A NEW CONVENIENT METHOD FOR THE SYNTHESIS OF PERFLUOROALKYL 2H-PYRROLE

The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formation of 2-perfluoroalkyl-2,5-dimethyl-2H-pyrrole (3) as a major product in good yield.     

A NEW METHOD FOR THE PREPARATION OF FULLEROL

ＡＮＥＷＭＥＴＨＯＤＦＯＲＴＨＥＰＲＥＰＡＲＡＴＩＯＮＯＦＦＵＬＬＥＲＯＬ￥ＤａＹｏｎｇＳＵＮ；ＺｉＹａｎｇＬＩＵ；ＸｉｎｇＨｕａＧＵＯ；ＹｉＭｉｎＳＨＥ；ＹｕＺＨＯＵ；ＳｈｕＹｉｎｇＬＩＵ（ＴｈｅＫｅｙＬａｂｏｒａｔｏｒｙｏｆＡｐｐｌｉｅｄＳｐｅｃ...     

A MODIFIED METHOD FOR THE PREPARATION OF GOETHITE

Synthetic goethite(α-FeOOH) was prepared in the laboratory using a modified version of Brauer's method.The process of steam-crystallization was prolonged and impurities were removed by dialysis.The products have been characterised by Surface Area Analyser and Scanning Electron Microscope, and proved to have larger Specific Surface Area than that in literature.     

A NEW METHOD FOR THE SYNTHESIS OF ARYLTHIOCYANATES

Arylthiocyanates could be synthesized by reaction of arylsulfonyl chlorides with cuprous cyanide with yields ranging from 42-80％.     

STUDIES ON THE SYNTHESIS OF ISOSARCOPHYTOL-A

A precursor 9 of isosarcophytol-A(1)was prepared from(■)-farnesol(3)through 6 steps.Isosarcophytol-A(1),a cembrane-type diterpenoid,was first isolated fromustralian soft coral(Nephthea brassica)in 1982,and its structure was estab-shed as(1,3,7,11-all ■,13■)-cembra-1,3,7,11-tetraen-13-ol,an isomer ofarcophytol-A■.As far as we know,its bioactivity and synthesis have noteen reported yet.     

STUDIES ON FLUOROALKYLATION AND FLUOROALKOXYLATION 17.A NEW METHOD FOR PREPARATION OF 2-FLUOROALKYL PYRROLE

The examples for fluoroalkylating heteroaromatic compounds are rather few.Wak-selman et.al.reported the reaction Of perfluoroalkyl iodides with N-methyl pyrroleunder thermal conditions,but failed for pyrrole tself.However,Kobayashi et.al.found that 2-trifluoromethyl pyrrole conld be obtained under UV irradiation for 3 days     

SYNTHESIS OF ANALOGUES OF HUPERZINE A 4．THE PREPARATION OF A PYRIMIDONE ANALOGUE OF HUPERZINE A

ＳＹＮＴＨＥＳＩＳＯＦＡＮＡＬＯＧＵＥＳＯＦＨＵＰＥＲＺＩＮＥＡ４．ＴＨＥＰＲＥＰＡＲＡＴＩＯＮＯＦＡＰＹＲＩＭＩＤＯＮＥＡＮＡＬＯＧＵＥＯＦＨＵＰＥＲＺＩＮＥＡ￥ＹｕｎＬｏｎｇＬＩ；ＸｕＣｈａｎｇＨＥａｎｄＤｏｎｇＬｕＢＡＩ（ＳｈａｎｇｈａｉＩｎｓ...     

A NEW METHOD FOR THE PREPARATION OF PHENOLS AND ITS DERIVATIVES

a-Oxo ketene dithioacetals 2 via 1,2-nucleophilie addition by methallyl magnesius chloride afforded corresponding alcohols (3). Treated with water or methanol and catalyzed by Lewis acid, the alcohols 3 were converted regiospecifical ly to substituted phenols 5' or related phenol methyl ethers 5 respectively. This reaction is a novel approach to the synthesis of phenols and their derivatives starting from non-aromatic precursors.     

STUDIES ON THE REACTION OF SULFUR,SELENIUM AND TELLURIUM WITH SODIUM HYDROXIDE UNDER PHASE TRANSFER CATALYSIS(Ⅱ).A CONVENIENT METHOD FOR THE SYNTHESIS OF BI(ACYL)DISULFIDES

A simple and general method for the synthesis of bi(acyl)disulfides isreported.Sulfur is allowed to react with sodium hydroxide to give sodium disulfideat 65℃ under PTC,which can react with acyl halides to afford bi(acyl)disulfides ingood to excellent isolated yields.The effects of solvents and phase transfercatalysts are discussed.     

A CONVENIENT WAY FOR SYNTHESIS OF C-FUNCTIONALIZED MACROCYCLIC DIOXOTETRAAMINE

A novel,simple approach to synthesis of macrocyclic dioxo-tetraamine ligands bearing pendent coordinating groups was described.Reduction of coumarin derivatives with sodium borohydride and thenaminolysing the products with triethylenetetraamine,correspondingmacrocyclic dioxotetraamine ligands were obtained.     

A NEW METHOD FOR THE SYNTHESIS OF METHACRYLIC ACID FROM ISOBUTYRALDEHYDE

Isobutyraldehyde was used as starting material via three steps: oxidation, chlorination and dehydro-chlorination to yield methacrylic acid. The total yield of methacrylic acid is 49.7%.     

STUDIES ON THE SYNTHESIS OF Ti_3O_5 BY MICROWAVE INDUCED PLASMA METHOD

ＳＴＵＤＩＥＳＯＮＴＨＥＳＹＮＴＨＥＳＩＳＯＦＴｉ_３Ｏ_５ＢＹＭＩＣＲＯＷＡＶＥＩＮＤＵＣＥＤＰＬＡＳＭＡＭＥＴＨＯＤ￥ＡｉＭｉｎＹＵ；ＷｅｎＧｕｏＸＵ；ＷｅｎＪｕｎＹＡＮＧ；ＱｕａｎＺｈｏｎｇＬＩａｎｄＱｉｎＨａｎＪＩＮ（ＤｅｐａｒｔｍｅｎｔｏｆＣ...     

STUDIES ON THE TOTAL SYNTHESIS OF CIMICIFUGAMIDEFROM CIMICIFUGA DAHURICA

ＳＴＵＤＩＥＳＯＮＴＨＥＴＯＴＡＬＳＹＮＴＨＥＳＩＳＯＦＣＩＭＩＣＩＦＵＧＡＭＩＤＥＦＲＯＭＣＩＭＩＣＩＦＵＧＡＤＡＨＵＲＩＣＡＰｉｎｇＹｕＤＩＮＧ；ＸｉａｏＸｉａｎｇＺＨＵ；ＭｅｎｇＳｈｅｎＣＡＩ（ＤｅｐａｒｔｍｅｎｔｏｆｏｒｇａｎｉｃＣｈｅｍｉｓ...     

STUDIES ON HETEROMACROCYCLIC POLYETHER （XIV） THE SYNTHESIS OF SELENACROWNETHER WITH HYDROXY GROUP AND DISELENA－AZA－CROWNETHER

ＳＴＵＤＩＥＳＯＮＨＥＴＥＲＯＭＡＣＲＯＣＹＣＬＩＣＰＯＬＹＥＴＨＥＲ（ＸＩＶ）ＴＨＥＳＹＮＴＨＥＳＩＳＯＦＳＥＬＥＮＡＣＲＯＷＮＥＴＨＥＲＷＩＴＨＨＹＤＲＯＸＹＧＲＯＵＰＡＮＤＤＩＳＥＬＥＮＡ－ＡＺＡ－ＣＲＯＷＮＥＴＨＥＲＨａｎＳｈｅｎｇＸｕ；Ｊｕ...     

STUDIES ON THE SYNTHESIS AND REACTIONS OF N－（1－OXO－4－CARBONYL－2，6，7－TRIOXA－1－PHOSPHABICYCLO ［2．2．2］ OCTANE）－N＇－ARYL THIOUREAS

ＳＴＵＤＩＥＳＯＮＴＨＥＳＹＮＴＨＥＳＩＳＡＮＤＲＥＡＣＴＩＯＮＳＯＦＮ－（１－ＯＸＯ－４－ＣＡＲＢＯＮＹＬ－２，６，７－ＴＲＩＯＸＡ－１－ＰＨＯＳＰＨＡＢＩＣＹＣＬＯ［２．２．２］ＯＣＴＡＮＥ）－Ｎ’－ＡＲＹＬＴＨＩＯＵＲＥＡＳＹｕＧｕｉＬＩ；Ｘｕ...     

STUDIES ON THE SYNTHESIS OF NOVEL ISONUCLEOSIDE FROM D-GLUCOSE

ＳＴＵＤＩＥＳＯＮＴＨＥＳＹＮＴＨＥＳＩＳＯＦＮＯＶＥＬＩＳＯＮＵＣＬＥＯＳＩＤＥＦＲＯＭＤ－ＧＬＵＣＯＳＥ￥ＨｏｎｇＷｕＹＵ；ＬｉｎｇＴａｉＭＡ；ＬｉＨｅＺＨＡＨＧ（ＳｃｈｏｏｌｏｆＰｈａｒｍａｃｅｕｔｉｃａｌＳｃｉｅｎｃｅｓＢｅｉｊｉｎｇＭｅｄｉ...     

STUDIES ON THE SYNTHESIS OF BAIMUXINOL BY CATALYTIC HYDROGENATION OF DEHYDROBAIMUXINOL

Baimuxinol, a 4-hydroxymethyl agarofuran isolated from Aquilaria Sinensis, was synthsizd. The stereoselectivity of catalytic hydrogenation of dehydrobaimuxino and its derivatives was studied.     

A SIMPLE METHOD FOR THE SYNTHESIS OF 2-AMINO-1-(4′-METHOXYPHENYL)-PROPANE

Synthesis of 2-amino-1-(4′-methoxyphenyl)-propane (II) starting from p-anisaldehyde (1) in 67% overall yield is described. Key reactions involved Horner–Wadswoth–Emmons olefination of 1 to form the ester 2 and Hoffmann degradation of amide 5 to obtain the amine II.     

A NEW METHOD FOR PREPARATION OF β-LACTAM SULFOXIDES

Abstract

Penicillin sulfoxides (II) are key intermediates in chemical transformations of penicillins to cephalosporins. Oxidation of the sulfur atom in penicillin nucleus (I) to the sulfoxide (II) has been studied and a new economically feasible method developed.     

STUDIES ON THE SYNTHESIS OF THE SPIROKETAL FRAGMENT OF AZADIRACHTIN(Ⅰ)

The stereoselective synthesis of substituted [2,2,1]-bicyclo-heptan-2-one 12,a supposed intermediate to the spiroketal fragment of azadi-rachtin was described.When 12 was treated with mCPBA in CH_2Cl_2 in the pres-ence of excess amount of solid sodium bicarbonate,only 13 was obtained.Thespiroketal intermediate 20 was converted from 9 through 5 steps by an alterna-tive route.