Macroheterocyclic Compounds with p-Diamines of the Diaryl Series

The reactions of indane-1,3-dione with 4,4′-diaminodiphenyl sulfone, 4,4′-diaminodiphenyl sulfide, and 4,4′-diaminodiphenyl ether were used to synthesize symmetrical macroheterocyclic compounds.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 6, 2005, pp. 1017–1021.Original Russian Text Copyright © 2005 by Berezina, Vorob’ev, Vorob’eva, Sadova.     

Macroheterocyclic Compounds Based on Nitro- and Chloro-1,3-indandiones

Macroheterocyclic compounds of symmetrical structure were prepared by reactions of 4- and 5-nitro-1,3-indandions and 4-chloro-1,3-indandione with m-phenylenediamine.     

Complexes of Macroheterocyclic Compounds Having 2,3-Dicyanopyrazine Fragments

Cobalt(II), copper(II), and nickel(II) complexes of macroheterocyclic compounds on the basis of 2,3-dicyanopyrazine were synthesized, and their IR and UV spectra were examined.     

Macroheterocyclic Compounds with Thiadiazole Fragments. Synthesis and Properties

The reactions of 1-imino-2-phenyl-1H-inden-3-amine with 3,5-diamino-1,2,4- and 2,5-diamino-1,3,4- thiadiazoles were used to synthesize linear 1: 2 and 2: 1 condensation products, as well as symmetrical macroheterocyclic compounds. The synthesized compounds were characterized by IR, UV, and ¹Н NMR spectroscopy.     

An Analytical Approach to Metabolic Profiling of Aromatic Compounds Using Liquid Chromatography

Abstract

An analytical approach to metabolic profiling of aromatic compounds is described for both conjugated and “free” metabolites in biological systems. Initially, an ethyl acetate extraction removes the less polar metabolites. A salting-out procedure using Sephadex G-10 is combined with reverse-phase high-performance liquid chromatography (HPLC) to analyze the water-soluble conjugates directly using sequential uv and fluorescence detection. The “free” metabolites are also derived from individual conjugate peaks by enzymatic or hydrolytic procedures and then re-chromatographed by HPLC. Metabolites in the ethyl acetate fraction are similarly analyzed by reverse-phase HPLC. The utility of this method is demonstrated for 2-acetylaminofluorene (2-AAF and 4-ethylsulfonyl-naphthalene-1-sulfonamide (ENS), two compounds of interest in the study of murine bladder carcinogenesis.     

Complexes of Macroheterocyclic Compounds Derived from Substituted 1,2,4-Triazoles with Tetravalent Metals

Symmetrical marcoheterocyclic compounds derived from substituted 1,2,4-triazoles were reacted with tin(IV) and titanium(IV) chlorides to prepare the corresponding metal complexes. Macroheterocyclic compounds insoluble in organic solvents give mixtures of products on complex formation.     

Macroheterocyclic Compounds with 2,3-Pyridino(pyrazino)pyrrole and 1,3,4-Thiadiazole Residues

Novel symmetrical macroheterocyclic compounds were prepared by the reactions of 2,3-dicyanopyridine and 2,3-dicyanopyraine with 2,5-diamino-1,3,4-thiadiazole in butanol in the presence of sodium butylate. Physicochemical properties and biological activity of the products were studied.     

The Effect of Macroheterocyclic Compounds and Their Metallocomplexes on Temperature-Frequency Characteristics of Aluminum Oxide Electrolytic Capacitors

Russian Journal of Electrochemistry - The effect of addition of mactoheterocyclic compounds of the ABAB and A′BBB types, in which A (1,3-phenylene or 2,6-pyridine)moiety, A′...     

Efficient Approach to Pure Entacapone and Related Compounds

A new and efficient process through a new intermediate, (2E)-2-cyano-3-(3,4-dihydroxy-5-nirtrophenyl)prop-2-enoic acid 15, has been described for preparing substantially pure entacapone 1. This new intermediate 15 was prepared by Knoevenagel condensation of 3,4-dihydroxy-5-nitrobenzaldehyde 2 with 2-cyanoacetic acid 14 and was further condensed with diethylamine to get pure entacapone 1. Some of the important process-related impurities of entacapone (17, 18, 19, and 20) were also prepared easily from this intermediate 15.     

利用“微视频”引领高三总复习——以“元素化合物”为例

在高三元素化合物一轮复习中,秉承新课程理念设计了8个微视频应用于课堂教学。结合具体实例阐述微视频的设计思路、包含的内容和呈现方式,简介如何使用微视频及其教学效果。     

Novel Approach to the Synthesis of Phosphorus Sulfur Organic Compounds and Their Metal Complexes

Abstract

The reaction of elemental phosphorus (P_{ti 4}) and sulfur with protonodonor reagents (alcohols, phenols, and thiols) has been studied in the presence of amines and complexes based on trialkyltrithiophosphites and transition metal halides. A novel approach to the synthesis of phosphorus sulfur organic compounds has been proposed on the basis of these reactions.     

A Novel Approach to the Synthesis of C-Glycosyl Compounds: The Wittig Rearrangement

Abstract

Partially protected benzyl α-and β-pyranosides undergo Wittig rearrangement reactions on treatment with strong bases in tetrahydrofuran to give hydroxymethylphenyl C-glycosyl derivatives. Two products were generally obtained and all Wittig rearrangement products retained the configuration at the migrating anomeric center. In benzene, benzyl 4,6-O-isopropylidene-β-D-glucopyranoside reacted with n-butyl lithium to give addition to the anomeric center accompanied by ring opening with loss of the aglycone. Allyl glycosides do not give Wittig rearrangement products.     

Synthesis of Homochiral Phosphorus Compounds: the Chiron Approach

Abstract

A large variety of structurally diversified optically active phosphine oxides can be derived from a single readily available homochiral (-)-S-methylphenylvinylphosphine oxide through elaboration of its versatile vinyl functionality.     

System Approach to the Identification of Organic Compounds in Complex Mixtures of Environmental Pollutants

A system approach to the identification of unknown compounds in complex mixtures by gas chromatography–mass spectrometry is proposed. The approach involves the detection of a system of components of common origin or simultaneously present in test samples (homologous series, isomer series, processing products in industry, degradation products in nature, and total of components present in enterprises" wastes) in the spectra of identified compounds followed by the purposive search for the other components of the found system.     

A Comprehensive Stability Study of Vardenafil Using Quality by Design Approach

Chromatographia - A novel, dual gradient LC method for quantification of vardenafil (VR) and its degradant products was developed with a multivariate approach. In the QbD approach, primary...     

An Efficient and Mild Deprotection of 1,3-Oxathiolanes to Carbonyl Compounds Using the Superoxide Ion

An efficient deprotection of 1,3-oxathiolanes to carbonyl compounds has been achieved under the mild reaction conditions of tetraethylammonium superoxide in an aprotic medium at room temperature.