A NEW METHOD FOR x-ACETYLTHIOFORMANILIDES

In this paper, we report a new method for preparingacetylthioformanilides from substituted pyruvanilides an Lawessow Reagent.in DME at room temperature. Some new x -acetylthioanilides aresynthesized by this method.     

THE CHOICE OF OPIOID RECEPTOR SUBTYPE IN ISOLATED PREPARATIONS BY OHMEFENTANYL

Ohmefentanyl has significant inhibitory actions on the electrically evoked contractions of guinea pigileum and mouse vas deferens. Their IC_(50) values are 0.15 nM and 0.89 nM, respectively. In the guinea pigileum and the mouse vas deferens, both μ-antagonist naloxone and (μ+κ)-antagonist Mr. 2266 antagonizereadily the agonist action of ohmefentanyl, indicating that ohmefentanyl acts on μ-receptors in the guineapig ileum and the mouse vas deferens. Like other μ-agonists, ohmefentanyl has agonist activity but noantagonist action in the rat vas deferens. In the rabbit vas deferens, the activity of ohmefentanyl is veryweak. The IC_(50) value is 149 nM. These results further indicate that ohmefentanyl is a potent and selectiveμ-agonist.     

A NEW POLYMERIC FLAME RETARDANT ADDITIVE FOR NYLON

The present paper deals with the use of a new polymeric flame retardant material, polyphenylene sulphide (PPS) for plastics. Incorporation of 15—20% PPS into nylon-6 has provided UL V-0 rating for the system and there is enhancement in tensile and flexural properties. The results obtained on the thermal, crystallization and flow characteristics of the nylon-PPS system upto a loading of 40% PPS are also discussed.     

A NEW ARTIFICIAL PHOTOSYNTHESIS COMPOUND FOR PHOTOELECTRIC CONVERSION

A new triad model compound porphyrin-viologen-carbazole wassynthesized to mimic photosynthesis.A mechanism including photoinducedelectron transfer and two-step charge separation was suggested.This triadcompound was easy to form LB film and rather high photodriven voltage andcurrent were obtained with only one layer of LB film On the surface of SnO_2conductive glass.     

A NEW METHOD FOR THE PREPARATION OF FULLEROL

ＡＮＥＷＭＥＴＨＯＤＦＯＲＴＨＥＰＲＥＰＡＲＡＴＩＯＮＯＦＦＵＬＬＥＲＯＬ￥ＤａＹｏｎｇＳＵＮ；ＺｉＹａｎｇＬＩＵ；ＸｉｎｇＨｕａＧＵＯ；ＹｉＭｉｎＳＨＥ；ＹｕＺＨＯＵ；ＳｈｕＹｉｎｇＬＩＵ（ＴｈｅＫｅｙＬａｂｏｒａｔｏｒｙｏｆＡｐｐｌｉｅｄＳｐｅｃ...     

A NEW SYNERGIST FOR INTUMESCENT FLAME RETARDANT POLYPROPYLENE

The synergistic effects of silicotungstic acid (SiW_(12)) as a carelyst in the phosphorus-nitrogen compounds AM-based intumescent flame-retardant (IFR) polypropylene (PP) were studied using the limiting oxygen index(LOI), the UL-94test, thermogravimetric analysis (TGA), real time Fourier transform infrared (FTIR), laser Raman spectroscopy (LRS). TheLOI data show that SiW_(12) added to PP/IFR systems has a synergistic FR effect with an IFR additive named AM. The TGAdata show that SiW_(12) apparently increases the thermal stability of the PP/IFR systems at high temperature (T>500℃). TheFTIR results provide the positive evidence that IFR can improve the thermal stability of PP and SiW_(12) can induce a higherrate of formation of phosphoric acid and its derivatives. The LRS measurements provide useful information on thecarbonaceous microstructures. In short, a suitable amount of SiW_(12) (1.5 wt%) exerts synergistic effects with the IFR byincreasing the LOI value and the thermal stability at high temperature and promoting the formation of charred structures onthe burning PP surface.     

A NEW METHOD FOR THE SYNTHESIS OF ARYLTHIOCYANATES

Arylthiocyanates could be synthesized by reaction of arylsulfonyl chlorides with cuprous cyanide with yields ranging from 42-80％.     

A NEW METHOD FOR PREPARATION OF β-LACTAM SULFOXIDES

Abstract

Penicillin sulfoxides (II) are key intermediates in chemical transformations of penicillins to cephalosporins. Oxidation of the sulfur atom in penicillin nucleus (I) to the sulfoxide (II) has been studied and a new economically feasible method developed.     

A NEW RAPID FLUOROMETRIC METHOD FOR DETERMINATION OF SULFONAMIDES

Ａ ＮＥＷ ＲＡＰＩＤ ＦＬＵＯＲＯＭＥＴＲＩＣ ＭＥＴＨＯＤ ＦＯＲ ＤＥＴＥＲＭＩＮＡＴＩＯＮ ＯＦ ＳＵＬＦＯＮＡＭＩＤＥＳ￥ＨｕａｉＮａＬＩａｎｄＹｕｎＸｉａｎｇＣＩ（ＤｅｐｔｏｆＣｈｅｍｉｓｔｒｙ．ＰｅｋｉｎｇＵｎｉｖｅｒｓｉｔｙ．Ｂｅｉｊ...     

A NEW METHOD FOR SYNTHESIS OF O-ISOPROPYL SUBSTITUTED AROMATIC COMPOUNDS

Heteroatom-directed aromatic lithiation reactions usedfor the regiospecific synthesis of o-isopropyl substituted phenolic andbenzyl alcoholic compounds are described.     

A NEW MODEL FOR CONCENTRATION DEPENDENCE OF POLYMER CHAIN DIMENSIONS

A new model for concentration dependence of polymer chain dimensions over the wholeconcentration range was proposed. The hydrodynamic volume of a solvated macromoleculewas found to be a universal function of the degree of coil overlapping (c/c~*). The radiusof gyration (R_g) and the expansion coefficient (α) of polymer in solution or in bulk. pre-dicted by this model are much better in agreement with the experimental data of small angleX-ray scattering and neutron scattering from literature, than with the values predicted byother models and theories.     

A NEW POLYMER-BOUND 1,2-DIOL AS A PROTECTING AGENT FOR SYMMETRICAL DIALDEHYDE

A novel polymer-bound 1,2-diol, 3-polystyrylsulfonyl-1,2-propanediol (6) had been prepared by the reaction of sodium polystyrylsulfinate with allyl bromide, followed by oxidation and. hydrolysis or directly with 3-chloro-1,2-propanediol in the presence of a phase transfer catalyst, n-tetrabutylammonium iodide. The capacity of resin 6 for terephthaidehyde reached 1.43 mmol/g. The aldehydic groups attached to polymer 6 reacted with hydroxylamine hydrochloride or reduced by sodium borohydride giving p-formylbenzaldoxime (yield: 89%)and p-formyl-benzalcohol (yield: 734%), respectively. The high yields of these polymer-supported reactions showed that the polymer 6 possessed the effective isolation of its reactive sites.     

A NEW MODEL OF FROST HEAVE PREDICTION FOR CLAYEY SOILS

After analysing the results of systematic experimental research on frost susceptibility tests, a new frost heave prediction model, including the heave ratio η and rate R, is first proposed in this paper. Six main factors influencing frost heave are considered: initial water content W, initial dry unit weight γd, frost penetration rate Vf, groundwater level Hw, plasticity index Ip and ion content S. The model could be expressed by: η= B0WB1γBd2VB31·exp(B4Hw)exp(B5Ip)exp(B6S) and R = B'0WB'1γB'2dexp(B'3Hw)exp(B'4Ip)exp(B'5S) with a good reliability, where B0 to B6 and B'0 to B'5 are the characteristic constants of clayey soils. The effect of each factor on frost susceptibility of soils is discussed also.     

A NEW KINETIC FLUOROMETRIC METHOD FOR THE DETERMINATION OF EPINEPHRINE

ＡＮＥＷＫＩＮＥＴＩＣＦＬＵＯＲＯＭＥＴＲＩＣＭＥＴＨＯＤＦＯＲＴＨＥＤＥＴＥＲＭＩＮＡＴＩＯＮＯＦＥＰＩＮＥＰＨＲＩＮＥ￥ＸｉｎＧｕｏＷＵ，ＲｕＸｉｕＣＡＩ，ＺｈｉＸｉｎＬＩＮ，ＪｉｅＫｅＣＨＥＮＧ（ＤｅｐａｒｔｍｅｎｔｏｒＣｈｅｍｓｉｔｙ，Ｗｕｈ...     

A NEW METHOD FOR CALCULATING THE ABSORPTION AMOUNT OF DRUG

In this paper, a new method is suggested for calculating the absorption amount of drug. The method is based on the general linear compartment model for pharmacokinetics, hence applicable to any proper linear compartment model for pharmacokinetics. For the linear one compartment model, it is in agreement with the Wagner-Nelson method which is often used nowadays. For the linear two compartment model, it has advantages over the Loo-Riegelman method, which is also in common use in, for example, simplicity in mathematical derivation, less computation, etc. And it can be easily extended to some particular nonlinear compartment model.     

OPIOID & RECEPTOR IRREVERSIBLE INHIBITORS 1.SYNTHESIS AND ABSOLUTE CONFIGURATION OF OHMEFENTANYL ISOTHIOCYANATE ENANTIOMERS

ＯＰＩＯＩＤ　＆　ＲＥＣＥＰＴＯＲ　ＩＲＲＥＶＥＲＳＩＢＬＥ　ＩＮＨＩＢＩＴＯＲＳ　１．ＳＹＮＴＨＥＳＩＳ　ＡＮＤ　ＡＢＳＯＬＵＴＥ　ＣＯＮＦＩＧＵＲＡＴＩＯＮ　ＯＦ　ＯＨＭＥＦＥＮＴＡＮＹＬ　ＩＳＯＴＨＩＯＣＹＡＮＡＴＥ　ＥＮＡＮＴＩＯＭＥＲＳＯＰ...     

A NEW HYBRID THERMOCHEMICAL CYCLE FOR PRODUCTION OF HYDROGEN FROM WATER

A new hybrid cycle to produce hydrogen from water, which consists of a thermochemical reaction (3) and an electrochemical reaction (4), has been devised.2KNO_3+I_2→2KI+2NO+2O_2, (3)2NO+3/2 O_2+2KI+H_2O→2KNO_3+I_2+H_2. (4)The change in free energy of the reaction (3) decreases as temperature rises. and the temperature, at which the △G° is zero, is about 950 K. The electrochemical reaction (4) could be divided intoanode 2I~-→I_2+2e~- (7)andcathode 2H~++2e~-→H_2 (8)in electrolysis cell with an ion-exchange resin. So, the standard equilibrium decomposition voltage of the reaction (4) is 0.54 V.The preliminary experimental investigations were carried out. The yields of the reaction (3) increase as the temperature rises, and KNO_3 is converted into KI casily and rapidly, when reacting with gaseous iodine above 1000 K. The polarizations of the electrolysis reaction were small. The sum of the equilibrium decomposition voltages and overvoltages—0.56, 0.65 and 0.78 V at 100, 500 and 1000 mA·cm~(-2), respe     

A NEW METHOD FOR THE PREPARATION OF PHENOLS AND ITS DERIVATIVES

a-Oxo ketene dithioacetals 2 via 1,2-nucleophilie addition by methallyl magnesius chloride afforded corresponding alcohols (3). Treated with water or methanol and catalyzed by Lewis acid, the alcohols 3 were converted regiospecifical ly to substituted phenols 5' or related phenol methyl ethers 5 respectively. This reaction is a novel approach to the synthesis of phenols and their derivatives starting from non-aromatic precursors.     

A NEW ACTIVE DIESTER FOR SELECTIVE POLYMERIZATION TO FORM FUNCTIONAL POLYAMIDES

A new synthetic route to polyamides and hydroxyl polyamides was established, based on the selecting (?)-acylation of three novel typical active diesters: the active diester of N-hydroxy- (?) 4-epoxy-5-cyclohexene-2, 3-dicarboximide( HOEC), such as N, N'-(temphthaloyldioxy) bis(1, 4- epoxy - 5 - cyclohexene- 2, 3 - dicarboximide.) ( PBOEC), N, N'- ( isophthaloyl - dioxy) bis (1,4-epoxy-5-cyclohexene-2, 3-dicarboximide)(IPBOEC) and N, N' -(adipoyldioxy) his (1,4-epoxy-5-cyclohexene-2, 3-dicarboximide) ( ADOEC)with aliphatic diamines and 1,3-diamino-2-hydroxypropane. The polycondensation occurs at room temperature in solution without added catalyst. Dipolar aprotic solvents which include dimethyl sulfoxide, N- methyl - 2- pyrrolidone and dimethylformamide were used as solvents for polymerization. The selective N-acylation of two active diesters was performed as a model reaction study.     

A NEW METHOD FOR STUDYING ACIDITY CLASSIFICATION OF COMPLEX SOLID SURFACE

Ａ　ＮＥＷ　ＭＥＴＨＯＤ　ＦＯＲ　ＳＴＵＤＹＩＮＧ　ＡＣＩＤＩＴＹ　ＣＬＡＳＳＩＦＩＣＡＴＩＯＮ　ＯＦ　ＣＯＭＰＬＥＸＳＯＬＩＤ　ＳＵＲＦＡＣＥＮＥＷＭＥＴＨＯＤＦＯＲＳＴＵＤＹＩＮＧＡＣＩＤＩＴＹＣＬＡＳＳＩＦＩＣＡＴＩＯＮＯＦＣＯＭＰＬＥＸＳＯＬ...