共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Said A. S. Ghozlan Mohammed A. Al‐Omar Abd El‐Galil E. Amr Korany A. Ali Ahmed A. Abd El‐Wahab 《Journal of heterocyclic chemistry》2011,48(5):1103-1110
In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 10a , 10b , 11 , 11a , 11b , 12 , 12a , 12b , 13 , 13a , 13b , 14 , 15 based on N2′,N6′‐diphenylthiosemi‐carbazide pyridine‐2,6‐dicarbohydrazide 2 , which has been obtained from the corresponding dihydrazide 1 . The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011). 相似文献
3.
Xiayun Wang Yiwen Zhu Min Zhang Dongliang Lu Qun Qian Yali Chen Weiguo Cao Liping Song Hongmei Deng 《中国化学》2011,29(10):2119-2123
An efficient and convenient method for synthesis of 3,5‐bis‐carbamoyl‐2,6‐dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5‐bis(3′,5′‐dimethyl‐1′‐pyrazolyl‐carbonyl)‐2,6‐dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis. 相似文献
4.
Daniel P. Martone Andrew W. Maverick Frank R. Fronczek 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(6):m238-m239
The title compound, [CuCl2(C7H9N)4], lies on a site of crystallographic 42 (D4) symmetry in the space group P4/nnc, and is isomorphous with the Ni and Co analogues. The Cu and Cl atoms thus lie on a fourfold axis, and the 3,5‐lutidine ligands lie on twofold axes. The Cu—Cl distance is 2.7649 (7) Å and the Cu—N distance is 2.0510 (12) Å. The space group of the Co analogue is revised from Pnnn to P4/nnc. 相似文献
5.
Synthesis and Investigation of 2,6‐Bis(picrylamino)‐3,5‐dinitro‐pyridine (PYX) and Its Salts 下载免费PDF全文
Prof. Dr. Thomas M. Klapötke Dr. Jörg Stierstorfer Michael Weyrauther Tomasz G. Witkowski 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(25):8619-8626
2,6‐Bis(picrylamino)pyridine ( 1 ; pre‐PYX) and 2,6‐bis(picrylamino)‐3,5‐dinitropyridine ( 2 ; PYX) were synthesized using an improved literature method. Compounds 1 and 2 were reinvestigated in detail and the X‐ray structures ( 1 : ρ=1.698 g cm?3 at 173 K; 2 : ρ=1.757 g cm?3 at 298 K) are given. The reactions of 2 with different bases, such as alkali metal hydroxides (sodium, potassium, rubidium, cesium), and N‐bases (ammonia, hydrazine, hydroxylamine, guanidinium carbonate, aminoguanidine bicarbonate) are reported, as well as metathesis reactions producing energetic salts. Several energetic compounds were synthesized and characterized for the first time using vibrational (IR, Raman) and multinuclear NMR spectroscopy, mass spectrometry, elemental analysis, and DSC. The crystal structures of four energetic salts were determined using low temperature single‐crystal X‐ray diffraction. Heats of formation for the metal‐free species were calculated using the Gaussian 09 software. Detonation parameters were estimated using the EXPLO5 program. The sensitivities towards impact, friction, and electrostatic discharge were also determined. 相似文献
6.
Hong‐Fei Lu Liang‐Ze Zhang Ding‐Ming Wu Jun‐Tao Zhou 《Journal of heterocyclic chemistry》2011,48(5):1140-1144
A series of novel 2, 6‐diaromatic‐aminopurines (6a–6t) have been synthesized from guanine and characterized fully. The effects of different catalysts on the N‐alkylation of 2‐position of purine ring were discussed. J. Heterocyclic Chem., (2011). 相似文献
7.
Nouria A. Al‐Awadi Mehul Patel Hicham H. Dib Mervat Abdelkhalik 《Journal of heterocyclic chemistry》2007,44(5):989-992
Flash vacuum pyrolysis (FVP) of 1,7‐bis‐(3‐aroylideneamino)‐4,6,10,12‐tetramethyl‐2,8‐dioxo‐1,7‐diazacyclododeca‐3,5,9,11‐tetraene‐3,9‐dicarbonitriles 11a‐c at 650°C and 0.02 Torr yielded 5,7‐dimethyl‐3‐(4‐methylbenzoyl)‐pyrazolo[1,5‐a]pyridine‐4‐carbonitrile 14 , 4,6‐dimethyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitrile 16 and 3‐aryl‐3‐oxo‐propionitriles 17a,b . A plausible mechanism is suggested to account for the formation of the products. 相似文献
8.
Brian T. Holmes Clifford W. Padgett William T. Pennington 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(10):o602-o603
The title compound, C5H3I2N, crystallizes in the polar space group Fmm2, with crystallographic mm2 symmetry imposed on the molecule. Molecules are linked through C—H?N hydrogen bonding to form chains which are, in turn, joined through weak I?I halogen‐bonding interactions to form layers. The pyridine ring lies parallel to the polar z axis and has the N atom pointing in the +z direction. The layers stack in a polar fashion normal to the a axis and the absolute structure has been determined. 相似文献
9.
Karine A. Eliazyan Lusya V. Shahbazyan Vergine A. Pivazyan Emma A. Ghazaryan Aleksandr P. Yengoyan 《Heteroatom Chemistry》2009,20(7):405-410
By means of regioselective S‐alkylation of 1H‐1,2,4‐triazole‐3‐thiol ( 1 ), a series of S‐substituted derivatives 2a‐j were synthesized. In certain conditions, the reaction of 2 with arylsulfochlorides, arylisocyanates, and quaternary ammonium salts of azines corresponding compounds were obtained 1‐arylsulfonyl‐ (3a‐d) , 1‐arylcarbonamido‐ ( 4a,b ), and 1‐azinyl‐1,2,4‐ ( 6a‐p ) triazoles. Structures of compounds were confirmed by 1H NMR and elemental analyses. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 20:405–410, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20565 相似文献
10.
Malcolm A. Halcrow Colin A. Kilner 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(7):m424-m426
The title compound, [CuI(C17H21N5)]·CH2Cl2, contains a tetracoordinate CuI centre with an unusual distorted tetrahedral stereochemistry, which has also been observed in other CuI complexes containing this tridentate ligand. This distortion is probably a result of intermolecular steric contacts between the I? ligand and a neighbouring CH2Cl2 molecule. 相似文献
11.
The reaction of substituted phenyl isocyanates with 2‐amino‐2‐phenylpropanenitrile and 2‐amino‐2‐(4‐nitrophenyl)propanenitrile has been used to prepare substituted 1‐(1‐cyanoethyl‐1‐phenyl)‐3‐phenylureas. In anhydrous phosphoric acid the first products to be formed from 1‐(1‐cyanoethyl‐1‐phenyl)‐3‐phenylureas are phosphates of 4‐methyl‐4‐phenyl‐2‐phenylimino‐5‐imino‐4,5‐dihydro‐1,3‐oxazoles, which on subsequent hydrolysis give the respective ureidocarboxylic acids. On prolongation of the reaction time, the phosphates of 4‐methyl‐4‐phenyl‐2‐phenylimino‐5‐imino‐4,5‐dihydro‐1,3‐oxazoles rearrange to give phosphates of 5‐methyl‐4‐imino‐3,5‐diphenylimidazolidin‐2‐ones, and these are subsequently hydrolysed to the respective substituted 5‐methyl‐3,5‐diphenylimidazolidin‐2,4‐diones. The ureidocarboxylic acids were also prepared by alkaline hydrolysis of 5‐methyl‐3,5‐diphenylimidazolidin‐2,4‐diones. The 5‐methyl‐3,5‐diphenylimidazolidin‐2,4‐diones and ureidocarboxylic acids were characterised by their 1H and 13C NMR spectra. Structure of the 5‐methyl‐5‐(4‐nitrophenyl)‐3‐phenylimidazolidine‐2,4‐dione was verified by X‐ray diffraction. The alkaline hydrolysis of individual imidazolidine‐2,4‐diones was studies spectrophoto‐metrically in sodium hydroxide solutions at 25 °C. The rate‐limiting step of the base catalysed hydrolysis consists in decomposition of the tetrahedral intermediate. The reaction is faster if electron‐acceptor sub‐stituents are present in the 3‐phenyl group of imidazolidine‐2,4‐dione cycle. The pKa values of individual 5‐methyl‐3,5‐diphenylimidazolidine‐2,4‐diones have been determined kinetically. 相似文献
12.
Bahman Tamami Hamid Yeganeh 《Journal of polymer science. Part A, Polymer chemistry》2001,39(21):3826-3831
To prepare novel polyimides with enhanced thermal stability and high solubility in common organic solvents, diamine monomers, 4‐aryl‐2,6 bis‐(4‐amino phenyl)pyridine, were introduced. The diamines were reacted with three different conventional aromatic dianhydrides including pyromellitic dianhydride, benzophenone tetracarboxylic dianhydride, and hexafluoroisopropylidene‐2,2‐bis(phthalic‐dianhydride) (6FDA) in dimethylacetamide solvent to obtain the corresponding polyimides via the polyamic acid precursors and chemical imidization. The monomers and polymers were characterized by Fourier transform infrared spectroscopy, 1H NMR, mass spectroscopy, and elemental analysis; and the best condition of polymerization and imidization were obtained via the study of model compound. The polyimides showed little or no weight loss by thermogravimetric analysis up to 500 °C, and those derived from 6FDA exhibited good solubility in various polar solvents. © 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 39: 3826–3831, 2001 相似文献
13.
Martins Ikaunieks Sergey Belyakov Marina Madre 《Journal of heterocyclic chemistry》2006,43(4):943-948
The synthesis of novel 2‐amino‐9‐alkoxyalkylpurine derivatives with both identical and different sulfur containing substituents at positions 6 and 8 of the purine cycle has been accomplished. The thionation and alkylation of the key intermediate ‐ 2‐[2‐(acetylamino)‐6,8‐dichloro‐9H‐purin‐9‐yl]methoxyethyl acetate or its reactions with thiolates were used. The structures of compounds obtained were confirmed by spectroscopic data and X‐ray diffraction analysis. 相似文献
14.
Larry D. Bratton Bruce D. Roth Bharat K. Trivedi Paul C. Unangst 《Journal of heterocyclic chemistry》2000,37(5):1103-1108
The preparation of several novel 3,5‐substituted‐indole‐2‐carboxamides is described. A 5‐nitro‐indole‐2‐carboxylate was elaborated to the 3‐benzhydryl ester, N‐substituted ester, and carboxylic acid intermedi ates, followed by conversion to the amide and then reduction of the 5‐nitro group to the amine. Indole‐2‐carboxamides with 3‐benzyl and 3‐phenyl substituents were prepared in four steps from either a 3‐bromo indole ester using the Suzuki reaction or from a 3‐keto substituted indole ester. N‐Alkylation of ethyl indole‐2‐carboxylate, followed by amidation and catalytic addition of 9‐hydroxyxanthene gave a 3‐xanthyl‐indole‐2‐carboxamide analog and a spiropyrrolo indole as a side product. 相似文献
15.
John E. T. Corrie V. Ranjit N. Munasinghe Wolfgang Rettig 《Journal of heterocyclic chemistry》2000,37(6):1447-1455
4‐Trifluoromethyl‐ or 6‐bromo‐substituted 7‐diethylaminocoumarin‐3‐carboxamide derivatives 2 and 3, each containing a maleimide have been synthesized as potential fluorescent labeling reagents for thiol groups in proteins and their fluorescence properties have been determined. The 4‐trifluoromethyl substituted compound 2 has a significantly greater Stokes shift than the comparable compound lacking this group, but both the new coumarins have low fluorescence quantum yields (?f). When a 4‐trifluoromethyl substituent is present, the 3‐carboxamide is unusually labile to hydrolysis. Bromination of ethyl 7‐diethylaminocoumarin‐3‐carboxylate 17 gave the 6‐ and 8‐bromo derivatives 18 and 19 respectively, and also the 8‐bromo‐7‐monoethylamino compound 20. ?f for the latter compound is 100‐fold greater than for its diethylamino analogue 19. Fluorescence lifetime measurements support an interpretation based on the twisted intramolecular charge transfer (TICT) model to explain these large differences in ?f. 相似文献
16.
A facile and effective method for the synthesis of some benzothiazole derivatives is described. The method involves the action of aryl aldehyde and o‐aminothiophenol in acetic acid resulting into in situ formation of the thiol substituted Schiff's base and its cyclization to 2‐aryl benzothiazole upon prolonged heating. 相似文献
17.
Andrey A. Prishchenko Mikhail V. Livantsov Olga P. Novikova Ludmila I. Livantsova Elena R. Milaeva 《Heteroatom Chemistry》2008,19(5):490-494
Convenient procedures for the synthesis of 2,6‐di‐tert‐butyl‐4‐methylphenol (ionol) mono‐, di‐, and triphosphorus derivatives, starting from the readily accessible 3,5‐di‐tert‐butyl‐4‐hydroxybenzaldehyde, are proposed, and some properties of the obtained compounds are presented. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:490–494, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20458 相似文献
18.
Bernard Refouvelet Nadia Pellegrini Jean‐Franois Robert Gregorio Crini Olivier Blacque Marek M. Kubicki 《Journal of heterocyclic chemistry》2000,37(6):1425-1430
A series of new 2‐substituted thiazolidine‐4‐carboxamide derivatives which have potentially useful immunological properties, have been synthesized in a stereoselective manner by coupling 2‐subsituted thiazolidine‐4‐carboxylic acids with amines or amino esters. The structure of these compounds was established by combination of NMR methods and by X‐ray analysis. 相似文献
19.
Andrei S. Batsanov 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(6):e269-e270
The molecule of 3,5‐difluoro‐4‐nitropyridine N‐oxide, C5H2F2N2O3, is twisted around the C—NO2 bond by 38.5 (1)°, while the 3,5‐diamino analogue, 3,5‐diamino‐4‐nitropyridine N‐oxide monohydrate, C5H6N4O3·H2O, adopts a planar conformation stabilized by intramolecular hydrogen bonds, with a significant redistribution of π electrons. 相似文献
20.
Synthesis and asymmetric anionic polymerization of substituted 7‐aryl‐2,6‐dimethyl‐1,4‐benzoquinone methides 下载免费PDF全文
Takahiro Uno Hiroshi Ohta Atsushi Yamane Masataka Kubo Takahito Itoh 《Journal of polymer science. Part A, Polymer chemistry》2015,53(3):437-444
Substituted 7‐aryl‐2,6‐dimethyl‐1,4‐benzoquinone methides which have an electron‐donating methoxy substituent at the para‐position (p‐OMe, 2a ) or an electron‐withdrawing chloro one at the para‐ (p‐Cl, 2b ), meta‐ (m‐Cl, 2c ) , and ortho‐positions (o‐Cl, 2d ) of the benzene ring were synthesized, and their asymmetric anionic polymerizations using the complex of lithium 4‐isopropylphenoxide with (?)‐sparteine were carried out in toluene at 0 °C. The polymers with negative specific rotation were obtained for all of four monomers, and the polymer obtained from 2a showed smaller specific rotation value than that of polymer having no substituent (p‐H, 1 ) on the phenyl group and the polymers obtained from 2b–d showed larger ones. It was found that the kind of a substituent and its substitution position on the phenyl group affect significantly the optical activity of polymers. The largest specific rotation value of [α]435= ?153.2° was obtained in the polymerization of 2d with an ortho‐chloro substituent. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 437–444 相似文献