Microwave-Assisted Synthesis of Six-Membered O,O-Heterocycles

The development of new strategies for synthesis of six-membered O,O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in two oxygen atoms containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered O,O-heterocycles.     

Microwave-Assisted Synthesis of Six-Membered S-Heterocycles

The development of new strategies for synthesis of six-membered S-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in sulfur-containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered S-heterocycles.     

Applications of Microwaves in the Synthesis of Polycyclic Six-Membered N,N-Heterocycles

The development of new strategies for the synthesis of polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of six-membered polycyclic heterocyclic compounds containing two nitrogen atoms is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered polycyclic N,N-heterocycles.     

Microwave-Assisted Synthesis of Five-Membered O-Heterocycles

The development of new strategies for synthesis of five-membered O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen-containing five-membered heterocyclic compound synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of five-membered O-heterocycles.     

Microwave-Assisted Synthesis of Seven- and Higher-Membered O-Heterocycles

The development of new strategies for synthesis of medium-sized O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen-containing seven- and higher-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of O-heterocycles. The literature data are summarized based on the size of cycles.     

Polycyclic Six-Membered N-Heterocycles: Microwave-Assisted Synthesis

The development of new strategies for synthesis of polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing six-membered polycyclic heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of N-heterocycles.     

Review on the Synthesis of Six-MemberedN,N-Heterocycles by Microwave Irradiation

Abstract

The development of new strategies for synthesis of small-sized heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of six-membered heterocyclic compounds containing two nitrogen atoms is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of N,N-heterocycles.     

Microwave-Assisted Synthesis of Fused Polycyclic Six-Membered N-Heterocycles

The development of new strategies for synthesis of fused polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing six-membered fused polycyclic heterocyclic compounds synthesis is presented, focusing on the developments in the past 5 to 10 years. This contribution covers the literature concerning the total synthesis of fused polycyclic N-heterocycles.     

Greener and Expeditious Synthesis of Fused Six-Membered N,N-Heterocycles Using Microwave Irradiation

The development of new strategies for the synthesis of fused heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of fused six-membered heterocyclic compounds containing two nitrogen atoms is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of fused N,N-heterocycles.     

Ruthenium catalysis in six-membered O-heterocycles synthesis

Due to significant biological activity associated with N-, O-, and S-heterocycles, several reports for their synthesis have appeared in recent decades. Traditional approaches require expensive or highly specialized equipment or would be of limited use to the synthetic organic chemist due to their highly inconvenient approaches. This review summarizes the applications of ruthenium metal with emphasis of their synthetic applications for oxygen-containing six-membered heterocylces. In summary, this review article describes the synthesis of heterocyclic rings containing different heteroatoms.     

Perspectives of ionic liquids applications for the synthesis of five- and six-membered O,N-heterocycles

A considerable attention has been paid on the use of ionic liquids in chemical research. Modern synthetic chemistry is benefited as ionic liquid methodology provided an environmentally benign approach. In comparison to traditional processes the use of ILs resulted in improved, complimentary or alternative selectivities in organic synthesis. This review focuses on the advances in the development of innovative applications of ionic liquids for the synthesis of five- and six-membered O,N-heterocycles.     

Efficiently Aerobic Dehydrogenation of N-Heterocycles and Hydrocarbons over MnAl Oxides

Dehydrogenation of saturated N-heterocycles and hydrocarbons provides an important route to corresponding aromatic compounds. Herein, an efficient and selective MnAlO-catalyzed aerobic oxidative dehydrogenation of five- and six-membered N-heterocycles, imines and hydrocarbons is presented. The reaction features excellent yields of the products, mild reaction conditions, readily available and reusable catalyst. Various N-heterocycles and hydrocarbons can be tolerated by the reaction system and transformed to the corresponding aromatic counterparts. Mechanistic studies revealed that the reaction proceeds mainly through an electron transfer mechanism.     

The Construction of Highly Substituted Piperidines via Dearomative Functionalization Reaction

Nitrogen heterocycles play a vital role in pharmaceuticals and natural products, with the six-membered aromatic and aliphatic architectures being commonly used. While synthetic methods for aromatic N-heterocycles are well-established, the synthesis of their aliphatic functionalized analogues, particularly piperidine derivatives, poses a significant challenge. In that regard, we propose a stepwise dearomative functionalization reaction for the construction of highly decorated piperidine derivatives with diverse functional handles. We also discuss challenges related to site-selectivity, regio- and diastereoselectivity, and provide insights into the reaction mechanism through mechanistic studies and density functional theory computations.     

Review of Microwave-Assisted Synthesis of Benzo-Fused Six-Membered N,N-Heterocycles

The development of new strategies for synthesis of fused heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing benzo-fused six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of benzo-fused N,N-heterocycles.     

Microwave-Assisted Synthesis of Five-Membered O,N,N-Heterocycles

The development of new strategies for synthesis of five-membered O,N,N-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen and two nitrogen atoms containing five-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of five-membered O,N,N-heterocycles.     

Green synthesis of three- to five-membered O-heterocycles using ionic liquids

The investigation for replacement of organic solvents in organic synthesis is a growing area of interest due to increasing environmental issues. The use of ionic liquid salts as solvents and catalysts in organic reactions has gained extensive interest. Ionic liquids provided a new environmentally benign and improved alternative to traditional methods in modern synthetic chemistry. The aim of present review is to focus on the applications of ionic liquids for the synthesis of O-heterocycles.     

Microwave-Assisted Synthesis of Five-Membered O,N-Heterocycles

The development of new strategies for the synthesis of five-membered O,N-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen- and nitrogen-containing five-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of five-membered O,N-heterocycles.     

Microwave-Assisted Synthesis of Seven-Membered S-Heterocycles

The development of new strategies for synthesis of medium-sized S-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in sulfur-containing seven-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of S-heterocycles. The literature data are summarized based on the size of cycles.     

Efficient and versatile single pot approach to dipyrromethanes and bis(heterocyclyl)methanes

An efficient single pot route is presented involving the use of O, N-perhydro 1,3-heterocycles as carbonyl equivalents for the synthesis of 5-substituted dipyrromethanes, 5,10-disubstituted tripyrranes and bis(heterocyclyl)methanes.     

Peroxydation du dihydro-2,3 4H pyranne et du dihydro-2,3 furanne. Etude de réactivités

Free radical reactions of unsaturated O-heterocycles with t-butyl hydroperoxide in the presence of cuprous salt gives peroxides. Their analysis leads to the determination of reactivities in H-abstraction. Allylic hydrogen is ten times more reactive than hydrogen in the α position of the heteroatom.