Olivomycin and related antibiotics

Conclusions On the basis of its chemical properties and spectral characteristics, structure I has been established for the aglycone of the olivomycin antibiotics, olivin.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 4, pp. 304–316, 1969For part XIII, see [1], and for a preliminary communication, see [2]. The subject matter of the present paper was presented in part at the International Congress on Antibiotics (Prague, 1964), and at the IX-th Mendeleev Conference on General and Applied Chemistry (Kiev, 1965).     

Olivomycin and related antibiotics

Summary 1. From the culture fluid of the ray fungusActinomyces olivoreticuli four individual antibiotics, olivomycins A, B, C, and D have been isolated.2. The acid degradation of olivomycins A, B, C, and D has been carried out with the formation of the aglycone olivin and the carbohydrates olivomycose, olivomose, olivose, oliose, and (or) their derivatives.3. The qualitative and quantitative monomeric composition of olivomycins A, B, C, and D has been elucidated and their empirical formulas have been established.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 5, pp. 331–339, 1967For previous communications, see [1]; for Communication IX, see [2].     

Olivomycin and related antibiotics

Conclusions It has been shown that the five monosaccharide residues forming the carbohydrate moiety of the antibiotic olivomycin A form two unbranched chains attached to the hydroxyls in positions 2 and 6 of the aglycone and terminated by isobutyrylolivomycose and olivomose.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 6, pp. 561–566, 1969For a preliminary communication, see [1], and for part XVI, see [2].     

Olivomycin and related antibiotics

Conclusions It has been shown that olivomose, which forms part of the carbohydrate moiety of olivomycins A, B, C, and D, possesses the structure of 4-O-methyl-2, 6-dideoxy-D-lyxo-hexose (VI).Khimiya Prirodnykh Soedinenii, Vol. 5, No. 2, pp. 103–109, 1969     

Olivomycin and related antibiotics

Summary It has been shown that olivomycose has the structure of 3-C-methyl-2, 6-dideoxy-L-arabino-hexose. In olivomycins A and C, this sugar is present in the form of the 4-O-isobutyrate, and in olivomycin B in the form of the 4-O-acetate.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 6, pp. 405–410, 1967For preliminary communication, see [1].     

Design and synthesis of ansamycin antibiotics

Ansamycin antibiotics are a class of microbial metabolites that exhibit an array of biological activities. This review covers the synthetic chemistry and biological activity of benzenic ansamycins from 1989 to 2007. In the first section, synthetic approaches to the C15-benzene ansamycins (geldanamycin and related) are discussed. Access to the C17-benzene ansamycins (or ansatrienins) is disclosed in the second half of this article.     

Bioactivity-based screening of antibiotics and hormones

Bioactivity-based screening methods are relatively cheap, quick and easy to use tools. Especially with respect to antimicrobial residues and compounds with hormonal activity, they form a very cost-effective alternative to physical chemical methods in large-scale surveillance and monitoring programs, where their main purpose is to identify samples that require additional chemical confirmation. A major advantage is their intrinsic capability to detect unknown compounds and new hazards. This review shows an overview of the available methods and their potential and limitations for regulatory control.     

Estimation of the molecular volumes of the reaction products between beta-lactam antibiotics and aminoglycoside antibiotics, and those of the degradation products of beta-lactam antibiotics by isotachophoresis

The correlative equations between the molecular volume and the qualitative indication (hR) for beta-lactam antibiotics, the reaction products between beta-lactam antibiotics and kanamycin, and the degradation products of beta-lactam antibiotics were hR = 0.32 + 0.080 VA2/3//Z/(N = 15, r = 0.972 for penicillins) and hR = 0.04 + 0.072 VA2/3//Z/(N = 12, r = 0.987 for cephems). Where VA is van der Waals volume (A3/molecule), hR is the relative step height in the isotachopherogram, and Z is the electric change, respectively. According to these equations, the molecular volumes of the reaction products between beta-lactam antibiotics and the other aminoglycoside antibiotics, and those of the degradation products of beta-lactam antibiotics can be estimated from the value of hR. Also according to the step height in the isotachopherogram, the reaction products or the degradation products may be estimated directly when the electric charge is known. It was confirmed that a molecule of aminoglycoside antibiotics reacted with a molecule of beta-lactam antibiotics. Therefore, the inactivation of aminoglycoside antibiotics is much greater than for beta-lactam antibiotics when the clinical doses of these antibiotic combinations are used.     

A new Eu-MOF for ratiometrically fluorescent detection toward quinolone antibiotics and selective detection toward tetracycline antibiotics

Development of new self-calibrating fluorescent sensing methods has been a popular research field with the aim of protecting the human health and environment sustainability. In this work, a novel Eu-based metal organic framework(MOF) Eu(2,6-NDC)(COO)(BUC-88) was developed by employing 2,6-NDC(2,6-naphthalenedicarboxylic acid) as bridging ligands. BUC-88 performed different sensing process toward quinolone antibiotics and tetracyclines antibiotics in terms of fluorescence intensity and color. BUC...     

Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds

This review covers the biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds, particularly from the molecular genetic perspectives. 195 references are cited.