Syntheses,Characterizations, Crystal structures,and Antitumor Activities of Arenetelluronic Triorganotin Esters

Six new arenetelluronic triorganotin esters, namely (R₃Sn)₄[ArTe(μ‐O)(OH)O₂)]₂ (Ar = Ph, R = Me: 1 , R = Ph: 2 ; Ar = 3‐Me‐Ph, R = Me: 3 , R = Ph: 4 , Ar = 3‐Cl‐Ph, R = Me: 5 , R = Ph: 6 ), were prepared by treating arenetelluronic acids with the corresponding R₃SnCl (R = Me, Ph) with potassium hydroxide in methanol. All complexes were characterized by elemental analysis, FT‐IR, NMR (¹H, ¹³C, ¹¹⁹Sn) spectroscopy, and X‐ray crystallography. The structural analyses indicate that these complexes are isostructural as Sn₄Te₂ moiety, in which the Te₂(μ₂‐O)₂ units are situated in the center and each Te atom is coordinated with two OSnR₃ groups on the side. Complexes 1 , 3 , and 5 show one‐dimensional chain and two‐dimensional network supramolecular structures by intermolecular C H···O or C H···Cl interactions. The antitumor activities of these complexes reveal that most arenetelluronic triorganotin esters have powerful antitumor activities with certain regularity.     

On the reactivity of metal and organometallic halides toward R3Sn?O?SnR3 systems

Interaction of metallic salts (M = Hg, Sb, and Te) with bis(triorganotin)oxide, (R₃Sn)₂O, where (R = C₆H₅, p‐CH₃C₆H₄, and cyclo‐C₆H₁₁) at room temperature proceeded with the simultaneous cleavage of the Sn C and Sn O bonds, invariably yielding R₂SnO along with other products. Thus the treatment of HgX₂ (X = Cl, CN, SCN) with (R₃Sn)₂O resulted in the formation of polymeric diorganotin oxide R₂SnO along with R₃SnX and RHgX derivatives. The reaction of SbCl₃ with (R₃Sn)₂O was found to give R₂SnO, R₃SnCl, and RSbCl₂, whereas interaction with SbCl₅ provided R₂SnO, R₂SnCl₂, and R₂SbCl₃. Treatment of TeCl₄ with (R₃Sn)₂O provided R₂SnO, R₃SnCl, and RTeCl₃ at room temperature. At reflux temperature, reaction of PhTeCl₃ with (R₃Sn)₂O yielded R₂SnO, R₃SnCl, and mixed diorganotellurium dichloride, RPhTeCl₂. The course of reaction indicated the instability of Sn O Sn system proceeding via a four‐centered mechanism, providing organometallic compounds in profitable yield. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:278–283, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20547     

Organtin complexes of 2,5‐dithiobiurea (H2dtbu): The crystal structures of (Ph3Sn)2(dtbu) and [(n‐Bu)2SnCl]2(dtbu)

A series of organotin(IV) complexes of two types, [R₃Sn]₂(dtbu) (R = PhCH₂ 1 , Ph 2 , n‐Bu 3 , H₂dtbu = 2,5‐dithiobiurea), [R₂SnCl]₂(dtbu) (R = PhCH₂ 4 , Ph 5 , n‐Bu 6 ) have been synthesized and characterized by elemental analysis, IR, and NMR (¹H, ¹¹⁹Sn) spectroscopy. The structures of 2 and 6 have been determined by X‐ray crystallography. Crystal structures show that both complexes 2 and 6 are the symmetric dinuclear unit. Interestingly, supramolecular structures show that complex 2 has formed a linear chain through N H⋅⋅⋅S hydrogen bonding and 6 has formed a two‐dimensional network in perfect bc plane connected through N H⋅⋅⋅Cl hydrogen bonding and nonbonded S⋅⋅⋅S interactions. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:435–442, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20456     

Syntheses and crystal structures of triorganotin (IV) derivatives with 2,2′‐bipyridine‐4,4′‐dicarboxylic acid

Four organotin complexes with 2,2′‐bipyridine‐4,4′‐dicarboxylic acid, H₂dcbp: (Ph₃n)₂(dcbp) 1 , [(PhCH₂)₃n]₂(dcbp) ⋅ 2CH₃OH 2 , [(Me₃Sn)₂(dcbp)]_n 3 , [(Bu₃Sn)₂(dcbp)]_n 4 have been synthesized. The complexes 1–4 were characterized by elemental, IR, ¹H, ¹³C, ¹¹⁹n NMR, and X‐ray crystallographic analyses. Crystal structures show that complex 1 is a monomer with one ligand coordinated to two triorganotin moieties, and a 1D infinite polymeric chain generates via intermolecular C H⋅⋅⋅N hydrogen bond; complex 2 is also a monomer and forms a 2D network by intermolecular O–H⋅⋅⋅O weak interaction; both of complexes 3 and 4 form 2D network structures where 2,2′‐bipyridine‐4,4′‐dicarboxylate acts as a tetradentate ligand coordinated to trimethyltin and tri‐n‐butyltin ions, respectively. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:19–28, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20506     

Synthesis,structural characterization,and properties of triorganotin complexes of Schiff base derived from 3-aminobenzoic acid and salicylaldehyde or 2,4-pentanedione

Six new triorganotin 3-(salicylideneamino)benzoates ( 1a – 1c ) and 3-(4-oxo-2-penten-2-ylamino)benzoates ( 2a – 2c ), 3-(2-HOC₆H₄CH=N)C₆H₄COOSnR₃, and 3-(CH₃COCH=C(CH₃)NH)C₆H₄COOSnR₃ (R = Ph, a ; Cy, b ; Bu, c ) have been synthesized by one-pot reaction of 3-aminobenzoic acid, salicylaldehyde (or 2,4-pentanedione), and triorganotin hydroxide and characterized by elemental analysis, infrared, and nuclear magnetic resonance (¹H, ¹³C, and ¹¹⁹Sn) spectra. The crystal structures of 1a , 1b , and 2a – 2c have been determined by the single crystal X-ray diffraction. Complexes 1a and 2a exhibit a 44-membered macrocyclic tetramer and a polymeric zigzag chain, respectively, in which tin atoms show trans-[C₃SnO₂] trigonal bipyramidal geometry with the axial positions being occupied by the carboxylate oxygen atom and the phenolic (or ketone) oxygen atom from another ligand. Complex 1b adopts a distorted tetrahedral geometry at tin, and there are two molecules differing in the relative orientation of the carboxylate toward the imino group. Compounds 2a ⋅CH₃OH, 2b ⋅H₂O, and 2c ⋅H₂O are five-coordinated mononuclear adducts with one coordinated solvent molecule and display different supramolecular organizations in which there are the centrosymmetric R₂²(16), R₄²(22), and R₆⁴(34) macrocycle motifs formed by the O–H⋅⋅⋅O, N–H⋅⋅⋅O, and C–H⋅⋅⋅O hydrogen bonds. The fluorescence spectrum indicates that the complexes may be explored for potential blue luminescent materials. Compared to cisplatin, these compounds exhibit enhanced cytotoxic efficacy and can be considered as anticancer agents for further study.     

Organotin(IV) Carboxylates of Substituted α‐Cinnamic Acid,RnSn(OCOC(R2)=CHR1)4 – n: Synthesis,Spectroscopic Characterization and Biological Evaluation

Di‐ and triorganotin(IV) carboxylates, R_nSn(OCOC(R²)=CHR¹)_4–n (n = 2 and 3; R = Me, Et, n‐Bu, Ph; R¹ = 3‐CH₃O‐4‐OHC₆H₃, R² = C₆H₅) were prepared by reacting the corresponding organotin(IV) chloride with the silver salt of the (E)‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐phenylpropenoic acid. The title compounds were investigated and characterized by elemental analysis, infrared (FT‐IR), multinuclear (¹H, ¹³C, ¹¹⁹Sn) NMR, and mass spectrometry, and possible structures were proposed. The complexes and ligand acid ( HL ) have been evaluated in vitro against various bacteria and fungi. The results noticed during the biocidal activity screenings proved their in vitro biological potential. They were also tested for cytotoxicity.     

Ecofriendly synthesis,antimicrobial and antispermatogenic activity of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone and 4′‐nitrobezanilide thiosemicarbazone

New series of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone (L¹H) and 4′‐nitrobenzanilide thiosemicarbazone (L²H) of the type [R₃Sn(L)] (R = ‐CH₃, ‐C₆H₅ and n‐C₄H₉) were synthesized under microwave irradiation. All the complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz., IR, UV–vis, ¹H, ¹³C and ¹¹⁹Sn NMR. The central tin atoms of these complexes are all five‐coordinated with trigonal bipyramidal geometry. In order to assess their growth inhibitory potency semicarbazone, thiosemicarbazone and their triorganotin(IV) complexes were tested in vitro against some pathogenic fungi and bacteria. Also the ligands and their organotin(IV) complexes were studied to assess the effects of long‐term ingestion of these compounds on fertility, body and reproductive organ weights. The biochemical analyses were also performed on blood samples and reproductive organs of male rats. The findings have been presented in this paper. Copyright © 2009 John Wiley & Sons, Ltd.     

Some novel triorganotin(IV) derivatives of β, δ-triketones

Thirty triorganotin(IV) derivatives of the type R₃Sn(R′COCHCOCH₂COR″) and [R₃Sn]₂ (R′COCHCOCHCOR″) (where R = CH₃, C₂H₅, nC₃H₇, nC₄H₉ and C₆H₅ and R′ = R″ = CH₃, C₆H₅ or R′ = C₆H₅, R″ = CH₃) have been synthesised by the interaction of R₃SnCl with mono- or disodium salt of 2, 4, 6-heptanetrione, 1-phenyl-1, 3, 5-hexanetrione and 1, 5-diphenyl-1, 3, 5-pentanetrione in 1:1 and 2:1 molar ratios, respectively. The complexes have been examined by their molecular weight, IR, PMR and elemental analyses and their tentative structures assigned. Both “Z” and “E” forms have been identified in the 1:1 complexes in equilibrium with the enol form containing five coordinate tin. The 2:1 derivatives contain one five- and other four coordinated tin(IV) except the phenyl analogue where both the tins are five coordinated.     

Syntheses and Characterization of Organotin(IV) Complexes Derived from 2‐Mercapto‐1,3,4‐thiadiazole

Four organotin complexes of the types [(Ph₃Sn)(C₂HN₂S₂)] ( 1 ), [(CH₃)₃Sn(C₂HN₂S₂)]_n ( 2 ), [(Bu₂Sn)(C₂HN₂S₂)₂] ( 3 ), and [(Me₂Sn)₄(C₂HN₂S₂)₂(µ ₃‐O)₂(C₂H₅O)₂] ( 4 ) have been obtained by 2‐mercapto‐1,3,4‐thiadiazole and triorganotin chloride or diorganotin dichloride. All the complexes were characterized by elemental analysis, IR and NMR spectroscopy, and X‐ray diffraction analyses, which revealed that complexes 1 and 3 are mononuclear structures, complex 1 can further form a one‐dimensional (1D) helical chain, and complex 3 can further form a 22‐membered macrocycle through the intermolecular C–H·N hydrogen bond; complex 2 is a 1D infinite chain linked by intermolecular N→Sn and S→Sn bonding interactions; complex 4 is a typical ladder structure. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 00:1–8, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.21046     

Synthesis,structure, and fungicidal activity of triorganotin (4H‐1,2,4‐triazol‐4‐yl)benzoates

A series of triorganotin (4H‐1,2,4‐triazol‐4‐yl)benzoates have been synthesized by the reaction of 4‐(4H‐1,2,4‐triazol‐4‐yl)benzoic acid and 3‐(4H‐1,2,4‐triazol‐4‐yl)benzoic acid with (R₃Sn)₂O (R = Et, n‐Bu and Ph) or R′₃SnOH (R′ = p‐tolyl and cyclohexyl). The molecular structure of tri(p‐tolyl)tin 3‐(4H‐1,2,4‐triazol‐4‐yl)benzoate determined by X‐ray crystallography displays that the tin atom adopts a five‐coordinate distorted trigonal bipyramidal geometry with the carboxyl oxygen atom and the nitrogen atom on 1‐position of triazole ring occupying the apical position. Moreover, this complex forms a polymeric chain by the intermolecular Sn–N interactions. All these complexes show good antifungal activities in vitro against Alternaria solani, Cercospora arachidicola, Gibberella zeae, Physalospora piricola, and Botrytis cinerea. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 20:411–417, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20566     

Thermal Decomposition Kinetics of Some Di‐ and Triorganotin(IV) Carboxylates Derived from para‐Nitrophenylethanoic Acid

Thermogravimetric (TG) investigations of organotin(IV) carboxylates with the general formula R_mSnL_4−m (where R=CH₃, C₂H₅, n‐C₄H₉, C₆H₅, cyclo‐C₆H₁₁, n‐C₈H₁₇, m=2, 3, and L=para‐nitrophenylethanoate anion) have been performed. Derivative thermogravimetry (DTG) and differential thermal analysis (DTA) techniques, Horowitz‐Metzger method and the fundamental thermodynamic relations are used to evaluate the thermokinetic parameters of each thermal degradation pattern. Results reveal that the thermal stability is functional to Sn C and Sn O bonds. In the case of R₂SnL₂, activation energy, reaction order and pre‐exponential factor associated with the bulk degradation processes increase as the alkane chain length increases. Hence, Oct₂SnL₂ is thermally more stable than Bu₂SnL₂, which in turn is more resistant to thermal dissociation than Et₂SnL₂. The same phenomenon is not observed for R₃SnL compounds because their degradation is highly irregular. Furthermore, R₂SnL₂ has larger values of kinetic parameters than those of corresponding triorganotin(IV) para‐nitrophenylethanotes. Thermodynamic parameters of these compounds also reinforce the above facts.     

Aluminum five‐ and six‐coordination in bis(acetylacetonato)aminoalkoxides

Reactions of bis(acetylacetonato)aluminum(III)‐di‐μ‐isopropoxo‐di‐isopropoxo aluminum(III), [(CH₃COCHCOCH₃)₂Al(μ‐OPrⁱ)₂Al(OPrⁱ)₂] with aminoalcohols, (HO R NR¹R²) in 1:1 and 1:2 molar ratios in refluxing anhydrous benzene yielded binuclear complexes of the types [(CH₃COCHCOCH₃)₂Al(μ‐OPrⁱ)₂Al(O R NR¹R²)(OPrⁱ)] and [(CH₃COCHCOCH₃)₂Al(μ‐OPrⁱ)₂Al(O R NR¹R²)₂] (R   (CH₂)₃ , R¹ = R² = H; R =  CH₂C(CH₃)₂ , R¹ = R² = H; R =  (CH₂)₂ , R¹ = H, R² =  CH₃; and R   (CH₂)₂ , R¹ = R² = CH₃), respectively. All these compounds are soluble in common organic solvents and exhibit sharp melting points. Molecular weight determinations reveal their binuclear nature in refluxing benzene. Plausible structures have been proposed on the basis of elemental analysis, molecular weight measurements, IR, NMR (¹H, ¹³C, and ²⁷Al), and FAB mass spectral studies. ²⁷Al NMR spectra show the presence of both five‐ and six‐coordinated aluminum sites. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:518–522, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10184     

Diorganotin(IV) and triorganotin(IV) derivatives of diphenic acid

The diorganotin(IV) and triorganotin(IV) derivatives R₂SnA (R = Me, n-Pr, n-Bu, n-Oct) and (R₃Sn)₂A [R = Me, Ph, cyclohexyl (Cyh); A = an anion of diphenic acid] have been prepared and characterized by elemental analysis, IR, ¹H and ¹³C NMR spectroscopies. Tetrahedral tin forms a part of a diphenate cyclic ring in the diorganotin complexes with unidentate carboxylates, which have further been used for the synthesis of cyclic acid anhydrides. The soluble dinuclear triorganotin complexes (Me, Ph) possess symmetrically bonded carboxylates while the less soluble compound (Cyh₃Sn)₂A has two asymmetrically bonded carboxylates. All have a trigonal bipyramidal structure with R₃Sn units remote from each other.     

Syntheses and crystal structures of triorganotin(IV) complexes of schiff base derived from 4‐amino‐5‐phenyl‐4H‐1,2,4‐trizole‐3‐thiol

Four triorganotin complexes of the types [(Ph₃Sn)(C₁₅H₁₀FN₄S)] ( 3 ), [(CH₃)₃Sn(C₁₅H₁₀FN₄S)]_n ( 4 ), [(Ph₃Sn)(C₁₃H₉FN₄S₂)] ( 5 ), and [(CH₃)₃Sn(C₁₃H₉FN₄S₂)]_n ( 6 ) have been obtained by Schiff base compound 1 (derived from 4‐fluorobenzaldehyde) and compound 2 (derived from thiophene‐2‐carboxadehyde) with triorganotin chloride in the presence of sodium ethoxide. All the complexes were characterized by elemental analysis, IR, and NMR spectroscopies, and X‐ray diffraction analyses, which revealed that complexes 3 and 5 are mononuclear structures, complex 4 and 6 are one‐dimensional zigzag infinite chains via N → Sn and S → Sn bonding interactions. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:583–591, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20481     

Platinum(II) Mixed Ligand Complexes with Thiourea Derivatives,Dimethyl Sulphoxide and Chloride: Syntheses,Molecular Structures,and ESCA Data

The platinum(II) mixed ligand complexes [PtCl(L^1‐6)(dmso)] with six differently substituted thiourea derivatives HL, R₂NC(S)NHC(O)R′ (R = Et, R′ = p‐O₂N‐Ph: HL¹; R = Ph, R′ = p‐O₂N‐Ph: HL²; R = R′ = Ph: HL³; R = Et, R′ = o‐Cl‐Ph: HL⁴; R₂N = EtOC(O)N(CH₂CH₂)₂N, R′ = Ph: HL⁵) and Et₂NC(S)N=CNH‐1‐Naph (HL⁶), as well as the bis(benzoylthioureato‐κO, κS)‐platinum(II) complexes [Pt(L^{1, 2})₂] have been synthesized and characterized by elemental analysis, IR, FAB(+)‐MS, ¹H‐NMR, ¹³C‐NMR, as well as X‐ray structure analysis ([PtCl(L¹)(dmso)] and [PtCl(L^{3, 4})(dmso)]) and ESCA ([PtCl(L^{1, 2})(dmso)] and [Pt(L^{1, 2})₂]). The mixed ligand complexes [PtCl(L)(dmso)] have a nearly square‐planar coordination at the platinum atoms. After deprotonation, the thiourea derivatives coordinate bidentately via O and S, DMSO bonds monodentately to the Pt^II atom via S atom in a cis arrangement with respect to the thiocarbonyl sulphur atom. The Pt—S‐bonds to the DMSO are significant shorter than those to the thiocarbonyl‐S atom. In comparison with the unsubstituted case, electron withdrawing substituents at the phenyl group of the benzoyl moiety of the thioureate (p‐NO₂, o‐Cl) cause a significant elongation of the Pt—S(dmso)‐bond trans arranged to the benzoyl‐O—Pt‐bond. The ESCA data confirm the found coordination and bonding conditions. The Pt 4f_7/2 electron binding energies of the complexes [PtCl(L^{1, 2})(dmso)] are higher than those of the bis(benzoylthioureato)‐complexes [Pt(L^{1, 2})₂]. This may indicate a withdrawal of electron density from platinum(II) caused by the DMSO ligands.     

Synthesis,Structure, and Reactivity of Hydridoiridium Complexes Bearing a Pincer‐Type PSiP Ligand

A series of iridium tetrahydride complexes [Ir(H)₄(PSiP‐R)] bearing a tridentate pincer‐type bis(phosphino)silyl ligand ([{2‐(R₂P)C₆H₄}₂MeSi]⁻, PSiP‐R, R=Cy, iPr, or tBu) were synthesized by the reduction of [IrCl(H)(PSiP‐R)] with Me₄N ⋅ BH₄ under argon. The same reaction under a nitrogen atmosphere afforded a rare example of thermally stable iridium(III)–dinitrogen complexes, [Ir(H)₂(N₂)(PSiP‐R)]. Two isomeric dinitrogen complexes were produced, in which the PSiP ligand coordinated to the iridium center in meridional and facial orientations, respectively. Attempted substitution of the dinitrogen ligand in [Ir(H)₂(N₂)(PSiP‐Cy)] with PMe₃ required heating at 150 °C to give the expected [Ir(H)₂(PMe₃)(PSiP‐Cy)] and a trigonal bipyramidal iridium(I)–dinitrogen complex, [Ir(N₂)(PMe₃)(PSiP‐Cy)]. The reaction of [Ir(H)₄(PSiP‐Cy)] with three equivalents of 2‐norbornene (nbe) in benzene afforded [Ir^I(nbe)(PSiP‐Cy)] in a high yield, while a similar reaction of [Ir(H)₄(PSiP‐R)] with an excess of 3,3‐dimethylbutene (tbe) in benzene gave the C H bond activation product, [Ir^III(H)(Ph)(PSiP‐R)], in high yield. The oxidative addition of benzene is reversible; heating [Ir^III(H)(Ph)(PSiP‐Cy)] in the presence of PPh₃ in benzene resulted in reductive elimination of benzene, coordination of PPh₃, and activation of the C H bond of one aromatic ring in PPh₃. [Ir^III(H)(Ph)(PSiP‐R)] catalyzed a direct borylation reaction of the benzene C H bond with bis(pinacolato)diboron. Molecular structures of most of the new complexes in this study were determined by a single‐crystal X‐ray analysis.     

Syntheses,characterizations and crystal structures of new triorganotin complexes with 2‐mercaptopyrimidine and 4‐amino‐2‐mercaptopyrimidine

Four triorganotin(IV) complexes with 2‐mercaptopyrimidine (HSpym) and 4‐amino‐2‐mercaptopyrimidine (HSapym) of the type, R₃SnL (L= Spym, R=Ph, 1; R=PhCH₂, 2; L=Sapym, R=Ph, 3; R=PhCH₂, 4), were synthesized. All the complexes 1–4 have been characterized by elemental, IR, ¹H NMR, and X‐ray crystallography diffraction analyses, which revealed that the structures of 1–4 are penta‐coordinated with R₃Sn‐coordinated to the thiol S and heterocyclic N atoms, and the structural distortion for each is a displacement from tetragonal toward trigonal bipyramidal geometry. The complex 1 is a one‐dimensional chain complex, while compounds 3 and 4 are dimers due to the existence of N···H hydrogen bonding. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:69–75, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20068     

Synthesis, Characterization and Biological Activity of Diorganotin（IV） Complexes of N-（3,5-Dibromosalicylidene）-α-amino Acid

The diorganotin（Ⅳ） complexes of N-（3,5-dibromosalicylidene）-α-amino acid, R2Sn（2-O-3,5-Br2C6H2CH= NCHRCOO）（where R=H, Me, i-Pr, Bz; R＇=n-Bu, Cy）, were synthesized by the reactions of diorganotin dichlorides with in situ formed potassium salt of N-（3,5-dibromosalicylidene）-α-amino acid and characterized by elemental analysis, IR and NMR （^1H, ^13C and ^119Sn） spectra. The crystal structures of n-Bu2Sn（2-O-3,5-Br2C6H2CH= NCHRCOO）（R=i-Pr, Bz） and Cy2Sn（2-O-3,5-Br2C6H2CH=NCHRCOO）（R=Me, Bz） were determined by X-ray single crystal diffraction and showed that the tin atoms are in a distorted trigonal bipyramidal geometry to form five- and six-membered chelate rings with the tridentate ligand. Bioassay results indicated that the compounds possess better in vitro antitumour activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7, than cis-platin and moderate anti-bacterial activity against two bacteria, E. coli and S. aureus.     

Syntheses and Crystal Structure of Six－coordinated Diorgnotin Complexes with 2,5－Dimercapto－4－phenyl－1,3,4－thiodiazole

The reactions of diorganotin dichloride [Ph_2SnCl_2, (PhCH_2)_2-SnCl_2 or (n-Bu)_2SnCl_2] with potassium salt of 2,5-dimercapto-4-phenyl-1, 3, 4-thiodiazole gave complexes R_2Sn (S_3N_2C_8H_5)_2(4: R=Ph; 5: R=PhCH_2 and 6: R=n-Bu), respectively.Characterizations were carried out for all complexes by IR, ~1HNMR spectra and X-ray crystallography analysis. Including theSn…N interaction, the three complexes all have six-coordinateddistorted octahedral geometry. Based on the requence of stereo-chemical constraint sequence, phenyl≈benzyl>n-butyl, the lessthe effect of the stereochemical constraint of R groups, the     

The Ruthenostannylene Complex [Cp*(IXy)H2Ru‐Sn‐Trip]: Providing Access to Unusual Ru‐Sn Bonded Stanna‐imine,Stannene, and Ketenylstannyl Complexes

Reactivity studies of the thermally stable ruthenostannylene complex [Cp*(IXy)(H)₂Ru Sn Trip] ( 1 ; IXy=1,3‐bis(2,6‐dimethylphenyl)imidazol‐2‐ylidene; Cp*=η⁵‐C₅Me₅; Trip=2,4,6‐iPr₃C₆H₂) with a variety of organic substrates are described. Complex 1 reacts with benzoin and an α,β‐unsaturated ketone to undergo [1+4] cycloaddition reactions and afford [Cp*(IXy)(H)₂RuSn(κ²‐O,O‐OCPhCPhO)Trip] ( 2 ) and [Cp*(IXy)(H)₂RuSn(κ²‐O,C‐OCPhCHCHPh)Trip] ( 3 ), respectively. The reaction of 1 with ethyl diazoacetate resulted in a tin‐substituted ketene complex [Cp*(IXy)(H)₂RuSn(OC₂H₅)(CHCO)Trip] ( 4 ), which is most likely a decomposition product from the putative ruthenium‐substituted stannene complex. The isolation of a ruthenium‐substituted stannene [Cp*(IXy)(H)₂RuSn(Flu)Trip] ( 5 ) and stanna‐imine [Cp*(IXy)(H)₂RuSn(κ²‐N,O‐NSO₂C₆H₄Me)Trip] ( 6 ) complexes was achieved by treatment of 1 with 9‐diazofluorene and tosyl azide, respectively.