盐酸地尔硫卓药物树脂复合物的制备及其体外释药动力学研究

本文以强酸性阳离子交换树脂为载体，制备了盐酸地尔硫卓(DH)药物树脂复合物。研究了DH与001×7树脂的交换反应动力学以及药物树脂复合物在去离子水、0.5mol/L、1.0mol/L、2.0mol/L NaCl和在0.5mol/L HCl以及0.5mol/L KCl溶液中的释药动力学。结果表明，在制备药物树脂的过程中，随温度的升高，药物与树脂的交换速率增加，及有利于反应的进行；药物树脂复合物在去离子水中不释放药物，但其释放随释放介质浓度的增加而增加，并且属于粒扩散的离子交换控制，粒扩散系数Dr随离子强度的增加而增加，DH的释药动力学过程符合对数方程（Visuanathan方程），001×7树脂可有效地控制DH在体外的释放。     

盐酸维拉帕米药物树脂复合物的制备及其体外释药动力学

口服药物树脂控释给药系统;交换反应动力学;盐酸维拉帕米药物树脂复合物的制备及其体外释药动力学     

新型大颗粒离子交换树脂的表征和催化活性

用红外、核磁及热分析技术表征由溶胶-凝胶法制备、具有离子交换性能的大颗粒树脂催化剂，证实了树脂催化剂由含苯基及含硅的化合物构成，热稳定性高于商品离子交换树脂近100℃。对该树脂催化剂进行磺化反应的最佳条件为：温度，25℃；浓度，氯磺酸：三氯甲烷-1：4（Vo1）；时间，12h。其缩醛化反应的催化活性与商品大孔离子交换树脂相当。     

《功能高分子材料》

全书共分17章，结合功能高分子材料的结构开发性能，制备方法及领域，对离子交换树脂，吸附树脂，离子交换纤维和活性碳纤维，高分子膜分离材料，高分子色谱固定相，高分子试剂。     

载镍炭化树脂催化剂的制备──树脂预处理及交换对炭化树脂表面性能的影响

球形炭化树脂作为催化剂载体具有许多独特的优点，为炭素材料催化剂开拓了新的前景。在诸多炭化树脂催化剂的制备方法中，离子交换－炭化法具有许多优点，是重要的制备方法之一。本文从Ｄ１５２大孔弱酸阳离子交换树脂为前驱载体，用不同的预处理方法先制成钙型Ｄ１５２树脂（Ｃａ／Ｄ１５２），然后同Ｎｉ的ＮＨ３－ＮＨ４＋水溶液、乙醇水溶液进行离子交换，再经炭化后制成了高分散度、高强度的栽体镍炭化树脂（Ｎｉ／Ｃ）催化剂。本文对各种制备条件与（Ｎｉ／Ｃ）催化剂的结构性能的关系进行了讨论。     

载镍炭化树脂催化剂的制备—树脂预处理及交换对碳化树脂表面性…

球形炭化树脂作为催化剂载体具有许多独特的优点，为炭素材料催化剂开拓了新的前景。在诸多炭化树脂催化剂的制备方法中，离子交换－炭化法具有许多优点，是重要的制备方法之一。本文从Ｄ１５２大孔弱酸阳离子交换树脂为前驱载体，用不同的预处理方法先制成钙型Ｄ１５２酸阳离子交换树脂为前驱载体，用不同的预处理方法先制成钙型Ｄ１５２树脂，然后同Ｎｉ的ＮＨ３－ＮＨ＾＋４水溶液、乙醇水溶液进行离子交换，再经炭化后制成了高分     

阳离子交换树脂对钙拮抗剂的吸附及控释特性

离子交换树脂是一类功能高分子材料．长期以来应用于分析化学、蛋白质化学、纯水制备等领域．近年来 ,离子交换树脂也逐渐应用于ＤＲＳ的研究和开发 ,即口服药物树脂复合物缓释给药系统 (ＯｒａｌＤｒｕｇ ＲｅｓｉｎＣｏｎｔｒｏｌｌｅｄＲｅｌｅａｓｅＳｙｓｔｅｍ,ＯＤＲＣＲＳ)．与其他的给药系统相比,ＯＲＣＲＳ的最主要的优点是能制成稳定性良好的液体控释制剂,供儿童及有吞咽困难的老年人服用［１ ３］．中枢镇咳药美沙芬药物树脂复合物液体控释制剂（Ｄｅｌｓｙｍ）的上市被认为是药物控释技术的一大突破［４］．盐酸维拉帕米 (…     

离子交换树脂转型过程的溶胀动力学跟踪方法

本文在前文共聚物小球溶胀性能的快速自动测定方法的基础上，仪器经改进增加了自动进、出溶液的装置，成功地跟踪了离子交换树脂在柱中转型时的树脂应力变化的速度，为更科学地研究离子交换树脂及改进工艺提供了新的研究方法。     

“粉末包埋”型离子交换树脂的研究

本文介绍了一种新型树脂—“粉末包埋树脂”的合成及性能。在三聚氰胺—甲醛的预聚浆液中加入无机离子交换剂磷钼酸铵(AMP),经悬浮聚合,可得到含有AMP的珠状“粉末包埋树脂”AMP—MF。这类树脂具有AMP的特殊选择性及优良的机械性能。珠状树脂适宜柱层析操作,克服了粉末状无机离子交换剂AMP不适于工业操作的缺点。本合成方法为制备特大孔型缩聚珠提供了一新的合成途径。     

食品中痕量稀土元素微型高效富集器离子交换预富集—ICP—AES—联 …

本文研究了食品中痕量稀土元素的离子交换预富集－ＩＣＰ－ＡＥＳ在线分析方法，筛选出４种对各稀土元素具有较好富集性能，并适于微型富集器使用的高效树脂（包括离子交换树脂、螯合树脂和螯合纤维树脂），该分析系统可用于矿泉水、贻贝、牡蛎、茶叶等食品标样中ｎｇ／ｍｌ及μｇ／ｇ级痕量稀土元素测定。所得结果与推荐值相吻合。该分析系统测定精密度符合痕量分析要求，富集倍数可达１７￣３０倍，检出限为０．０８￣５．５ｎｇ／     

离子交换树脂药物载体在给药系统中的应用

离子交换树脂作为药物传递系统的有效载体,由于具有多种优良特性,已经受到药剂学家们的高度关注。本文就缓释、控释给药、靶向给药、离子导入透皮、鼻腔、眼部给药、胃漂浮剂给药、掩盖药物苦味和脉冲给药等方面在药剂学中的应用研究进行了概述。     

Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids

In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3‐sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly‐[2‐(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion‐controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.     

超分子结构姜黄素插层镁铝水滑石的组装、结构及缓释性能

以镁铝水滑石为主体, 以中药提取物姜黄素为客体, 由共沉淀法、离子交换法和焙烧复原法三种不同方法组装得到超分子结构复合材料——姜黄素插层镁铝水滑石. 并用XRD, IR, HPLC等手段对该材料进行了表征. 结果表明, 共沉淀法和离子交换法成功组装得到两种不同结构的姜黄素插层产物, 使材料的层间距扩大为0.82～1.36 nm, 层间客体姜黄素阴离子是以平行或者单层垂直的定位方向排列于层间的. 考察了该材料在不同pH值的磷酸盐缓冲溶液中的缓释性能, 其缓释历程为客体阴离子与介质中 的离子交换过程. 该研究指出了阴离子层状材料——水滑石在中药释释剂领域的应用潜力.     

Controlled drug release studies of atenolol using differently sulfonated acryloxyacetophenone and methyl methacrylate copolymer resins as drug carriers

2-Acryloxyacetophenone(AAP) was prepared and subjected to suspension polymerization with methyl methacrylate(MMA) using azobisisobutyronitrile(AIBN) as free radical initiator.The differently sulfonated AAP-MMA cross-linked copolymer cationic exchange resins were prepared by sulfonation with concentrated sulphuric acid at 70 °C.Several characteristics of the prepared resins were evaluated,i.e.FTIR,the ion-exchange capacity(IEC),thermo gravimetric analysis(TGA),particle size distribution and microscopic morphology.The resin characteristics were altered with degree of sulfonation,providing that differently sulfonated resins could be prepared.The behavior of atenolol(ATL) loading and in vitro release in the USP stimulated gastric and intestinal fluids of the obtained resins were evaluated.The drug loaded in the resin increased with increasing degree of sulfonation and hence the drug binding site in resin employed.The drug release was lower from the resins with higher content of sulfonic group due to the increase in the diffusive path depth.The drug release was a little lower in stimulated gastric fluid(SGF) than in stimulated intestinal fluids(SIF).The basic groups,ionized to a little greater extent in SGF and preferred binding with the resin rather than releasing.Hence,the differently sulfonated resins could be utilized as novel carriers for drug delivery.     

聚电解质复合物在药物控释中的应用

近年来聚电解质复合物在药物控释领域受到重视。对聚电解质复合物在响应型药物控释、细胞免疫隔离移植、多肽蛋白质药物的缓释及其基因治疗等领域的应用进行了综述。     

Gelrite‐Based In Vitro Gelation Ophthalmic Drug Delivery System of Gatifloxacin

The conventional ophthalmic solutions have demonstrated poor bioavailability and low therapeutic response due to rapid precorneal elimination of drug, which could be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol‐gel transition in the cul‐de‐sac. The present work describes the formulation of an ophthalmic delivery system of an antibacterial agent, Gatifloxacin, based on the concept of ion‐activated in situ gelation; the rheological properties of the formulation and in vitro release of the drug were evaluated. Gelrite gellan gum, a novel vehicle for ophthalmic delivery system, which gels in the presence of mono/divalent cations present in the tear fluid, was used as the gelling agent. The developed formulation showed pseudoplastic rheology and was therapeutically efficacious and provides sustained release of the drug over a 12‐hour period. The developed system is thus a viable alternative to conventional eye drops.     

聚乳酸载药微球制备及释药性能研究最新进展

对可生物降解材料聚乳酸作为药物载体制备微球制剂的研究状况进行了综述。针对目前限制聚乳酸微球制剂临床应用存在的问题,重点介绍了降低药物突释,提高药物包封率,改善多肽和蛋白药物微球释药性能等方面研究的最新进展。聚乳酸载药微球在药物传输中有着广阔的研究和应用前景。     

基于HPMCP包覆介孔SBA-15的pH敏感药物缓释系统

以肠溶性包衣材料羟丙甲纤维素邻苯二甲酸酯(HPMCP)为原料,在负载法莫替丁(Famo)的SBA-15药片表面包覆聚合物膜,成功制备了一种新型的pH敏感药物缓释系统, 并考察了此缓释系统在不同pH释放环境中的释放行为. 结果表明: 在模拟胃液中(SGF, pH=1.2),HPMCP能致密包覆在药片表面,从而明显延缓Famo的释放速度;而在模拟肠液中(SIF, pH=7.5),HPMCP能够迅速溶于缓释溶液中,因而对Famo释放速度的影响甚微. 因此,可以将这种新型智能药物缓释系统应用于肠道靶向给药.     

Recent Progress in Transdermal Nanocarriers and Their Surface Modifications

Transdermal drug delivery system (TDDS) is an attractive method for drug delivery with convenient application, less first-pass effect, and fewer systemic side effects. Among all generations of TDDS, transdermal nanocarriers show the greatest clinical potential because of their non-invasive properties and high drug delivery efficiency. However, it is still difficult to design optimal transdermal nanocarriers to overcome the skin barrier, control drug release, and achieve targeting. Hence, surface modification becomes a promising strategy to optimize and functionalize the transdermal nanocarriers with enhanced penetration efficiency, controlled drug release profile, and targeting drug delivery. Therefore, this review summarizes the developed transdermal nanocarriers with their transdermal mechanism, and focuses on the surface modification strategies via their different functions.     

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Molecularly imprinted polymer (MIP) has gained wide interest among researchers due to its unique molecular recognition of the template that is suitable as a drug carrier. Therefore, the preparation and formulation of the MIP are significant to suit the needs of the intended use. Due to its significance in drug delivery, this review aims to highlight various methods in the preparation of MIP, the composition for both controlled and stimuli-responsive drug delivery systems, and the release mechanism of the drugs. In drug delivery systems, MIP should have a sustained release performance as well as flexibility in surface modification for targeted delivery via a range of stimuli-responses, including  external stimuli (magnetic, light) and internal stimuli (pH, temperature, redox, biological). The properties of sustained release and targeted delivery of the MIP can improve the drug's therapeutic efficacy as well as the breakthrough for the tumor targeting application.