共查询到20条相似文献,搜索用时 78 毫秒
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在微波辐射无溶剂条件下快速、高产率地合成了2,4,6-三芳基吡啶四氟硼酸盐化合物, 并对其进行核磁共振、红外光谱、元素分析表征. 同时得到了化合物4f的晶体, 对其进行了X单晶射线衍射表征. 结果表明, 该晶体属正交晶系, 空间群Pbca, a=2.1050(2) nm, b=1.64360(17) nm, c=2.9209(3) nm, α=β=90.00°, γ=90.00°, Dc=1.276 g•cm-3, V=10.1057(17) nm-3, Z=16. 相似文献
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微波辐射下,以芳香醛和芳香酮为起始原料,由一锅法合成2,4,6-三芳基硫代吡喃盐,然后直接加入水合肼反应,几乎以定量收率仅只生成3,5,7.三芳基-4H-1,2-二氮杂(艹卓)衍生物.该法以水为反应溶剂且中间盐不用分离,具有操作简单、条件温和、产率高、环境友好等优点.产物经元素分析、1H NMR、MS表征了其结构. 相似文献
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无溶剂条件下,用氨基磺酸催化芳香醛,2-氨基苯并咪唑和β-二羰基化合物的三组分反应,简单而方便地得到了苯并[4,5]咪唑并[1,2-a]嘧啶类衍生物.该法具有产率高,成本低廉,环境友好,适应性广简捷方便等优点. 相似文献
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Ratnadeep S.Joshi Priyanka G.Mandhane Mohammad U.Shaikh Rajesh P.Kale Charansingh H.Gill 《中国化学快报》2010,21(4):429-432
<正>A simple and efficient method has been developed;benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate(KH_2PO_4) under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent yields.The method for synthesis of product,the reaction mixture was reflux in ethanol for 40-90 min.The present method is simple,efficient,and cost-effective. 相似文献
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Fifteen dihydropyrimidinthiones have been synthesized by microwave-assisted Biginelli reactions without any solvent or catalyst. The advantages of this novel protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and catalysts. 相似文献
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Phase-transfer-catalyzed, highly versatile, and high-yielding protocol for the synthesis of 2,4,5-triaryl-1H-imidazoles was developed through response surface methodology (RSM). The effects of different solvents, reaction paths, and phase-transfer catalysts (PTCs) in different concentrations were envisioned. Three independent variables (catalyst, catalyst loading, and solvent volume) identified by one-factor-at-a-time (OFAT) study were screened through full factorial design at two levels. The analysis of variance results suggested the significance of catalyst PEG400 and solvent glacial acetic acid at 5 h reaction. The optimum reaction conditions suggested by the RSM were the use of PEG400 (10.61 mol%) and glacial acetic acid (10.71 mL) for 5 h cycloocondensation. The experimental yield of 4,5-diphenyl-2-nitrophenyl-1H-imidazole (97%) was in agreement with predicted yield (97.5%). 相似文献
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A facile procedure for the synthesis of 2,4,5-triarylimidazoles is being reported starting from benzil, aromatic aldehyde and ammonium acetate. The reactions were carried out with catalyst-free, solvent-free and under microwave irradiation conditions in high yield (80–99%) with short time (3–5 min) and environmental benign, as well as convenient operation. The structures of the compounds have been confirmed on the basis of their IR, 1H NMR, and/or 13C NMR, MS, and elemental analyzer. 相似文献
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M. Gopalakrishnan P. Sureshkumar V. Kanagarajan J. Thanusu 《Research on Chemical Intermediates》2007,33(6):541-548
Condensation of structurally diverse aldehydes including heterocyclic aldehydes, like furfural, with various amines in the
presence of calcium oxide affording the corresponding imines in solvent-free conditions in good to excellent yields under
microwave irradiation is described. A comparative study has been done under thermal conditions. The synergy between dry media
and microwave irradiation in this reaction is evaluated by condensing less electrophilic aldehydes with poorly nucleophilic
amines. The main advantages of this environmentally friendly protocol are the use of the non-toxic and inexpensive reagent
calcium oxide and the considerable rate enhancement in comparison with a thermal reaction. 相似文献
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Juan I. Sarmiento-Sánchez Adrián Ochoa-Terán Lorenzo A. Picos-Corrales Lorenzo U. Osuna-Martínez Julio Montes-Ávila Pedro Bastidas-Bastidas 《Green Chemistry Letters and Reviews》2016,9(4):196-202
Benzoxazinediones exhibit potential as versatile synthons in the synthesis of wide variety of heterocyclic compounds with biological activity. In this work, an efficient and eco-friendly one-step synthesis of benzoxazine-2,4-diones from phthalic anhydrides derivatives and trimethylsilyl azide using the microwave technique was developed and compared with conventional heating. Microwave irradiation plays a critical role in driving the reaction and providing access to products and/or regioisomers not available from conventional heating. Thus, the regioselectivity of the reaction may be modulated by the irradiation time. Depending on the method employed the benzoxazinediones were isolated with yields in the range of 30–90%. 相似文献
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Highly substituted pyridine derivatives have been accessed through an efficient, one-pot, multicomponent reaction of aldehydes, malononitrile, and ammonium acetate in the presence of triethylamine as a catalyst under solvent-free conditions. This procedure affords the desired products in high purity and has advantages such as short reaction time, excellent yields, and simple workup procedure. This procedure affords the desired products in moderate to high yields and has such advantages as short reaction time and simple workup procedure. 相似文献
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《Green Chemistry Letters and Reviews》2013,6(4):603-607
Abstract An efficient and convenient method for the preparation of 3-benzylquinazolin-4(1H)-one derivatives under solvent-free and catalyst-free conditions by the reaction of isatoic anhydride, benzylamine, and aromatic aldehydes was reported. In reported papers, ammonia water, ammonium salt, and aromatic amine were often used to synthesize quinazolin-4(1H)-one derivative, but benzylamine was seldom used in this synthesis. This article offers a green method for the synthesis of 3-benzylquinazolin-4(1H)-one derivative used benzylamine as starting material. This methodology has the advantages of short reaction time, mild reaction conditions, easy work-up, and environmental friendliness. 相似文献
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《Tetrahedron letters》2003,44(18):3709-3712
4-Aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones have been prepared in one-pot condensation from Meldrum's acid, methyl acetoacetate and the appropriate benzaldehyde in the presence of ammonium acetate using microwave irradiation without solvent. This rapid method produced pure products in high yields (81-91%) due essentially to a specific non-thermal microwave effect (17-28%) by conventional heating under the same conditions. 相似文献
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The one-pot, three-component condensation of benzil, benzonitrile derivatives and primary amines on the surface of silica gel under solvent-free conditions and microwave irradiation provided tetrasubstituted imidazoles in high yields. 相似文献