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《Green Chemistry Letters and Reviews》2013,6(2):141-147
Abstract α-N-substituted furan derivatives as new dipolarophiles have been employed in 1,3-dipolar cycloaddition reaction with α-chloro nitrones under microwave irradiation and found to afford exclusively novel regioselective 5-spiro cycloadducts with high yield in a very short reaction time.
Acknowledgements
Financial support from University Grants Commission, New Delhi (grant no:34-304/2008-SR) is gratefully acknowledged. We are also grateful to Dr M.P. Kharel, Principal, Sikkim Government College for providing facilities and also to Sophisticated Analytical Instrumentation Facility, Central Drug Research Institute, Lucknow for providing spectral data. 相似文献2.
《Green Chemistry Letters and Reviews》2013,6(3):291-301
Abstract Anilines react with two equivalents of allyl bromide in aqueous ethanol in the presence of Mg–Al hydrotalcites (Mg/Al = 5, 3, 2) at room temperature to give N,N-diallylanilines in good yield. Hydrotalcites (HTs) are mild and efficient catalysts, which can be easily recovered and reused. In this project, efforts are made to check the activity of the calcined and uncalcined HTs. Also, the methodology can be extended for the synthesis of various N,N-diallylanilines.
Acknowledgements
MRS is thankful to the UGC, New Delhi, for a fellowship under UGC-SAP programme. 相似文献3.
《Green Chemistry Letters and Reviews》2013,6(4):321-325
Abstract An efficient and environmentally benign protocol for the synthesis of 3-(2′-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones has been developed. The synthesis of these pharmacologically important compounds can be achieved by the three component condensation of isatoic/5-chloroisatoic anhydride, aldehyde, and 2-aminobenzothiazole in water: ethanol (1:1, v/v) without the aid of any catalyst.
Acknowledgements
SK thanks CSIR New Delhi (India) for the grants of junior and senior research fellowships. 相似文献4.
《Green Chemistry Letters and Reviews》2013,6(4):327-339
Abstract Heterogeneous Tin (IV) hydrogen phosphate nanodisks [Sn(HPO4)2.H2O] efficiently catalyzed the one-pot three component condensation of aromatic aldehydes, β-ketoesters and urea to produce 3,4–dihydropyrimidin-2-ones under solvent-free conditions at room temperature. Also, the catalyst is equally applicable for the preparation of 1,5–benzodiazepines under the same reaction conditions. The optimum load of the catalyst required is 10 mole% and reusable. Hence, the process is green.
Acknowledgements
The authors thank the Director, Dr. P.G. Rao, HOD, Dr. J.C.S. Kataky, Synthetic Organic Chemistry Division and the Analytical Division of NEIST, Jorhat, Assam, India, for their help. P.H. thanks CSIR, New Delhi, for the research fellowship. 相似文献5.
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Abstract Less-toxic, moisture-stable, inexpensive, and ecofriendly zirconium oxychloride octahydrate (ZrOCl2 · 8H2O) in aqueous acetone (1:1) mediates the conversion of oximes to carbonyl compounds in moderate to good yields. This green methodology is applicable to both aldoximes and ketoximes with tolerance to >C?C<, -NO2, -OH, and -Cl groups. The reaction and workup are simple.
ACKNOWLEDGMENTS
LNS and AJT are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for financial support. SD thanks Tezpur University for the institutional fellowship. The support to record NMR spectra at the Indian Institute of Technology (IIT), Guwahati, is gratefully acknowledged. 相似文献12.
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Abstract 10-Hydroxycamptothecin is prepared by chemoselective catalytic hydrogenation of the B-ring of camptothecin over PtO2 with sulfur moderators followed by oxidation using iodobenzenediacetate. New moderators (viz. thioanisole, dimethyl sulfide, diphenyl sulfide, 2-mercapto ethanol), which moderate the hydrogenation of the B- ring of camptothecin, are being explored.
ACKNOWLEDGMENTS
The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work, and support from analytical colleagues is highly appreciated. 相似文献14.
Abstract A simple and efficient method for multicomponant synthesis of 3,4-dihydropyrimidinones has been reported. All the reactions were carried out using samarium triflate as catalyst (10 mol%) at acetonitrile reflux. This procedure is applicable to a variety of substrates such as aliphatic, aromatic, and heterocyclic aldehydes.
ACKNOWLEDGMENT
A. R. R. is thankful to the Council of Scientific and Industrial Research, New Delhi, for providing a fellowship. 相似文献15.
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Ramakrishna V. S. Nirogi Rama Sastri Kambhampati Prabhakar Kothmirkar Sobhanadri Arepalli Narasimha Reddy G. Pamuleti Anil K. Shinde 《合成通讯》2013,43(19):2835-2851
Abstract Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical entities of biological importance, such as 2-piperazinymethyl thienopyrimidines (6, 8), 4-dimethylaminoethoxy thienopyrimidines (11), and 3-dimethylaminoethyl thienopyrimidines (12). All the compounds thus synthesized were screened for their invitro biological activities. Some of the compounds displayed promising serotonin 5-HT6 receptor antagonist activities.
ACKNOWLEDGMENT
The support received from the Discovery Analytical Department and Venkateswarlu Jasti, CEO, Suven Life Sciences Ltd., Hyderabad, is gratefully acknowledged. 相似文献19.