热烈庆祝中国科学院化学研究所成立五十周年：中国科学院化学研究所五十年

2006年，是中国科学院化学研究所五十华诞。五十年来，化学研究所经历了筹建初创、“十年动乱”、科技体制改革和“知识创新工程”等几个重要历史时期。多年来，化学所在各级领导的亲切关怀下，在国内外各界的无私支援和大力支持下，经过几代人的共同努力，为化学科学的发展、为国家经济建设和国防建设做出了重要贡献。今日的化学所，已经发展成为在国内外有一定影响，以基础研究为主，有重点地开展国家急需的、有重大战略需求的高新技术创新研究，并与高新技术产业化协调发展的多学科、综合性国立化学研究机构。     

庆祝中国科学院化学研究所成立55周年!

中国科学院化学研究所成立于1956年,2011年是化学所的55周年华诞! 化学所是以基础研究为主,有重点地开展国家急需的、有重大战略目标的高新技术创新研究,并与高新技术应用和转化工作相协调发展的多学科、综合性研究所。经过55年的发展,化学所以深厚的学科积累、优秀的人才队伍和雄厚的研究实力,成为在国内外有重要影响的化学研...     

六十载勇攀高峰 新起点再创辉煌——写在中国科学院化学研究所建所60周年之际

正金秋十月,中国科学院化学研究所迎来了60周岁的生日。60年来,化学所经历了筹建初创、"十年动乱"、科技体制改革和"知识创新工程"、"率先行动"计划等几个重要历史时期。在各级领导的亲切关怀下,在国内外各界的无私支援和大力支持下,几代化学所人共同努力,顽强拼搏,勇攀高峰,形成了"创新、求是、团结、奉献"的优秀文化,为我国科技事业、国民经济和国防建设     

·前言·庆祝中国科学院化学研究所成立55周年

中国科学院化学研究所成立于1956年,2011年是化学所的55华诞!化学所是以基础研究为主,有重点地开展国家急需的、有重大战略目标的高新技术创新研究,并与高新技术应用和转化工作相协调发展的多学科、综合性研究所.经历55年的发展壮大,化学所以深厚的学科积累、优秀的人才队伍和雄厚的研究实力,已经成为在国内外有重要影响的化学研究机构,为化学     

中国科学院化学研究所

中国科学院化学研究所始建于1956年，是中国科学院成立后创建的第一个综合性化学研究所，是以基础研究为主，有重点地开展国家急需的、有重大战略目标的高新技术创新研究，并与高新技术应用和转化工作相协调发展的多学科、综合性研究所，是中国化学科学最重要的研究机构之一。     

中国科学院化学研究所

中国科学院化学研究所始建于1956年,是中国科学院成立后创建的第一个综合性化学研究所,是以开展基础研究为主,有重点地开展国家急需的、有重大战略目标的高新技术创新研究,并与高新技术应用和转化工作相协调发展的多学科、综合性研究所,是中国化学科学最重要的研究机构之一。     

坚持传承创新打造检测品牌——写在上海材料研究所成立60周年之际

时间跨越到公元2006年,上海材料研究所的理化检测工作伴随着上海材料研究所60周年大庆的来临,已走过了60个年头。回顾历史,展望未来,倍感任重,更觉路漫漫其修远兮。1上材检测历史追溯上海材料研究所开展理化检测工作可追溯到上海解放前夕,1946年成立的南京国民政府资源委员会所属中央材料试验所即是上海材料研究所的前身。当年陶正耀先生等被选派赴美学习并选购一批先进的测试设备,如60吨万能材料试验机、布氏和洛氏硬度计、冲击试验机、大型金相显微镜、化学分析仪器及标准物质等,至今实验室里还可看到一些当年购进的仪器设备。上海材料研…     

中国科学院兰州化学物理研究所色谱技术研究开发中心

中国科学院兰州化学物理研究所色谱中心是我国从事色谱柱研发和生产历史最长、规模最大、实力雄厚的单位。60年代初就开始铜毛细管色谱柱的研究;     

中国科学院兰州化学物理研究所色谱技术研究开发中心

中国科学院兰州化学物理研究所色谱中心是我国从事色谱柱研发和生产历史最长、规模最大、实力雄厚的单位。60年代初就开始铜毛细管色谱柱的研究;70年代初进行玻璃毛细管柱的研究,研制和推广了独特的     

中国科学院成都有机化学研究所1847有机（药物）合成技术创新实验室

我实验室拥有25名职业研发专家与数量变化的在读研究生及其他科研人员,是“不对称合成与手性技术中心”的核心组成部分,是完全依靠市场机制与企业合作求得生存和发展的科研团体。通过在市场上10多年的艰苦创业及与国内众多医药化工企业通力合作,有数十个具有重大创新（专利）知识产权的医药产品已经或即将陆续进入生产和市场,逐渐建立了自己的特点与品牌。     

低碳造纸化学品大有可为

面对低碳经济对我国的压力和挑战,提出低碳造纸是新一轮的造纸技术革命,低碳造纸化学品大有可为。并根据我国造纸国情,介绍了可降低木材纤维用量、节能降耗和环保治理等的低碳造纸化学品的现状与发展,提出了一些思考和建议。     

Use of Formax High-Throughput Platform to Create a Specific Emulsion

The Formax high-throughput platform is capable of rapidly mapping out the formulation and process parameters required to produce an array of emulsions with a range of particle sizes. The specific emulsion in this instance is a stable emulsion with a small droplet size, preferably submicron. Using a combination of design of experimental software and high-throughput experimentation, the factors required to produce the emulsion with smallest droplet size were identified. Additionally, this work produced a template which allows the quick and efficient mapping of process and formulation space to determine for new systems which variables have the greatest impact upon the emulsion produced. (Supplemental materials are available for this article. Go to the publisher's online edition of the Journal of Dispersion Science and Technology to view the free supplemental file.)     

巧用信息手段，打造疫情中无机化学云课堂

Aiming at the requirement of "suspending classes without stopping learning" in the epidemic situation of new coronary pneumonia, a variety of information technologies were used to construct a cloud classroom of inorganic chemistry. How to use Tencent classroom, Superstar learning and WeChat public account to construct this "inorganic chemistry" cloud class was introduced. The teaching effect of Inorganic Chemistry was discussed.     

Two Possible Strategies for Drug Modification of Gemcitabine and Future Contributions to Personalized Medicine

Drug repurposing is an emerging strategy, which uses already approved drugs for new medical indications. One such drug is gemcitabine, an anticancer drug that only works at high doses since a portion is deactivated in the serum, which causes toxicity. In this review, two methods were discussed that could improve the anticancer effect of gemcitabine. The first is a chemical modification by conjugation with cell-penetrating peptides, namely penetratin, pVEC, and different kinds of CPP6, which mostly all showed an increased anticancer effect. The other method is combining gemcitabine with repurposed drugs, namely itraconazole, which also showed great cancer cell inhibition growth. Besides these two strategies, physiologically based pharmacokinetic models (PBPK models) are also the key for predicting drug distribution based on physiological data, which is very important for personalized medicine, so that the correct drug and dosage regimen can be administered according to each patient’s physiology. Taking all of this into consideration, it is believed that gemcitabine can be repurposed to have better anticancer effects.     

In Situ Generation of Organic Peroxide to Create a Nanotubular Uranyl Peroxide Phosphate

Current synthetic pathways for uranyl peroxide materials introduce high initial concentrations of aqueous H₂O₂ that decline over time. Alternatively, in situ generation of organic peroxide would maintain constant concentrations of peroxide over prolonged periods of time and open new pathways to novel uranyl peroxide compounds. Herein, we demonstrate this concept through the synthesis of a nanotube‐like uranyl peroxide phosphate ( NUPP ), Na₁₂[(UO₂)(μ‐O₂)(HPO₄)]₆(H₂O)₄₀, making use of the inhibited autoxidation of benzaldehyde in benzyl alcohol solutions in the presence of phosphonate ligands. The unique feature of NUPP is the bent dihedral angle U‐(μ‐O₂)‐U (123.9°±0.4° to 124.6°±0.5°), which allows hexameric uranyl peroxide macrocycles to adopt the nanotubular topology and prevents the formation of nanocapsules. Raman spectroscopy of the solution phase confirms our mechanistic understanding of the reaction pathway and confirms that consistent levels of peroxide are generated in situ over an extended period of time.     

与时俱进，不断开创物理化学课程建设新局面

As a necessary basic theory course for undergraduates majoring in chemistry, materials, pharmacy, chemical engineering, and biology, physical chemistry plays an important role in cultivating talents to meet the needs of social and economic development. Over the years, the teaching team of physical chemistry of East China University of Science and Technology has carried out the curriculum reform and innovation persistently based on "Team building as the foundation, resource building as the root, mode innovation as the soul, ability training as the origin". This paper will summarize our thinking and experience in striving for the first-class course from the aspects of first-class team construction, first-class resource construction, teaching connotation innovation, teaching mode exploration, and extract the experience that can be used as reference by teaching peers.     

Pomegranate By-Products as Natural Preservative to Prolong the Shelf Life of Breaded Cod Stick

This work evaluated the efficacy of pomegranate byproducts, specifically peel powder, as valid preservatives for food quality. Ready-to-cook cod sticks breaded with pomegranate peel powder were prepared. Shelf-life tests were conducted on breaded cod sticks during refrigerated storage (17 days) at 4 °C, monitoring the pH, microbiological and sensory quality. In addition, the nutritional quality of both the breaded and control samples was assessed. The results highlighted that active samples showed higher phenol and flavonoid content and higher antioxidant activity compared to the control fish, suggesting that pomegranate peel powder was responsible for a significant increase in cod stick nutritional quality. Furthermore, the cod stick active breading led to a delay in microbial growth without affecting the sensory properties; rather, it helped slow down the sensory attribute decline during the refrigerated storage. The data suggest that using pomegranate byproducts in breaded cod stick was effective in prolonging its shelf life, as well as improving its nutritional quality. Therefore, pomegranate peel powder can be considered as a potential resource as natural food preservative.     

Development of a facile sensor for the determination of Brilliant Blue FCF in beverages

A facile method was developed for the detection of Brilliant Blue FCF (BB FCF) (E133), a synthetic soluble colorant in common beverages. The method is based on a new composite of multi-walled carbon nanotube (MWCNT)-graphite oxide (GO)-room temperature ionic liquids (MWCNT/GO-RTIL) of 1-butyl-3-methylimidazolium hexafluorophosphate with high dispersibility and strong conductivity. Differential pulse stripping voltammetry (DPSV) and the MWCNT/GO-RTIL composite-modified glassy carbon electrode (GCE) were used to determine the BB FCF in this work. Under the optimum experimental conditions, the oxidation current of BB FCF was proportional to its concentration in two linear ranges, from 6.34 μg kg^?1 to 7.93 × 10² μg kg^?1 and 7.93 × 10² μg kg^?1 to 7.93 × 10³ μg kg^?1.

The detection limit was down to 3.01 μg kg^?1 at signal-to-noise ratio of 3. Also, this method has been successfully applied in the determination of BB FCF in common beverage samples, including RIO cocktail, Bacardi Breezer and Reinnbow rum dinks. The assay results of BB FCF in drink samples obtained by the proposed method were in a good agreement with the reference values detected by high performance liquid chromatography (HPLC). The proposed method provided a useful tool for the assay of BB FCF in drink samples.     

展望今后化学之发展

展望今后化学之发展唐有祺际此世纪交替之时，正好就化学这个学科有所回顾，并展望今后之发展。然兹事体大，且难免仁、智之见，此举意在抛砖引玉，何如？１化学的地位和作用在自然科学的各个分支中，化学侧重在原子－分子水平上研究物质的组成、结构和性能以及相互转化的...     

Natural Polymers-Based Materials: A Contribution to a Greener Future

Natural polymers have emerged as promising candidates for the sustainable development of materials in areas ranging from food packaging and biomedicine to energy storage and electronics. In tandem, there is a growing interest in the design of advanced materials devised from naturally abundant and renewable feedstocks, in alignment with the principles of Green Chemistry and the 2030 Agenda for Sustainable Development. This review aims to highlight some examples of the research efforts conducted at the Research Team BioPol4fun, Innovation in BioPolymer-based Functional Materials and Bioactive Compounds, from the Portuguese Associate Laboratory CICECO–Aveiro Institute of Materials at the University of Aveiro, regarding the exploitation of natural polymers (and derivatives thereof) for the development of distinct sustainable biobased materials. In particular, focus will be given to the use of polysaccharides (cellulose, chitosan, pullulan, hyaluronic acid, fucoidan, alginate, and agar) and proteins (lysozyme and gelatin) for the assembly of composites, coatings, films, membranes, patches, nanosystems, and microneedles using environmentally friendly strategies, and to address their main domains of application.