Cover Picture: Electrophoresis 6'2010

Issue no. 6 is a regular issue consisting of 18 full research papers. The first paper is a “Fast Track” contribution involving microchip electrophoresis of Alu elements for gender determination and inference of human ethnic origin. The remaining 17 papers are distributed over 5 different parts: Part I is on some trends in CEC; Part II deals with enantioseparations; Part III describes some novel detection approaches; Part IV has investigations on proteomics and proteins; Part V tackles the subjects related to pathogens, bacteria and the binding of aptamers to small solutes.     

Cover Picture: Electrophoresis 4'2010

Issue no. 4 is a regular issue with Emphasis on “Bioanalysis”. Part I has 12 articles on bioanalysis featuring methodologies for proteomics, proteins, peptides and nucleic acids. Part II has 5 papers on interactive CE, e.g., MEEKC, MEKC and ACE. The remaining 2 articles make up Part III, and are concerned with the regulation of flow in microfluidics and sensitivity enhancement in CEC. Featured articles include: Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in gel electrophoresis. (( 10.1002/elps.200900441.R1 )) An effective SCAR‐PCR method derived from restriction site amplified polymorphism (RSAP) for the identification of female Schistosoma japonicum of zoonotic significance. (( 10.1002/elps.200900615.R1 )) Rapid and sensitive DNA targets detection using enzyme amplified electrochemical detection based on microchip. (( 10.1002/elps.200900538.R1 ))     

Cover Picture: Electrophoresis 12'2010

Issue no. 12 is a regular issue comprising 19 contributions distributed over five distinct parts. Part I has 7 articles describing novel methodologies pertaining to proteins and proteomics. Part II has 3 research papers on CEC stationary phases and CEC‐MS. Part III is on detection approaches including a review article on the advances and applications of chemiluminescence coupled to CE. Part IV has two papers on enantioseparations, and Part V has four contributions on aptamers, human genetic, preparative FFE and microchannels. Featured articles include: Simplified method for concentration of mitochondrial membrane protein complexes (( 10.1002/elps.201000019 )) Analysis of low‐molecular mass aldehydes in drinking waters through capillary electrophoresis with laser‐induced fluorescence detection (( 10.1002/elps.200900734 )) Selection of aptamers for signal transduction proteins by capillary electrophoresis (( 10.1002/elps.200900543 ))     

Cover Picture: Electrophoresis 20'2010

Issue no. 20 is a regular issue comprising 17 contributions distributed over 7 distinct parts. Part I has 3 research articles on particle analysis. Part II has 2 research articles dealing with hyphenated techniques such as CITP‐CZE and CE‐ESI‐MS. Part III reports a variety of methodologies and systems for proteins and proteomics that are described in 4 research articles. Gel DNA: theory and visualization are treated in 2 research articles making up part IV. Part V has 2 contributions that describe CE systems for water analysis. The following Part VI is on affinity and Immunoaffinity CE and has 2 research articles. The last 2 articles in this issue (Part VII) are on MEEKC and free flow electrophoresis. Featured articles include: Dielectrophoretically patterned carbon nanotubes to sort microparticles ((doi: 10.1002/elps.201000104 )) Analysis of 5‐methyltetrahydrofolate in human blood, serum and urine by on‐line coupling of capillary isotachophoresis and zone electrophoresis ((doi: 10.1002/elps.201000193 ))     

Cover Picture: Electrophoresis 21'2010

Issue no. 21 is a regular issue with "Emphasis on Nucleic Acids" and comprises 17 contributions distributed over 4 distinct parts. Part I is on nucleic acids and has 8 research articles on various aspects of nucleic acid research including an automated instrument for human STR identification, a high resolution chip‐CE assay for rapid detection of gene mutations and amplifications, a fluorescence‐based sequence‐specific primer PCR, pulsed field CE for RNA separation, methylated DNA immunoprecipitation sequencing, PCR‐SSCP, DNA methylation, and analysis of SNPs. Part II has 4 research articles dealing with studies on protein and proteomics analysis, e.g., microchip IEF, CE analysis of microheterogeneous glutelin subunits in rice, protein precipitation methods and prefractionation of plasma for proteomic analysis. Part III has 2 contributions that describe the separation of the enantiomers of DL‐isocitric acid by CE and the analysis of trace degradation products of S‐adenosylmethionine, which are decarboxylated diastereomers, by CE. The last 3 articles in this issue (Part IV) are on novel methodologies for facile interfacing of CE with MS, electrokinetic chromatography for the determination of contaminants and impurities of heparin samples, and particle electrophoresis. As such, issue no. 21 is packed with the latest developments and innovations in the field. Featured articles include: An automated instrument for Human STR identification: design, characterization, and experimental validation (doi: 10.1002/elps.201000305 )) Miniature flowing atmospheric‐pressure afterglow ion source for facile interfacing of capillary electrophoresis with mass spectrometry (doi: 10.1002/elps.201000350 )) Capillary electrophoresis for analysis of microheterogeneous glutelin subunits in rice (Oryza sativa L.). (doi: 10.1002/elps.201000333 ))     

Cover Picture: Electrophoresis 2'2010

Issue no. 2 has 19 contributions including one Fast Track contribution on “Thermophoresis of ssDNA”. The remaining 18 articles cover a wide variety of investigation involving nucleic acids, cells, viruses, interactive CE, detection methodologies in CE, enantioseparations, and studies on proteins and proteomics. Further selected articles include: Capillary electrophoresis of bone marrow stromal cells with uptake of heparin‐functionalized poly(lactide‐co‐glycolide) nanoparticles during differentiation towards neurons. (( 10.1002/elps.200900336 )) Ghrelin‐liposome interactions. Characterization of liposomal formulations of an acylated 28‐amino acid peptide using capillary electrophoresis. (( 10.1002/elps.200900394 ))     

Cover Picture: Electrophoresis 3'2012

Issue no. 3 is a regular issue consisting of 17 contributions distributed over 5 separate parts. The issue starts with 4 research articles on micro‐ and nanofluidics making up Part I. This is followed by Part II that has 5 research articles involving studies on proteins, peptides and proteomics. Part III has 3 contributions dealing with studies on nucleic acids. Part IV has 3 research articles on enantioseparation methodologies. The last part (Part V) consists of 2 contributions on various aspects of preconcentration in CE of drug of abuse and their metabolites and the sensitive monitoring for ribonucleotide reductase activity. This issue, with as few as 17 contributions, is rich in very important ideas in the field for further investigations. Featured articles include: Modeling of droplet traffic in interconnected microfluidic ladder devices (( 10.1002/elps.201100320 )) Role of streaming potential on pulsating mass flow rate control in combined electroosmotic and pressure‐driven microfluidic devices (( 10.1002/elps.201100414 )) Carotid atherosclerotic plaques: Proteomics study after a low‐abundance protein enrichment step (( 10.1002/elps.201100395 )) Quantitative experimental determination of primer‐dimer formation risk by free‐solution conjugate electrophoresis (( 10.1002/elps.201100452 )) Electromembrane extraction combined with cyclodextrin‐modified capillary electrophoresis for the quantification of trimipramine enantiomers (( 10.1002/elps.201100426 ))     

Cover Picture: Electrophoresis 2'2012

Issue no. 2 is a regular issue consisting of 18 contributions distributed over 5 distinct parts. The issue has an “Emphasis on Proteins and Proteomics” with 7 contributions featured in Part I. This is followed by Part II that has 4 research articles on nanopore and nanoparticles based analyses. Part III has 2 contributions on agarose gel electrophoresis for the analysis of the structure fluidity of a phage T3 DNA packaging intermediate and analyzing RNA quality. Part IV has two research articles on microchip capillary electrophoresis with poly(ethylene glycol)‐coated microfluidic devices and poly(dimethylsiloxane) microchips using a mixture of ionic and zwitterionic surfactants. The last part (Part V) consists of 3 contributions on CE of some common controlled stimulants, CE test of a blood‐brain barrier model and the simultaneous determinations of nitrite and nitrate in human plasma by CE. This issue is populated by a collection of very important research articles. It is a must read. Featured articles include: The challenge to quantify proteins with charge trains due to isoforms or conformers (( 10.1002/elps.201100321 )) Electrophoretically‐driven SDS removal and protein fractionation in the shotgun analysis of membrane proteomes (( 10.1002/elps.201100364 )) Modeling and simulation of nanoparticle separation through a solid state nanopore (( 10.1002/elps.201100201 )) A novel open‐tubular capillary electrochromatography with magnetic nanoparticle coating as stationary phase (( 10.1002/elps.201100337 )) Direct visualization of electrophoretic mobility shift assays using nanoparticle‐aptamer conjugates (( 10.1002/elps.201100308 ))     

Cover Picture: Electrophoresis 11'2011

Issue no. 11 is a regular issue consisting of 17 contributions distributed over 6 distinct parts: Part I is on fundamentals and methodologies containing 4 research articles dealing with electrokinetic transport through nanochannels, electroosmotic flow in polygonal ducts, analysis of complex samples by mass spectrometry using a sample pretreatment by preparative CITP, and CE analysis of inorganic cations in post‐blast residue extracts; Part II has 5 contributions on various aspects of proteomics and proteins including structural analysis of the recombinant therapeutic product rFVIII, electrophoretic characterization of proteins isolated by various extraction methods from ejaculated and capacitated boar sperms, CE separations of proteins using cationic poly(amidoamine) dendrimers, hemoglobin depletion in erythrocyte cytosolic samples, and peptide fractionation by acid pH SDS‐free electrophoresis; Part III is on separations of malignant cells, and particle capture in a droplet using dielectrophoresis; Part IV has two contributions on CEC separations; Part V consists of two papers on genetic variability and amplification; Part VI is on food analysis with one review article on CE applications in food analysis and one research paper on the determination of betaines in vegetable oils by CE‐MS. Thus, issue no. 11 covers many important subjects. Featured articles include: Electrokinetic transport through nanochannels (( 10.1002/elps.201000564 )) Interdigitated comb‐like electrodes for continuous separation of malignant cells from blood using dielectrophoresis (( 10.1002/elps.201000625 )) Experimental study of dielectrophoresis and liquid dielectrophoresis mechanisms for particle capture in a droplet (( 10.1002/elps.201000548 )) Thirty years of capillary electrophoresis in food analysis laboratories: Potential applications (( 10.1002/elps.201000541 ))     

Cover Picture: Electrophoresis 12'2011

Issue no. 12 is a regular issue consisting of 18 contributions distributed over 4 distinct parts: Part I is on protein and proteomics methodologies containing 6 research articles dealing with new fluorescent probe for gel electrophoresis of proteins, treatment of serum samples with combinatorial library beads, glycoproteomics analysis of haptoglobin multimers, micropreparative isoelectric focusing in a suspended drop, and 2‐DE and MALDI‐TOF‐MS analysis of the therapeutic protein abatacept; Part II has 4 contributions on various approaches of genotyping; Part III treats on‐line concentration and sensitivity enhancement of angiotensins and pyridine‐triphenylborane and its degradation products; Part IV has 6 contributions on some aspects of fundamentals and methodologies involving EMMA, effects of carbon dioxide in CE at high pH, particle sorting by dielectrophoresis, CE‐electrochemiluminescence with ionic liquid, enantioseparation by monolithic imprinted capillary clamped in a chip, and infrared‐based temperature measurements in CE. In summary, issue no. 12 covers many important subjects in the field. Featured articles include: Design and synthesis of new fluorescent probe for rapid and highly sensitive detection of proteins via electrophoretic gel stain (( 10.1002/elps.201000691 )) Glycoproteomic analysis and molecular modeling of haptoglobin multimers (( 10.1002/elps.201000464 )) PCR‐free digital minisatellite tandem repeat genotyping (( 10.1002/elps.201000073 )) A dielectrophoretic continuous flow sorter using integrated microelectrodes coupled to a channel constriction (( 10.1002/elps.201000675 ))     

Cover Picture: Electrophoresis 2'09

Regular issues provide a wide range of research and review articles covering all aspects of electrophoresis. Here you will find cutting‐edge articles on methods and theory, instrumentation, nucleic acids, CE and CEC, miniaturization and microfluidics, proteomics and two‐dimensional electrophoresis. Issue no. 2 has a “Fast Track” paper on the attomole protein analysis by capillary isoelectric focusing (CIEF) with LIF detection based on a post‐column sheath flow cuvette employing Chromeo P503 as a fluorogenic reagent for protein labeling before CIEF analysis. Further selected topics of issue 2 are: Influence of image‐analysis software on quantitation of two‐dimensional gel electrophoresis data A PDMS sheath flow cuvette for high‐sensitivity LIF measurements in CE     

Cover Picture: Electrophoresis 15'09

Issue no. 15 is a regular issue consisting of 20 research papers distributed over 7 different parts dealing with various fundamental studies, analytical methodologies, various aspects of proteins and protein biomarkers, affinity studies, genetics, pathogens and toxins, and enantioseparations.