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1.
Xiaobin Peng Chao GaoYuying Huang Junbiao PengNaoki Aratani Atsuhiro Osuka 《Tetrahedron letters》2012,53(9):1156-1159
The reactions at the benzylic positions of meso-alkyl-substituted porphyrins have been achieved via the reaction with DDQ in the presence of alcohol or water for the first time, and ethenyl porphyrins from methoxylated porphyrins and an acetoxy porphyrin from the hydroxyl porphyrin were prepared. 相似文献
2.
Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines 总被引:1,自引:0,他引:1
Gen Rong Qiang Xiang Mei Wu Qin Wang Wen Pei 《中国化学快报》2007,18(12):1469-1470
A practical synthesis of symmetrical vicinal diamines with broad chemistry scope is described.The key step is the ultrasonicwave promoted tandem-reaction,two-step reaction sequence combining Mannich double condensations with benzo- triazole,glyoxal and primary or secondary amines and reduction of the bis(benzotriazole)-adducts with sodium borohydride proceeded smoothly in tetrahydrofuran in high yield at room temperature. 相似文献
3.
A novel strategy of solid phase synthesis of N-cycloguanidinyl-formyl peptides has been established and investigated which involved coupling orthogonal protected diaminoacid with resin bound peptide, α-amino group deprotection, guanidinylation of α-amino group by bis-Cbz-1H-pyrazole-1-carboxamidine followed by cleavage and cyclization in solution, and finally removing Cbz by palladium catalyzed hydrogenation. Through this method, cycloguanidine could be introduced to either N-terminus or sidechain of designated peptides. The reaction conditions were facile, straightforward, and totally adaptive to common solid phase peptide synthesis strategy. 相似文献
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5.
Frédéric C. Bargiggia 《Tetrahedron letters》2006,47(19):3191-3193
A versatile synthesis of α and α′ disubstituted N-hydroxypiperidine and N-hydroxypyrrolidine by consecutive double 1,4-addition of hydroxylamine on the corresponding bis α,β-unsaturated diester is described. This reaction takes place an environmentally friendly (ethanol/water) system and at room temperature. 相似文献
6.
A new route to C2-symmetric diamines via an asymmetric reductive dimerization of 1-acylpyridinium salts and their benzo derivatives is described. This method is practical as the starting heterocycles and chiral auxiliaries are readily available. The titanium reducing agent is inexpensive and easy to prepare. Several novel enantiopure C2-symmetric diamine derivatives were synthesized using this method. 相似文献
7.
Shuai Meng Bishwa Raj Bhetuwal Padam P. Acharya 《Journal of carbohydrate chemistry》2019,38(2):109-126
Synthesis of a variety of sugar lactols (hemiacetals) has been accomplished in moderate to excellent yields by using bromine-mediated oxidation of thioglycosides. It was found that acetonitrile is the optimal solvent for this oxidation reaction. This approach involving bromine as oxidant is superior to that using N-bromosuccinimide (NBS) which produces byproduct succinimide often difficult to separate from the lactol products. 相似文献
8.
Internal affairs: the first general palladium-catalyzed intermolecular diamination of internal alkenes employs different nitrogen sources, which add to the alkene in a regio- and diastereoselective fashion. The resulting diamination products can be converted directly into a known ligand motif. 相似文献
9.
The oxidation of gem-disilylalkanes, which can be derived from 1,1-disilylethene, alkyllithiums and alkyl halides, affords the corresponding ketones. 相似文献
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11.
P. Veeraraghavan Ramachandran Debanjan Biswas Marek P. Krzeminski Guang-Ming Chen 《Tetrahedron letters》2010,51(2):332-336
An enantioselective synthesis of C2-symmetric bis-homoallylic aromatic and heteroaromatic diamines in 54-89% yields, in 73-94% de and ?98% ee has been achieved via the allylboration of the corresponding N,N′-bis(trimethylsilyl)dialdimines and N,N′-bis(diisobutylalumino)dialdimines with B-allyldiisopinocampheylborane in the presence of methanol, followed by alkaline hydrogen peroxide workup. One-pot synthesis of stable N,N′-bis(benzaldimine-triethylborane) complexes and subsequent allylboration to afford benzene diamines is also described. 相似文献
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13.
A new method for synthesizing phenolic N-benzylazacyclophanes starting from tyramine is presented here. Computational calculations showed that macrocyclization is favored by the formation of hydrogen bond-based templates; these templates are not affected by including benzyl groups in the nitrogen atom of the tyramine moiety. The results showed that N-benzyl groups with electron-donating substituents have more nucleophilic nitrogen atoms, thereby favoring macrocyclization, while electron-withdrawing groups favor polymerization. 相似文献
14.
Mohamad SoueidanFlorence Hélion Jean-Louis NamyJan Szymoniak 《Tetrahedron letters》2011,52(12):1348-1350
The reductive coupling of imines in the presence of the lanthanide-originated zirconocene equivalent allows the synthesis of vicinal diamines or imidazolidines under mild conditions in good yields with high diastereoselectivity. 相似文献
15.
A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct conversion of the Alloc-, Cbz-, and Boc-carbamate compounds to ureas was achieved in the presence of DABAL-Me3, an air stable and easily handled reagent. Using this reaction method, both protected aromatic and aliphatic amines were successfully transformed into various trisubstituted and tetrasubstituted ureas with high yields without side product. Our findings offer promising guidelines for direct preparation of useful ureas from N-Alloc-, N-Cbz-, and N-Boc-carbamates. 相似文献
16.
Eric A. Voight Matthew S. Bodenstein Norihiro Ikemoto Michael H. Kress 《Tetrahedron letters》2006,47(11):1717-1720
Conditions have been developed for the selective reduction of N-Boc-protected amino acid-derived secondary amides, avoiding the formation of overreduction and cyclic urea byproducts. The method is showcased by the efficient formal synthesis of NK-1 antagonist LY303870. 相似文献
17.
A broad range of vicinal diamines based on styrene oxide are synthesisedvia mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds
with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are
of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds
are in progress. 相似文献
18.
[reaction: see text] An efficient method for the preparation of optically pure unsymmetrical vicinal diamines by the SmI(2)-induced reductive cross-coupling of nitrones with chiral N-tert-butanesulfinyl imines was developed. This is the first successful example of the highly diastereoselective and enantioselective cross-coupling between two different imine species. It provides a straightforward access to enantiopure unsymmetrical vicinal diamines that are widely applicable in asymmetric synthesis. 相似文献
19.
[reaction: see text] Expanding the scope of enantioselective catalysis via DKR, transfer hydrogenation of a variety of cyclic alpha-halo ketones was accomplished using the Noyori/Ikariya (R,R)- or (S,S)-I catalysts and either HCO(2)H/Et(3)N or HCO(2)Na/n-Bu(4)NBr in H(2)O/CH(2)Cl(2) as the hydrogen sources. Good yields of vicinal bromo-, chloro-, and fluorohydrins with excellent de and ee levels were achieved in most cases after a simple tuning of reaction conditions. 相似文献
20.
Alma Viso Roberto Fernández de la Pradilla Aída Flores Ana García 《Tetrahedron》2007,63(33):8017-8026
A short and efficient synthesis of mono- and bicyclic ketopiperazines bearing methoxycarbonyl substituents is described. The route entails selective protection and solvolysis of N-sulfinylimidazolidines to provide vicinal diaminoesters with the nitrogen atoms suitably differentiated. Then, an N-acylation/cyclization protocol renders the ketopiperazines. In addition a diastereoselective route to an analog of the natural diketopiperazine DKP 593A through a 2-piperidinylglycinate available by this method is described. 相似文献