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1.
Catalytic amount of chlorotrimethylsilane (TMSCl) was found to be an effective silicon Lewis acid catalyst in catalyzing the Michael‐type Friedel–Crafts reactions of indoles and chalcones to afford corresponding 3‐substituted indole derivatives in good to excellent yields. The method is metal‐free, has mild reaction conditions, and generates good yields of products with greater selectivity, which make it a useful and attractive process for the synthesis of different indole derivatives.  相似文献   

2.
Recently, indoles are considered interesting heterocyclic compounds due to their wide range of biological activities such as antimicrobial activity. Herein, some new indole derivatives containing heterocyclic moieties were synthesized using 3-chloro-1H-Indole-2-carbaldehyde (1) as a starting material, then allowed to react with compounds containing active methylene under Knoevenagel condensation and afforded the corresponding compounds (2, 3, 9). Also, the compound (1) when allowed to react with hydrazine derivatives gave the corresponding thiosemiccarbazone, semicarbazone, and hydrazone derivatives (4, 5, 6). Reaction of thiosemicarbazone derivatives with α-halognated carbonyl compounds gave the thiazolyl indole derivatives (10, 12a–b). Cyclic chalcones (11a–c) were obtained when compound (10) reacted with different aromatic aldehydes. The structures of all new synthesized compounds were confirmed on the basis of spectral analysis, IR, 1H NMR, 13C NMR, and MS spectroscopy. All synthesized compounds were evaluated for their antimicrobial activity. Compounds (2, 5, 7, 8, 11a, 12a) showed high antibacterial activity and compounds (3, 6, 9, 10, 11a, 12a) showed high antifungal activity.  相似文献   

3.
The most probable planar conformations of 22 indole analogs of chalcones were established on the basis of dipole moment measurements. The introduction of substituents into the phenyl ring of 1-(3-indolyl)-3-phenylpropenones causes a change in the dipole moments, which, in the 3-propenone series, correlates with the Hammett constants.Translated from Khimiya Geterotsiklicheskih Soedinenii, No. 8, pp. 1083–1086, August, 1972.  相似文献   

4.
Because of the great biological importance of substituted indole derivatives, in the present study, a series of pyrazolylindole, thiazolylindole, and pyrimidinylindole derivatives have been synthesized with good yield. The precursor indolyl chalcone 2a – d was prepared by reaction of 3‐chloro‐1H‐indole‐2‐carbaldehyde 1 with different ketones. Then, compounds 3b – d , 4 , and 5a – d have been synthesized by the reaction of chalcones 2a – d with hydrazine, phenylhydrazine, and thiosemicarbazide. When the chalcone derivative 2b subjected to react with hydroxylamine hydrochloride gave isoxazolylindole derivative 6b . N‐thiazolidine pyrazolyl indole 7 was obtained by reacting compound 5a with ethyl chloroacetate. On the other hand, when chalcone derivative 2b allowed to react with urea and thiourea gave the corresponding pyrimidinylindole derivatives 8 and 9 . Finally, when chalcone derivative 2b reacted with ethyl cyanoacetate or malononitrile gave pyridinylindole derivatives 10 and 11 . The structures of the all synthesized compounds were elucidated on the basis of spectral analysis infrared, NMR, and mass spectroscopy. Some of the synthesized compounds were screened for their antimicrobial and anti‐inflammatory activity. Compound 4b was the highest antibacterial activity against all strains of bacteria with values higher than those of the corresponding reference antibiotics (ciprofloxacin and levofoxacin, respectively) and almost the same as (gemifloxacin, moxifloxacin, clindamycin, gentamycin, and streptomycin). Compounds 4 , 5 , 6 , and 7 showed high anti‐inflammatory activity compared with the standard drug indomethacin.  相似文献   

5.
A simple and novel bimetallic catalyst, an iron and magnesium complex (Fe‐Mg‐hexamethylphosphoramide (HMPA)), with dual activation was found to be an effective and promising catalyst for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This novel catalytic system has the advantages of highly efficient, mild reaction conditions and exhibits high reactivity and selectivity, which make it a useful and attractive process for the synthesis of indole derivatives.  相似文献   

6.
Iron–palladium is a superior bimetallic catalyst in the presence of acetylacetone (Acac) with remarkable synergistic effect for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This catalytic system has the advantages of mild reaction conditions, smaller amount of metal salts, high yields of the desired products and operational simplicity, which make it a useful and promising process for the synthesis of indole derivatives. Copyright © 2009 John Wiley & Sons, Ltd.  相似文献   

7.
A number of novel 13-membered chalcone-imidazole derivatives were prepared and have been synthesized and characterized by IR, 1H NMR, 13C NMR and elemental analysis, the results conformed well to expected structures. Substituted acetophenones and benzaldehydes were condensed using the Claisen–Schmidt base-catalyzed aldol condensation. Methyl on the aromatic ring of chalcones was brominated by NBS, and then the resulting mixture was reacted with imidazole to get the target compound. Several chalcones showed in vitro antibacterial activity against Gram-bacterial. The results showed that these are potential antibacterial compounds.  相似文献   

8.
Chalcones are of interest to medicinal chemists because their structures can be easily modified with various functional groups. The syntheses and biological activities of chalcones from natural sources are well known. In this study, 24 2′‐hydroxychalcones bearing methoxy substituents were synthesized, among which five are new. The NMR data for all synthesized chalcones are described for the first time. The complete assignments of the 1H and 13C NMR data can be used for the identification of newly discovered and widely isolated, synthesized chalcones. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献   

9.
2-Acetyl naphthalene reacts with various methoxy substituted benzaldehyde in the presence of 10 % sodium hydroxide solution giving functionalized chalcones. The synthesized chalcones when further reacted with hydrazine hydrate in the presence of acetic acid afforded N-acetyl pyrazolines. All the synthesized products were confirmed by various spectral data such as FTIR, 1H NMR, 13C NMR, and HRMS studies. All the synthesized compounds were screened for cytotoxicity against various cell lines.  相似文献   

10.
This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic mechanisms via an in silico study of eleven chalcones synthesized from two acetophenones. Five were synthesized from a prenylacetophenone isolated from a plant that grows in the Andean region of the Atacama Desert. The cytotoxic activity of all the synthesized chalcones was tested against breast cancer cell lines using an MTT cell proliferation assay. The results suggest that the prenyl group in the A-ring of the methoxy and hydroxyl substituents of the B-ring appear to be crucial for the cytotoxicity of these compounds. The chalcones 12 and 13 showed significant inhibitory effects against growth in MCF-7 cells (IC50 4.19 ± 1.04 µM and IC50 3.30 ± 0.92 µM), ZR-75-1 cells (IC50 9.40 ± 1.74 µM and IC50 8.75 ± 2.01µM), and MDA-MB-231 cells (IC50 6.12 ± 0.84 µM and IC50 18.10 ± 1.65 µM). Moreover, these chalcones showed differential activity between MCF-10F (IC50 95.76 ± 1.52 µM and IC50 95.11 ± 1.97 µM, respectively) and the tumor lines. The in vitro results agree with molecular coupling results, whose affinity energies and binding mode agree with the most active compounds. Thus, compounds 12 and 13 can be considered for further studies and are candidates for developing new antitumor agents. In conclusion, these observations give rise to a new hypothesis for designing chalcones with potential cytotoxicity with high potential for the pharmaceutical industry.  相似文献   

11.
The condensation of 3:5-dichloro-2hydroxy acetophenone with various aldehydes afforded chalcones, which were converted into the corresponding 6:8-dichloroflavanones by the action of dilute ethanolic hydrochloric acid. The oxidation of chalcones by means of selenium dioxide and by alkaline hydrogen peroxides gave 6:8-dichloro-flavones and -flavonols respectively. Incidentally, some chalcones from 3:5-dichloro-2-methoxyacetophenone were also prepared.  相似文献   

12.
Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti-inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and O-methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of (1)H and (13)C NMR spectra.  相似文献   

13.
A new one-pot strategy has been developed, wherein abundantly available methoxylated phenylpropenes are directly transformed into corresponding dienones (1,5-diarylpenta-2,4-dien-1-ones) and enones (chalcones and cinnamic esters) via allylic oxidation-condensation or allylic oxidation-esterification sequences. Preliminary antimalarial activity studies of the above synthesized diaryldienones and enones against Plasmodium falciparum (Pf3D7) have shown them to be promising lead candidates for developing newer and economical antimalarial agents. In particular, two enones (12b and 13b) were found to possess comparatively better activity (IC(50) = 4.0 and 3.4 μM, respectively) than licochalcone (IC(50) = 4.1 μM), a well known natural antimalarial compound.  相似文献   

14.
A series of bioinspired transformations that are applied to convert strictosidine aglycones into monoterpenoid indole alkaloids is reported. The highly reactive key intermediates, strictosidine aglycones, were prepared in situ by simple removal of a silyl protecting group from the silyl ether derivatives, and converted selectively via bioinspired transformations under substrate control into heteroyohimbine- and corynantheine-type, and akagerine and naucleaoral related alkaloids. Thus, concise, divergent total syntheses of 13 monoterpenoid indole alkaloids, (−)-cathenamine, (−)-tetrahydroalstonine, (+)-dihydrocorynantheine, (−)-corynantheidine, (−)-akagerine, (−)-dihydrocycloakagerine, (−)-naucleaoral B, (+)-naucleidinal, (−)-naucleofficines D and III, (−)-nauclefiline, and (−)-naucleamides A and E, were accomplished in fewer than 13 steps.  相似文献   

15.
13C-n.m.r. chemical shifts of 10 acrylophenones (1-substituted phenylprop-2-en-1-ones) are reported. The additivity parameters for the substituent effect of the acryloyl group in the aromatic ring and of the benzoyl group in ethylene were calculated. Comparison of ethene chemical shifts in chalcones (1,3-diphenylpropenones) with calculated values yielded good results, showing that cross conjugation in these molecules is of little importance. Chemical shifts in acrylophenones and chalcones can therefore be calculated as linear combinations of the mutual effects of the constituent groups.  相似文献   

16.
Several biological effects of chalcones have been reported to be associated with their thiol reactivity. In vivo, the reactions can result in the formation of small-molecule or protein thiol adducts. Both types of reactions can play a role in the biological effects of this class of compounds. Progress of the reaction of 4-methyl- and 4-methoxychalcone with glutathione and N-acetylcysteine was studied by the HPLC-UV-VIS method. The reactions were conducted under three different pH conditions. HPLC-MS measurements confirmed the structure of the formed adducts. The chalcones reacted with both thiols under all incubation conditions. The initial rate and composition of the equilibrium mixtures depended on the ratio of the deprotonated form of the thiols. In the reaction of 4-methoxychalcone with N-acetylcysteine under strongly basic conditions, transformation of the kinetic adduct into the thermodynamically more stable one was observed. Addition of S-protonated N-acetylcysteine onto the polar double bonds of the chalcones showed different degrees of diastereoselectivity. Both chalcones showed a Michael-type addition reaction with the ionized and non-ionized forms of the investigated thiols. The initial reactivity of the chalcones and the equilibrium composition of the incubates showed a positive correlation with the degree of ionization of the thiols. Conversions showed systematic differences under each set of conditions. The observed differences can hint at the difference in reported biological actions of 4-methyl- and 4-methoxy-substituted chalcones.  相似文献   

17.
An efficient approach has been developed for the synthesis of naturally occurring prenylated chalcones viz. kanzonol C(1), stipulin(2), crotaorixin(3), medicagenin(4), licoagrochalcone A(5) and abyssinone D(6) along with the pyranochalcones paratocarpin C(7), anthyllisone(8) and 3-O-methylabyssinone A(9).The key step of the synthesis is a Claisen–Schmidt condensation. Subsequently, their anti-inflammatory effects were investigated in lipopolysaccharides(LPSs)-induced RAW-264.7 macrophages. Of the synthesized chalcones, compounds 5(IC_(50)= 10.41 μmol/L), 6(IC_(50)= 9.65 μmol/L) and 8(IC_(50)= 15.34 μmol/L) show remarkable activity with no cytotoxicity. Compound 9(IC_(50)= 4.5 μmol/L)exhibits maximum(83.6%) nitric oxide(NO) inhibition, but shows slight cytotoxicity. The results reveal that the chalcones bearing the prenyl group at 3- and/or 5-position on ring A(acetophenone moiety), i.e.,1–4 and 7 show weak, or no inhibition activity, whereas chalcones having the prenyl group only on ring B(aldehyde part), i.e., 5, 6 and 8 show significant activity on the production of inflammatory mediated NO with no cytotoxicity.  相似文献   

18.
Indole‐3‐carboxylic acid hydrazide 3 was prepared and was treated with aromatic aldehydes in ethanol to give the corresponding hydrazone derivatives 4–7 in good yields. The indole carbohydrazide was incorporated into the 3‐indolyloxadiazoles 8–11 and 18 , 3‐indolyltriazoles 13–17 and 35 , 3‐indolylpyrazole derivatives 19–23 and carbamate derivatives 26–27 . Furthermore, interaction of the carboazide 24 with hydrazine hydrate in refluxing toluene afforded the corresponding semicarbazide derivative 30 . The thiadiazine derivative 34 was also prepared. Some of these compounds were screened in vitro for their antibacterial and antifungal activity.  相似文献   

19.
A newly developed synthesis [1–3] of chalcones (arylstyryl ketones), based on condensing aryl--chlorovinylketones with ethers of mono- and dihydric phenols in the presence of stannic chloride, is extended. A number of chalcones not previously described are obtained in good yield and derivatives prepared. Hitherto undescribed nitroketones are obtained by addition of nitromethane and 2-nitropropane to an activated double bond of the chalcones and a thiophene analog of a chalcone.  相似文献   

20.
The practical synthesis of a series of tricyclic indole-2-carboxylic acids, 7-chloro-3-arylaminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylic acids, as a new class of potent NMDA-glycine antagonists is described. The synthetic route to the key intermediate 12a comprises a regioselective iodination of 4-chloro-2-nitrotoluene, modified Reissert indole synthesis, Jeffery's Heck-type reaction with allyl alcohol, Wittig-Horner-Emmons reaction, and iodination at the indole C-3 position. The key step in the route is an intramolecular cyclization of 12a to give the tricyclic indole structure. Two methods of cyclization, (1) an intramolecular radical cyclization of 12a and (2) a sequence of intramolecular Heck reaction of 12a followed by a 1,4-reduction, were performed. The resulting tricyclic indole diester 13a was selectively hydrolyzed to afford the desired tricyclic indole monocarboxylic acid 16 on a multihundred gram scale without any chromatographic purifications. Optical resolution of 16 to (-)-isomer 17 and (+)-isomer 18 was carried out, and the resulting isomers were derivatized, respectively. Evaluation of the optically active derivatives for affinity to the NMDA-glycine binding site using the radio ligand binding assay with [(3)H]-5,7-dichlorokynurenic acid revealed that the derivatives of (-)-isomer 17 were more potent than the others and that especially substituted anilide (-)-isomer 24 (K(i) = 0.8 nM) showed high affinity.  相似文献   

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