An efficient one‐pot three‐component reaction for synthesis of spirooxindole derivatives in water media under catalyst‐free condition

An efficient, clean, and environmentally benign synthesis of spirooxindole derivatives by one‐pot three‐component reaction of isatins, malononitrile, and carbonyl compound in the absence of catalysis in water was described. A variety of spirooxindole derivatives were obtained with excellent yields within short reaction time. This novel protocol has the advantages of convenient operation, low cost, and environmental benign. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:673–677, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20723     

A three‐component,one‐pot synthesis of oxazinoquinolin‐3‐one derivatives

Oxazino[5,6‐f]quinolin‐3‐one derivatives have been synthesized in a one‐pot, and efficient process by condensation of 6‐quinolinol, aromatic aldehydes and urea under microwave‐assisted and thermal solvent‐free conditions.     

(Bromodimethylsulfonium) bromide–catalyzed one‐pot three‐component synthesis of imidazo[1,2‐a]pyridines

(Bromodimethylsulfonium) bromide–catalyzed one‐pot multicomponent reaction of 2‐aminopyridine with aromatic aldehyde(s) and TMSCN yielding N‐benzylidene‐2‐phenylimidazo[1,2‐a]pyridines exclusively has been described. The reaction is solvent free, versatile, and takes significantly short time. J. Heterocyclic Chem., (2011).     

Highly efficient iron‐catalyzed allylation of aromatic aldehydes with allyltriethoxysilane: one‐pot and practical synthesis of homoallyl ethers

FeCl₃ was found to be an active catalyst for the one‐pot allylation reaction of aromatic aldehydes with allyltriethoxysilane under mild and simple conditions, which resulted in the direct synthesis of homoallyl ethers with very high chemoselectivity and yields. Various types of homoallyl ethers were obtained in excellent yields (up to 99%). Copyright © 2008 John Wiley & Sons, Ltd.     

Polyethylene glycol mediated one‐pot three‐component synthesis of new 4‐thiazolidinones

An efficient one‐pot three‐component cyclocondensation of 4‐(p‐toulyl sulfonoxy) benzaldehyde, aryl amines, and mercaptoacetic acid in polyethylene glycol 400 (PEG‐400) was conducted to obtain new 2,3‐disubstituted‐4‐thiazolidinones. This route is economical and ecofriendly. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:166–170, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20766     

Triton B catalyzed three‐component,one‐pot synthesis of 2‐amino‐2‐chromenes at ambient temperature

A one‐pot, three‐component synthesis of 2‐amino‐2‐chromenes is described at ambient temperature by the reaction of an aldehyde and malononitrile or ethyl cyanoacetate with α‐naphthol or β‐naphthol in ethanol in presence of a catalytic amount of Triton B. J. Heterocyclic Chem., (2011).     

An efficient one‐pot three‐component synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives catalyzed by L‐proline

L ‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).     

A facile,one‐pot,green synthesis of polysubstituted 4H‐pyrans via piperidine‐catalyzed three‐component condensation in aqueous medium

An efficient, one‐pot method was described for the synthesis of various polysubstituted 4H‐pyrans via piperidine catalyzed three‐component condensation in aqueous medium. The reaction could be promoted effectively by adding sodium dodecyl sulfate to aqueous medium. J. Heterocyclic Chem., (2010).     

An efficient one‐pot synthesis of pyrazolo[3,4‐b]pyridinone derivatives catalyzed by L‐proline

A series of 3‐methyl‐1,4‐disubstituted‐4,5‐dihydro‐1H‐pyrazolo[3,4‐b]pyridine‐6(7H)‐ones was synthesized via the three‐component reaction of aldehyde, 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine, and Meldrum's acid catalyzed by L ‐proline. This protocol has the advantages of easier work‐up, milder reaction conditions, and high yields. J. Heterocyclic Chem., (2011).     

An efficient one‐pot synthesis of pyridazinones and phthalazinones using HY‐zeolite

The first one‐pot synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides, and ArNHNH₂ in the presence of efficient recyclable heterogeneous catalyst, HY‐zeolite, in high yield and short reaction time is reported. J. Heterocyclic Chem., (2011).     

Ligand‐free,copper‐catalyzed,one‐pot,three‐component synthesis of novel 1,2,3‐triazole‐linked indoles in magnetized water

Magnetized water (MW) is used as a green and new solvent‐promoting medium for the one‐pot, three‐component synthesis of novel 1,2,3‐triazole‐linked indoles catalyzed by copper iodide. A broad range of 2‐aryl‐1‐(prop‐2‐ynyl)‐1H‐indole‐3‐carbaldehydes were reacted with alkyl halides and sodium azide via copper‐catalyzed azide–alkyne cycloaddition reactions in MW in the absence of any ligand. This method offers the advantages of short reaction times, green procedure, low cost, simple work‐up, quantitative reaction yields, and no need for any organic solvent.     

An efficient synthesis of polyhydroacridine derivatives by the three‐component reaction of aldehydes,amines and dimedone in ionic liquid

In this paper the preparation of 3,3,6,6‐tetramethyl‐9,10‐diaryl‐1,2,3,4,5,6,7,8,9,10‐decahydroacridine‐1,8‐dione derivatives from aldehydes, aromatic amines and 5,5‐dimethyl‐1,3‐cyclohexanedione in 1‐n‐butyl‐3‐methylimidazolium bromide ([bmim]Br) is described. The structures of these compounds were characterized by elemental analysis, IR and ¹H NMR spectra and further confirmed by single crystal X‐ray diffraction analysis.