Sylvone,a new furanoid lignan ofpiper sylvaticum

The structure of a novel 2,3,4- trisubstituted furanoid lignan, designated sylvone, was established as $\text{1}$ from detailed spectroscopical and chemical studies.     

(+)-Africanal,a new lignan of the aryltetrahydronaphthalene class

The absolute configuration (1R,2R,3R,3aS) and structural relationships of africanal, a novel lignan from Olea africana, are defined.     

A new furanoid diterpene from Caesalpinia pulcherrima

A new cassane-type diterpene isovouacapenol E (1) was isolated from the leaves of Caesalpinia pulcherrima, together with the known compounds caesaldekarin A (3), spathulenol (4), caryophyllene oxide (5), phytol, and sitosterol. The structure of 1 was elucidated by spectral data interpretation.     

Officinalioside,a new lignan glucoside from Borago officinalis L.

A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC₅₀: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC₅₀ > 100 μM).     

Konyanin: a new lignan from hapuophyllum vulcaniclm

Konyanin ($\text{1}$), obtained from $\text{Haplophyllum vulcanicum}$ (Rutaceae), is the first known 1,4-dihydroarylnaphthalene lignan in which the lactone carbonyl is bonded to C-3 rather than to C-2. Detailed NMR spectral data have been complied for the accompanying lignans (-)-kusunokinin ($\text{5}$) and diphyllin ($\text{7}$).     

Patavine, a new arylnaphthalene lignan glycoside from shoot cultures of Haplophyllum patavinum

A new arylnaphthalene lignan glycoside, patavine (1), together with five known lignans, justicidin B (2), diphyllin (3), tuberculatin (4), majidine (5), and arabelline (6) were isolated from shoot cultures of Haplophyllum patavinum. The structure of the new compound was elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR experiments and mass spectrometry. The cytotoxicity of compounds 1, and 3-6 against LoVo human colon carcinoma cells was investigated.     

Malabarolide,a novel furanoid bisnorditerpenoid from tinospora malabarica

A novel furanoid bisnorditerpene has been isolated from the fresh stems of Tinospora malabarica Miers (Menispermaceae) and structurally characterized using X-ray crystallographic and spectroscopic techniques.     

用核磁共振测定桂花中一个新的内酯化合物的结构

Lignans are widely distributed secondary metabolites in Oleaceae plant. They are also of rapidly growing interest because of their effect of anticancer. Oleaceae plants distribted in the whole China. There are serval epieudesmin-type lignan 1 to be isolated from Oleaceae plants. It is reported the lignan exbibits the activity of anticancer and antioxidant.     

A new lignan from Gynostemma pentaphyllum

A new lignan ligballinone 1 with the know ligballinol 2 were isolated from plant Gynostemma pentaphyllum.Their structures were determined through spectroscopic methods including ESI-MS,1D and 2D NMR (1H,13C,DEPT,1H-1H COSY,HMQC,RMBC) and X-ray diffraction experiment for 2.     

A new lignan from Oxytropis myriophylla

The 70% alcohol extract of Oxytropis myriophylla (PALL.) DC. (Leguminosae) exhibited high radical scavenging activity (IC(50) value: 88.0?μg?mL(-1) and 86.7?μg?mL(-1)) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. Further chemical investigation led the isolation of one new lignan, namely myriophylloside G (1), together with three known compounds. Their structural elucidations of all the compounds were based on extensive spectroscopic methods, including HRESIMS and 2D NMR experiments (HSQC, HMBC and (1)H-(1)HCOSY) and by comparison with reference values.     

Bufadienolides and a new lignan from the bulbs of Urginea maritima

Thirty three compounds were obtained from the bulbs of Urginea maritima (Liliaceae). The compounds were identified by means of fast atom bombardment mass spectrometry (FAB-MS), nuclear magnetic resonance (1H-NMR), (13C-NMR), nuclear overhauser effects (NOE) and two dimensional (2D) NMR. Ten of them were new natural compounds. Nine were bufadienolides and only one was lignan in these compounds.     

A new pinoresinol-type lignan from Ligularia kanaitizensis

A new pinoresinol-type Lignan, 9alpha-angloyloxypinoresinol (1), was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz, in addition to a known compound, 9alpha-hydroxypinoresinol (2). The structure of this new lignan (1) was established on the basis of 1D and 2D NMR experiments. Anti-HIV-1 RT biological assay showed that 1 was inhibitory to HIV-1 RT.     

A new aryltetrahydronaphthalene lignan from Epimedium brevicornum

A new aryltetrahydronaphthalene lignan,(+)-cycloolivil formaldehyde condensate(1),was isolated from the whole plants of Epimedium brevicornum(Berberidaceae).Its structure was elucidated on the basis of MS,1D and 2D NMR techniques.     

Saracoside: a new lignan glycoside from Saraca indica, a potential inhibitor of DNA topoisomerase IB

Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3, (+)5'-methoxyisolarciresinol-9'-O-beta-D-glucopyranoside and nudiposide, and a phenolic glucopyranoside, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, which has been isolated for the first time from this species. The isolated lignan glycosides exhibit potent DNA topoisomerase IB inhibitory activity.     

A new cyclobutane lignan from Cinnamomum balansae

A new cyclobutane lignan, named cinbalansan (6), was isolated from the leaves of Cinnamomum balansae, along with five known compounds, 1,2-dimethoxy-4-(1-E-propenyl)benzene (1), 1,2-dimethoxy-4-(1-Z-propenyl)benzene (2), 1,2-dimethoxy-4-(2-propenyl)benzene (3), 3,4-dimethoxybenzaldehyde (4), and E-(3,4-dimethoxyphenyl)-2-propenal (5). The structure of cinbalansan was shown to be 1beta,2beta,3alpha,4alpha-1,2-dimethyl-3,4-bis(3,4-dimethoxyphenyl)cyclobutane by a combination of 1H-, 13C-NMR, and NOE- experiments and by direct analysis of the 1H-NMR spectrum by the method of X-application.     

A new lignan and a new sesquiterpene from Eurotia ceratoides (L.)

A new lignan, rayalinol (1) and a new sesquiterpene kairatene (2) were isolated from Eurotia ceratoides (L.) along with four hitherto unreported syringaresinol, dehydrodiconiferyl aldehyde, dihydrodehydrodiconiferyl alcohol, and dehydrodiconiferyl alcohol and two previously reported constituents ferulic acid and β-sitosterol. The structures of the new constituents were elucidated by extensive spectroscopic means and chemical evidences. Rayalinol is a biogenetically interesting compound with a hitherto unreported 9a homolignane skeleton. Its biosynthetic origin is suggested.     

A new furofuran lignan from Piper terminaliflorum Tseng

The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2–4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undecatrienoyl]pyrrolidine (4). Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS, and by comparison with the literature. Compounds (2–4) were isolated from Piper terminaliflorum Tseng for the first time. All isolated compounds (1–4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).