Triterpene glycosides ofAstragalus and their genins. VI. Cycloasgenin C fromAstragalus taschkendicus

A new isoprenoid — cycloasgenin C — has been isolated from the roots of the plantAstragalus taschkendicus C. Bge, and on the basis of chemical transformations and spectral characteristics its structure has been established as 24(R)-cycloartane-3β,6α,16β,24,25-pentaol.     

Triterpene glycosides ofAstragalus and their genins. VIII. Askendoside C fromAstragalus taschkendicus

A new glycoside of the cycloartane series — askendoside C — has been isolated from the roots of the plantAstragalus taschkendicus Bge., and its structure has been established on the basis of chemical transformations and spectral characteristics as 24R-cycloartane-3,6,16,24,25-pentaol 3-[0--L-arabinopyranosyl-(12)--D-xylopyranoside].Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 173–180, March–April, 1983.     

Triterpene glycosides ofAstragalus and their genins. Liv. askendoside G fromAstragalus taschkendicus

Chromatography of the polar fraction of a methanolic extract of the roots ofAstragalus taschkendicus Bunge (Leguminosae) has given a new triterpene glycoside of the cycloartane series, askendoside G, having the structure of 24R-cycloartane-3,6,16, 24, 25 pentaol 3-O-[(-L-arabinopyranosyl)-(12)--D-xylopyrano-side] 16-O--D-glucopyranoside.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 723–727, September–October, 1996. Original article submitted May 1, 1996.     

Triterpene glycosides ofAstragalus and their genins. IX. Askendoside D fromAstragalus taschkendicus

A new glycoside of the cycloartane series — askendoside D — has been isolated from the roots of the plantsAstragalus taschkendicus Bge., and on the basis of chemical transformations and spectral characteristics its structure has been established as 20S, 24R-epoxycycloartane-3, 6, 16, 25-tetraol 3-0-[0--L-arabinopyranosyl-(1 2)--D-xylopyranoside] 6-0--D-xylopyranoside.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 180–185, March–April, 1983.     

Triterpene glycosides ofAstragalus and their genins. III. Cycloasgenin a fromAstragalus taschkendicus

The new isoprenoid cycloasgenin A has been isolated from the roots of the plantAstragalus taschkendicus C. Bge., and its structure has been established on the basis of chemical transformations and spectral characteristics as 6α,11α,16β, 25-tetrahydroxy-20(S), 24(R)-epoxycycloartan-3-one.     

Triterpene glycosides ofAstragalus and their genins. XXII. Cycloorbicoside A fromAstragalus orbiculatus

The quantitatively main glycoside — cycloorbicoside A — has been isolated from the epigeal parts of the plantAstragalus orbiculatus, and on the basis of chemical transformations and spectral characteristics its structure has been established as (23R,24S)-16β,23:16α,24-diepoxycycloartane-3β,7β,25-triol 3-0-β-D-xylopyranoside.     

Triterpene glycosides ofAstragalus and their genins. XVII. Cycloasgenin B fromAstragalus tashkendicus

The roots ofAstragalus tashkendicus Bge. have yielded a new triterpenoid — cycloasgenin B – the structure of which has been established on the basis of chemical transformations and spectral characteristics as (24R)-6α,11α,16β,24,25-pentahydroxycycloartan-3-one.     

Triterpene glycosides ofAstragalus and their genins

The roots of Astragalus taschkendicus Bunge (Leguminosae) have yielded the new cycloartane glycoside askendoside F which is 24R-cycloartan-3β,6α,16β,24, 25-pentaol 3-O-[O-α-L-arabinopyranosyl-(1→2)-β-D-xylopyranoside] 25-O-D-glucopyranoside, and D-3-O-methyl-chiro-inositol.     

Triterpene glycosides ofAstragalus and their genins. XV. Cyclosiversiosides B and D fromAstragalus basineri

Two new glycosides have been isolated from the roots of the plantAstragalus basineri Trautv. — cyclosiversiosides B and D. It has been shown that cyclosiversioside B is cyclosiversigenin 3-O-(2,3-di-O-acetyl--D-xylopyranoside)-6-O--D-glucopyranoside. Cyclosiversioside D is cyclosiversigenin 3-O-(2-O-acetyl--D-xylopyranoside)-6-O--D-glucopyranoside.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 188–191, March–April, 1984.     

Triterpene glycosides ofAstragalus and their genins. IV. Cyclosieversioside E — A new diglycoside fromAstragalus sieversianus

A new glycoside of the cycloartane series has been isolated from the roots of the plantAstragalus sieversianus Pal.; it is cyclosieversigenin 3,6-di-O-β-xyloside.     

Triterpene glycosides ofAstragalus and their genins XLIX. Structures of cycloalpigenin C and cycloalpioside C

The structures of the new cycloartane triterpenoid cycloalpigenin C and its glycoside cycloalpioside C, isolated from the epigeal pan of Astragalus alopecurus Pall. (Leguminosae), have been determined. Cycloalpigenin C is 20R, 24S-epoxycycloartane-3,12,16, 25-tetraol, and cycloalpioside C is the 3-O- D-xylopyranoside of cycloalpigenin C.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 88–95, January–February, 1995. Original article submitted October 25, 1994.     

Triterpene glycosides ofAstragalus and their genins. VII. Structures of cyclosieversiosides A and C

Two new glycosides, cyclosieversiosides A and C, have been isolated from the roots ofAstragalus sieversianus Pall.Cyclosieversioside A is cyclosieversigenin 3-0-(2′,3′-di-0-acetyl-β-D-xylopyranoside) 6-0-β-D-xylopyranoside. Cyclosieversioside C is cyclosieversigenin 3-0-(2′-0-acetyl-β-D-xylopyranoside) 6-0-β-D-xylopyranoside.     

Triterpene glycosides ofAstragalus and their genins LVII. The structure of cyclopycnanthogenin

A new cycloartane methysteroid cyclopycnanthogenin, has been found in stems of the plantAstragalus pycnanthus Boriss. (Leguminosae). Its structure has been determined on the basis of IR, mass, and¹H and¹³C NMR spectra with the involvement of DEPT experiments and 2M¹H−¹H and¹H−¹³C chemical shift correlations [¹H−¹H COSY and¹H−¹³C (HMQC)] and also 2M NMR correlations of long-range¹H−¹³C interactions (HMBC). Cyclopycnanthogenin is 6α, 16β, 25-trihydroxy-20R, 24S-epoxycycloartane-3-one. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 515–518, July–August, 1998.     

Triterpene glycosides ofAstragalus and their genins LV. Structure of cycloorbigenin A

The structure of the new cycloartane triterpenoid cycloorbigenin A, isolated fromAstragalus orbiculatus, has been established on the basis of spectral characteristics. Cycloorbigenin A is (23R,24S)-16,2316,24-diepoxycycloart-6-ene-3,25-diol.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 848–850, November–December, 1997.     

Triterpene glycosides ofAstragalus and their genins. II. The structure of cyclosieversigenin

The bitter plantAstragalus sieversianus has yielded a new isoprenoid cyclosieversigenin the structure of which has been established on the basis of spectral characteristics and chemical transformations as 20(S),24(R)-epoxycycloartane-3,6,16, 25-tetraol.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 67–76, January–February, 1981.     

Triterpene glycosides ofAstragalus and their genins. V. Structure of cyclosieversioside F

A new glycoside of the cycloartane series has been isolated from the roots of the plantAstragalus sieversianus Pall. and it has been shown to be cyclosieversigenin 6-0-β-D-glucopyranoside 3-0-β-D-xylopyranoside.     

Triterpene glycosides ofAstragalus and their genins LVIII. The structure of dihydrocycloorbigenin A

The herbage of the plantAstragalus orbiculatus Lebed. (Leguminosae) has yielded the new cycloartane triterpenoid dihydrocycloorbigenin A, which has the structure of (23R, 24S)-16β, 23; 16α, 24-diepoxycycloartane−3β, 25-diol. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 519–522, July–August, 1998.