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In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared, owing to the wide variety of their biological activity. This review introduces the key concepts of solid-phase methodology and combinatorial synthesis with particular focus on the important role of solid-phase synthesis in the synthesis of nitrogen-containing five-membered ring heterocycles. 相似文献
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Solid-phase organic synthesis is a rapidly expanding area of synthetic chemistry which is being widely exploited in the search for new medicinally important compounds using combinatorial techniques. In recent decades, a large number of reports related to solid-phase synthesis of heterocycles have appeared because of the wide variety in their biological activity. In this review, we report the important role of solid-phase synthesis in the synthesis of oxygen-bearing heterocycles. 相似文献
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Navjeet Kaur 《合成通讯》2013,43(1):35-69
The development of new strategies for synthesis of polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing six-membered polycyclic heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of N-heterocycles. 相似文献
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The development of new strategies for synthesis of six-membered S-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in sulfur-containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered S-heterocycles. 相似文献
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The development of new strategies for synthesis of six-membered O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in oxygen-containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six membered O-heterocycles. 相似文献
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The development of new strategies for synthesis of six-membered O,O-heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in two oxygen atoms containing six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered O,O-heterocycles. 相似文献
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Navjeet Kaur 《合成通讯》2013,43(3):273-299
The development of new strategies for synthesis of fused polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing six-membered fused polycyclic heterocyclic compounds synthesis is presented, focusing on the developments in the past 5 to 10 years. This contribution covers the literature concerning the total synthesis of fused polycyclic N-heterocycles. 相似文献
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Navjeet Kaur 《合成通讯》2013,43(3):300-330
The development of new strategies for synthesis of fused heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in nitrogen-containing benzo-fused six-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of benzo-fused N,N-heterocycles. 相似文献
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Navjeet Kaur 《合成通讯》2013,43(14):1599-1631
The development of new strategies for the synthesis of polycyclic heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of six-membered polycyclic heterocyclic compounds containing two nitrogen atoms is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of six-membered polycyclic N,N-heterocycles. 相似文献
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Greener and Expeditious Synthesis of Fused Six-Membered N,N-Heterocycles Using Microwave Irradiation
Navjeet Kaur 《合成通讯》2013,43(13):1493-1519
The development of new strategies for the synthesis of fused heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of fused six-membered heterocyclic compounds containing two nitrogen atoms is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of fused N,N-heterocycles. 相似文献
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Josef Stadlwieser Ernst P. Ellmerer-Müller Andreas Tak Najib Maslouh Willi Bannwarth 《Angewandte Chemie (International ed. in English)》1998,37(10):1402-1404
A nine-step (!) solid-phase synthesis and subsequent cleavage with cyclization from the polymeric support were the keys to preparing high-quality molecular libraries of thiazolylhydantoines 1 from modified amino acid building blocks. Each step in the synthesis is different. Because the final cyclization cleaves only molecules that have been successfully constructed, the products obtained are pure. R1, R2=alkyl; R3=aryl, arylO; R4=allyl. 相似文献
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A new method upon adopting a solid-phase strategy for synthesis of N-aryl succinimides is described here, using the silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with N-arylsuccinamic acids. The main advantage of this method is the recyclability of SBBC. 相似文献
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Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance. Nitrogen-containing heterocycles have compatible structures and properties with exceptional biological activity for the drug design of antiviral agents. They provided a broad spectrum of interference against viral infection at various stages, from blocking early viral entry to disrupting the viral genome replication process by targeting different enzymes and proteins of viruses. This review focused on the synthesis and application of antiviral agents derived from various nitrogen-containing heterocycles, such as indole, pyrrole, pyrimidine, pyrazole, and quinoline, within the last ten years. The synthesized scaffolds target HIV, HCV/HBV, VZV/HSV, SARS-CoV, COVID-19, and influenza viruses. 相似文献
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Navjeet Kaur 《合成通讯》2013,43(4):403-431
The development of new strategies for the synthesis of small-sized heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in three nitrogen atoms containing fused five-membered heterocyclic compounds synthesis is presented, focusing on the developments in the past 5–10 years. This contribution covers the literature concerning the total synthesis of N,N,N-heterocycles. The literature data are summarized based on the type of cycles. 相似文献
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