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1.
A. E. Lyuts V. V. Zamkova O. V. Agashkin S. A. Tarakov K. D. Praliev 《Chemistry of Heterocyclic Compounds》1987,23(2):210-213
The fragmentation of the stereoisomers of 1-(3-phenyl-2-propynyl)-2-methyldecahydroquinolin-4-one(ol) under electron impact was investigated. The elemental composition of the characteristic ions was determined from the high-resolution mass spectra.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 250–253, February, 1987. 相似文献
2.
A. V. Golovchenko S. G. Pil’o V. S. Brovarets A. N. Chernega B. S. Drach 《Russian Journal of General Chemistry》2005,75(3):425-431
Acylation products of 2-aryl-5-hydrazino-4-X-1,3-oxazoles [X = C(O)OAlk, P(O)(OAlk)2], when heated in acetic acid or ethanol, undergo recyclization and transform into the derivatives of 1,3,4-oxadiazol-2-ylglycine or its phosphonyl analog. A similar rearrangement also occurs in the reactions of 2-alkyl(aryl)-5-hydrazino-1,3-oxazole-4-carbonitriles with carboxylic acid chlorides in pyridine, but it is accompanied by additional cyclization involving the amide residue and nitrile group, yielding 2-(5-amino-1,3-oxazol-4-yl)-1,3,4-oxadiazole derivatives.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 3, 2005, pp. 461–467.Original Russian Text Copyright © 2005 by Golovchenko, Pil’o, Brovarets, Chernega, Drach. 相似文献
3.
I. L. Shegal V. L. Nirenburg V. F. Degtyarev I. Ya. Postovskii 《Chemistry of Heterocyclic Compounds》1966,1(4):390-393
Determination of the acidity constants of 1-aryltetrazolinethiones-5, 4-aryl-1, 2, 4-triazolinethiones-3, 1-aryltetrazolinones-5, 4-aryl-1, 2, 4-triazolinones-3 shows that carbonyl compounds are 10–1–10–2 times less acid than compounds with a thione group. Acidities are found to increase considerably, 103–104 times, on passing from triazole compounds to tetrazole ones. 4-Aryl-1, 2, 4-triazolinones-3 and 1-aryl-tetrazolinones-5 are aminomethylated and cyanoethylated and the reactions found to take place at the amide nitrogen atom.For Part VI see [1]. 相似文献
4.
Stevens rearrangement of ammonium salts containing 2-propynyloxy or tert-butoxycarbonylmethyl groups
Babakhanyan A. B. Ovakimyan S. A. Grigoryan V. V. Kocharyan S. T. 《Russian Journal of General Chemistry》2004,74(8):1221-1226
The Stevens rearrangement of ammonium salts containing 2-alkenyl, 2-alkynyl, or benzyl groups along with 2-propynyloxy or tert-butoxycarbonylmethyl was studied. Under the action of a suspension of sodium phenolate in benzene the salts containing a 2-propynyloxycarbonylmethyl group form 2-propynyl esters of 2-dialkylamino-4-pentenoic acids, whereas with sodium methylate as the basic reagent, rearrangement is preceded by an almost complete transesterification. The salts containing a tert-butoxycarbonylmethyl group undergo almost no transesterification under the action of sodium methylate. The tert-butyl fragment in the ester group of the salt with a benzyl group exerts a fairly strong effect on the regiochemistry of the rearrangement and on the prototropic isomerization of the 3,2-Stevens rearrangement of the salts with 2-butynyl or 3-phenyl-2-propynyl groups.Translated from Zhurnal Obshchei Khimii, Vol. 74, No. 8, 2004, pp. 1321–1326.Original Russian Text Copyright © 2004 by Babakhanyan, Ovakimyan, Grigoryan, Kocharyan.This revised version was published online in April 2005 with a corrected cover date. 相似文献
5.
V. V. Shchepin P. S. Silaichev R. V. Shchepin M. A. Ezhikova M. I. Kodess 《Russian Journal of Organic Chemistry》2005,41(4):527-534
Zinc enolates derived from 1-aryl-2,2-dibromoalkanones react with N-cyclohexyl-2-oxochromene-3-carboxamides to give N-cyclohexyl-1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxamides mainly as cis isomers with respect to the substituents in positions 1 and 1a. Reactions of the same zinc enolates with N-benzyl-2-oxochromene-3-carboxamide and N-benzyl-6-bromo-2-oxochromene-3-carboxamide lead to formation of 1-aryl-2-benzyl- and 1-aryl-2-benzyl-6-bromo-1-hydroxy-9c-alkyl-1,2,9b,9c-tetrahydro-5-oxa-2-azacyclopenta[2,3]cyclopropa[1,2-a]naphthalene-3,4-diones. The reaction of zinc enolates with N-aryl-2-oxochromene-3-carboxamides in a weakly polar solvent (diethyl ether or ethyl acetate) affords mixtures of cis-N-aryl-1-aroyl-1-alkyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxamides and their cyclic isomers, 9c-alkyl-1,2-diaryl-1-hydroxy-1,2,9b,9c-tetrahydro-5-oxa-2-azacyclopenta[2,3]cyclopropa[1,2-a]naphthalene-3,4-diones, the latter prevailing. N-Substituted 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxamides in which the aroyl group on C1 and the carboxamide group on C1a are arranged trans are formed by reactions of zinc enolates with the corresponding 2-oxochromene-3-carboxamides in the presence of hexamethylphosphoric triamide.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 4, 2005, pp. 539–546.Original Russian Text Copyright © 2005 by V. Shchepin, Silaichev, R. Shchepin, Ezhikova, Kodess. 相似文献
6.
R. Abele E. Abele K. Rubina O. Dzenitis P. Arsenyan I. Shestakova A. Nesterova I. Domracheva J. Popelis S. Grinberga E. Lukevics 《Chemistry of Heterocyclic Compounds》2002,38(7):867-872
We have developed a two-step method for synthesis of 3-(hetarylthio)-1-propynyl(trimethyl)silanes from thiols in a phase-transfer catalysis system HCCCH2Br-solid K2CO3-18-crown-6-toluene followed by reaction with n-BuLi-Me3SiCl in ether or THF. We have observed that 3-[1,3-bis(trimethylsilyl)-2-propynyl]thioindole displays high cytotoxicity in HT-1080 and MG-22A tumor cell lines. 相似文献
7.
E. V. Resnyanskaya A. V. Tverdokhlebov A. A. Tolmachev Yu. M. Volovenko 《Russian Journal of Organic Chemistry》2005,41(2):257-260
A method was developed for preparation of 5-amino-4-(4-aryl-2-thiazolyl)-2,3-dihydro-2-pyrrolones by alkylation of 4-aryl-2-thiazolylacetonitriles by N-substituted chloroacetamides in the presence of K2CO3. In 1-(1-naphthyl)-substituted pyrrolones atropoisomerism was observed.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 2, 2005, pp. 266–269.Original Russian Text Copyright © 2005 by Resnyanskaya, Tverdokhlebov, Tolmachev, Volovenko. 相似文献
8.
2-Phenyl-5-(1-propynyl)thiophene (1), isolated from Coreopsis grandiflora, and 2-(1-propynyl)thiophene (5), an immediate precursor in the synthesis of junipal (2), were synthesized in high yield by a Pd-catalyzed reaction between propyne and 2-iodo-5-phenylthiophene (4) or 2-iodothiophene (6), respectively. Reaction of 5 with the Vilsmeier reagent derived from POCl3 and N-methylformanilide (MFA) afforded a mixture from which it was possible to isolate (E)-3-chloro-2-methyl-3-(2-thienyl)acrolein (10) in 37.7% yield. The structure and stereochemistry of 10 was unequivocally established by X-ray diffraction of a single crystal of the 2,4-dinitrophenylhydrazone of 10. GLC analysis showed that 10 was contaminated by ca 7% with an isomer to which, on the basis of 1H-NMR and mass spectra, the structure of (Z)-3-chloro-2-methyl-3-(2-thienyl)acrolein (11) was attributed.Contrary to what was expected from the literature, junipal (2) represented only a minor component in the reaction mixture obtained by the Vilsmeier reaction on 5.Reaction of 1 with POCl3 and MFA afforded (44.6% yield) a (E)-3-chloro-2-methylacrolein to which the structure 15 was attributed. Compound 15 was also contaminated by ca 10% of an isomer 16, which very probably corresponded to the (Z)-stereoisomer of 15. 相似文献
9.
Depending on the conditions, bromination of 4-aryl-5-nitro-6-phenyl-3,4-dihydropyrimidine-2(1H)-ones and subsequent dehydrobromination gives either 4-aryl-5-nitro-6-phenylpyrimidin-2(1H)-ones or their mixtures with the corresponding 4-aryl-5-bromo-6-methoxy-5-nitro-6-phenyltetrahydropyrimidin-2-ones which are formed as two diastereoisomers.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 3, 2005, pp. 425–430.Original Russian Text Copyright © 2005 by Sedova, Gatilov, Shkurko. 相似文献
10.
A. P. Molchanov A. V. Stepakov R. R. Kostikov 《Russian Journal of Organic Chemistry》2005,41(1):75-86
Halogenation of 1-substituted 7-aryl-2,3,7-triazabicyclo[3.3.0]oct-2-ene-6,8-diones gives different products, depending on the substituent in position 1 (R1): when R1 = Ar, 6-chloro-3-azabicyclo[3.1.0]hexanes are formed, while compounds with R1 = H or Me give rise to 2- or 4-chloro-2,3,7-triazabicyclo[3.3.0]oct-2-ene-6,8-diones whose thermolysis leads to formation of the corresponding 6-chloro-3-azabicyclo[3.1.0]hexanes. Chlorination of 7-aryl-1,2,7-triazaspiro[4.4]non-1-ene-6,8-diones yields 3-chloro-1,2,7-triazaspiro[4.4]non-1-ene-6,8-diones, and thermolysis of the latter affords 1-chloro-5-azaspiro[2.4]heptanes.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 78–88.Original Russian Text Copyright © 2005 by Molchanov, Stepakov, Kostikov. 相似文献
11.
S. G. Kon’kova G. M. Abovyan A. Kh. Khachatryan A. E. Badasyan G. A. Panosyan M. S. Sargsyan 《Russian Journal of Organic Chemistry》2005,41(7):1043-1045
Acrylonitrile reacts with aromatic aldehyde imines containing a hydroxy group in the β- or γ-position to give 70–85% of the corresponding 2-aryl-3-cyanoethyltetrahydro-1,3-oxazines or 2-aryl-3-cyanoethyl-1,3-oxazolidines, respectively. The results of these reactions are rationalized in terms of ring-chain isomerism of the initial imines.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 7, 2005, pp. 1064–1066.Original Russian Text Copyright © 2005 by Kon’kova, Abovyan, Khachatryan, Badasyan, Panosyan, Sargsyan. 相似文献
12.
M.-G. A. Shvekhgeimer O. A. Ushakova V. V. Nesterov M. Yu. Antipin 《Chemistry of Heterocyclic Compounds》2005,41(2):181-186
2-Cyanoaryldiazonium bisulfates, obtained by the action of nitrosyl sulfuric acid on isatin 3-hydrazone and its 5-bromo and 5-nitro derivatives, couple with 1-aryl-3-methylpyrazol-5-ones and form 4-arylhydrazones of 1-aryl-3-methylpyrazole-4,5-diones. It was established on the basis of data of IR, UV, and 1H NMR spectra and of X-ray structural analysis that the coupling products exist in the hydrazone form stabilized by an intramolecular hydrogen bond.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 210–215, February, 2005. 相似文献
13.
V. S. Matiichuk N. D. Obushak V. M. Tsyalkovskii 《Russian Journal of Organic Chemistry》2005,41(7):1050-1054
Meerwein reactions of arenediazonium bromides with methyl and ethyl acrylates gave 3-aryl-2-bromopropionic acid esters which were subjected to cyclocondensation with N-(2-pyridyl)- and N-(6-methyl-2-pyridyl) thioureas to obtain 5-R1-benzyl-2-(R2-2-pyridylimino)thiazolidin-4-ones. The latter were shown to exist in solution as E isomers of the imino form.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 7, 2005, pp. 1071–1075.Original Russian Text Copyright © 2005 by Matiichuk, Obushak, Tsyalkovskii. 相似文献
14.
Nucleophilic Substitution of Chlorine with Hydrazine,Methylhydrazine, and 1,1-Dimethylhydrazine in 5-Aryl-2-chloromethyl-1,3,4-oxadiazoles 总被引:4,自引:0,他引:4
A. B. Baranov V. G. Tsypin A. S. Malin B. M. Laskin 《Russian Journal of Applied Chemistry》2005,78(3):465-468
The reactions of 1,1-dimethylhydrazine, methylhydrazine, and hydrazine hydrate with 5-aryl-2-chloromethyl-1,3,4-oxadiazoles were studied. The structures and compositions of the final products were confirmed by 1H NMR spectroscopy and elemental analysis.__________Translated from Zhurnal Prikladnoi Khimii, Vol. 78, No. 3, 2005, pp. 470–473.Original Russian Text Copyright © 2005 by Baranov, Tsypin, Malin, Laskin. 相似文献
15.
Susan A. Bourne Katherine L Gifford Nash Fumio Toda 《Journal of inclusion phenomena and macrocyclic chemistry》1999,34(2):169-187
The 2-hexanone inclusion compounds of hexakis(3-hydroxy-3,3-diphenyl-2-propynyl)benzene and 1,2,3,5,6,7-hexakis(3-hydroxy-3,3-diphenyl-2-propynyl)naphthalene have been prepared and characterised by single crystal X-ray diffraction and thermal analysis. The kinetic parameters and mechanisms for the desolvation reaction have also been determined for both compounds. 相似文献
16.
A. P. Molchanov V. V. Diev J. Kopf R.R. Kostikov 《Russian Journal of Organic Chemistry》2005,41(2):194-203
Carbonyl ylide generated from methyl cis-3-diazoacetyl-2,2-diphenyl-1-cyclopropanecarboxylate in the presence of Rh2(OAc)4 when brought into reaction of 1,3-dipolar cycloadditionя with N-arylmaleimides afforded substituted 4-aryl-7-methoxy-9,9-diphenyl-12-oxa-4-azatetracyclo-[5.4.1.02,6.08,10]dodecene-3,5,11-triones. Concurrent processes resulted in formation of cycloheptatrienes, hydroxyacetylcyclopropanecarboxylates, and benzophenone. Carbonyl ylide generated from methyl cis-2-diazoacetyl-1-cyclopropanecarboxylate in the same reaction gave rise to exo- and endo-4-aryl-7-methoxy-12-oxa-4-azatetracyclo[5.4.1.02,6
.08,10] dodecene-3,5,11-triones.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 2, 2005, pp. 205–213.Original Russian Text Copyright © 2005 by Molchanov, Diev, Kopf, Kostikov. 相似文献
17.
Reformatsky reagent obtained by treatment of methyl α-bromoisobutyrate with zinc reacts with dimethyl 2-arylmethylidenemalonates to give trimethyl 2-aryl-3-methylbutane-1,1,3-tricarboxylates. The reaction of the same compound with ethyl 3-aryl-2-(4-methylphenylcarbamoyl)acrylates yields cyclic products, ethyl 4-aryl-5,5-dimethyl-1-(4-methylphenyl)-2,6-dioxopiperidine-3-carboxylates. Treatment of the latter with morpholine and phenylhydrazine leads to the corresponding 4-aryl-5,5-dimethyl-1-(4-methylphenyl)-2,6-dioxopiperidine-3-carboxylic acid morpholides and phenylhydrazides. The products are formed as a single diastereoisomer.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 7, 2005, pp. 1034–1038.Original Russian Text Copyright © 2005 by Shchepin, Fotin. 相似文献
18.
M. M. Krayushkin B. V. Lichitskii A. P. Mikhalev A. A. Dudinov S. N. Ivanov 《Russian Journal of Organic Chemistry》2005,41(1):87-90
Reactions of 1-aryl-2-(2,5-dimethylthiophen-3-yl)-2-hydroxyethanones with thiols in trifluoroacetic acid lead to formation of substituted 1-aryl-2-(2,5-dimethylthiophen-3-yl)-2-sulfanylethanones.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 89–92.Original Russian Text Copyright © 2005 by Krayushkin, Lichitskii, Mikhalev, Dudinov, lvanov. 相似文献
19.
V. V. Shchepin A. E. Korzun N. Yu. Poroshina 《Russian Journal of General Chemistry》2005,75(4):597-604
Zinc enolates generated from 1-aryl-2-bromoalkanones and zinc react with dimethyl 2-(1-arylmethylene)malonate to form dimethyl 2-(2-alkyl-1,3-diaryl-3-oxopropyl)malonates. The latter react with benzylamine or cyclohexylamine to form the corresponding disubstituted amides, while the reactions with piperidine, morpholine, and p-methoxyaniline provide monosubstituted amides of the corresponding target derivatives.__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 4, 2005, pp. 636–641.Original Russian Text Copyright © 2005 by Shchepin, Korzun, Poroshina. 相似文献
20.
V. N. Britsun A. N. Borisevich L. S. Samoilenko M. O. Lozinskii 《Russian Journal of Organic Chemistry》2005,41(2):283-288
Reactions of N-phenyl-3-oxobutanethioamide with 3-aryl-2-propenoyl chlorides in acetone in the presence of potassium carbonate give rise to 4-aryl-5-acetyl-1-phenyl-6-thioxopiperidin-2-ones, 2-aryl-5-acetyl-6-phenylamino-2,3-dihydro-4H-thiopyran-4-ones, and 6-aryl-2-acetonylidene-3-phenyl-5,6-dihydro-4H-1,3-thiazin-4-ones whose structure was proved both by spectral methods and chemical transformations.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 2, 2005, pp. 292–296.Original Russian Text Copyright © 2005 by Britsun, Borisevich, Samoilenko, Lozinskii. 相似文献