In-line phase contrast for weakly absorbing materials with a microfocus x-ray source

For weakly absorbing materials, image contrast can be enhanced by phase contrast in formation. The effectiveness of the in-line phase contrast technique relies on its ability to record intensity data which contain information on the x-ray's phase shift. Four kinds of approaches to the relationship between intensity distribution and phase shift are reviewed and discussed. A micro-focal x-ray source with high geometrical magnification is used to acquire phase contrast images. A great improvement on image quality is shown and geometrical parameters are modified for comparison between different imaging positions.     

Elemental x-ray imaging using Zernike phase contrast

We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images are subtracted to obtain the target element: one is at the absorption edge of the target element and the other is near the absorption edge. The x-ray exposure required by this method is expected to be significantly lower than that of conventional absorption-based x-ray elemental imaging methods. Numerical calculations confirm the advantages of this highly efficient imaging method.     

近场X射线位相衬度成像及位相恢复算法

理论分析了X射线衍射位相成像和近场位相恢复算法。定义了一个最佳成像距离，给出了基于最佳成像距离和特征空间频率的衍射场光强分布新的表达形式。基于模拟位相物体给出了数值模拟结果。由此得出了探测距离和多色辐照对相衬图像和位相恢复结果的影响。本文给出的结果将对同轴x射线相衬成像实验具有一定的指导作用。     

Simple phase extraction in x-ray differential phase contrast imaging

A fast and simple method to extract phase-contrast images from interferograms is proposed, and its effectiveness is demonstrated through simulation and experiment. For x-ray differential phase contrast imaging, a strong attenuation signal acts as an overwhelming background intensity that obscures the weak phase signal so that no obvious phase-gradient information is detectable in the raw image. By subtracting one interferogram from another, chosen at particular intervals,the phase signal can be isolated and magnified.     

Shifting curves based on the detector integration effect for x-ray phase contrast imaging

In theory, we find that the actual function of the analyzer grating in the Talbot–Lau interferometer is segmenting the self-images of the phase grating and choosing integral areas, which make sure that each period of self-images in one detector pixel contributes the same signal to the detector. Furthermore, in the case of the lack of an analyzer grating, the shifting curves are still existent in theory as long as the number of fringes is non-integral in a detector pixel, which is a sufficient condition for creating shifting curve. The sufficient condition is available for not only the Talbot–Lau interferometer and the inverse geometry of Talbot–Lau interferometer, but also the x-ray phase contrast imaging system based on geometrical optics. In practical applications, we propose a method to improve the performances of the existing systems by employing the sufficient condition. This method can shorten the system length, is applicable to large period gratings, and can use the detectors with large pixels and large field of view. In addition, the experimental arrangement can be simplified due to the lack of an analyzer grating. In order to improve detection sensitivity and resolution, we also give an optimal fringe period.We believe that the theory and method proposed here is a step forward for x-ray phase contrast imaging.     

微聚焦管硬x射线位相衬度成像

利用微聚焦管硬x射线光源进行同轴位相衬度成像实验，所用的光源聚焦尺寸最小可达0.5μm.根据微聚焦硬x射线管的光学传递函数，对光源尺寸、相干长度等因素对成像分辨率的影响进行了分析.对新鲜的未经任何处理的生物样品进行了位相衬度成像，分辨率在10μm左右，并和吸收衬度成像进行了对比.实验结果表明利用微聚焦管作为硬x射线光源，多色硬x射线位相衬度成像可以得到比吸收衬度成像高得多的分辨率. 关键词： 位相衬度成像 微聚焦管x射线源 吸收衬度成像 光学传递函数     

硬x射线同轴相衬成像的相位恢复

基于角谱的概念，分析了硬x射线同轴相衬成像过程，在传统相位恢复算法GS算法的基础上 ，提出了基于角谱传播的相位恢复算法——迭代角谱法（IASA），并利用数值法模拟研究了 相衬成像和相位恢复过程，从理论上验证了这一相位恢复算法. 关键词： 相位恢复 相位衬度 角谱 硬x射线     

基于图像信噪比的X射线同轴相衬成像系统设计

通过对具有二维高斯型相位分布特征物体的X射线同轴相衬成像技术进行理论分析,提出了一种基于图像信噪比的成像系统优化设计方法。采用数值模拟的方式分别对亚微焦点源、激光驱动微焦点源和同步辐射源三种X射线源下的成像系统进行了优化设计,结果表明：相对于最大化衬度的系统优化设计方法,信噪比优化设计方法在较小降低衬度的前提下,可以较好地改善图像信噪比并得到更为合理的成像距离。     

Single-shot grating-based x-ray differential phase contrast imaging with a modified analyzer grating

X-ray grating interferometer has attracted widely attention in the past years due to its capability in achieving x-ray phase contrast imaging with low brilliance source. However, the widely used phase stepping information extraction method reduces system stability and prolongs data acquisition time by several times compared with conventional x-ray absorptionbased imaging. The mechanical stepping can be avoided by using a staggered grating, but at the cost of low vertical spatial resolution. In this paper, employing a modified staggered grating and the angular signal radiography, we proposed a single-shot grating-based x-ray differential phase contrast imaging with decent vertical spatial resolution. The theoretical framework was deduced and proved by numerical experiments. Absorption, phase, and scattering computed tomography can be performed without phase stepping. Therefore, we believe this fast and highly stable imaging method with decent resolution would be widely applied in x-ray grating-based phase contrast imaging.     

利用定量相衬成像消除X射线同轴轮廓成像中散射的影响

在所有的相衬成像方法中，X射线同轴轮廓成像由于光路简单、不需要任何光学元件而备受关注.其缺点是无法直接消除散射的影响，从而限制了它在生物医学等领域中的应用.利用数字模拟方法研究了引入散射前后轮廓像的质量随样品到探测器距离的变化情况.模拟结果表明直接轮廓成像存在一个最佳成像距离，因而无法通过改变样品到探测器距离来减小散射的影响.利用定量相衬成像不受成像距离限制的特点，研究了远距离成像时散射的影响.结果表明，样品到探测器的距离增大到一个临界值时，散射对重构像的影响可降到一个极值，此时成像质量得到了明显改善. 关键词： 散射 X射线同轴轮廓成像 定量相衬成像     

Simulation study of phase retrieval for hard X-ray in-line phase contrast imaging

X-ray phase contrast imaging (XPCI) is a novel method that exploits the phase shift for the incident X-ray to form an image. For light elements such as carbon, hydrogen and oxygen, the phase-shift term can be up to 1000 times greater than the absorption term in the hard X-ray energy region. So XPCI has attracted much attention in recent years. Various methods for XPCI have been proposed and demonstrated on synchrotron devices and other X-ray sources[1―13], particularly the in-line metho…     

多点光源相衬成像法应用于内爆背光照相实验

针对常规内爆背光照相中存在的光源均匀性差、 靶丸图像烧蚀层与气体层界面不清晰、 瞄准精度差等关键问题设计了新型的背光照相靶. 在神光II大型激光装置上采用阵列点光源结合相衬成像的方式获取了清晰的靶丸烧蚀层与气体层界面信息, 同时具备光源均匀性好, 成像视场大的优点; 采用诊断狭缝限光的方式大大提高了瞄准精度使得整体图像质量优于常规靶设计. 实验结果表明, 激光驱动等离子体产生的点光源结合相衬成像方法在精密物理诊断中具有重要的作用, 可以广泛应用于惯性约束聚变以及高能量密度物理研究. 关键词： 惯性约束聚变 背光照相 针孔点背光 相衬成像     

数字相衬法成像

本文给出了数字相衬法成像的技术,并对激光扫描声显微镜的数据进行了处理,结果表明数字相衬法的像比普通方法的像更好.和相位板相比,数字方法简单易行,用途广泛.     

X射线相位衬度成像

文章使用形象、生动、通俗、易懂的语言,介绍X射线相位衬度成像的基本概念,物理思想和方法,其中包括X射线的基本性质、光的波粒二象性、同步辐射X射线光源和常规非相干X射线光源的相位相干性,以及X射线相位衬度成像方法、三维成像的基本原理和相位衬度成像的最新进展,将抽象的相位、相位一阶导数和相位二阶导数概念与形象的光波阵面平移、倾斜和弯曲等形变联系在一起,着重介绍相位衬度成像发展中的创新思想,力图使读者能分享人类文明在这个学科发展中积累的精神财富.     

X射线相位衬度成像

文章使用形象、生动、通俗、易懂的语言,介绍X射线相位衬度成像的基本概念,物理思想和方法,其中包括X射线的基本性质、光的波粒二象性、同步辐射X射线光源和常规非相干X射线光源的相位相干性,以及X射线相位衬度成像方法、三维成像的基本原理和相位衬度成像的最新进展,将抽象的相位、相位一阶导数和相位二阶导数概念与形象的光波阵面平移、倾斜和弯曲等形变联系在一起,着重介绍相位衬度成像发展中的创新思想,力图使读者能分享人类文明在这个学科发展中积累的精神财富.     

X射线同轴相衬成像的参数优化系统

通过对具有2维高斯型相位分布特征的物体的X射线同轴相衬成像技术进行理论分析,建立了成像系统参数优化系统。优化系统明确了图像衬度、信噪比、分辨力和探测器抽样数等成像质量评价参数对射线源能量、源焦斑尺寸、探测器分辨力、成像几何和物体结构特性等系统参数的依赖关系。采用数值模拟,分别对亚微焦点源、激光驱动微焦点源和同步辐射源3种X射线源下的成像系统相关参数进行了优化。结果表明,优化系统很好地完成了系统的优化工作。     

硬X射线相位光栅的设计与研制

针对在普通实验室和医院实现40—100keVX射线相衬成像的需求,考虑到成像系统参数、X射线源空间相干特性及光栅衍射效率,设计出硅基相位光栅结构参数.利用我们已发展的光助电化学刻蚀技术研制出直径为5英寸的相位光栅,其空间周期为5.6μm,线宽为2.8μm,深度为40—70μm.在理论分析的基础上,通过提高硅片两端有效工作电压和修正Lehmann电流密度公式,解决了实际刻蚀过程中出现的钻蚀问题.由实验结果可知,本方案对制作大面积高精度相位光栅十分有效。     

X射线相衬成像应用于惯性约束核聚变多层球壳靶丸检测

随着惯性约束核聚变(ICF)研究的逐步深入,尤其是氘氚(DT)燃料层球壳梯度掺杂的广泛应用,对轻物质界面的诊断需求日益增长.在北京同步辐射形貌成像站的微米CT机上利用类同轴相衬成像方法获取了三层球壳靶丸的相衬图像,最佳空间分辨率达到了2μupm,衬度达到12%;通过分析边缘增强函数和衬度传递函数之间的关系,总结出一套完整的类同轴相衬成像方法,同时将相衬成像结果与吸收成像结果对比.实验结果表明,X射线相衬成像在轻物质界面的分辨中具有明显的优势,能够广泛应用于ICF研究、医学断层扫描CT装置和生物结构等前沿科学领域.     

X射线相衬成像法在线表征冷冻靶技术

阐述了冷冻靶类球面物体X射线相衬成像机理;Tracepro软件模拟研究证明了X射线相衬成像法能用于冷冻靶燃料层参数的表征;研制了在线表征冷冻靶的X射线相衬成像实验装置,利用该装置开展了二乙烯基苯泡沫球壳及实际氘氘冷冻靶的X射线相衬成像实验研究,获得了玻璃微球内氘氘冷冻层X射线相衬图像,成像分辨力达1.5 m;利用X射线相衬成像法可同时表征烧蚀球壳及冷冻燃料层,为惯性约束聚变实验提供冷冻靶参数。     

Microbubbles containing gadolinium as contrast agents for both phase contrast and magnetic resonance imaging

Portal vein imaging is an important method for investigating portal venous disorders. However, the diagnostic requirements are not usually satisfied when using single imaging techniques. Diagnostic accuracy can be improved by combining different imaging techniques. Contrast agents that can be used for combined imaging modalities are needed. In this study, the feasibility of using microbubbles containing gadolinium (MCG) as contrast agents for both phase contrast imaging (PCI) and magnetic resonance imaging (MRI) are investigated. MCG were made by encapsulating sulfur hexafluoride (SF₆) gas with gadolinium and lyophilized powder. Absorption contrast imaging (ACI) and PCI of MCG were performed and compared in vitro. MCG were injected into the main portal trunk of living rats. PCI and MRI were performed at 2 min and 10 min after MCG injection, respectively. PCI exploited the differences in the refractive index and visibly showed the MCG, which were not detectable by ACI. PCI could facilitate clear revelation of the MCG‐infused portal veins. The diameter of the portal veins could be determined by the largest MCG in the same portal vein. The minimum diameter of clearly detected portal veins was about 300 µm by MRI. These results indicate that MCG could enhance both PCI and MRI for imaging portal veins. The detection sensitivity of PCI and MRI could compensate for each other when using MCG contrast agents for animals.