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1.
Eight flavonoids were isolated from Sophora flavescens. Among them, three prenylflavanones: (2S)-6[2(3-hydroxyisopropyl)-5-methyl-4-hexenyl]-5-methoxy-7,2', 4'-trihydroxyflavanone (1), (2S)-5, 4'-dimethoxy-8-lavandulyl-7, 2'-dihydroxy flavanone (2) and (2S)-8-(5-hydroxy-2-isopropenyl-5-methylhexyl)-7-methoxy-5,2', 4'-trihydroxyflavanone (3) are new compounds. Their chemical structures were determined by spectral methods including 2D NMR. 相似文献
2.
Two New Antibacterial Flavanones from Sophoraflavescens 总被引:1,自引:0,他引:1
Mei Ai CAO Xiao Bai SUN Pei Hua ZHAO Cheng Shan YUAN 《中国化学快报》2006,17(8):1048-1050
The dry root of Sophora flavescens, which is a well-known Chinese herbal medicine, has been used for the treatment of diarrhea, gastrointestinal hemorrhage and eczema1. Here we report the structure elucidation of two new flavanones isolated from this plan… 相似文献
3.
Two novel lavandulyl flavonoids, (2S)-7-methoxyl-4",5"-dihydroxynorkurarinone (1) and (2S)-6"-hydroxynorkurarinone-7-O-beta-D-galactoside (2), were isolated from the rhizome of Sophora flavescens. Their structures were elucidated by spectral methods, including 2D NMR spectroscopy. Both compounds showed cytotoxic activity against Hela cells, with 2 being more active than 1. 相似文献
4.
5.
Y Ding R H Tian J Kinjo T Nohara I Kitagawa 《Chemical & pharmaceutical bulletin》1992,40(11):2990-2994
Three new oleanene glycosides, sophoraflavosides II-IV (2-4) were isolated together with sophoraflavoside I (1) as the corresponding methyl ester forms from Sophorae Radix, the fresh roots of Sophora flavescens AITON (Leguminosae). Their structures have been elucidated as oxytrogenin 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-beta -D- glucuronopyranoside (2), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-beta -D-glucuronopyranosyl oxytrogenin 22-O-alpha-L-arabinopyranoside (3) and 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-beta -D-glucuronopyranosyl oxytrogenin 22-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranoside (4), along with unambiguous characterization as 3 beta,22 beta,24-trihydroxyolean-12-en-29-oic acid for their sapogenol, named oxytrogenin (5) on the bases of chemical reactions and spectral analyses. 相似文献
6.
Peilan Ding Daofeng Chen KennethF. Bastow AlexanderK. Nyarko Xihong Wang Kuo‐Hsiung Lee 《Helvetica chimica acta》2004,87(10):2574-2580
Three new flavonoids, which are isoprenylated by fused 2,2‐dimethyl‐3,4‐dihydro‐2H‐pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A–C ( 1 – 3 ). Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques. Flavenochromane C ( 3 ) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB‐Vin (drug‐resistant variant KB) cell lines with IC50 values ≤1.7 μM , and significant activity against the MCF‐7 (breast adenocarcinoma) cell line with an IC50 value of 3.6 μM . Flavenochromane B ( 2 ) displayed slightly lower inhibitory effects (IC50 3.2–6.9 μM ) as compared with 3 . 相似文献
7.
Following a detailed study, a reversed-phase high performance liquid chromatographic method (HPLC) has been developed and validated for analysis of three bioactive alkaloids, matrine, sophoridine and oxymatrine, in Sophora flavescens Ait. HPLC separation of the alkaloids was performed on a Kromasil C(18) column and detected by ultraviolet absorbance at 208 nm. The column temperature was maintained at 40 degrees C. A mobile phase composed of 0.01 mol/L KH(2)PO(4) buffer-methanol-triethylamine in the ratios 94:6:0.01 (v/v) was found to be the most suitable for this separation at a fl ow-rate of 1.0 mL/min and enabled the baseline separation of the three analytes free from interferences with isocratic elution. The analysis time was 24 min per injection. The calibration was linear in the range of 0.2-120.0 micro g/mL for matrine, 0.2-115.2 micro g/mL for sophoridine and 0.2-110.4 micro g/mL for oxymatrine, respectively. For assaying Sophora Flavescens Ait. samples, the relative standard deviations were 2.0% for matrine, 2.8% for sophoridine and 1.8% for oxymatrine analysis. The average recoveries of matrine, sophoridine and oxymatrine were 93.9, 95.3 and 93.5% for the Sophora flavescens Ait. samples, respectively. The method has been successfully applied to the simultaneous determination of matrine, sophoridine and oxymatrine in Sophora Flavescens Ait. samples collected in different habitats. 相似文献
8.
Supercritical fluid extraction (SFE) was used to extract quinolizidine alkaloids from Sophora flavescens Ait. (Kushen). An orthogonal test L(9)(3)(4) including pressure, temperature, flow rate of CO(2) and the amount of modifier was performed to get the optimal conditions. The process was then scaled up by 30 times with a preparative SFE system under 25 MPa, 50 degrees C and a flow rate of CO(2) (2l/min) and the amount of modifier (0.04 ml/min). The crude extracts were separated and purified by high-speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of chloroform-methanol-2.3 x 10(-2)M NaH(2)PO(4) (27.5:20:12.5, v/v), and the collected fractions were analyzed by high-performance liquid chromatography (HPLC). Three kinds of quinolizidine alkaloids were obtained, yielding 10.02 mg of matrine, 22.07 mg of oxysophocarpine and 79.93 mg of oxymatrine with purities of 95.6, 95.8, 99.6% in one-step separation, respectively. 相似文献
9.
Chi Zhang Yan‐Min Wang Feng‐Chun Zhao Liang‐Mian Chen Qi‐Wei Zhang Hui‐Min Gao Zhi‐Min Wang 《Helvetica chimica acta》2014,97(11):1516-1525
Two new compounds, (?)‐(6aR,11aR)‐4‐methoxy‐8,9‐(methylenedioxy)pterocarpan 3‐O‐β‐D ‐glucopyranoside ( 1 ) and 5‐hydroxy‐7‐methoxyisoflavone 4′‐O‐β‐D ‐xylopyranosyl‐(1→6)‐β‐D ‐glucopyranoside ( 2 ), were isolated, together with 30 known compounds from the stems and leaves of Sophora flavescens Aition . Their structures were elucidated by extensive spectroscopic analysis, including HR‐ESI‐MS data. A preliminary comparison of phenolic metabolite profiles, based on the qualitative HPLC analysis, indicated that the composition of the roots and the aerial parts were significantly different. 相似文献
10.
A new, polymer‐confined, ionic liquid sorbent was developed by a process involving polymerization and modification. The obtained particles were successfully used as a special sorbent in SPE process to isolate matrine and oxymatrine from Sophora Flavescens Ait. Different washing and elution solvents, such as ethanol, methanol, acetonitrile and methanol/triethylamine (90:10, v/v), were evaluated. Compared with the C18 and NH2 sorbents, the amino‐imidazolium polymer sorbent exhibited higher selectivity. Quantitative analysis was carried out by using a C18 column. The two compounds exhibited good linearity from 5×10?3 to 0.50 mg/mL (r2>0.99). The bound amounts between target compounds and proteins were obtained by this sorbent. After three recycles of amino‐imidazolium polymer, the extract amounts of the target compounds were not significantly decreased. 相似文献
11.
Contrary to its lower brominated congeners, the flame retardant decabromodiphenylether (DecaBDE) is not banned by the decision 2005/717/EG of the European Union. But the question of the bioavailability and bioaccumulation of this second most used flame retardant worldwide becomes subject of more intense research. In the present study, we developed a microwave-assisted method for the extraction of DecaBDE from polymers. Owing to its main use in electrical and electronic appliances and according to the fire safety standard UL94 V-0, the extraction procedure was carried out for the model compounds polyethylene and polystyrene. Special emphasis has been given to an accurate optimization by an experimental response surface design. Quantification was performed by means of HPLC-DAD. In order to achieve comparable data, extraction was also performed with classic Soxhlet extraction. To compare these results with an independent technique, microwave-induced oxygen combustion and ion chromatography complete this study. 相似文献
12.
Jingjing Li Yan Lin Lei He Rongxiu Ou Tao Chen Xu Zhang Qirui Li Zhu Zeng Qingde Long 《Molecules (Basel, Switzerland)》2021,26(23)
Sophora flavescens is a regularly used traditional Chinese medicine. In an attempt to discover adequate active agents, the isoprenoid flavonoids from S. flavescens were further investigated. In this work, two new compounds (1–2, kurarinol A-B) together with 26 known ones (3–28) were isolated and elucidated on the basis of extensive NMR, UV and MS analyses. Furthermore, the antioxidant activity of all constituents was assessed through ABTS, PTIO and DPPH methodologies and also were evaluated for cytotoxic activity by three tumor cell lines (HepG2, A549 and MCF7) and one human normal cell line (LO2 cells). As a result, a multitude of components revealed significant inhibitory activity. In particular, compound 1–2 (kurarinol A-B), two new flavanonols derivatives, exhibited the most potent ABTS inhibitory activity with IC50 of 1.21 µg/mL and 1.81 µg/mL, respectively. Meanwhile, the new compound 1 demonstrated remarkable cytotoxicity against three cancer cells lines with IC50 values ranging from 7.50–10.55 μM but showed little effect on the normal cell. The two new isoprenoid flavonoids could be promising antioxidant and anti-tumor nature agents. 相似文献
13.
秦岭苦参中苦参碱立体异构体晶体结构研究 总被引:4,自引:0,他引:4
从秦岭地区苦参中经过溶剂提取和酸化分离得到一种生物碱盐酸盐结晶1,该 晶体不对称单元含有一对新的苦参碱非对映异构体,绝对构型分别是1S,5S6S, 7R,11R,16S和1S,5S,6S,7R,11R,16R,命名为顺式新苦参碱(cis- neomatrine)和反式新苦参碱(trans-neomatrine)。1的晶体结构(C_(15)H_(24) N_2O·C_(15)H_(24)N_2O·2HCl·5H_2O)属正交晶系,空间群P2_12_12_1, a = 0. 8053(2) nm, b = 1.3464(5) nm, c = 3.0971(9) nm, V = 3.3580(18)nm~3, Z = 4, μ=0.244 mm~(-1), F(000) = 1432, R = 0.0467, wR = 0.1129。顺式新苦参 碱和反式新苦参碱的A环、B环和C环为式构象,D环为半椅式构象,其中A/B为反式 稠合,A/C和B/C为顺式稠合,两种立异构体的区别是顺式新苦参碱的C/D顺式稠 合,反式新苦参碱的C/D反式稠合。 相似文献
14.
Iuliana Dincutoiu Beth L. Parker 《International journal of environmental analytical chemistry》2013,93(15):1113-1125
A new method for volatile organic compounds (VOCs) extraction from low-permeability media, such as clay, has been developed and tested using trichloroethylene (TCE) as a model compound. The method is based on microwave-assisted extraction (MAE), which uses microwave energy to heat the extracting solvent and the sample. MAE allows the extraction process to be carried out at elevated temperatures and pressures, which dramatically reduces the time required to complete the process. A custom-made PTFE vessel was used for extraction investigations. TCE analysis was performed using gas chromatography with electron capture detection (GC-ECD). Three different solvents were tested: methanol, 1?:?1 hexane?:?acetone mixture, and 10?:?1 hexane?:?acetone mixture. A comparison of TCE recoveries from clay samples using the new method and the standard methanol extraction method was carried out. The newly developed method and the method currently in use were found to recover similar amounts of TCE. The major advantage of the MAE technique is the very short time needed to obtain complete analyte recovery (6–10?min), which makes it possible to analyse a large number of samples without the need for sample preservation or prolonged storage. Thus, the new method is much more efficient than the existing methods. The technique has a good potential for field application. 相似文献
15.
Microwave-assisted extraction of solanesol from tobacco leaves 总被引:7,自引:0,他引:7
Solanesol is the starting material for many high-value biochemicals, including co-enzyme Q10 and Vitamin K analogues. In the present study, a microwave-assisted extraction (MAE) technique has been developed for the fast extraction of solanesol from tobacco leaves. Compared to heat-reflux extraction, MAE reduced extraction time and obtained higher percentage extracted of solanesol. The effect of microwave on cell destruction of plant material was observed by scanning electron microscopy (SEM). The microwave-assisted extraction efficiency was further improved by adding NaOH into the extraction solvent, and the maximum percentage extracted of solanesol reached 0.91% (weight solanesol/weight tobacco) in 40 min at an optimum NaOH concentration of 0.05 M. The developed MAE integrated with saponification process provided an efficient method for solanesol recovery from tobacco leaf materials, and it also alleviated emulsification in the following separation and purification procedure as well. 相似文献
16.
Microwave-assisted extraction of ginsenosides from ginseng root 总被引:2,自引:0,他引:2
The extractions of ginsenosides Rg1 and Rb1 from ginseng root under atmospheric pressure by focused microwave-assisted technique have been investigated. The parameters used for the optimization were solvent composition, extraction time, and applied microwave power. The ginsenosides were quantified by high-performance liquid chromatography equipped with UV/Vis detector. The results of the 15-min microwave-assisted extraction (0.28% of Rg1 obtained in 70% water-ethanol and 1.31% of Rb1 obtained in 30% water-ethanol under 150 W of microwave power) were better than that from 10-h conventional solvent extraction (0.22% of Rg1 and 0.87% of Rb1 obtained in 70% water-ethanol). 相似文献
17.
Microwave-assisted extraction (MAE) of polycyclic aromatic compounds (PACs) from coal is shown to give the same pattern of compounds as Soxhlet extraction. MAE requires only 10 mL solvent and 10 min extraction time whereas Soxhlet uses 200 mL and takes 24 h. Although the yields were lower, dichloromethane (DCM) was preferred to pyridine, N-methyl-2-pyrrolidone (NMP), and NMP with CS2 because the pattern of the PACs is shown to be independent of solvent and DCM is a much more convenient solvent to work with. 相似文献
18.
Microwave-assisted extraction (MAE) of polycyclic aromatic compounds (PACs) from coal is shown to give the same pattern of compounds as Soxhlet extraction. MAE requires only 10 mL solvent and 10 min extraction time whereas Soxhlet uses 200 mL and takes 24 h. Although the yields were lower, dichloromethane (DCM) was preferred to pyridine, N-methyl-2-pyrrolidone (NMP), and NMP with CS2 because the pattern of the PACs is shown to be independent of solvent and DCM is a much more convenient solvent to work with. 相似文献
19.
Singh A Sabally K Kubow S Donnelly DJ Gariepy Y Orsat V Raghavan GS 《Molecules (Basel, Switzerland)》2011,16(3):2218-2232
A response surface method was used to optimize the microwave-assisted extraction parameters such as extraction time (t) (min), solvent (methanol) concentration (S) (v/v) and microwave power level (MP) for extraction of antioxidants from potato peels. Max. total phenolics content of 3.94 mg g?1 dry weight (dw) was obtained at S of 67.33%, t of 15 min and a MP of 14.67%. For ascorbic acid (1.44 mg g?1 dw), caffeic acid (1.33 mg g?1 dw), ferulic acid (0.50 mg g?1 dw) max contents were obtained at S of 100%, t of 15 min, and MP of 10%, while the max chlorogenic acid content (1.35 mg g?1 dw) was obtained at S of 100%, t of 5 min, and MP of 10%. The radical scavenging activity of the extract was evaluated by using the DPPH assay and optimum antioxidant activity was obtained at S of 100%, t of 5 min, and MP of 10%. 相似文献