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1.
Tris-, di-(organotitanium) substituted tungstosilicates α、β-[(CpTi)3(SiW9O37)]7- and γ-[(Cp-Ti)2(SiW10O38)]6- were prepared by the reaction of Cp2TiCl2 (Cp = η5-C5H5) with α、β-SiW9O349- (noted α、β-SiW9), γ-SiWO368- (noted γ-SiW10) . The products were characterized by means of elemental analysis, IR, 1H NMR, 183W NMR and polarography. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the A-XWg or γ-SiW10 units. And the organotitanium substituted compounds showed promising in vitro antitumor activity in two of human tumor cell lines.  相似文献   

2.
《Mendeleev Communications》2022,32(6):763-765
New Niii complexes based on the substituted 2-(2-hydroxy-phenyl)benzoxazole have been synthesized from the corresponding ligands and nickel acetate. The crystal structure of bis[2-(1,3-benzoxazol-2-yl-κN)-4,5-dichloro-3-(methoxycarbonyl)phenolate-κO]nickel(ii) has been determined by X-ray diffraction. The new Niii complexes have been screened for their antibacterial, protistocidal and fungistatic activities  相似文献   

3.
Poly(1,6‐hexane‐9,9,9′,9′,9″,9″‐hexahexyl‐7,2′;7′,2″‐terfluorene‐2,7″‐dicarboxylate) (PTFHHC6) has been synthesized and characterized. This polymer exhibits strong emission in the blue range, both in solution (quantum yield of 76%) and in the solid state. Moreover, PTFHHC6 presents some advantages over other polyfluorene derivatives since its solid‐state fluorescence spectrum does not show any excimer formation and does not vary upon thermal treatment. Electrochemical measurements have revealed a reversible p‐n dopable polymer. This aromatic polyester shows promising optical and electrical properties for the development of blue light‐emitting diodes.  相似文献   

4.
Synthesis, spectroscopic characterization and in vitro pharmacological and cancer cell growth inhibitory activity studies of new silicon-containing compounds based on the indomethacin scaffold are now reported. Amidation of the indomethacin carboxylate group using amino-functional silanes generated a series of novel lipophilic derivatives of indomethacin. The pharmacological activity of these derivatives tested against human recombinant cyclooxygenase-1 and 2 demonstrated that the silicon-containing derivatives are cyclooxygenase-2 (COX-2) selective. The silicon-containing amides of indomethacin demonstrated in vitro growth inhibitory activity against human MiaPaCa-2 pancreatic carcinoma cells at low μM concentrations. The 3a and 3c derivatives exhibited the most potent in vitro antiproliferative activity, with IC50 <6.0 μM, compared to unmodified indomethacin having an IC50100 μM. We dedicate this paper to Prof. Mitsuo Kira, outstanding organosilicon chemist and valued friend.  相似文献   

5.
6.
Four new compounds, [Me4N]4H5[(RGe)3(XW9O34−n)2] (R = HOOCCH2CH2, HOOCCH2(m-NO2C6H4)CH, X = P, n = 0; X = Sb, n = 1) have been prepared from trichlorogermanium precursors and lacunary polyoxometallates ([PW9O34]9− and [SbW9O33]9−). The products were characterized by means of elemental analysis, IR spectroscopy, 1H NMR and 183W NMR spectroscopy. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the XW9 units in water. The organogermanium substituted complexes showed promising activity against two human tumor cell lines (leucocythemia Hela cells and S180 cells) in vitro and [Me4N]4H5[(HOOCCH2CH2Ge)3(SbW9O33)2] exhibited some certain antitumoral activity in vivo and can increase the immune ability of the spleen.  相似文献   

7.
Polyketone resins have been prepared by the Friedel-Crafts polymerization of dithiophenylidenecyclopentanone (Ⅰ), dithiophenylidenecyclohexanone (Ⅱ) and dithiophenylideneacetone (Ⅲ) with adipoyl, sebacoyl and terephthaloyl dichlorides using boron trifluoride as catalyst and carbon disulphide as solvent. Polymers were characterized with IR, 1 H-NMR, and the results showed the presence of carbonyl of ketonic groups in the main chain. The polyketones have inherent viscosities of 0.40-0.70 dL/g. All the polymers are semicrystalline and most of them are partially soluble in most common organic solvents but freely soluble in aprotic solvents. The temperatures of 50% weight loss are as high as 185℃ to 280℃ in air, indicating that these aromatic polyketones have excellent thermal stability. All the polyketones were tested for their antimicrobial activity against bacteria and fungi.  相似文献   

8.
Metal complexes of Schiff base derived from condensation of o-vanilin (3-methoxysalicylaldehyde) and sulfametrole [N(1)-(4-methoxy-1,2,5-thiadiazole-3-yl)sulfanilamide] (H2L) are reported and characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV-vis and thermal analysis (TGA). From the elemental analyses data, the complexes were proposed to have the general formulae [M2X3(HL)(H2O)5].yH2O (where M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X=Cl, y=0-3); [Fe2Cl5(HL)(H2O)3].2H2O; [(FeSO4)2(H2L)(H2O)4] and [(UO2)2(NO3)3(HL)(H2O)].2H2O. The molar conductance data reveal that all the metal chelates were non-electrolytes. The IR spectra show that, H2L is coordinated to the metal ions in a tetradentate manner with ON and NO donor sites of the azomethine-N, phenolic-OH, enolic sulphonamide-OH and thiadiazole-N. From the magnetic and solid reflectance spectra, it is found that the geometrical structures of these complexes are octahedral. The thermal behaviour of these chelates shows that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters, such as, E*, DeltaH*, DeltaS* and DeltaG* are calculated from the DrTG curves using Coats-Redfern method. The synthesized ligand, in comparison to their metal complexes also were screened for their antibacterial activity against bacterial species, Escherichia coli, Salmonella typhi, Bacillus subtillus, Staphylococcus aureus and Fungi (Aspergillus terreus and Aspergillus flavus). The activity data show that the metal complexes to be more potent/antimicrobial than the parent Shciff base ligand against one or more microbial species.  相似文献   

9.
《印度化学会志》2022,99(12):100788
Diazotization of p-nitro aniline followed by coupling with 3-methyl-1-phenyl pyrazole to procure biologically active azo-dye ligand 3-methyl-4-[(E)-(4-nitrophenyl) diazenyl]-1-phenyl-1H-pyrazol-5-ol (NDP) and also the array of transition metal complexes of aforementioned azo-dye ligand has been carried off along with the use of metal complex to detect pesticides electrochemically. Structural verification of synthesized compounds was carried out via 1H and 13C NMR along with the percentage of C,H,N, molecular weights, Infra-red, UV-Visible spectra and molar conductance of ligand and its complexes was observed. Also TGA, P-XRD and CV measurements were noted. An antimicrobial potency was evaluated by well diffusion method and antioxidant efficacy by DPPH technique. Molecular docking studies was used and MTT tests were conducted on MCF-7 and Hela cell lines to investigate anticancer potency. Upon utilizing physical and spectroscopic techniques to characterize the novel azo-dye ligand and its transition coordinated compounds justified the bi-dentate nature of ligand. Further CV measurements showed that the synthesized Co(II) complex exhibited excellent electrocatalysis properties for the electrochemical sensing of pesticide(Ammonium salt of glyphosate 71% SG) with wider linear range of 0.1 μM–0.8 μM and detection limit 0.033 μM. Mn(II) and Co(II) complex displayed good anti-microbial activity along with cytotoxic potency whereas Co(II) and Cu(II) compounds indicated good anti-oxidant activity. Thus, NDP and its complexes being structurally supported via spectral data and CV studies affirms that Co(II) is strongly useful in detecting pesticide. And lastly it was found that all metal complexes have admirable bioefficacy when compared to ligand.  相似文献   

10.
A new series of mono and binuclear Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), La(III), Ru(III), Hf(IV), ZrO(II) and UO(2)(II) complexes of phenylaminodibenzoylhydrazone have been synthesized and characterized by elementals analyses, IR UV-vis spectra, magnetic moments, conductances, thermal analyses (DTA and TGA) and electron spin resonance (ESR) measurements. The IR spectral data show that, the ligand behaves as a neutral bidentate type (15 and 16), monobasic bidentate type (6), or monobasic tridentate type (5, 7, 8, 10, 11, 13, 14, 17-21) or dibasic tridentate type 2-4, 9 and 12 towards the metal ion. Molar conductances in DMF solution indicate that, the complexes are non-electrolytes. The ESR spectra of solid complexes (9 and 10) show axial and non-axial types indicating a [Formula: see text] ground state with significant covalent bond character. However, complexes (11 and 12), show isotropic type, indicating manganese(II) octahedral geometry. Antibacterial and antifungal tests of the ligand and its metal complexes are also carried out and it has been observed that the complexes are more potent bactericides and fungicides than the ligand.  相似文献   

11.
Rigid aromatic polyesters containing alkoxy or phenyl-substituted oligophenyls were prepared. Soluble polymers were obtained also in cases where phenyl-substituted quinquephenyl diols were combined with asymmetric phenyl-substituted terephthalic acid. The synthesized polyesters were characterized by viscosimetry, gel permeation chromatography, thermal analysis, and dynamic mechanical analysis. The temperature dependence of the intrinsic viscosity was sensitive to the type of side groups. Thermogravimetry has shown that polyesters with aromatic substituents were stable up to 380–400°C. The glass transition temperatures of the polyesters with aromatic side groups were in the 220–260°C range as determined by DSC. Polyesters with hexyloxy side chains show crystallinity. Dynamic mechanical analysis showed that in the cases where aromatic substituents were used to increase solubility, the obtained polymers have very useful mechanical properties at high temperatures. The polymer having the quinquephenyl unit in the main chain has an almost constant modulus up to 340°C. © 1996 John Wiley & Sons, Inc.  相似文献   

12.
Russian Journal of General Chemistry - Two series with the general formula of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles and their isosteric...  相似文献   

13.
Synthesis of thiazoles was carried out from allyl thioureas using different cyclizing agents such as hydrogen chloride gas and bromine. Synthesized compounds were characterized by IR, 1H and 13C NMR, mass spectrometry, and elemental analysis. The synthesized thiazoles were evaluated for their antibacterial activity against Gram postitive (Lactobacillus bulgaris and Streptococcus mitis) and Gram negative (Yersinia) as well as antifungal activity against Aspergillus niger fungi.  相似文献   

14.
A series of phosphorylated and thiophosphorylated compounds of 2‐substituted benzimidazoles have been synthesized by the reaction of POCl3 and PSCl3 with 2‐substituted benzimidazoles in different molar ratios. The compounds have been characterized by elemental analyses, infrared, and 1H NMR and 31P NMR spectral studies. These compounds were found to be insecticidal when tested against Periplenata americana. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:154–157, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20385  相似文献   

15.
The synthesis and antimicrobial activity of palladium(II) and platinum(II) complexes derived from heterocyclic bidentate ligands, namely 2‐(2′‐aminophenyl)benzoxazole [L1H2], 2‐(2′‐hydroxyphenyl)benzoxazole [L2H], and 2‐(2′‐mercaptophenyl)benzoxazole [L3H], are reported here. These complexes have been characterized by elemental analyses, molecular weight determinations, conductance measurements, infrared, 1H NMR, and electronic spectral studies. The resulting colored complexes are monomeric in nature. On the basis of above‐described studies, square‐planar geometry has been suggested for the resulting complexes. The ligands and their metal complexes were tested against certain microorganisms to assess their antimicrobial properties. The results indicate that the metal complexes are found more active than the parent ligands. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:44–50, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20578  相似文献   

16.
Metal complexes of Schiff base derived from 2-thiophene carboxaldehyde and 2-aminobenzoic acid (HL) are reported and characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance and thermal analysis (TGA). The ligand dissociation as well as the metal-ligand stability constants were calculated pH metrically at 25 degrees C and ionic strength mu=0.1 (1M NaCl). The complexes are found to have the formulae [M(HL)2](X)n.yH2O (where M=Fe(III) (X=Cl, n=3, y=3), Co(II) (X=Cl, n=2, y=1.5), Ni(II) (X=Cl, n=2, y=1) and UO2(II) (X=NO3, n=2, y=0)) and [M(L)2] (where M=Cu(II) (X=Cl) and Zn(II) (X=AcO)). The molar conductance data reveal that Fe(III) and Co(II), Ni(II) and UO2(II) chelates are ionic in nature and are of the type 3:1 and 2:1 electrolytes, respectively, while Cu(II) and Zn(II) complexes are non-electrolytes. IR spectra show that HL is coordinated to the metal ions in a terdentate manner with ONS donor sites of the carboxylate O, azomethine N and thiophene S. From the magnetic and solid reflectance spectra, it is found that the geometrical structure of these complexes are octahedral. The thermal behaviour of these chelates shows that the hydrated complexes losses water molecules of hydration in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters, such as, E*, DeltaH*, DeltaS* and DeltaG* are calculated from the DrTG curves using Coats-Redfern method. The synthesized ligands, in comparison to their metal complexes also were screened for their antibacterial activity against bacterial species, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus pyogones and Fungi (Candida). The activity data show that the metal complexes to be more potent/antibacterial than the parent Schiff base ligand against one or more bacterial species.  相似文献   

17.
A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b, 2e, 2g and 2h exhibited good antibacterial activity, almost equal to that of Ciprofloxacin used as standard.  相似文献   

18.
Two Schiff bases were synthesized by reaction of 2-(4'-aminophenyl)benzoxazole derivatives with 4-N,N-diethylaminobenzaldehyde. UV-visible (UV-vis) and steady-state fluorescence in solution were applied in order to characterize its photophysical behavior. The Schiff bases present absorption in the UV region with fluorescence emission in the blue-green region, with a large Stokes' shift. The UV-vis data indicates that each dye behaves as two different chromophores in solution in the ground state. The fluorescence emission spectra of the dye 5a show that an intramolecular proton transfer (ESIPT) mechanism takes place in the excited state, whereas a twisted internal charge transfer (TICT) state is observed for the dye 5b. Theoretical calculations were performed in order to study the conformation and polarity of the molecules at their ground and excited electronic states. Using density functional theory (DFT) methods at theoretical levels BLYP/Aug-SV(P) for geometry optimizations and B3LYP/6-311++G(2d,p) for single-point energy evaluations, the calculations indicate that the lowest energy conformations are in all cases nonplanar and that the dipole moments of the excited state relaxed structures are much larger than those of the ground state structures, which corroborates the experimental UV-vis absorption results.  相似文献   

19.
磺酰胺类化合物是继磺酰脲与咪唑啉酮除草剂之后开发的乙酰乳酸合成酶 (ALS)抑制剂的另一重要领域 ,已筛选出一些高活性的新品种[1~ 3] 。为寻找新的性能优良的活性物质 ,进一步研究活性与结构的关系 ,本文设计将磺酰胺类和酰胺类除草剂的基本骨架用一个亚甲基 CH2 连结起来 ,相当于在磺酰脲桥链中间插入了一个亚甲基 ,共合成了 1 6个新的邻烷氧基羰基苯磺酰胺衍生物( 2a~ 2p) ,并初步测试了它们的生物活性。1 实验部分1 1 仪器和试剂JEOLFX 90Q型、BRUKERAC P2 0 0型核磁共振仪 ,TMS为内标 ;Shimad…  相似文献   

20.
Reaction of dithioacid (ArCS2CH2CO2H, Ar = phenyl, 2‐furyl or 2‐thienyl) with nBu2SnO gives monomeric (ArCS2CH2CO2)2Sn(Bun)2 in a 2:1 molar ratio, and dimeric {[(ArCS2CH2CO2)Sn(Bun)2]2O}2 in a 1:1 molar ratio, respectively, which have been characterized by IR, NMR (1H, 13C and 119Sn) spectra and elemental analyses. X‐ray crystal structure analyses indicate that the compound [(C4H3S)CS2CH2CO2]2Sn(Bun)2 is monomeric with the tin atom occupying a skew‐trapezoidal bipyramidal geometry. In addition, this compound forms a three‐dimensional structure through the weak intermolecular SS and SnO interactions. Compound {[((C4H3S)CS2CH2CO2)Sn(Bun)2]2O}2 is a centrosymmetric dimer with a cyclic Sn2O2 unit, in which the coordination modes of the two crystallographically unique carboxylic ligands are different. One acts as monodentate ligand by the carboxylate oxygen atom, the other bridges two tin atoms via only one carboxylate oxygen atom. Furthermore, each tin atom in this compound locates a distorted trigonal bipyramidal geometry. Biological activities of these organotin compounds show that they have hardly acaricidal activity, but display certain activities on fungi. In mononuclear tin compounds, the inhibition percentage of [(C4H3S)CS2CH2CO2]2Sn(Bun)2 in vitro for Alternaria solani and Physolospora piricola is 57.1% and 43.9%, respectively, while in dimers {[((C4H3O)CS2CH2CO2)Sn(Bun)2]2O}2 shows high inhibition percentage for Gibbereila zeae (52.6%) and Physolospora piricola (50.0%), respectively. Copyright © 2006 John Wiley & Sons, Ltd.  相似文献   

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