溴代卓酚酮基础的双查尔酮的合成（英文）

卓酚酮基础的双查尔酮3,3′-{(1E,1′E)-1,4-苯撑双[(1E)-3-羰基并-1-烯-1,3-二基]}双卓酚酮(1)与2.1倍或4.2倍物质的量的液溴在乙酸溶剂中直接进行溴化反应.该溴化反应选择性的发生在卓酚酮环上,得到相应的7-溴卓酚酮(2)和5,7-二溴卓酚酮基础的双查尔酮(3),收率分别为81%和73%,其结构通过波谱数据和元素分析得以证实.     

3-取代酚酮5位偶联产物的溴氧化成环反应

报道了采用溴氧化3-异丙烯基(艹卓)酚酮和3-肉桂酰基(艹卓)酚酮合成杂环并(艹卓)酮化合物的新方法。3-异丙烯基(艹卓)酚酮5位偶联产物1a～1f和3-肉桂酰基(艹卓)酚酮5位偶联产物3a～3d分别在吡啶介质中与过量溴作用生成5-取代苯偶氮基-7-溴-3-甲基-8-氢环庚并呋喃-8-酮2a～2f和6-取代苯偶氮基-2-苯基-8-溴-4,9-二氢环庚并吡喃-4,9-二酮4a～4d。     

Zhuo酮和Zhuo酚酮化合物合成新进展

对Ｚｈｕｏ酮和Ｚｈｕｏ酚酮化合物最新合成进展从亲电取代反应，缩合反应和还原反应等几个方面进行了综述。     

3-(2-喹啉基)酚酮的卤代和硝化反应

众所周知酚酮环可以进行多种亲电取代反应。我们曾研究过3—乙酰基酚酮、3—乙酰胺基酚酮和3—肉桂酰基酚酮的亲电取代反应。最近报道了喹啉基取代酚酮的合成,这些化合物分子中的酚酮环和喹     

10-芳香基甲叉基蒽酮衍生物合成方法的改进

芳香醛;对叔丁基酚;10-芳香基甲叉基蒽酮衍生物合成方法的改进     

卓酚酮基础的查尔酮衍生物(E)-5-溴-3-(3-芳基丙烯酰基)卓酚酮的合成(英文)

3-乙酰基-5-溴-卓酚酮与不同取代的苯甲醛类化合物通过Claisen-Schmidt缩合反应合成一系列结构新颖的卓酚酮取代的查尔酮类衍生物。该方法使用5%KOH溶液作为催化剂,50%甲醇水溶液作为溶剂,具有操作简便、反应条件温和、收率高等优点。所合成标题化合物的结构经IR、1H NMR、MS和元素分析得以证实。     

缩杂环卓酮系化合物合成研究的新进展

本文以3-乙酰基卓酚酮化学为中心,综述了与具有两个以上的亲核基团的试剂进行成环反应来合成缩杂环卓酮系化合物的研究新进展.     

3-取代卓酚酮5位偶联产物的溴氧化成环反应

报道了采用溴氧化3-异丙烯基卓酚酮和3-肉桂酰基卓酚酮合成杂环并卓酮化合物的新方法。3-异丙烯基卓酚酮5位偶联产物1a-1f和3-肉桂酰基卓酚酮5位偶联产物3a-3d分别在吡啶介质中与过量溴作用生成5-取代苯偶氮基-7-溴-3-甲基-8-氢环庚并呋喃-8-酮2a-2f和6-取代苯偶氮基-2-苯基-8-溴-4,9-二氢环庚并吡喃-4,9-二酮4a-4d。     

聚芳醚酮单体结构与反应活性的研究

利用从头算ＲＨＦ方法研究了聚芳醚酮单体４，４’－对苯二酚、４，４’－联苯二酚及４，４’－二氟苯酮。结果表明，它们的苯环皆存在一定的扭转，首次给出联苯二酚全优化结构，其苯环二面角为５１．８°，活性稍强于对苯二酚，但引入更多的链支化活特点，含联苯基聚芳醚醚酮的链支化比不含联苯基的ＰＥＥＫ严重，故前者结晶性差，反应机理及实验还表明：前者凝胶化的浓硫酸溶液中存在一种羰基被极化后的红色阴离子。     

3-羟基雌甾-1,3,5(10),15-四烯-17-酮的高效合成

以雌酚酮为原料,以取代的苯甲酰作为雌酚酮酚羟基的保护基,乙二醇为雌酚酮羰基的保护基,经过溴代、脱溴和水解等5步反应,通过优化反应路线、反应试剂及反应条件,以65%的高收率制得3-羟基雌甾-1,3,5(10),15-四烯-17-酮.中间体及目标产物的结构经过元素分析、核磁共振波谱(NMR)和电喷雾电离-质谱(ESI-MS)确证.     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.