共查询到19条相似文献,搜索用时 187 毫秒
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合成了一种新的对-叔丁基杯[8]芳烃的高效液相色谱键合固定相,考察了多环芳烃、苯甲酸酯、邻苯二甲酸酯、苯的单官能团取代物在该键合相上的反相液相色谱保留行为,并以甲醇-水作为流动相分离了氨基苯酚的邻、间、对取代位置异构体.研究结果发现,该键合相具有明显的反相特征,并讨论了可能的分离机理. 相似文献
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将超分子自组装技术与色谱键合硅胶固定相制备技术相结合,采用γ-[(2,3)-环氧丙氧]丙基三甲氧基硅烷(KH-560)为偶联剂,首次将一种葫芦[6]脲单轮烷(CB6MR)键合到硅胶上,制备了一种新型的葫芦[6]脲单轮烷键合固定相(CB6MRBS)。通过元素分析、红外光谱和热分析对该固定相进行了结构表征。以中性、酸性、碱性化合物和二取代苯位置异构体等溶质为探测因子,分别在反相和正相色谱模式下对固定相的色谱性能和保留机理进行了研究。结果表明:CB6MRBS是一种多模式键合固定相,具有良好的正相和反相色谱性能,对位置异构体具有较高的识别能力,尤其是可有效地用于碱性化合物的分离分析。其保留机理存在氢键、静电、π-π和疏水作用等多种作用力机制,协同作用提高了CB6MRBS对溶质的分离选择性。由于CB6MR配体中含有酰胺基和众多极性羰基,CB6MRBS可能在络合色谱面有应用前景。 相似文献
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Summary For the first time calix[6]arene has been chemically combined with silica gel via a longer spacer to prepare calix[6]arene-bonded
silica gel stationary phase for high-performance liquid chromatography (HPLC). The separation of positional isomers and polycyclic
aromatic hydrocarbons on the calix[6]arene-bonded phase was achieved with methanol-water as mobile phase. Some nucleosides
were also separated on the bonded phase. The reversed-phase chromatographic performance of the bonded phase was studied. The
results showed that the calix[6]arene-bonded phase was highly hydrophobic. A possible separation mechanism has been proposed. 相似文献
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In recent years, calix[n]arenes (n=4,5,6,7,8) as stationary phase have been introduced into the field of chromatography. In our previous works, we have synthesized, characterized and evaluated two different silica-bonded calix[n]arenes (n=4,6) stationary phase, on which the chromatographic behavior of PAHs, positional isomers,nucleosides and bases was investigated. In this paper we report the preparation of calix[8]arene bonded silica stationary phase, and characterization of its structure and chromatographic behavior. 相似文献
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Bromoacetate‐substituted [3‐(2‐O‐β‐cyclodextrin)‐2‐hydroxypropoxy]propylsilyl‐appended silica particles (BACD‐HPS), an important and useful synthetic intermediate for preparation of novel types of macrocycles‐capped β‐CD‐bonded silica particles including crown ether/cyclam/calix[4]arene‐capped β‐CD‐bonded silica particles, have been prepared and used as chiral stationary phase for HPLC. This synthetic stationary phase is characterized by means of elemental analysis. For the first time, the chromatographic behavior of BACD‐HPS was systematically evaluated with several disubstituted benzenes and some chiral drug compounds under both normal and RP conditions in HPLC. The results show that BACD‐HPS has excellent selectivity for the separation of aromatic positional isomers and chiral isomers of some drug compounds when used as stationary phase in HPLC. 相似文献
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Calix[4]arene-capped [3-(2-O-beta-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (C4CD-HPS), a new type of substituted beta-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by treatment of bromoacetate-substituted [3-(2-O-beta-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (BACD-HPS) with calix[4]arene oxyanions in anhydrous N-methyl-2-pyrrolidone. The synthetic stationary phase is characterized by means of elemental analysis. This new type of CSP has a chiral selector with two recognition sites: calix[4]arene and beta-cyclodextrin (beta-CD). The chromatographic behavior of C4CD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase conditions. The results show that C4CD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of calix[4]arenes and beta-CDs. 相似文献
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Wenfen Zhang Yongming Zhang Guangrui Zhang Xin Ba Shaige Xia Wuduo Zhao Dan Yin Shusheng Zhang 《Journal of separation science》2019,42(7):1374-1383
A new water‐soluble tetra‐proline‐modified calix[4]arene‐bonded silica stationary phase was prepared straightforwardly by an indirect method and characterized by elemental analysis, energy dispersive Spectrometry, solid‐state 13C NMR spectroscopy, Fourier‐transform infrared spectroscopy, and thermogravimetric analysis. Due to the simultaneous introduction of polar tetra‐proline and nonpolar calix[4]arene, the developed column possessing a double retention mode of reverse‐phase liquid chromatography and hydrophilic interaction liquid chromatography. A series of hydrophobic and hydrophilic test samples, including nucleosides and nucleotides, amines, monosubstituted benzenes, chiral compounds, and phenols, were used to evaluate the developed stationary phase. A rapid separation capability, high separation efficiency, and selectivity were achieved based on the multiple interactions between solutes and tetra‐proline‐modified calix[4]arene‐bonded silica stationary phase. Moreover, the developed stationary phase was further used to detect and separate hexamethylenetetramine in rice flour. All the results indicated the potential merits of the developed stationary phase for simultaneous separation of complex hydrophobic and hydrophilic samples with high selectivity. 相似文献
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合成了两种新型的杯(4)芳烃衍生物:5-1′,1′-二甲基十一烯氧基苯基甲基-11,17,23-三-1,1-二甲基乙基-25,26,27,28-四苄氧基杯(4)芳烃C(4)TB)及5-1′,1′-二甲基十一烯氧基苯基甲基-11,17,23-三-1′,1′-二甲基-25,26,27,28-四乙氧羰甲氧基(C(4)TECM)其结构经元素分析IR,^1HNMR,MS的数据证实,分别将其与OV-1701固 相似文献
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Preparation and characterization of six calixarene bonded stationary phases for high performance liquid chromatography 总被引:1,自引:0,他引:1
Six calixarene bonded silica gel stationary phases were prepared and characterized by elemental analysis, infrared spectroscopy and thermal analysis. Their chromatographic performance was investigated by using PAHs, aromatic positional isomers and E- and Z-ethyl 3-(4-acetylphenyl) acrylate isomers as probes. Separation mechanism based on the different interactions between calixarenes and analytes were discussed. The chromatographic behaviors of those analytes on the calixarene columns were influenced by the supramolecular interaction including pi-pi interaction, space steric hindrance and hydrogen bonding interaction between calixarenes and analytes. Notably, the presence of polar groups (-OH, -NO(2) and -NH(2)) in the aromatic isomers could improve their separation selectivity on calixarene phase columns. The results from quantum chemistry calculation using DFT-B3LYP/STO-3G* base group were consistent with the retention behaviors of PHAs on calix[4]arene column. 相似文献