共查询到20条相似文献,搜索用时 15 毫秒
1.
通过小样品精密自动绝热量热计测定了合成并提纯的 4,6 二甲基 N 苯基 2 嘧啶胺 (嘧霉胺 )在 78~ 3 91K温区的摩尔热容 .量热实验发现 ,该化合物在 3 63~ 3 72K温区 ,有一固 -液熔化相变过程 ,经三次重复测量 ,得其熔化温度、摩尔熔化焓及摩尔熔化熵分别为 :( 3 70 78± 0 0 8)K ,( 2 1 2 3 3± 0 0 13 )kJ·mol-1 和 ( 5 7 2 7± 0 15 )J·mol-1 ·K-1 .通过分步熔化法得到该物质绝对纯样品的熔点为 3 71 0 3 1K .用差示扫描量热 (DSC)技术对该物质的固 -液熔化过程作了进一步研究 ,结果与绝热量热法一致 相似文献
2.
Fluorinated N-[2-(haloalkyl)phenyl]imidoyl chloride, which was readily available from the corresponding anilines by using Uneyama's one-pot synthesis of fluorinated imidoyl chloride, was found to be a key intermediate for the facile synthesis of 2-fluoroalkyl substituted indole derivatives via the Grignard cyclization process. The bromination of 3-methyl group of 3-methyl-2-trifluoromethyl indole with NBS/CCl4 led to the formation of 3-bromomethyl substituted indole which can be further utilized to synthesize some new and biologically interested indole derivatives. 相似文献
3.
4.
Kena Zhang Hui Li Jingya Li Dapeng Zou Yangjie Wu Yusheng Wu 《Tetrahedron letters》2017,58(20):1976-1979
An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives were obtained in good to excellent yields using DavePhos as optimal ligand for Pd-catalyzed Buchwald-Hartwig amination reaction. After a mild and efficient acidolysis the amination products could be obtained successfully. 相似文献
5.
Tosylation of N-aryl amidoxime in the presence of TEA produces the corresponding benzimidazoles in high yields. 相似文献
6.
Vadabingi Nagalakshmamma Mavallur Varalakshmi Kollu Umapriya Mallepogu Venkataswamy Chintha Venkataramaiah Kedam Thyaga Raju Ponne Venkata Chalapathi Chamarthi NagaRaju 《中国化学会会志》2020,67(7):1289-1295
A series of new bis sulfonamide/carbamate derivatives of bis-(4-aminophenyl)methane 3 ( a–d )/ 5 ( a–f ) were synthesized from bis-(4-aminophenyl)methane ( 1 ) using various pharmacologically active sulfonyl chlorides 2 ( a–d ) and carbonochloridates 4 ( a–f ) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR (1H and 13C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2-diphenyl-1-picrylhydrazyl, NO, and H2O2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities. 相似文献
7.
8.
Zheng Bao Zhao Hui Xia Zheng Yuan Gui Wei Jiang Liu College of Pharmacy Shanxi Medical University Taiyuan China First Clinical College Shanxi Medical University Taiyuan China 《中国化学快报》2007,18(6):639-642
For searching a better 4-aminosalicylic acid derivative with higher activity and less side effects against the inflammatory bowel disease, 4-aminosalicylic acid (4-ASA) was protected by benzyloxycarbonyl and acetyl, respectively. The resultant was hydrogenized to remove protective group of amino group, then the product was reacted with NaNO2 to give diazonium salt, which was conjugated with salicylic acid, hydroxybenzene, TV-salicyloyl glycine acid to get azo derivatives of 4-ASA. The azo derivatives were hydrolyzed under the alkaline condition to get the target products. All compounds were characterized by FT-IR, 1H NMR, 13C NMR spectra in details. New derivatives of 4-ASA were characterized. The synthetic route was reasonable and feasible. 相似文献
9.
M. Emin Günay Osman Dayan Ayta Gürhan Gke Muhittin Aygün Bekir etinkaya Orhan Büyükgüngr 《Polyhedron》2008,27(18):3607-3610
Treatment of N,N′-bis(mesityl)pyridine-2,6-carboxyimidoyl dichloride, 1, in toluene solution with [Pt(PPh3)4] at 100 °C afforded a novel platinacyclic compound, 3, in 63% yield, instead of the expected compound 2. The molecular and crystal structures of the title compound, 3, have been determined by the single crystal X-ray diffraction technique. The coordination geometries around the Pt atoms are distorted square-planar. In the crystal structure, the molecules are linked by a pair of C–H···N hydrogen bonds into a centrosymmetric dimer with an ring, centred at (1/2,1/2,1/2). 相似文献
10.
11.
Shi Fei Sheng~a Hui Xia Zheng~b Jiang Liu~a Zheng Bao Zhao~ 《中国化学快报》2008,19(4):419-422
To explore the better prodrug of 4-aminosalicylic acid(4-ASA)with higher activity and less side effects against the inflammatory bowel disease.4-ASA,after a succession of synthesis process,was conjugated with various carder molecules to get seven azo derivatives of 4-ASA.All compounds were characterized by FT-IR,^1H NMR,^13C NMR spectras in detail.New derivatives of 4-ASA were definituded. 相似文献
12.
A series of thiourea derivatives have been synthesized. Their structures were confirmed by MS and 1H NMR. Several compounds showed potent activities as antagonists of CCR4 receptor. 相似文献
13.
Yue Mei Jia Xiao Mei Liang Xue Qin.Fang Jing Ping Wu Dao Quan Wang Chang Hui Rui Xian Lin Fan Hai Yan Zhao Yun Xia Wang 《中国化学快报》2007,18(8):895-898
Six new 4"-benzyloxyimino-4"-deoxyavermectin B la derivatives were synthesized from avermectin Bla by the selective protection of C-5-hydroxy group, oxidation of C-4"-hydroxy group, and deprotection followed by reaction with O-substituted hydroxylamine hydrochlorides. Their structures were confirmed by IR, 1H NMR, 13C NMR and MS. Insecticidal activities of the derivatives against Phopalosiphum pseudobrassicae, Spodoptera exigua and Pluteua xylosteua were evaluated. 相似文献
14.
Bogdan A. Demydchuk Kostyantyn M. Kondratyuk Andrey N. Korniyenko Vladimir S. Brovarets Roman Y. Vasylyshyn Andrey Tolmachev 《合成通讯》2013,43(19):2866-2875
A four-step preparative-scale synthesis of eight 2-alkyl- and arylsubstituted thiazole-4-sulfonyl chlorides from chloralamides is reported. Good yields and easy availability of starting materials are valuable advantages of the procedure that gives access to formerly unattainable building blocks. 相似文献
15.
A novel one-pot protocol for the synthesis of substituted 2-aminooxazoline from isonitriles and 2-aminoethanol was developed and the reactions involved imidoyl diiodide intermediates,which were generated by mixing isonitriles and iodine in CH2C12 at room temperature. 相似文献
16.
New 4-aminoquinolines having a -CF2CH-(heteroaryl)-OH moiety are obtained in moderate yields from the electrochemical catalyzed reaction of the corresponding 4-amino-3-chlorodifluoroacetyl-2-methoxyquinoline in the presence of heteroaryl aldehydes. A one-pot intramolecular zinc mediated aromatic nucleophilic substitution also gave access to novel difluorinated 5-aminodihydropyrano[2,3-b]quinolin-4-ones. 相似文献
17.
<正>A series of new 4-substituted benzoxazolone derivatives were synthesized according to a convenient method,their anti-inflammatory and analgesic activities in vivo were evaluated.All of them were new compounds,the structures of all the synthesized compounds were confirmed by ~1H NMR,~(13)C NMR,ESI-MS and HR-MS.Most of the compounds exhibited anti-inflammatory activity. 相似文献
18.
V. N. Yarovenko A. S. Nikitina I. V. Zavarzin M. M. Krayushkin L. V. Kovalenko 《Russian Chemical Bulletin》2007,56(8):1624-1630
A series of new 2-thioxo-1,3-thiazolidin-4-one derivatives containing arylidene, arylazo, and aminomethylene fragments in
position 5 of the rhodanine cycle was synthesized.
Dedicated to Academician V. A. Tartakovsky on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1564–1569, August, 2007. 相似文献
19.
N. Z. Tugusheva L. M. Alekseeva A. S. Shashkov V. V. Chernyshev V. G. Granik 《Russian Chemical Bulletin》2006,55(8):1475-1486
New approaches to the synthesis of the previously unknown pyrimidine, 4-amino-2-pyridone, and 4-aminopyridine derivatives
were developed based on the reactions of enaminoamides with dimethylformamide dimethyl acetal. New structural modifications
of 4-amino-2-pyridone derivatives were performed. Numerous compounds of this type, which are of interest for biological studies,
were prepared.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1421–1432, August, 2006. 相似文献
20.
4-Arylpyridines 5 that contain electron-withdrawing groups such as nitrile, methyl ester, fluoride, and trifluoromethyl on the benzene ring were synthesized in moderate yields (29-63%) by reaction of mixed copper, zinc aryl organometallics 1 with various 1-(ethoxycarbonyi)pyridinium chlorides 2 followed by o-chloranil oxidization under reflux in toluene. 相似文献