应用激光解吸质谱和十二烷基硫酸钠—聚丙烯酰胺凝胶电泳分析蛇毒？…

应用基质辅助激光解吸电离飞行时间质谱（ＭＡＬＤＩ－ＴＯＦ－ＭＳ）和ＳＤＳ－聚丙烯酰胺凝胶电流对吉林省两地市的同种白眉蝮蛇蛇毒中具有抗栓塞药效的精氨酸酯酶进行了分析了分析和比较。ＭＡＬＤＩ－ＴＯＦ－ＭＳ法具有快速、准确度高、灵敏度高的优点,两种方法结合,互为补充,取得了令人满意的结果。ＭＡＬＤＩ－ＴＯＦ－ＭＳ完全可以直接用作蛇毒成分分离过程中重要的研究手段。     

基质辅助激光解吸电离飞行时间质谱研究（I）：林芳烃化合物

采用基质辅助激光解吸电离飞行时间质谱（ＭＡＬＤＩ－ＴＯＦ－ＭＳ）对杯芳烃化合物进行了分析。探讨了样品的制备条件、仪器操作参数等因素对测定结果的影响。２５种样品的质谱数据表明,利用ＭＡＬＤＩ－ＴＯＦ－ＭＳ可非常方便地得到灵敏度、分辨率、准确度均较高,且易于识别和解析的质谱图,为此类化合物的质谱表征提供和建立了一种新的高效分析方法。     

AB INTIO THEORETICAL STUDY OF MIXED CLUSTER AICB

ＡＢ　ＩＮＴＩＯ　ＴＨＥＯＲＥＴＩＣＡＬ　ＳＴＵＤＹ　ＯＦ　ＭＩＸＥＤ　ＣＬＵＳＴＥＲ　ＡＩＣＢＡＢＩＮＴＩＯＴＨＥＯＲＥＴＩＣＡＬＳＴＵＤＹＯＦＭＩＸＥＤＣＬＵＳＴＥＲＡＩＣＢ￥ＧｕａｎｇＰｉｎｇＬＩ；ＡｎＭｉｎＴＩＡＮａｎｄＧｕｏＳｅｎＹＡＮ（Ｄ...     

ESR DETECTION OF ACTIVE INTERMEDIATES PRODUCED BY VIOLOGENMEDIATED REDUCTION OF SUBSTITUTED NITROARENES

ＥＳＲＤＥＴＥＣＴＩＯＮＯＦＡＣＴＩＶＥＩＮＴＥＲＭＥＤＩＡＴＥＳＰＲＯＤＵＣＥＤＢＹＶＩＯＬＯＧＥＮＭＥＤＩＡＴＥＤＲＥＤＵＣＴＩＯＮＯＦＳＵＢＳＴＩＴＵＴＥＤＮＩＴＲＯＡＲＥＮＥＳ￥ＦｕＴｉａｎＬＩＵ；ＬｉｎｇＪｕｎＢＡＩ；ＨｏｎｇＬＩａｎｄＢｉ...     

单分散聚苯胺齐聚物的激光解吸电离质谱

采用基质辅助激光解吸电离飞行时间质谱（ＭＡＬＤＩ－ＴＯＦ－ＭＳ）技术分别对８个单分散的聚苯胺齐聚物进行了分析研究。实验结果表明,ＭＡＬＤＩ－ＴＯＦ－ＭＳ不但可以作为分析单分散聚苯胺齐聚物的直观、准确、快速的分析工具,而且可以为合成路线的确定提供有利的证据。     

PROTEIN IMMOBILIZATION ON CHEMICALLY MODIFIED CELLULOSE MEMBRANE AND AFFINITY SEPARATION OF α－INTERFERON

ＰＲＯＴＥＩＮ　ＩＭＭＯＢＩＬＩＺＡＴＩＯＮ　ＯＮ　ＣＨＥＭＩＣＡＬＬＹ　ＭＯＤＩＦＩＥＤ　ＣＥＬＬＵＬＯＳＥ　ＭＥＭＢＲＡＮＥ　ＡＮＤ　ＡＦＦＩＮＩＴＹ　ＳＥＰＡＲＡＴＩＯＮ　ＯＦ　α－ＩＮＴＥＲＦＥＲＯＮＰＲＯＴＥＩＮＩＭＭＯＢＩＬＩＺＡＴＩＯＮ...     

SYNTHESIS OF POLYSUBSTITUTED AROMATIC COMPOUNDS 3.THE DIELS-ALDER REACTION OF PHENYLSELENO SUBSTITUTED DIENES WITH DIMETHYL ACETYLENEDICARBOXYLATE

ＳＹＮＴＨＥＳＩＳ　ＯＦ　ＰＯＬＹＳＵＢＳＴＩＴＵＴＥＤ　ＡＲＯＭＡＴＩＣ　ＣＯＭＰＯＵＮＤＳ　３．ＴＨＥ　ＤＩＥＬＳ－ＡＬＤＥＲ　ＲＥＡＣＴＩＯＮ　ＯＦ　ＰＨＥＮＹＬＳＥＬＥＮＯ　ＳＵＢＳＴＩＴＵＴＥＤ　ＤＩＥＮＥＳ　ＷＩＴＨ　ＤＩＭＥＴＨＹＬ　Ａ...     

INVESTIGATION ON CARBON FIBER MICROELECTRODES ⅩⅨ． HETEROGENEOUS CATALYTIC REACTION AT METHYLENE BLUE／NAFION MODIFIED MICROCYLINDER CARBON FIBER ELECTRODE AND THE DETERMINATION OF HEMOGLOBIN

ＩＮＶＥＳＴＩＧＡＴＩＯＮ　ＯＮ　ＣＡＲＢＯＮ　ＦＩＢＥＲ　ＭＩＣＲＯＥＬＥＣＴＲＯＤＥＳ　ⅩⅨ．　ＨＥＴＥＲＯＧＥＮＥＯＵＳ　ＣＡＴＡＬＹＴＩＣ　ＲＥＡＣＴＩＯＮ　ＡＴ　ＭＥＴＨＹＬＥＮＥ　ＢＬＵＥ／ＮＡＦＩＯＮ　ＭＯＤＩＦＩＥＤ　ＭＩＣＲＯＣＹＬ...     

PRACTICAL METHOD FOR SYNTHESIS OF NEW GLYCOLIPIDS N－［4（DIALKYL－L－GLUTAMATECARBONYLETHYLCARBO－NYLAMINO）BUTYL］LACTOBIONAMIDES

ＰＲＡＣＴＩＣＡＬＭＥＴＨＯＤＦＯＲＳＹＮＴＨＥＳＩＳＯＦＮＥＷＧＬＹＣＯＬＩＰＩＤＳＮ－［４（ＤＩＡＬＫＹＬ－Ｌ－ＧＬＵＴＡＭＡＴＥＣＡＲＢＯＮＹＬＥＴＨＹＬＣＡＲＢＯ－ＮＹＬＡＭＩＮＯ）ＢＵＴＹＬ］ＬＡＣＴＯＢＩＯＮＡＭＩＤＥＳ￥ＺｈｏｎｇＺｈｉ...     

PRELIMINARY STUDIES ON THE IMMUNOCHEMICAL BEHAVIOR OF BSA-TTA-Eu CONJUGATES

ＰＲＥＬＩＭＩＮＡＲＹ　ＳＴＵＤＩＥＳ　ＯＮ　ＴＨＥ　ＩＭＭＵＮＯＣＨＥＭＩＣＡＬ　ＢＥＨＡＶＩＯＲ　ＯＦ　ＢＳＡ－ＴＴＡ－Ｅｕ　ＣＯＮＪＵＧＡＴＥＳＰＲＥＬＩＭＩＮＡＲＹＳＴＵＤＩＥＳＯＮＴＨＥＩＭＭＵＮＯＣＨＥＭＩＣＡＬＢＥＨＡＶＩＯＲＯＦＢＳＡ...     

利用手持技术改进测定乙醇分子结构实验

利用压强传感器代替排水集气法,改进测定乙醇分子结构实验的仪器装置,并探索最佳反应条件。另外,设计两个空白实验,结合压强变化曲线对实验误差进行相关讨论。     

光谱仪测试范围的扩展

由于石化行业的生产需要，其材质的使用具有多样性和广泛性，经常会出现顾客委托的测试样品的一个或几个元素跨越光谱仪现有测试程序测量范围的情况。本法通过对光谱仪测试原理的认识，根据光谱仪的测试能力及标样的采集，实现了一个或几个元素测量范围的扩展，并对其测量的影响因素进行了研究。     

Influence of viscosity of medium on processes of oxygen quenching of excited states of mesoporphyrin

The oxygen quenching rate constants for singlet and triplet excited states of the dimethyl ester of mesoporphyrin IX increase with decreasing viscosity of the medium and reach a maximum at a viscosity of approximately 0.4 mPa·sec, after which the rate constants begin to decrease. The drop in rate constant with increasing fluidity of the medium may be related to a nonequilibrium character of the elementary act in the interaction of the reactants in the solvent cage. In viscous media such as isopropyl alcohol, isobutyl alcohol, and isoamyl alcohol, the reaction radius is greater than the sum of the radii of the reacting particles. The long-range character of these processes is due to the relatively weak dependence of the quenching probability on distance.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 25, No. 2, pp. 161–167, March–April, 1989.     

Dichroism of absorption and polarization of phosphorescence of molecules of the closed form of nitrobenzospirothiopyran

The spectral-polarization characteristics of absorption and phosphorescence of molecules of the initial form of nitro-substituted indolinospirobenzothiopyran were studied in oriented polyethylene films and in solutions with different polarity. An oscillator model of the electron transitions responsible for the formation of absorption and luminescence spectra was suggested. It was established that the principal differences in the spectral and photophysical properties of the compound studied and its oxygen-containing analog are associated with the fact that the electronegativity of the S atom is lower than that of the O atom. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1143–1146, June, 1997.     

Determination of heats of detonation and influence of components of composite explosives on heats of detonation of high explosives

The heats of detonation of 20 simple high explosives and explosive mixtures were determined by means of an adiabatic detonation calorimeter designed by the authors. The results indicated that the performance of the instrument was reliable and the experimental data were very accurate. For explosive mixtures, there was a linear accumulative relationship between the heats of detonation of the explosive mixture and its components. Accordingly, the heats of detonation of explosive mixtures could be calculated directly from the heats of detonation of simple explosives and the characteristic heats of other components. The experiments showed that the gold or brass shell of the cylindrical charge could be substituted by a thick-walled porcelain shell, which had the advantage of cheapness.

     

物质分配系数的测定实验改进

实验教学目的是从解决实际问题出发,以实验技术训练和实验设计思想培养为目标。介绍了将单一的物质分配系数测定实验改进为综合实验,提高了实验效果及实验资源利用率。     

Neutral diterpenoids of oleoresins of five species of conifers of Transcarpathia

The compositions of the neutral diterpenoids of the oleoresins of five species of conifers growing in the Transcarpathia have been studied. It has been found that the oleoresins ofAbies alba M.,Larix decidua M., andPicea excelsa L. contain more than 50% of neutral diterpenoids. The group and qualitative compositions of the oxygen-containing diterpenoids have been determined. In the oleoresins ofAbies alba,Picea excelsa, andPicea abies tertiary alcohols — cis-abienol and isocembrol — predominate, while inLarix decidua the main component is the hydroxy ester larixyl acetate. Primary alcohols related to the resin acids have been found in all the oleoresins investigated. Features of the distribution of diterpenoids according to the species of conifers have been revealed. The results obtained are necessary for the chemotaxonomy of conifers of the family Pinceae.Novosibirsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR. Translated from Khimiya Prirodynkh Soedinenii, No. 6, pp. 812–816, November–December, 1988.     

Calculation of enthalpies of hydrogenation of hydrocarbons

Sets of hydrogen molecule equivalents have been developed which permit the calculation of hydrogenation of different types of carbon-carbon bonds from ab initio total energies (3-21G and 6-31G* basis sets, and, to a more limited extent, for MP2/6-31G* data) of reactants and products. The calculated enthalpies of hydrogenation are in good agreement with experiment for unstrained molecules, with average errors on the order of 2 kcal/mol. The 6-31G* equivalents allow the enthalpies for strained molecules to be calculated accurately, but the 3-21G equivalents do not. The equivalents for both basis sets have been tested by calculating the enthalpies of hydrogenation of carbon-carbon bonds in nitrogen- and oxygen-containing organic molecules, free radicals, and classical carbocations. The results are in good agreement with experiment in most cases.     

非那雄胺合成工艺改进

非那雄胺能抑制5α-还原酶的活性,明显降低二氢睾酮水平,是一种治疗良性前列腺增生的有效药品。该合成工艺以甾烯酮酸为原料,将其与氯化亚砜反应,无须分离即与叔丁胺反应得17β-酰胺化合物,再氧化开环,环合,氢化,脱氢合成了非那雄胺。经元素分析、IR、1HNMR、13CNMR、MS分析表征了其结构。该法无须使用昂贵的2,2-二吡啶二硫化物和剧毒药品苯亚硒酸酐,且以乙酸铵代替氨气,降低了对设备的要求和腐蚀,更适用于工业生产。