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1.
M. S. Frasinyuk A. V. Turov V. I. Vinogradova V. P. Khilya 《Chemistry of Natural Compounds》2007,43(2):176-180
8-Aminomethyl derivatives of 7-hydroxycoumarins were prepared by reaction of methylene-bis-cytisine and substituted 7-hydroxycoumarins.
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 145–148, March–April, 2007. 相似文献
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V. A. Saprykina V. I. Vinogradova R. F. Ambartsumova T. F. Ibragimov A. Sultankulov Kh. M. Shakhidoyatov 《Chemistry of Natural Compounds》2004,40(6):582-584
Several new derivatives were prepared by reaction of 3-alkylthio-5-chloroacetamido-1,2,4-thiadiazoles with cytisine.Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 479–480, November–December, 2004.This revised version was published online in April 2005 with a corrected cover date. 相似文献
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N. V. Gorbulenko T. M. Tkachuk T. V. Shokol V. V. Semeniuchenko A. V. Turov V. P. Khilya 《Chemistry of Heterocyclic Compounds》2007,43(5):569-575
The interaction has been studied of a series of substituted 3-hetaryl-7-hydroxychromones with amino acids and formaldehyde
(reactants ratio 1: 1: 2 respectively). In the case of glycine and Het = 3-isoxazolyl the product of aminomethylation at position
8 of the chromone was obtained, and with other Het (including Het = 4-phenyl-1,2,4-triazol-3-yl) 2-[6-alkyl-3-hetaryl-4-oxo-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]-oxazin-9-yl]acetic
acids were formed. With β-alanine and Het = 4-phenyl-1,2,4-triazol-3-yl the corresponding β-substituted propionic acid was
synthesized, but proline did not participate in the reaction, leading to bis(6-ethyl-3-hetaryl-7-hydroxychromon-8-yl)methane.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 683–689, May, 2007. 相似文献
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V. A. Saprykina V. I. Vinogradova R. F. Ambartsumova T. F. Ibragimov Kh. M. Shakhidoyatov 《Chemistry of Natural Compounds》2006,42(4):470-472
Several new derivatives were prepared by reacting N-1(5-R-thiazol-2-yl)-2-chloroacetamides and N-1(6-R-benzothiazol-2-yl)chloroacetamides with cytisine.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 379–380, July–August, 2006. 相似文献
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M. S. Frasinyuk V. I. Vinogradova S. P. Bondarenko V. P. Khilya 《Chemistry of Natural Compounds》2007,43(5):590-593
New substituted 4-chloromethylcoumarins that were used as alkylating agents to modify cytisine were synthesized by Pechmann
condensation. A series of 4-(12-cytisylmethyl)coumarins containing pharmacophores of the natural heterocycles coumarin and
cytisine in a single molecule was prepared. The alkylation gave the best results if diisopropylethylamine was used as the
base.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 485–488, September–October, 2007. 相似文献
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Yu. M. Volovenko T. A. Volovnenko A. V. Dobrydnev 《Chemistry of Heterocyclic Compounds》2006,42(5):594-599
3-Cyano-3-hetaryl-2-oxopropyl thioacetates were obtained by the acylation of hetarylacetonitriles with acetylmercaptoacetyl
chloride. Their reaction with amines led to the formation of 2-amino-3-hetaryl-4(H)-oxothiophenes.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 680–685, May, 2006. 相似文献
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《Journal of Chemical Sciences》2007,119(2):83-89
3-Hydroxychromones (3HC), exhibit dual emissions highly sensitive to solvent properties due to excited state intramolecular
proton transfer (ESIPT). Therefore, 3HCs find wide applications as fluorescence probes in biological systems. Here, it is
particularly important to understand the fluorescence behaviour of 3HCs in polar environments. Herein, we studied 3-hydroxyflavone,
2-(2-furyl)-3-hydroxychromone and 2-(2-benzofuryl)-3-hydroxychromone in high polarity solvents characterized by different
H-bond donor abilities, donor concentrations and acceptor abilities. Our results show that the dual emissions of the dyes
are insensitive to solvent basicity but strongly depend on the two other parameters. Moreover, furyl-and benzofuryl-substituted
dyes were significantly more sensitive than the 3-hydroxyflavone to H-bond donor ability, while all three dyes showed roughly
equivalent high sensitivity to H-bond donor concentration. These results can be explained by different mechanisms. Thus, the
sensitivity of all three dyes to increasing concentrations of H-bond donors probably results from increase in the population
of solvated dye with disrupted intramolecular H-bonds. Meantime, the sensitivity to H-bond donor ability of the solvent, observed
mainly with furyl and benzofuryl dyes, is probably related to the strength of the H-bonds between the solvent and the 4-carbonyl
group of the dye with intact intramolecular H-bonds. The present results provide new insights for further applications of
3HC derivatives as environment-sensitive probes and labels of biological molecules. 相似文献
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Reaction of cytisine with 1-mono- and 1,3-disubstituted 5-arylmethylbarbituric acids in the presence of formaldehyde results in aminomethylation of C-5 to form the corresponding 5-cytisylmethylbarbituric acids. The structures of the products are found using PMR spectroscopy and mass spectrometry. 1-Phenyl-5-(2,4-dimethoxybenzyl)-5-cytisylmethylbarbituric acid is obtained as a mixture of two steroisomers in an approximately 21 ratio.I. I. Mechnikov St. Petersburg State Medical Academy, 195067, St. Petersburg, Piskarevskii pr., 47; 2) ZAO Interbioscreen, 142432, Chernogolovka, Moscow District, Institutskii pr. 8. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 152–156, March–April, 2000. 相似文献
10.
M. Sc. Congjun Yu Prof. Dr. Frederic W. Patureau 《Angewandte Chemie (International ed. in English)》2018,57(36):11807-11811
A highly selective CuII‐catalyzed cross‐dehydrogenative ortho‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp2)?C(sp3) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed. 相似文献
11.
The reaction of cytisine with formalin in various solvents was studied. Methylene-bis-cytisine was produced in addition to
the expected N-methylolcytisine in all solvents except acetone, in which N-(3-oxobutyl)cytisine was produced.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 579–580, November–December, 2006. 相似文献
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间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应 总被引:9,自引:0,他引:9
间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮在20~25℃和催化量的浓盐酸催化下能直接进行Mannich反应, 用一步合成法合成15个1-芳基-3-芳胺基(3-硝基苯基)丙酮。产率为68~87%。产物结构经元素分析, IR, ^1H NMR, MS鉴定。本文还讨论了反应的适宜条件。 相似文献
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芳香胺参加的Mannich反应——3-芳氨基-3-苯基-1-(4-溴苯基)丙酮的合成 总被引:2,自引:0,他引:2
文献报道过芳香胺与苯甲醛生成的Schiff碱可在少量相应的芳香胺盐酸盐或浓盐酸催化下制备Mannich碱(Ⅰ),所用的Schiff碱系事先合成,且产率较低(15-68.9%)。本文报导用4-溴苯乙酮、苯甲醛和芳香胺在少量浓盐酸催化下能直接发生Mannich反应, 相似文献
16.
Sh. B. Rakhimov V. I. Vinogradova Yu. R. Mirzaev N. L. Vypova D. S. Kazantseva 《Chemistry of Natural Compounds》2006,42(4):462-469
The reductive alkylation of cytisine by various aromatic aldehydes was studied. Preliminary pharmacological investigations
of the synthesized compounds were performed.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 373–378, July–August, 2006. 相似文献
17.
Organic halides undergo smooth aminomethylation by secondary amines and aqueous formaldehyde promoted by metallic zinc under copper(I) catalysis. Good to excellent yields are obtained with primary, secondary, and tertiary iodides, allylic, propargylic, and benzylic bromides and with α-bromoesters. In most cases, DMSO is the best solvent, but dioxane is preferable for some more reactive halides. Additional experiments with radical quenchers and promoters and the use of ‘radical clocks’ indicate a stepwise reaction mechanism initiated by the attack of an alkyl radical to iminium ion. 相似文献
18.
I. E. Yakunina Yu. M. Atroshchenko I. V. Shahkheldyan K. I. Kobrakov N. A. Troizkiy O. I. Boikova 《Chemistry of Heterocyclic Compounds》2007,43(9):1174-1180
Aminomethylation has been accomplished of the anionic Yanovskii adduct of 2,4-dinitronaphthol and 3,4-dimethylenedioxyacetophenone.
The structure of the 3-substituted 9-[2-(3,4-methylenedioxyphenyl)-2-oxoethyl]-1,5-dinitro-7,8-benzo-3-azabicylo[3.3.1]non-7-en-6-one
was determined by two-dimensional homo-and heteronuclear correlation spectroscopy.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, 1382–1389, September 2007. 相似文献
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A. V. Tverdokhlebov A. B. Lyashenko Yu. M. Volovenko A. A. Tolmachev 《Chemistry of Heterocyclic Compounds》2004,40(12):1536-1542
2-Hetaryl-3-oxo-4-phthalimidobutyronitriles (and pentanonitriles) were obtained with high yields by C-acylation of hetarylacetonitriles with N-phthaloylglycine and -alanine chlorides respectively under the conditions of base catalysis. Hydrazinolysis of the phthaloyl protection in these compounds leads to the formation of 5-amino-4-hetaryl-2,3-dihydro-1H-3-pyrrolones.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1783–1790, December, 2004. 相似文献