共查询到14条相似文献,搜索用时 106 毫秒
1.
采用辛酸亚锡为催化剂,1,4-丁二醇为引发剂,制备了不同组成、不同分子量的ε-己内酯/L-丙交酯共聚物,并用GPC、FTIR、1H-NMR、DSC和XRD等分析方法表征了该共聚物的结构.结果表明通过改变初始投料中两单体的比例,可以调节共聚酯的分子结构;调节单体与引发剂的比例,可以调节共聚酯分子量,进而影响到其形态与性质.采用高分子量的共聚物进行电纺丝加工,得到了微米级超细纤维无纺布,由SEM可观察到纤维之间有不同程度的粘结.在孔隙率约为75%左右的情况下,该无纺布的抗拉强度可达6.1MPa,延伸率为500%. 相似文献
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采用辛酸亚锡为催化剂,1,4-丁二醇为引发剂,制备了不同组成、不同分子量的ε-己内酯/L-丙交酯共聚物,并用GPC、FTIR、1H-NMR、DSC和XRD等分析方法表征了该共聚物的结构.结果表明通过改变初始投料中两单体的比例,可以调节共聚酯的分子结构;调节单体与引发剂的比例,可以调节共聚酯分子量,进而影响到其形态与性质.采用高分子量的共聚物进行电纺丝加工,得到了微米级超细纤维无纺布,由SEM可观察到纤维之间有不同程度的粘结.在孔隙率约为75%左右的情况下,该无纺布的抗拉强度可达6.1 MPa,延伸率为500%. 相似文献
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对生物可吸收聚(丙交酯-co-乙交酯)(poly(lactide-co-glycolide),PLGA)与β-磷酸三钙(-βTCP)复合物体系进行了电纺.研究了PLGA的浓度,-βTCP与PLGA比例,加料速度,电压,喷头与接收体之间的距离等因素对电纺过程的影响,制备出纳米纤维膜,并用扫描电镜(SEM)等对纤维膜进行表征.结果表明,电纺溶液浓度越高,或者加料速度越快,纳米纤维的直径越粗.力学实验显示,复合物中-βTCP的含量增加使纳米纤维膜的拉伸强度和杨氏模量下降. 相似文献
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Min Sup Kim Indong Jun Young Min Shin Wonhee Jang Sun I. Kim Heungsoo Shin 《Macromolecular bioscience》2010,10(1):91-100
Composite nanofibers of poly(caprolactone) (PCL) and gelatin crosslinked with genipin are prepared. The contact angles and mechanical properties of crosslinked PCL‐gelatin nanofibers decrease as the gelatin content increases. The proliferation of myoblasts is higher in the crosslinked PCL‐gelatin nanofibers than in the PCL nanofibers, and the formation of myotubes is only observed on the crosslinked PCL‐gelatin nanofibers. The expression level of myogenin, myosin heavy chain, and troponin T genes is increased as the gelatin content is increased. The results suggest that PCL‐gelatin nanofibers crosslinked with genipin can be used as a substrate to modulate proliferation and differentiation of myoblasts, presenting potential applications in muscle tissue engineering.
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静电纺丝法制备聚乳酸/纳米磷酸钙复合纳米纤维及其表征 总被引:2,自引:0,他引:2
首先合成了纳米磷酸钙(NCP),用扫描电镜(SEM)和X射线衍射(XRD)进行了表征.再利用静电纺丝法制备了PLA/NCP复合纳米纤维,对纤维进行了TEM,SEM,XRD以及单轴拉力测试的表征.TEM和XRD测试表明,NCP已成功掺杂到聚乳酸纤维中,获得的纤维为复合纤维.SEM测试表明,NCP在溶液中浓度较小时,复合纳米纤维的形貌变化不大;NCP浓度超过PLA质量的7%后,纤维表面出现粒状物;随着浓度继续增大,粒状物逐渐增多,最后很难成纤.拉伸实验结果表明,复合纤维拉伸强度先随着NCP浓度的增加而增大,但NCP浓度超过7%后拉伸强度随着浓度的增加反而减小. 相似文献
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Shouyan Zhang Huanhuan Yan Jui‐Ming Yeh Xincui Shi Peibiao Zhang 《Macromolecular bioscience》2019,19(10)
Conducting polymers (CPs) is one of intelligent biomaterials with the specific properties of reversible redox states, which have a significant effects on the cell behaviors and nerve tissue regeneration. However, the effects of CPs with different electrical conductivity on the behaviors of nerve cells are rarely reported. Therefore, a kind of Poly(3‐hexylthiophene) (P3HT) with certain molecular weight is synthesized by Kumada catalyst transfer polymerization (KCTP) method and employed to prepare bioabsorbable and electroactive intelligent composites of Poly(3‐hexylthiophene)/Poly(glycolide‐lactide) (P3HT/PLGA). FeCl3 doping electroactive membranes with different electrical conductivities are prepared to investigate the cell behaviors. On the substrate with higher electrical conductivity, the proliferation of rat adrenal pheochromocytoma cells (PC12 cells) is significantly promoted and neurite length is increased obviously. In particular, the most significant improvements are the neuron gene expression of Synapsin 1 and microtubule‐associated protein 2 (MAP2) by the composites with high conductivity. These results suggest that P3HT/PLGA with suitable electrical conductivity have a positive role in promoting neural growth and differentiation, which is promising for advancing potential application of nerve repair and regeneration. 相似文献
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Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), commonly referred to PHBV, are promising materials for tissue engineering applications because they are biodegradable, non-toxic and biocompatible. The surface modified PHBV and hybrid PHBV allow favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under specific physiological conditions. We will shortly summarize what has been achieved in the PHBV tissue engineering area, namely, the surface modification reactions including functionalization and grafting reactions, as well as blending or compositing with other materials to improve the mechanical, thermal and hydrophilic properties, and the influence on cell-material interactions is also overviewed in the recent 5 years (from 2008 to 2012). 相似文献
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Polycaprolactone (PCL) is a bioresorbable and biocompatible polymer that has been widely used in long-term implants and controlled drug release applications. However, when it comes to tissue engineering, PCL suffers from some shortcomings such as slow degradation rate, poor mechanical properties, and low cell adhesion. The incorporation of calcium phosphate-based ceramics and bioactive glasses into PCL has yielded a class of hybrid biomaterials with remarkably improved mechanical properties, controllable degradation rates, and enhanced bioactivity that are suitable for bone tissue engineering. This review presents a comprehensive study on recent advances in the fabrication and properties of PCL-based composite scaffolds containing calcium phosphate-based ceramics and bioglasses in terms of porosity, degradation rate, mechanical properties, in vitro and in vivo biocompatibility and bioactivity for bone regeneration applications. The fabrication routes range from traditional methods such as solvent casting and particulate leaching to novel approaches including solid free-form techniques. 相似文献
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HyeongJin Lee SeungHyun Ahn Lawrence J. Bonassar GeunHyung Kim 《Macromolecular rapid communications》2013,34(2):142-149
A new cell‐printed scaffold consisting of poly(ϵ‐caprolactone) (PCL) and cell‐embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three‐dimensional (3D) shape. The hybrid scaffold exhibits a two‐phase structure consisting of cell (MC3T3‐E1)‐laden alginate struts able to support biological activity and PCL struts able to provide controllable mechanical support of the cell‐laden alginate struts. The hybrid scaffolds exhibit an impressive increase in tensile modulus and maximum strength compared to pure alginate scaffolds. Laden cells are homogeneously distributed throughout the alginate struts and the entire scaffold, resulting in cell viability of approximately 84%. 相似文献
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Dario Puppi Nicola Detta Anna Maria Piras Federica Chiellini David A. Clarke Gwendolen C. Reilly Emo Chiellini 《Macromolecular bioscience》2010,10(8):887-897
We have developed three‐dimensional electrospun microfibrous meshes of a novel star branched three‐arm poly(ε‐caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3‐E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds.
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Arie Wibowo Gusti U. N. Tajalla Maradhana A. Marsudi Glen Cooper Lia A.T.W. Asri Fengyuan Liu Husaini Ardy Paulo J.D.S. Bartolo 《Molecules (Basel, Switzerland)》2021,26(7)
Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive filler for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs’ properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 ± 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO3. Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 ± 0.42 MPa), more hydrophilic (contact angle of 76.8 ± 1.7°), conductive (2.3 ± 0.5 × 10−3 S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents. 相似文献
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Aayushi Randhawa Sayan Deb Dutta Keya Ganguly Dinesh K. Patel Tejal V. Patil Ki-Taek Lim 《Macromolecular bioscience》2023,23(1):2200278
The conversion of liquid resin into solid structures upon exposure to light of a specific wavelength is known as photopolymerization. In recent years, photopolymerization-based 3D printing has gained enormous attention for constructing complex tissue-specific constructs. Due to the economic and environmental benefits of the biopolymers employed, photo-curable 3D printing is considered an alternative method for replacing damaged tissues. However, the lack of suitable bio-based photopolymers, their characterization, effective crosslinking strategies, and optimal printing conditions are hindering the extensive application of 3D printed materials in the global market. This review highlights the present status of various photopolymers, their synthesis, and their optimization parameters for biomedical applications. Moreover, a glimpse of various photopolymerization techniques currently employed for 3D printing is also discussed. Furthermore, various naturally derived nanomaterials reinforced polymerization and their influence on printability and shape fidelity are also reviewed. Finally, the ultimate use of those photopolymerized hydrogel scaffolds in tissue engineering is also discussed. Taken together, it is believed that photopolymerized 3D printing has a great future, whereas conventional 3D printing requires considerable sophistication, and this review can provide readers with a comprehensive approach to developing light-mediated 3D printing for tissue-engineering applications. 相似文献