共查询到20条相似文献,搜索用时 78 毫秒
1.
2.
对天然产物Isocoene全合成研究方法进行了综述。分析了各合成路线的关键步 骤,并部分讨论了各方法的优缺点。 相似文献
3.
以2,3-二羟基苯甲酸为起始原料,通过酯化、Williams、水解、酰胺化、Robinson-Gabriel环化、脱保护等一系列反应成功合成了gymnothecaoxazoles A,总收率为20.0%,其结构经~1H NMR、~(13)C NMR和HRMS确证。此方法原料廉价易得,反应条件温和,操作简单,为快速制备gymnothecaoxazoles A提供了参考。 相似文献
4.
5.
研究了通过烯丙基环状氨基甲酸酯的脱环羧化得到2-取代-△^3-哌啶和吡咯烷的机理, 并讨论了应用这一反应于新疆党参碱的全合成。 相似文献
6.
7.
8.
9.
10.
11.
12.
13.
Prof. Won‐jin Chung Prof. Christopher D. Vanderwal 《Angewandte Chemie (International ed. in English)》2016,55(14):4396-4434
At last count, nearly 5000 halogenated natural products have been discovered. In approximately half of these compounds, the carbon atom to which the halogen is bound is sp3‐hybridized; therefore, there are an enormous number of natural products for which stereocontrolled halogenation must be a critical component of any synthesis strategy. In this Review, we critically discuss the methods and strategies used for stereoselective introduction of halogen atoms in the context of natural product synthesis. Using the successes of the past, we also attempt to identify gaps in our synthesis technology that would aid the synthesis of halogenated natural products, as well as existing methods that have not yet seen application in complex molecule synthesis. The chemistry described herein demonstrates yet again how natural products continue to provide the inspiration for critical advances in chemical synthesis. 相似文献
14.
15.
Although numerous glycosylation methods have been developed for the construction of glycosidic bonds, the pace of discovering rapid assembly strategies to access complex glycosidic linkages never stops. Over the last several years, we have introduced interrupted Pummerer reaction into carbohydrate chemistry and developed two pairs of latent/active glycosyl donors, OPTB/OPSB and SPTB/SPSB glycosides. After thorough investigation of the reaction mechanism and establishment of the substrate scopes, the extension of these novel glycosylation methods to synthesize naturally occurring biological active glycoconjugates was further illustrated. In this account, the development and especially the application of IPRm glycosylation in the synthesis of phenylethanoids and resin glycosides were introduced. 相似文献
16.
以对羟基苯甲醛和2,4-二羟基苯乙酮为起始原料,经过甲氧甲基化、溴代、Ullmann反应、羟醛缩合和脱保护等反应,完成了天然产物双查尔酮Luxenchalcone的全合成,关键步骤为Ullmann反应,重要中间体和目标产物的化学结构经 1H NMR,13C NMR和ESI-MS等表征确认. 相似文献
17.
Matthew R. Wilson Dr. Richard E. Taylor 《Angewandte Chemie (International ed. in English)》2013,52(15):4078-4087
Strained molecules continue to challenge the ingenuity of chemists as their high‐energy bonds serve as fuel for the promotion of complex synthetic transformations. Developments in this area have resulted in the recent emergence of strained alkenes as intermediates in natural product synthesis. This Minireview highlights these recent advances along with current developments toward understanding the unique reactivity of strained alkenes. 相似文献
18.
Tetrodotoxin, a toxic principle of puffer fish intoxication, is one of the most famous marine natural products due to its densely functionalized structure and potent toxicity. Despite its small molecular size (MW 319 g mol?1), tetrodotoxin has long been well known as a formidable molecule in natural product synthesis. We have devoted more than twenty years to developing synthetic strategies for this molecule, resulting in the preparation of a variety of analogues of tetrodotoxin for biological experiments. This account describes a brief history of tetrodotoxin research and an overview of our synthetic efforts toward tetrodotoxin with the underlying logic and strategy. 相似文献
19.
20.
A concise synthesis of novel cardiac glycoside analogues of rhodexin A, 14 and 24, having the BCD tricyclic system is described. The key constructive step is an inverse-electron demand Diels-Alder reaction of the silyl enol ether 4 and the 2-acetyldiene, 7 and 15. 相似文献