共查询到20条相似文献,搜索用时 15 毫秒
1.
P. M. Kochergin M. Yu. Gromov E. V. Aleksandrova S. Ya. Skachilova 《Chemistry of Heterocyclic Compounds》1996,32(2):238-242
Thiazolo[2,3-i]purine and its 7,8-alkyl(aryl, heteryl)derivatives were obtained by the cyclodehydration of 7hydroxy-7, 8-dihydrothiazolo[2, 3-i)purine and 6--oxoalkyl (aryl, heteryl)thiopurines in the presence of phosphoryl chloride, sulfuric, and polyphosphoric acids.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 265–270, February, 1996. 相似文献
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Conclusions Derivatives of 2-oxo-2,3-dihydro-1H-thieno[3,4-d]imidazole were synthesized from 4,5-di-substituted 2-imidazolinones.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2381–2383, October, 1987. 相似文献
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Russian Journal of Organic Chemistry - The alkylation of purine-6-thione with prenyl bromide and 3-butenyl bromide in the presence of alkali gave 6-[prenyl(but-3-enyl)sulfanyl]purines which reacted... 相似文献
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2-Hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one 2a and 7-hydroxy-5H-thiazolo[3,2-a]pyrimidin-5-one 2b, were obtained in high yields under mild conditions from the cyclization reactions of bis-(2,4,6-trichlorophenyl) malonate and 2-aminobenzothiazole or 2-aminothiazole, respectively. A new class of compounds, 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d]pyrimidin-4-ones and 6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones, were synthesized via the microwave assisted radical addition of compounds 2a and 2b to various alkenes using manganese(III) acetate. A preliminary acetylcholine esterase (AchE) inhibition test of compound 4e showed excellent (92%) inhibitory potential, comparable with the standard drug Donapezil®. 相似文献
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A. Monge V. Martinez-Merino M. A. Simon C. Sanmartin 《Journal of heterocyclic chemistry》1992,29(6):1545-1549
This paper reports the synthesis of new pyrido[2,3-d]pyrimidin-4-one derivatives as diuretic agents. Starting with 1,2-dihydro-5-nitro-2-oxo-3-pyridinecarboxylic acid 1 , ethyl 2-ethoxy-5-nitro-3-pyridincarboxylate 4 was obtained. Compound 4 reacts with ammonia, methylamine or S-methylpseudothiourea to give the respective 2-amino-5-nitro-3-pyridinecarboxamide derivatives 5 and 6 or 2-methylthio-6-nitro-3H-pyrido[2,3-d]pyrimidin-4-one 8. Treating carboxamide 5 with arylaldehydes and zinc dichloride, new 2-aryl-1,2-dihydro-6-nitro-3H-pyrido[2,3-d]pyrimidin-4-ones 9 were synthetised. These compounds reduced with iron(II) hydroxide gave 6-amino-2-aryl-1,2-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones 10 as expected. 相似文献
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Oxazinopurines were obtained in high yield by the reaction of 8-bromotheophylline with morpholinomethyl-, piperidinomethyl- or indolinomethyl-substituted oxiranes without isolation of the intermediate oxazolo[2,3-f]purine. 相似文献
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Aleksandrov A. A. Zablotskii D. A. El’chaninov M. M. 《Russian Journal of Organic Chemistry》2020,56(1):59-62
Russian Journal of Organic Chemistry - The condensation of quinolin-5-amine with thiophene-2-carbonyl chloride in propan-2-ol gave N-(quinolin-5-yl)thiophene-2-carboxamide. Treatment of the latter... 相似文献
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S. G. Dzhavakhishvili N. Yu. Gorobets V. N. Chernenko V. I. Musatov S. M. Desenko 《Russian Chemical Bulletin》2008,57(2):422-427
An efficient method for the synthesis of novel 3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones from various 2-dimethylaminomethylidenecyclohexane-1,3-diones, (1,3-thiazol-2-yl)acetonitriles, and dimethylformamide
dimethyl acetal was developed. These transformations proceeded through intermediate 2-[2-(4-aryl-1,3-thiazol-2-yl)-2-cyanoethenyl]-3-oxocyclohex-1-en-1-olates.
They were isolated as piperidinium salts and used in further heterocyclization reactions with aromatic amines, giving novel
1-aryl-3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones. These compounds were also obtained by preparative three-step “one pot” synthesis under controlled microwave irradiation.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 412–417, February, 2008. 相似文献
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Alkylation of various primary amines with crotyl bromide, followed by DMAP-promoted acylation with methyl malonyl chloride to 4 and then manganic triacetate dihydrate/cupric acetate induced radical cyclization, gave 1-substituted-4-vinyl-3-carbomethoxy-2-pyrrolidinones (5). Thiation to the thiolactams 6 and guanidine cyclization then gave a series of 2-amino-3,4-dihydro-4-oxo-5-vinyl-7-substituted pyrrolo[2,3-d]pyrimidines (7). Palladium-catalyzed C-C coupling with diethyl 4-iodobenzoylglutamate led in one step via an unexpected redox reaction to the diethyl esters 9 of a series of 7-substituted derivatives of ALIMTA (LY231514, MTA), from which the target analogues 10 were readily prepared by saponification. Attempted deprotection at position 7 was successful in only one case (9d, R = CH(2)C(6)H(3)(OMe)(2)(-3',4'), which resulted in a known pentultimate precursor (9, R = H) of ALIMTA. The 7-substituted derivatives 10 proved to be inactive in vitro as inhibitors of cell division. 相似文献
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Aleksandrov A. A. Elchaninov M. M. Tarakanova Yu. E. Tishina D. A. Shmanovsky M. L. Baidin A. A. 《Russian Journal of Organic Chemistry》2021,57(12):1983-1987
Russian Journal of Organic Chemistry - The acylation of pyridin-2-amine with furan-2-carbonyl chloride in propan-2-ol gave N-(pyridin-2-yl)furan-2-carboxamide, and treatment of the latter with... 相似文献
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A microscale synthesis (500 mg) of the product 3-[5-anilino-(2,3-d)-dioxole-1,3]-1-oxo-1, 3-dihydro-2-benzofurane (COR.01.126) is described. This method, which requires only four steps, is principally available for the 14C-labeled synthesis with labeled phthalic anhydride as starting material. 相似文献
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S. M. Ramsh A. V. Smirnova S. Yu. Solovyova Song Minyan 《Chemistry of Heterocyclic Compounds》2008,44(1):92-95
Mechanisms are given for reactions taking place upon heating 2-amino-5-benzylidene-1,3-thiazol-4(5H)-one in a medium consisting
of a secondary amine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 111–114, January, 2008. 相似文献
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Abdou O. Abdelhamid Ali A. Al-Atoom 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1629-1646
Abstract Thiazolylacetonitrile was used in the synthesis of coumarin, pyrazolo[4,3]pyrimidines, 1,3,4-thiadiazolines, aminothiophenes, and thiazoles in a good yields. Also, pyrazolo[4,5-d]triazolino[4,5-a]pyrimidines, pyrazolo[4,5-d]thiazolino[3,2-a]pyrimidines, and pyrazolo[4,5-d]tetrazolino[1,5-a]pyrimidines were synthesized from pyrazolo[4,5-d]pyrimidine. Structures of the newly synthesized were elucidated by elemental analysis, spectral data, and alternative synthesis routes whenever possible. Some synthesized compounds were tested for their antimicrobial activity. 相似文献
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Kolyamshin O. A. Mitrasov Yu. N. Danilov V. A. Avruiskaya A. A. Pylchikova Yu. Yu. Savinova N. P. 《Russian Journal of General Chemistry》2021,91(1):34-39
Russian Journal of General Chemistry - The reaction of 2-[3(4)-nitrophenyl]-5,5-dichloromethyl-1,3-dioxanes with potassium 4-aminobenzoate in dimethylformamide gave... 相似文献
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Yu. M. Volovenko T. A. Volovnenko A. V. Tverdokhlebov I. G. Ryabokon' 《Russian Journal of Organic Chemistry》2001,37(9):1323-1329
Reactions of 2-(4-aryl-1,3-thiazol-2-yl)-3-oxo-4-chlorobutyronitriles with primary aromatic amines result in nucleophilic substitution of the chlorine atom by amino group, followed by intramolecular addition of the secondary amino group to the cyano group. The products are 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)- 2,3-dihydro-1H-pyrrol-3-ones which are structurally related to the known antiischemic drugs. 相似文献
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The synthesis and spectroscopic properties of a new class of luminescent 1H-naphth[2,3-d]-imidazole compounds are described. The ultraviolet spectra of 2-(hydroxyaryl)-1H-naphth[2,3-d]-imidazole derivatives are presented and discussed. Significant effects of structure and physical state of the luminescent compounds are observed on the measured emission wave length throughout the visible spectrum. The luminescence quantum efficiency of one of the naphthimidazole derivatives is reported. 相似文献