A highly efficient addition of allylic bromides to carbonyl compounds promoted by Cp2TiCl2(cat.)/Zn system

Aldehydes or ketones reacted with allylic bromides in the presence of Cp₂TiCl₂(cat.)/Zn system at room temperature to give homo-allylic alcohols in high yields.     

Theoretical study of the oxidation of alcohols to the carbonyl compounds with N-bromosuccinimide and H2O2

Oxidation of both aliphatic and aromatic alcohols in the presence of N-bromosuccinimide and hydrogen peroxide under transition metal-free conditions has been studied by means of density functional theory (DFT) method. Solvent effect on the reaction is evaluated with the polarizable continuum model (PCM) and is compared with the experimental outcomes. In particular, the reaction mechanism is proposed and proved by theoretical study.     

An efficient and sustainable protocol for oxidation of alcohols to carbonyl compounds

A simple and extremely efficient protocol is developed for oxidation of alcohols to carbonyl compounds at room temperature by using green solvent lactic acid and green oxidant H₂O₂. This protocol provides high conversion under catalyst free conditions. The easy work up procedure allows high selectivity and good to excellent yields of carbonyl compounds with purity. We have performed wide range of substrates in present study with primary focus on reusability of lactic acid.     

Highly efficient RuCl3-catalyzed disproportionation of (diacetoxyiodo)benzene to iodylbenzene and iodobenzene; leading to the efficient oxidation of alcohols to carbonyl compounds

(Diacetoxyiodo)benzene (DIB) selectively oxidizes primary and secondary alcohols to the respective carbonyl compounds in the presence of RuCl₃ (0.8-1.0 mol %) at room temperature in aqueous acetonitrile. This reaction proceeds via an initial instantaneous Ru-catalyzed disproportionation of DIB to iodobenzene and iodylbenzene with the latter acting as the actual stoichiometric oxidant toward alcohols.     

Photocatalytic oxidation of primary and secondary benzylic alcohols to carbonyl compounds catalyzed by H3PW12O40/SiO2 under an O2 atmosphere

An efficient, selective and green procedure for the photocatalytic oxidation of primary and secondary benzylic alcohols to the corresponding aldehydes and ketones has been achieved using silica-encapsulated H₃PW₁₂O₄₀ as a recyclable heterogeneous photocatalyst in acetonitrile under oxygen gas as the sole reoxidant of the catalyst.     

Polymer bromide-DMSO: novel reagent system for the oxidation of alcohols to carbonyl compounds

A novel method for the oxidation of alcohols to aldehydes is described using polymer bromide-DMSO at room temperature. The condition described enables clean and fast conversion to desired carbonyl compounds and a broad range of substrates are tolerated. The resin recovery and recyclability make the protocol more ecofriendly.     

Expeditious oxidation of alcohols to carbonyl compounds using iron(III) nitrate

An efficient and solvent-free protocol for the oxidation of alcohols to corresponding carbonyl compounds using iron(III) nitrate nonahydrate has been developed.     

H2O2/SOCl2: a useful reagent system for the conversion of thiocarbonyls to carbonyl compounds

The H₂O₂/SOCl₂ reagent system has been used as a new and efficient reagent for deprotection of thiocarbonyls to carbonyl compounds. The salient features of this protocol are short reaction times, good chemoselectivity, clean reaction profiles, and simple work-up that preclude the use of toxic solvents.     

HbA/H2O2: an efficient biomimetic catalytic system for the oxidation of sulfides to sulfoxides

Human hemoglobin (HbA) catalyzed chemo-selective oxidation of sulfides to sulfoxides has been reported using hydrogen peroxide as an oxidant in a phosphate buffer. This biomimetic catalytic procedure was found to be simple, environmentally friendly, selective, and high yielding. Purified human oxyhemoglobin (HbA₀), crude human oxyhemoglobin, and ferryl oxyhemoglobin were used for sulfoxidation. HbA₀ and ferryl oxyhemoglobin (Fe⁺⁴O) efficiently catalyze the sulfoxidation reaction without over oxidation to the sulfone.     

Silica-supported zinc bromide (ZnBr2/SiO2): a highly efficient heterogeneous catalyst for coupling acid chlorides with terminal alkynes

Silica-supported zinc bromide (ZnBr₂/SiO₂) is an efficient heterogeneous catalyst for the rapid synthesis of ynones by cross-coupling of acid chlorides with terminal alkynes in good to excellent yields under solvent-free conditions at room temperature.     

I2O5: mild and efficient reagents for the oxidation of alcohols in water

The mild and efficient nature of HIO₃ and I₂O₅ as environmentally benign, commercially available, atom efficient, and safe reagents for the oxidation of alcohols has been demonstrated. Additionally, these oxidants are highly chemoselective, and effect smooth room temperature oxidation of various electron-rich alcohols with catalytic amounts of KBr in water.     

Combination of NH2OH·HCl and NaIO4: a new and mild oxidizing agent for selective oxidation of alcohols to carbonyl compounds

A new method for oxidation of alcohols to carbonyl compounds has been developed using NH₂OH·HCl and NaIO₄ under mild reaction conditions at room temperature. Application of the method for the synthesis of diiodo compound from α,β-unsaturated carbonyl compound is also described.     

Efficient and convenient oxidation of organic halides to carbonyl compounds by H2O2 in ethanol

Various primary and secondary organic bromides were oxidized by hydrogen peroxide in refluxing ethanol to give the corresponding aldehydes/and ketones in high yield up to 94%; organic chlorides were oxidized to the corresponding aldehydes/and ketones by the same oxidant in ethanol in the presence of 10 mol % of KBr as the catalyst.     

ZnBr2催化合成2-噁唑烷酮类化合物

在甲苯中,以ZnBr_2为催化剂、4-二甲氨基吡啶为碱,通过N-Boc取代的炔基胺类化合物的环化反应合成了5位取代的2-噁唑烷酮类化合物。考察了催化剂种类、碱、温度等对反应的影响,在优化条件下以良好的产率得到了一系列目标产物。     

Fe(Cp)2PF6: An efficient catalyst for cyanosilylation of carbonyl compounds under solvent free condition

An efficient method for the addition of trimethylsilyl cyanide (TMSCN) to various aldehydes and ketones has been described using Fe(Cp)₂PF₆ (2.5 mol%) as a catalyst under solvent free condition. Excellent yields of trimethylsilylether of cyanohydrin up to (94%) was achieved within 10 min.     

A new and highly effective method for catalytic oxidation of alcohols to the corresponding carbonyl compounds using the tris[(2-oxazolinyl)phenolato]manganese(III)/Oxone®/n-Bu4NBr oxidation system

Oxone® (2KHSO₅·KHSO₄·K₂SO₄) in the presence of mer-tris[(2-oxazolinyl)phenolato]manganese(III), Mn(phox)₃, as catalyst under biphasic reaction conditions (CH₂Cl₂/H₂O) and tetra-n-butylammonium bromide as phase transfer agent efficiently oxidises alcohols to their corresponding aldehydes and ketones at room temperature with very short reaction times (5 min) and good to quantitative yields.     

Bromamine-T/RuCl3 as an efficient system for the oxidation of tertiary amines to N-oxides

A variety of tertiary amines were efficiently and selectively oxidized to the corresponding N-oxides by bromamine-T using ruthenium trichloride as catalyst in alkaline (pH 8.4) acetonitrile/water (1:1) at 80 °C.