Studies on indian medicinal plants : part 91 1 -structure and synthesis of alamaridine,a novel 5-methylbenzopyrioquinolizine alkaloid from alangium lamarckii

The structure of alamaridine (1) a novel benzopyridoquinolizine alkaloid, was established by spectral data. However, its stereochemistry could only be determined now by a total synthesis involving the key cyclisation of an 1-methyl-2-pyridylmethyl-3,4-dihydroisoquinolinium salt 19a in presence of pivaloyl chloride and triethylamine. O-Benzyldehydroalamaridine thus formed was reduced by sodium cyanoborohydride and then deprotected to obtain alamaridine (1) and 5-epi-alamaridine (26). Isoalamaridine (27) and its 5-epimer (28) were also synthesised following the same route.     

4-dehydroxyepisarcovagine A,a new steroidal alkaloid from Sarcococca pruniformis Lindl.

A new steroidal alkaloid, 4-dehydroxyepisarcovagine A (1), along with seven known alkaloids, sarcovagine D (2), sarcovagenine C (3), epoxysarcovagenine D (4), Pachysamine L (5), Pachysamine E (6), sarcovagine A (7) and sarcovagine B (8), was isolated from the roots and stems of Sarcococca pruniformis Lindl. The structure of compound 1 was elucidated by means of spectroscopic analysis.     

Studies on indian medicinal plants,part LXXIX : Synthesis proves the structure of aristolindiqu inone

Aristolindiquinone ($\text{1}$) , the first naturally occurring 8-methyl-juglone earlier isolated from $\text{Aristolochia indica}$ has been synthesised from $\text{o}$-allyl-$\text{p}$-cresol in 7% overall yield.     

Solanopubamine,a rare steroidal alkaloid from Solanum schimperianum: Synthesis of some new alkyl and acyl derivatives,their anticancer and antimicrobial evaluation

Solanopubamine (3β-amino-5α, 22αH, 25βH-solanidan-23β-ol), a steroidal alkaloid was isolated from the alkaloidal fraction of Solanum schimperianum in significant yield. Its structure was established by IR, positive ESI-MS, 1D and 2D NMR. The presence of -3β-NH₂ and -23β-OH groups was achieved through methylation, acetylation or coupling with octadecanoic and undec-11-enoic acids to produce six derivatives (2–7). Their structures were confirmed by spectroscopic analyses. Solanopubamine and semi-synthetic analogs are investigated for their in vitro cytotoxicity against a panel of human cancer cell lines and anti-microbial activity. Solanopubamine showed good antifungal activity only against Candida albicans and C. tenuis with MIC of 12.5 μg/mL. Semi-synthesized compounds (2–7) have failed to show anti-tumor and anti-microbial activities.     

Macleayine,a new alkaloid from Macleaya cordata

Macleayine (1),a new natural occurring alkaloid with a unique spiro[furanone-piperidinedione] framework,was isolated from the aerial parts of Macleaya cordata.Its unusual structure was established by extensive spectroscopic analyses,computer-assisted structure elucidation software (ACD/Structure Elucidator),quantum chemistry calculations and ECD calculation.The result of virtual molecular docking predicted the compound can enhance the effects of insulin,and may be used to treat type II diabetes.     

Macleayine,a new alkaloid from Madeaya cordata

Macleayine(1),a new natural occurring alkaloid with a unique spiro[furanone-piperidinedione]framework,was isolated from the aerial parts of Madeaya cordata.Its unusual structure was established by extensive spectroscopic analyses,computer-assisted structure elucidation software(ACD/Structure Elucidator),quantum chemistry calculations and ECD calculation.The result of virtual molecular docking predicted the compound can enhance the effects of insulin,and may be used to treat type II diabetes.     

Selagoline, a new alkaloid from Huperzia selago

A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland. Their structures were determined using 600 and 800MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Possible role of selagoline as a precursor of 5,15-oxidolycopodane, a component of the classical alkaloids L28 and L31, is discussed.