Synthesis of Functional Derivatives of Benzofuran-5,6-dicarboxylic Acids

Russian Journal of General Chemistry - Synthetic routes to novel substituted benzofuran-5,6-dicarboxylic acids and furo[2,3-f]isoindole-5,7-diones via acid hydrolysis of the corresponding...     

1-酰基苯并咪唑及3-酰基-2-硫代噻唑烷酮衍生物的合成

苯并咪唑类化合物在杀菌剂研究中已取得可喜的结果,如苯菌灵、多菌灵,具有生物活性的酰基苯并咪唑类化合物已见报道,Richmond等研究发现保护性杀菌剂克菌丹在植物体内被代谢成具有内吸活性的含酰基硫代噻唑烷酮的氨基酸,杀菌和杀线虫剂N-244的结     

Synthesis of chalcones from 2-substituted 1-hydroxyindole-5,6-dicarbonitriles

Methods of synthesis of chalcones from 2-substituted 3-acetyl- and 3-formyl-1-hydroxyindole-5,6-dicarbonitriles under acidic conditions have been developed.     

Synthesis of 1-Acyl-3-Piperidones

The 1-acyl-3-piperidones ( 5 and 8 ) have been synthesised from N-benzylpiperidine-3,5-dione ( 1 ) via a reaction sequence, which is shown to be of general utility for the preparation of 1-acyl-3-piperidones. The total yields of 5 and 8 obtained from 1 are 35% and 31% respectively.     

Synthesis of 1-Acyl- and 1-Arylsulfonyl Derivatives of 3,5-Diamino-1,2,4-triazole

Acylation of 3,5-diamino-1,2,4-triazole with anhydrides and chlorides of alkane- and arenecarboxylic acids and arenesulfonyl chlorides in aqueous solutions and under phase-transfer catalysis was studied.__________Translated from Zhurnal Prikladnoi Khimii, Vol. 78, No. 5, 2005, pp. 790–795.Original Russian Text Copyright © 2005 by Chernyshev, Gaidukova, Zemlyakov, Taranushich.     

Phthalocyanines and Related Compounds: XXXIX. Synthesis of Derivatives of Some Substituted 1-Phenylnaphthalene-2,3-dicarboxylic Acids

Derivatives (dinitriles, anhydrides, imides, N-phenylimides) of substituted 1-phenylnaphthalene-2,3-dicarboxylic and 1-phenylphenanthrene-2,3-dicarboxylic acids were prepared by the reactions of 2-bromomethylbenzophenones with various dienophiles. Starting from these derivatives, gallium complexes of substituted tetra-1-phenyl-2,3-naphthalocyanines and tetra(1-phenyl-2,3-phenanthro)porphyrazine were synthesized.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 5, 2005, pp. 841–846.Original Russian Text Copyright © 2005 by Donyagina, Luk”yanets.     

Synthesis and Anti-influenza Virus Activity of Ethyl 6-Bromo-5-hydroxyindole-3-carboxylate Derivatives

A series of ethyl 6-bromo-5-hydroxyindole-3-carboxylate derivatives were synthesized and their in vitro anti-influenza virus activity was evaluated. All the compounds were characterized by ^1H NMR and MS.     

Synthesis of 3-Acyl-1,2-benzisoxazoles

A convenient method for the synthesis of 3-acyl-1,2-benzisoxazoles, which are unstable toward bases, is described. Base-catalyzed cyclization of 2-alkyl- and aryl-1,3-dithian-2-yl o-chlorophenylketoximes 4a-1 gave 3-(2-alkyl- and aryl-1,3-dithian-2-yl)-1,2-benzisoxazoles 8a-1 , which were converted into the corresponding 3-acyl-1,2-benzisoxazoles 1a-1.     

Synthesis of 1-Acyl-5-amino-4-ethoxycarbonylpyrazoles from Monohydrazides of Cyclohexenedicarboxylic Acids and Ethyl Ethoxymethylenecyanoacetate

Heating monohydrazides of cyclohexenedicarboxylic acids with ethyl ethoxymethylenecyanoacetate at reflux gives the corresponding N-substituted hydrazides. This reaction carried out in pyridine gives 1-acyl-5-amino-4-ethoxycarbonylpyrazoles. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1332–1335, September, 2005.     

新型苯并咪唑-5,6-二羧酸锌配合物的合成及其性能研究

以ZnSO₄·7H₂O和苯并咪唑-5,6-二羧酸为原料，采用水热法合成了一种新型的锌配合物{\[Zn(H₂-bidc)₂(H₂O)₄]·(H₂O)₄}_n[1 (CCDC: 1007038), H₃-bidc=苯并咪唑-5,6-羧酸]，产率48%，其结构经IR,元素分析和X-射线单晶衍射表征。结果表明：1属正交晶系，Pnnm空间群，晶胞参数a=9.6451(19) ， b=19.459(4) ， c=6.6895(13) ，α=β=γ=90°， V=1255.5(4) ³， Dc=1.634 g·cm^-3， Z=8。采用FL和TGA研究了1的性能。结果表明：1具有一定的热稳定性，最大发射峰位于420 nm和416 nm， 1的荧光发射属于发射配体荧光。     

Synthesis of Derivatives of 1,3,4-Oxadiazoles Based on Monohydrazides of 2-Aryl-4-methyl-4-cyclohexen-1,2-dicarboxylic Acids

The corresponding derivatives of 1,3,4-oxadiazoles have been synthesized by the reaction of monohydrazides of 2-aryl-4-methyl-4-cyclohexen-1,1-dicarboxylic acids with triethyl orthoformate or triethyl orthoacetate.     

Synthesis of indole-5,6- and carbazole-2,3-dicarboxylic acid functional derivatives

Principal synthetic approaches to the synthesis of indole-5,6- and carbazole-2,3-dicarboxylic acid functional derivatives are considered. The first of them consists in the construction of the indole ring from simpler aromatic compounds containing carboxy groups, cyano groups, or an imide fragment with subsequent reductive cyclization of the compounds formed. The second approach is based on the modification of a pyrrole or an indole fragment by the introduction of different functional groups with subsequent intramolecular cyclization to the corresponding heterocycles.     

Synthesis and Reactions of Derivatives of 2-Deoxyoct-3-Ulosonic Acids

Abstract

Decarboalkoxylations of branched chain 2-deoxyoct-3-ulosonic acid derivatives furnished the unbranched 2-deoxyoct-3-ulosonic acid esters and nitriles, respectively. The O-methylation and halogenalion of 2-deoxyoct-3-ulosonates are described.     

5,6-二氢-5-氧杂-1,3-二氮杂菲衍生物的合成

以2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(1)为起始原料, 在氢化钠作用下, 通过与羰基α-氢的Claisen缩合反应, 得到3-乙酰基-2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(2), 所得β-二酮与脲、硫脲和脒衍生物分别进行缩合关环, 生成5,6-二氢-5-氧杂-1,3-二氮杂菲衍生物3和4. 在相同的条件下, 吡喃酮1与草酸二乙酯进行缩合反应, 给出3-乙氧乙二酰 基-2,3-二氢-3-氧代-1,3-苯并(c)-α-吡喃(5), 选择3-氨基吡唑、2-氨基咪唑、3-氨基三唑、2-氨基苯并咪唑和3,5-二氨基吡唑-4-偶氮苯与5缩合, 分别环合成5,6-二氢-5-氧杂-1,3-二氮杂菲并和五元含氮杂环衍生物6～10. 所合成的新化合物均经核磁共振光谱、红外光谱及元素分析证明其结构.     

Synthesis of Saccharindicarboxylic Acids and Their Derivatives

Procedures were developed for preparing saccharindicarboxylic acids and their derivatives.__________Translated from Zhurnal Prikladnoi Khimii, Vol. 78, No. 2, 2005, pp. 347–348.Original Russian Text Copyright © 2005 by Aslanov, Mamedli, Guliev.     

Synthesis of Ether-Linked Di- and Trisaccharide Derivatives Part I- Synthesis Of Disaccharides from 5,6-Anhydro-D-Glucose Derivatives

Abstract

We have synthesized a series of A-O-B disaccharides of the type A(6→n)B obtained by linking the D-glucose derivative (A) with each of the D-fructose, D-galactose, D-glucose, xylitol and glycerol derivatives (B). The key step in each case is the nucleophilic attack of a monosaccharide alkoxide on the C-6 site of 3-O-alkyl-5,6-anhydro-1,2-O-isopropylidene-α-D-glucofuranose; each reaction was performed in toluene-DMSO and using KOH as the base.     

Synthesis of Derivatives of Pyrazolin-1H-3-ones from 2′-N-Substituted Monohydrazides of Cyclohexenedicarboxylic Acids

2-(6-Aryl-4-methylcyclohex-3-enecarbonyl)-4-ethoxycarbonylpyrazolin-1H-3-ones have been synthesized from 2′-N-(2,2-diethoxycarbonylvinyl)monohydrazides of 6-aryl-4-methylcyclohex-3-ene-1,1-dicarboxylic acids by boiling in DMF, pyridine, or toluene in the presence of potassium carbonate. Under analogous conditions, but without potassium carbonate, 2′-N-substituted hydrazides of cyclohexenecarboxylic acids are obtained. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1007–1011, July, 2005.