., aspertetronin A ( 3 ), aspertetronin B ( 4 ), gregatin E ( 5 ), and penicilliol A ( 6 ), were isolated from the cultures of an endophytic fungus Aspergillus sp. XW‐12, derived from the stems of Huperzia serrata. The structures of the new isolates were established by detailed interpretation of the 1D‐ and 2D‐NMR and HR‐ESI‐MS data. 相似文献
15.
Cheng‐Jian Tan Yu Zhang Ning‐Chuan Kong Ying‐Tong Di Xiao‐Jiang Hao 《Helvetica chimica acta》2015,98(1):72-77
Four new indole alkaloids, trigonoliimines D–G ( 1 – 4 , resp.), were isolated from Trigonostemon lii. Their structures were elucidated by spectroscopic methods, including extensive 1D‐ and 2D‐NMR experiments. 相似文献
16.
Xin‐Gang Cui Qing‐Jie Zhao Qiao‐Ling Chen Lei Xu Yan Song Yong‐Sheng Jin Dan‐Feng Xu 《Helvetica chimica acta》2008,91(1):155-158
Two new benzophenanthridine alkaloids, named 8‐methoxysanguinarine ( 1 ) and 8‐methoxyisodecarine ( 2 ), were isolated from the EtOH extract of the rhizoma of Zanthoxylum nitidum. Their structures were determined on the basis of spectroscopic analysis. 相似文献
17.
Yun Sun Jin‐Xiong Chen Lin Zhou Jia Su Yan Li Ming‐Hua Qiu 《Helvetica chimica acta》2012,95(7):1114-1120
Three new alkaloids, 3‐O‐acetylveralkamine ( 1 ), veralkamine 3‐(β‐D ‐glucopyranoside) ( 2 ), and 6,7‐epoxyverdine ( 3 ), together with five known alkaloids, veramitaline, veralkamine ( 4 ), angeloylzygadenine, veratroylzygadenine, and veramiline 3‐(β‐D ‐glucopyranoside), were isolated from the whole plants of Veratrum taliense. Their structures were elucidated on the basis of spectroscopic analysis, and the NMR data of veralkamine ( 4 ) are given for the first time. In addition, the cytotoxic activities of all isolated compounds, except for veramitaline, were tested. 相似文献
18.
Xi‐Bin Xiao Yue‐Xing Lin Geng‐Bo Xu Xu‐Bo Gong Ying Gu Jie‐Feng Tong Jing Yang 《Helvetica chimica acta》2011,94(3):404-409
A new naphthoquinone, 6‐hydroxy‐α‐dunnione ( 1 ) and a new binaphthoquinone, methyl 1,1′,4,4′‐tetrahydro‐3‐hydroxy‐1,1′,4,4′‐tetraoxo[2,2′‐binaphthalene]‐3′‐carboxylate ( 2 ), along with ten known compounds, including naphthoquinones, anthraquinones, and phenylethanoid glucosides, were isolated from the roots of Didymocarpus hedyotideus Chun . Their structures were identified by spectroscopic analyses, particularly 1D‐ and 2D‐NMR spectroscopy. The cytotoxic activities of the two new naphthoquinones were also evaluated. 相似文献
19.
A phytochemical investigation of the flowers of Salvia miltiorrhiza Bunge led to the isolation of two new oleanane‐ and ursane‐type triterpenoids, (3α)‐olean‐12‐ene‐3,23‐diol ( 1 ) and (3α)‐urs‐12‐ene‐3,23‐diol ( 2 ), as well as of four known triterpenoids. Their structures were elucidated on the basis of spectroscopic evidence, including 1D‐ and 2D‐NMR, HR‐MS, and the X‐ray analysis, and by comparison with literature data. 相似文献
20.
Chang‐Xin Zhou Xue‐Yao Wang Jian‐Xia Mo Jian Zhang Li‐She Gan 《Helvetica chimica acta》2011,94(2):347-354
Two new indolizidine alkaloids, (±)‐3‐oxoisoelaeocarpine ( 1 ) and (±)‐elaeocarpine N‐oxide ( 2 ), along with three known alkaloids, (±)‐isoelaeocarpine ( 3 ), (±)‐elaeocarpine ( 4 ), and (?)‐isoelaeocarpiline ( 5 ), were isolated from an EtOH extract of the branches and leaves of Elaeocarpus sphaericus. The structures of these compounds were determined by spectroscopic and chemical methods. Furthermore, enantiomers of compounds 1 and 3 were separated on a chiral CD‐Ph column, and their absolute configurations were determined by TD‐DFT (=time‐dependent density‐functional theory) quantum‐chemical calculations of their electronic circular dichroism (ECD) spectra. 相似文献