共查询到20条相似文献,搜索用时 0 毫秒
1.
N. E. Britikova L. A. Belova O. Yu. Magidsoh A. S. Elina 《Chemistry of Heterocyclic Compounds》1974,10(1):117-119
10-Chloro-2,4-dioxo derivatives of pyrimido[5,4-b]quinoline have been synthesized, and nucleophilic substitution reactions in these compounds have been studied. 相似文献
2.
Neelima Balkrishen Bhat Amiya Prasad Bhaduri 《Journal of heterocyclic chemistry》1984,21(5):1469-1472
Isoxazolo[5,4-b]quinolines have been prepared by reacting 3-acyl or aroyl-2-chloro-6-alkoxy or 6,7-dialkoxyquinolines with hydroxylamine. The method is of general applicability for obtaining this class of compounds and involves the use of easily available starting materials. 相似文献
3.
A. A. Krauze Z. A. Bomika Yu. É. Pelcher I. B. Mazheika G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1982,18(4):385-390
3-Oxoisothiazolo[5,4-b]pyridines were synthesized for the first time by the reaction of 3-cyanopyridine-2-thiones or bis(3-cyanopyridyl) disulfides with concentrated sulfuric acid. It is demonstrated that 3-carbamoylpyridine-2-thiones are formed as intermediates. The 3-oxoisothiazolopyridines were converted to 3-bromoisothiazolopyridines and pyridine-2-thiones. The bromination of pyridine-2-thione was studied.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 508–512, April, 1982. 相似文献
4.
A number of pyrimido[5,4-b]quinoline derivatives were synthesized. It is shown that in the reaction of 2,4,10-trichloropyrimido[5,4-b]quinoline (II) with strong nucleophilic reagents (OCH3 and SH) both of the halogens of the pyrimidine ring are replaced, while with amines substitution of the halogens of the pyrimidine ring proceeds successively; under more severe conditions, all three halogen atoms of II are replaced by amine residues. 相似文献
5.
6.
Alfredo Camparini Fabio Ponticelli Piero Tedeschi 《Journal of heterocyclic chemistry》1977,14(3):435-438
The synthesis and properties of 4,6-dichloro- (IV), 4-chloro- (XII) and 6-chloro-3-methyl-isoxazolo[5,4-b]pyridine (XI) are described. Depending on the reaction conditions compound IV with hydrazine or methoxide gave mono- or bi-substituted products. The halogen atom at the 4-position was shown to be the more mobile. 相似文献
7.
A. Monge V. Martinez-Merino E. Fernandez-Alvarez 《Journal of heterocyclic chemistry》1985,22(5):1353-1356
Starting with 2-chloro-3-pyridinecarboxylic acid 1 , three different routes to prepare 3-oxoisothiazolo-[4,5-b]pyridines 10 were studied. 相似文献
8.
A new and a more efficient synthesis of 10H-Indolo[3,2-b]quinoline (quindoline) is reported. The synthesis involved N-arylation of 3-aminoquinoline with triphenylbismuth diacetate followed by oxidative cyclization using paOadium(II) acetate. A selective N-alkylation methodology for quindoline was also developed. Alkylation on N-5 was obtained in sulpholane, while alkylation on N-10 was achieved in acetone in the presence of potassium hydroxide. A sequential N-5- and N-10 double alkylation procedure was also formulated. 相似文献
9.
An efficient synthesis of pyrazolo[3,4-b]quinolin-3-amine and benzo[b][1,8]naphthyridine derivatives
Elkholy YM 《Molecules (Basel, Switzerland)》2007,12(3):361-372
2-Oxo-4-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (10) reacted with hydrazine hydrate, phenylisothiocyanate or benzoyl chloride to give derivatives 12, 13 and 15, respectively. The latter two products were treated with hydrazine hydrate to afford pyrozole[3,4-b]quinolines derivatives 14 and 16, respectively. Compound 10 also reacted with acetonitrile dimer or malononitrile dimer to yield benzo[b][1,8]-naphthyridine derivatives. A single crystal X-ray crystallographic analysis was performed on compound 10, confirming its structure. 相似文献
10.
11.
Yoshiyuki Kawase Seiji Yamaguchi Osamu Maeda Akemi Hayashi Ichihiro Hayashi Kazuko Tabata Masako Kondo 《Journal of heterocyclic chemistry》1979,16(3):487-491
Benzofuro[2,3-b]quinoline ( Ia ) and its 11-methyl derivative ( Ib ) were synthesized by demethylcyclization of 3-(o-methoxyphenyl)-1,2-dihydroquinolin-2-ones (VIa,b). Benzofuro[2,3-b]quinoline-11-carboxylic acid (Id) was synthesized by chlorination followed by the action of potassium hydroxide of a lactone (IX) prepared by demethyl-cyclization of 3-(o-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (VIII). Isomeric benzofuro[3,2-c]quinoline (Ha) and its 6-methyl derivative (IIb) were synthesized by demethyl-cyclization of 3-(o-methoxyphenyl)-1,4-dihydroquinolin-4-ones (XIa,b). Both the methyl derivatives (Ib and IIb) were converted to the carboxylic acids (Id and IId) through condensation with benzaldehyde followed by oxidation. The benzofuroquinolines (Ia,b,d and IIa,b) thus obtained were oxidized to the corresponding N-oxides (IIIa,b,d and IVa,b). 相似文献
12.
The synthesis and characterization of a number of 3-aryl-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines and 3-aryl-6H-isoxazolo[5,4-d]pyrazolo[3,4–6]pyridines from common precursors, 5-benzoyl-4-chloro-1H-pyrazolo-[3,4-b]pyridines, has been described. The structures were determined by unambiguous chemical synthesis and by isolation and 13C nmr analysis of some key, isolated, intermediates. The ability of these compounds to displace [3H]flunitrazepam from CNS binding sites was also observed. 相似文献
13.
The synthesis and antibacterial evaluation of a number of isothiazolo[5,4-b]pyridine isosteres of nalidixic acid are described. 相似文献
14.
The hydrochlorides of the title compounds are obtained in moderate yields by refluxing 2-chloro-3-aminopyridine or 3-amino-4-chloropyridine, respectively, with an alkyl. Aralkyl-, or aryl isothiocyanate in absolute ethanol solution. A proof is presented that the 2-aminothiazolopyridine hydrochloride and not the isomeric o-chloropyridylthiourea is the product of this reaction. The free-bases may be obtained from the hydrochlorides with aqueous sodium bicarbonate. A mechanism for the formation of the thiazole ring is briefly considered. The interactions of 2-chloro-3-aminopyridine with l-substituted-5-mereapto-1H-tetrazoles are also described. 相似文献
15.
I. V. Zavarzin N. G. Smirnova V. N. Yarovenko M. M. Krayushkin 《Russian Journal of Organic Chemistry》2006,42(2):273-274
A convenient procedure was developed for preparation of thiazolo[5,4-b]pyridine-2-carboxamides by oxidation of monothiooxamides synthesized from 3-aminopyridine. 相似文献
16.
Hoh-Gyu Hahn Kee Hyuk Chang Wha Suk Lee Ji Uk Yoo 《Journal of heterocyclic chemistry》1996,33(6):2055-2057
A synthesis of new dihydrooxathiinoquinoline 4 is described. The key compound 6 was prepared by known methods from acetoacetanilide 1 . A condensation of β-chlorosulfide 6 in 75% aqueous sulfuric acid gave quinolone 5 . Conversion of 5 to 4 was achieved by treatment with potassium hydroxide in ethanol solution. 相似文献
17.
18.
19.
Treatment of 4-oxo-3,4-dihydropyrimido[4,5-6 ]quinoline (II) with phosphorus oxychloride and a dialkylaniline resulted in the introduction of a p-dialkylaminophenyl group at position-5, and reduction of the central (pyridine) ring, as well as substitution of oxygen by chlorine at po-sition-4, forming compounds considered to be 4-chloro-5-(p-dialkylaminophenyl)-5, 10-dihydro-pyrimido[4,5-6 ]quinolines (XV). Several 4-oxo-3,4-dihydropyrimido[4,5-b ]quinolines having phenyl substituents at position-5 were synthesized unequivocally, and could be readily reduced to the corresponding 4-oxo-5-phenyl-3,4,5,10-tetrahydropyrimido[4,5-6]quinolines, and the 4-oxo group replaced by chlorine, in the usual manner, leading to compounds related structurally to XV. Comparison of the chemical and physical properties of these compounds established the structure of XV, and a mechanism which rationalizes the formation of XV from II is presented. 相似文献