An optimized solenoidal head radiofrequency coil for low-field magnetic resonance imaging

Applications of low-field magnetic resonance imaging (MRI) systems (<0.3 T) are limited due to the signal-to-noise ratio (SNR) being lower than that provided by systems based on superconductive magnets (≥1.5 T). Therefore, the design of radiofrequency (RF) coils for low-field MRI requires careful consideration as significant gains in SNR can be achieved with the proper design of the RF coil. This article describes an analytical method for the optimization of solenoidal coils. Coil and sample losses are analyzed to provide maximum SNR and optimum B₁ field homogeneity. The calculations are performed for solenoidal coils optimized for the human head at 0.2 T, but the method could also be applied to any solenoidal coil for imaging other anatomical regions at low field. Several coils were constructed to compare experimental and theoretical results. A head magnetic resonance image obtained at 0.2 T with the optimum design is presented.     

Multiple Parallel Round Leg Design for Quadrature Birdcage Coil in Ultrahigh-Field MRI

Copper foil has been widely employed in conventional radio frequency (RF) birdcage coils for magnetic resonance imaging (MRI). However, for ultrahigh-field (UHF) MRI, current density distribution on the copper foil is concentrated on the surface and the edge due to proximity effect. This increases the effective resistance and distorts the circumferential sinusoidal current distribution on the birdcage coils, resulting in low signal-to-noise ratio (SNR) and inhomogeneous distribution of RF magnetic (B₁) field. In this context, multiple parallel round wires were proposed as legs of a birdcage coil to optimize current density distribution and to improve the SNR and the B₁ field homogeneity. The design was compared with three conventional birdcage coils with different width flat strip surface legs for a 9.4 T (T) MRI system, e.g., narrow-leg birdcage coil (NL), medium-leg birdcage coil (ML), broad-leg birdcage coil (BL) and the multiple parallel round wire-leg birdcage coil (WL). Studies were carried out in in vitro saline phantom as well as in vivo mouse brain. WL showed higher coil quality factor Q and more homogeneous B₁ field distribution compared to the other three conventional birdcage coils. Furthermore, WL showed 12, 10 and 13% SNR increase, respectively, compared to NL, ML and BL. It was proposed that conductor’s shape optimization could be an effective approach to improve RF coil performance for UHF MRI.     

Comparison of 12 Quadrature Birdcage Coils with Different Leg Shapes at 9.4 T

The purpose of this study was to analyse the relationship between the radio frequency (RF) coil performance and conductor surface shape for ultra-high field (UHF) magnetic resonance imaging. Twelve different leg-shaped quadrature birdcage coils were modeled and built, e.g., 4 mm-width-leg conventional birdcage coil, 7 mm-width-leg conventional birdcage, 10 mm-width-leg conventional birdcage coil, 13 mm-width-leg conventional birdcage coil, inside arc-shape-leg birdcage coil, outward arc-shape-leg birdcage coil, inside right angle-shape-leg birdcage coil, outward right angle-shape-leg birdcage coil, vertical 4 mm-width-leg vertical birdcage, 6 mm-width-leg vertical birdcage, 8 mm-width-leg vertical birdcage and 10 mm-width-leg vertical birdcage. Studies were carried out in both electromagnetic simulations with finite element method as well as in vitro saline phantom experiments at 9.4 T. Both the results of simulation and experiment showed that conventional birdcage coil produces the highest signal-to-noise ratio (SNR) while the vertical birdcage coil produces the most homogeneous RF magnetic (B ₁) field at UHF. For conventional birdcage coils, as well as the vertical birdcage coils, only the proper width of legs results in the best performance (e.g., B ₁ homogeneous and SNR). For vertical birdcage coils, the wider the leg size, the higher RF magnetic (B ₁) field intensity distribution.     

Design and Analysis of Microstrip-Based RF Birdcage Coil for 1.5 T Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) technique is widely used to capture the images of the liquid items inside the human body. The radio-frequency (RF) coil is one of the important modules present inside an MRI system, which plays a major role in image quality. In this work, a microstrip-based high-pass RF birdcage coil is proposed for 1.5 T MRI. The cylindrical-shaped birdcage coil consists of 12 microstrip radiating elements and tuning capacitors to achieve a resonance at 63.85 MHz. The coil is made up of 10 mm polytetrafluoroethylene substrate coated by a conducting transmission line of desired length and width. A finite difference time domain simulation is carried out to analyze the return loss (S₁₁), magnetic field homogeneity and Specific Absorption Rate (SAR) parameters of the RF coil. The SAR values of the proposed microstrip-based 1.5 T birdcage coil was compared with 3 T RF birdcage coil. The simulation results indicate the proposed birdcage coil structure gives optimal values of S₁₁, magnetic field homogeneity and SAR.     

B1 transmit phase gradient coil for single-axis TRASE RF encoding

Purpose

TRASE (Transmit Array Spatial Encoding) MRI uses RF transmit phase gradients instead of B₀ field gradients for k-space traversal and high-resolution MR image formation. Transmit coil performance is a key determinant of TRASE image quality. The purpose of this work is to design an optimized RF transmit phase gradient array for spatial encoding in a transverse direction (x- or y- axis) for a 0.2 T vertical B₀ field MRI system, using a single transmitter channel. This requires the generation of two transmit B₁ RF fields with uniform amplitude and positive and negative linear phase gradients respectively over the imaging volume.

Materials and Methods

A two-element array consisting of a double Maxwell-type coil and a Helmholtz-type coil was designed using 3D field simulations. The phase gradient polarity is set by the relative phase of the RF signals driving the simultaneously energized elements.

Results

Field mapping and 1D TRASE imaging experiments confirmed that the constructed coil produced the fields and operated as designed. A substantially larger imaging volume relative to that obtainable from a non-optimized Maxwell-Helmholtz design was achieved.

Conclusion

The Maxwell (sine)–Helmholtz (cosine) approach has proven successful for a horizontal phase gradient coil. A similar approach may be useful for other phase-gradient coil designs.     

Brain Imaging with Slotted Hybridized Magnetic Metamaterial Hat at 7-T MRI

Study of human pathologies and acquisition of anatomical images without any surgical intervention inside human body is possible because of magnetic resonance imaging (MRI), which is the keystone technique to characterize the psychology and neurochemistry of human body. However, for clinical trials, the study and cure of human diseases are followed by medical investigations of different animal anatomies. By employing different imaging techniques to animal anatomical models during their clinical trials yielded in exceptional image acquisition without any surgical invasion in the model, which resulted in noninvasive technique as compared to surgical invasion and opened the possibility to study human pathologies more precisely. This work exploits the notable properties of unique combination of multi-circular hybridized surface coils which can be used as hybridized magnetic metamaterial hat (HMMH). HMMH not only strengthens the uniformity of radio frequency (RF) rotational symmetry around its axis but also improves the signal-to-noise ratio (SNR) for rat’s brain imaging at 7-T MRI. We analyzed a periodic array of strongly coupled circular copper coils attached on circular coil shaped printed circuit board (PCB) substrate. In the design, some copper coils were inspired by the slot cavity loaded with parametric elements (capacitor and inductor). In addition, coils in the form of HMMH exploited the advantages of the hybrid modes which exhibited better and deeper RF sensitivity into the region of interest (ROI) as compared to single loop RF coil by exciting two Eigen modes simultaneously which resulted in homogenized magnetic field (B-field) and enhanced SNR at ROI. At resonance, the value of relative negative permeability, μ _r  = ?7 + j11 was achieved at 300 MHz for 7-T MRI. Furthermore, image quality at ROI was optimized by varying rat’s head position under magnetic resonance (MR) coil of MRI apparatus and in the presence or absence of HMMH. Design configuration and circuit model analysis were also done.     

Composite pulses for RF phase encoded MRI: A simulation study

BackgroundIn B₁ encoded MRI, a realistic non-linear phase RF encoding coil will generate an inhomogeneous B₁ field that leads to spatially dependent flip angles. The non-linearity of the B₁ phase gradient can be compensated for in the reconstruction, but B₁ inhomogeneity remains a problem. The effect of B₁ inhomogeneity on tip angles for conventional, B₀ encoded MRI, may be minimized using composite pulses. The objective of this study was to explore the feasibility of using composite pulses with non-linear RF phase encoding coils and to identify the most appropriate composite pulse scheme.MethodsRF encoded signals were simulated via the Bloch equation for various symmetric, asymmetric and antisymmetric composite pulses. The simulated signals were reconstructed using a constrained least squares method.ResultsRoot mean square reconstruction errors varied from 6% (for an asymmetric composite pulse) to 9.7% (for an antisymmetric composite pulse).ConclusionAn asymmetric composite pulse scheme created images with fewer artifacts than other composite pulse schemes in inhomogeneous B₀ and B₁ fields making it the best choice for decreasing the effects of spatially varying flip angles. This is contrary to the conclusion that antisymmetric composite pulses are the best ones to use for spin echo sequences in conventional, B₀ encoded, MRI.     

Intracranial microvascular imaging at 7 T MRI with transceiver RF coils

Purpose

To investigate intracranial microvascular images with transceiver radio-frequency (RF) coils at ultra-high field 7 T magnetic resonance imaging (MRI).

Materials and methods

We designed several types of RF coils for the study of 7 T magnetic resonance angiography and analyzed quantitatively each coil's performance in terms of the signal-to-noise ratio (SNR) profiles to evaluate the usefulness of RF coils for microvascular imaging applications. We also obtained the microvascular images with different resolutions and parallel imaging technique.

Results

The overlapped 6-channel (ch) transceiver coil exhibited the highest performance for angiographic imaging. Although other multi-channel coils, such as 4- or 8-ch, were also suitable for fast imaging, these coils performed poorly in homogeneity or SNR for angiographic imaging. Furthermore, the 8-ch coil was poor in SNR at the center of the brain, while it had the highest SNR at the periphery.

Conclusion

The present study has demonstrated that the overlapped 6-ch coil with large-size loop coils provided the best performance for microvascular imaging or angiography with the ultra-high-field 7 T MRI, mainly because of its long penetration depth together with high SNR.     

The effects of coupled B1 fields in B1 encoded TRASE MRI - A simulation study

Transmit Array Spatial Encoding (TRASE) is a novel MRI technique that encodes spatial information by introducing phase gradients in the transmit RF (B₁) magnetic field. Since TRASE relies on the use of multiple RF fields (B₁ fields with different phase gradients) for k-space traversal, a TRASE pulse sequence requires RF pulses that are produced by switching between the transmit coils (B₁ fields). However, interactions among the transmit RF coils can cause un-driven coils to produce unwanted B₁ fields that impair the spatial encoding. Therefore, TRASE is sensitive to B₁ field perturbations arising from inductive coupling among the RF transmit coils and any B₁ field isolation (coil decoupling) technique requires an understanding of the effects of the B₁ field interactions. The purpose of this study was to investigate the effects of B₁ field coupling using Bloch equation based simulations and to determine the acceptable level of B₁ field interactions for 2D TRASE imaging. The simulations show that 2D TRASE MRI (using a 3-coil setup) displays ideal performance for pairwise coupling constant lower than k = 0.01 while having acceptable performance up to k = 0.1. This translates into S₁₂ measurements of range ~(− 50 dB to −30 dB) required for successful 2D TRASE MRI in this study. This result is of crucial importance for designers of practical TRASE transmit array systems.     

B(1)(+)/actual flip angle and reception sensitivity mapping methods: simulation and comparison

Knowledge of the spatial distribution of transmission field B₁⁺ and reception sensitivity maps is important in high-field (≥3 T) human magnetic resonance (MR) imaging for several reasons: these include post-acquisition correction of intensity inhomogeneities, which may affect the quality of images; modeling and design of radiofrequency (RF) coils and pulses; validating theoretical models for electromagnetic field calculations; testing the compatibility with MR environment of biomedical implants. Moreover, inhomogeneities in the RF field are an essential source of error for quantitative MR spectroscopy. Recent studies have also shown that B₁⁺ and reception sensitivity maps can be used for direct calculation of tissue electrical parameters and for estimating the local specific absorption rate (SAR) in vivo.Several B₁⁺ mapping techniques have been introduced in the past few years based on actual flip angle (FA) mapping, but, to date, none has emerged as a standard. For reception sensitivity calculation, the signal intensity equation can be used where the nominal FA distribution must be replaced with the actual FA distribution calculated by one of the B₁⁺ mapping techniques.This study introduces a quantitative comparison between two known methods for B₁⁺/actual FA and reception sensitivity mapping: the double-angle method (DAM) and the fitting (FIT) method. Experimental data obtained using DAM and FIT methods are also compared with numerical simulation results.     

Helmholtz transceiver array for improving the |<Emphasis Type="Italic">B</Emphasis><Subscript>1</Subscript>|-field homogeneity at 7-T magnetic resonance imaging

A 16-channel transceiver radiofrequency (RF) array using Helmholtz coils was designed to improve the RF transmission |B ₁ ⁺ |-field homogeneity for human brain magnetic resonance imaging (MRI) at 7 T. A numerical simulation of the proposed Helmholtz transceiver array was performed using the finite-difference time-domain method—the subset of the finite-element method simulation. The simulation results of proposed 16-channel Helmholtz transceiver array were compared with the generally used rectangular transceiver array in term of their |B ₁ ⁺ |-field and specific absorption rate (SAR). The simulation of each single element in 16-channel Helmholtz and rectangular transceiver arrays was compared using water phantom in term of their magnetic flux |B ₁| homogeneity for the full width at half maximum. From the simulation results, the proposed 16-channel Helmholtz transceiver array configuration offers superior |B ₁ ⁺ |-field homogeneity and low SAR at 7 T. These modifications to the coil geometries of the transceiver array coil could be applied to a 7-T MRI, and also extended to increase the homogenous coverage on |B ₁ ⁺ |field with low SAR.     

Hybrid Monopole/Loop Coil Array for Human Head MR Imaging at 7 T

The monopole coil and loop coil have orthogonal radiofrequency (RF) fields and thus are intrinsically decoupled electromagnetically if they are laid out appropriately. In this study, we proposed a hybrid monopole/loop technique which could combine the advantages of both loop arrays and monopole arrays. To investigate this technique, a hybrid RF coil array containing four monopole channels and four loop channels was developed for human head magnetic resonance (MR) imaging at 7 T. In vivo MR imaging and g-factor results using monopole-only channels, loop-only channels and all channels of the hybrid array were acquired and evaluated. Compared with the monopole-only and loop-only channels, the proposed hybrid array has the higher signal-to-noise ratio (SNR) and better parallel imaging performance. Sufficient electromagnetic decoupling and diverse RF magnetic field (B₁) distributions of monopole channels and loop channels may contribute to this performance improvement. From experimental results, the hybrid monopole/loop array has low g-factor and excellent SNR at both periphery and center of the brain, which is valuable for human head imaging at ultrahigh fields.     

MRI methodological development of intervertebral disc degeneration: a rabbit in vivo study at 9.4 T

Intervertebral disc (IVD) degeneration is a complex process characterized by biochemical and structural changes in both the nucleus pulposus and the anulus fibrosus. In this study, we were able to obtain in vivo magnetic resonance (MR) images of the rabbit spine, with several MR imaging (MRI) contrasts (ρ, T₁ and T₂). We quantified several parameters (T₂, apparent diffusion coefficient, disc height and area) to differentiate between healthy and degenerative IVDs and to characterize the degeneration process. To our knowledge, there has not been any previous in vivo study of rabbit IVDs at high-field MRI (9.4 T).A custom radio frequency (RF) coil for 9.4 T was designed to match rabbit IVD morphology, to study the degeneration in vivo on a model of human lumbar disease. Our new probe, a custom half-birdcage-type coil, obtains the necessary exploration depth while meeting the requirements for signal homogeneity and sensitivity of the study. This design addresses some of the difficulties with constructing RF coils at high field strengths.     

The design of a body RF coil for low-field open MRI using pseudo electric dipole radiation and simulated annealing

The paper presents a new body RF coil design scheme for a low-field open MRI system. The RF coil is composed of four rectangular loops which are made of wide copper strips located near the surfaces of the bottom and top pole faces of the permanent magnet. The body RF coil has been designed by using the pseudo electric dipole radiation (PEDPR) method with the Metropolis algorithm. In the calculation of the RF fields via the finite difference time domain (FDTD) method, the computational time increases as the RF frequency becomes lower. Moreover, the computational process using the FDTD method takes a very long time when the RF coil is optimized. The optimization requires varying the configuration of the RF coil system and performing successive calculations of field strength and field homogeneity. When we perform these successive calculations, the computational time can be reduced by using the PEDPR method, where the segmented current elements of the RF coil are treated as pseudo electric dipole radiation sources. Because the RF coil is made of wide strips, the variation of the current density on the strip has been considered in the B₁-field calculation. For each configuration of the RF coil system, the current distribution is calculated via circuit analysis, where each copper strip is considered as a parallel combination of current element lines. The preliminary field calculation study by the FDTD method verifies both the circuit analysis method for the current distribution and the PEDPR method for the radiation field strength. The optimization of the RF coil configuration is performed by the Simulated Annealing (SA) process using the Metropolis algorithm. Simulations have been performed for a 10 MHz RF frequency. The optimized RF coil has four rectangular loops of 37 cm × 100 cm with 6.5 cm wide strips which are separated vertically 49 cm and horizontally center-to-center 63 cm. In the 25 cm diameter of spherical volume (DSV), the design results show a good field inhomogeneity of the B₁-field below 0.49 dB (5.8%).     

Large improvement of RF transmission efficiency and reception sensitivity for human in vivo 31P MRS imaging using ultrahigh dielectric constant materials at 7 T

In vivo ³¹P MRS provides a unique and important imaging tool for studying high-energy phosphate metabolism and bioenergetics noninvasively. However, compared to ¹H MRS, ³¹P MRS with a relatively low gyromagnetic ratio (γ) has a lower and limited sensitivity even at ultrahigh field. The proof of concept has been recently demonstrated that the use of high dielectric constant (HDC) materials between RF coil and object sample could increase MRI signal and reduce required RF transmission power for reaching the same RF pulse flip angle in the region of interest. For low-γ MRS applications operated at relatively lower frequency, however, it demands the dielectric materials with a much higher permittivity for achieving optimal performance. We conducted a ³¹P MRS imaging study using ultra-HDC (uHDC; with a relative permittivity of ~ 1200) material blocks incorporated with an RF volume coil at ultrahigh field of 7.0 T. The experimental results from phantom and human calf muscle demonstrate that the uHDC technique significantly enhanced RF magnetic transmit field (B₁⁺) and reception field (B₁⁻) and the gain could reach up to two folds in the tissue near the uHDC blocks. The overall results indicate that the incorporation of the uHDC materials having an appropriate permittivity value with a RF coil can significantly increase detection sensitivity and reduces RF transmission power for X-nuclei MRS applications at ultrahigh field. The uHDC technology could provide an efficient, cost-effective engineering solution for achieving high detection sensitivity and concurrently minimizing tissue heating concern for human MRS and MRI applications.     

一种可拆装式的脑外科手术用磁共振成像线圈

在临床磁共振成像(MRI)应用中,射频线圈的设计是非常关键的,针对不同的应用目的,合适的线圈能获得质量更好的图像. 有的应用需要线圈提供均匀性较好的射频场,而有的应用则需要线圈在特定区域内提供高的信噪比(SNR). 但是线圈很难同时得到好的射频场（B₁场）、空间均匀性和高的SNR,需要根据实际应用情况进行折衷设计. 针对MRI在脑外科手术中的应用特点,设计并制作了一种新颖的、适用于脑外科手术的MRI接收和发射共用射频线圈. 该线圈采用可分拆式结构,在脑外科手术支架上可以进行反复组装和拆卸,减少了MRI对医生手术的影响. 仿真结果和人体成像实验表明,该线圈能产生均匀的射频场、有较高的SNR和较大的成像范围,满足脑外科手术的需要.     

Practical design of a 4 Tesla double-tuned RF surface coil for interleaved 1H and 23Na MRI of rat brain

MRI is proving to be a very useful tool for sodium quantification in animal models of stroke, ischemia, and cancer. In this work, we present the practical design of a dual-frequency RF surface coil that provides (1)H and (23)Na images of the rat head at 4 T. The dual-frequency RF surface coil comprised of a large loop tuned to the (1)H frequency and a smaller co-planar loop tuned to the (23)Na frequency. The mutual coupling between the two loops was eliminated by the use of a trap circuit inserted in the smaller coil. This independent-loop design was versatile since it enabled a separate optimisation of the sensitivity and RF field distributions of the two coils. To allow for an easy extension of this simple double-tuned coil design to other frequencies (nuclei) and dimensions, we describe in detail the practical aspects of the workbench design and MRI testing using a phantom that mimics in vivo conditions. A comparison between our independent-loop, double-tuned coil and a single-tuned (23)Na coil of equal size obtained with a phantom matching in vivo conditions, showed a reduction of the (23)Na sensitivity (about 28 %) because of signal losses in the trap inductance. Typical congruent (1)H and (23)Na rat brain images showing good SNR ((23)Na: brain 7, ventricular cerebrospinal fluid 11) and spatial resolution ((23)Na: 1.25 x 1.25 x 5mm(3)) are also reported. The in vivo SNR values obtained with this coil were comparable to, if not better than, other contemporary designs in the literature.     

An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized ³He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B₀ coil design that produces an optimized 65 G (6.5 mT) magnetic field for ³He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pre-tuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D ³He images with up to 2.8 mm resolution, and present initial 2D and 3D ³He images of human lungs in both supine and upright orientations. ¹H MRI can also be performed for diagnostic and calibration reasons.     

Characterization of a 3D MEMS fabricated micro-solenoid at 9.4 T

We present for the first time a complete characterization of a micro-solenoid for high resolution MR imaging of mass- and volume-limited samples based on three-dimensional B(0), B(1) per unit current (B(1)(unit)) and SNR maps. The micro-solenoids are fabricated using a fully micro-electromechanical systems (MEMS) compatible process in conjunction with an automatic wire-bonder. We present 15 μm isotropic resolution 3D B(0) maps performed using the phase difference method. The resulting B(0) variation in the range of [-0.07 ppm to -0.157 ppm] around the coil center, compares favorably with the 0.5 ppm limit accepted for MR microscopy. 3D B(1)(unit) maps of 40 μm isotropic voxel size were acquired according to the extended multi flip angle (ExMFA) method. The results demonstrate that the characterized microcoil provides a high and uniform sensitivity distribution around its center (B(1)(unit) = 3.4 mT/A ± 3.86%) which is in agreement with the corresponding 1D theoretical data computed along the coil axis. The 3D SNR maps reveal a rather uniform signal distribution around the coil center with a mean value of 53.69 ± 19%, in good agreement with the analytical 1D data along coil axis in the axial slice. Finally, we prove the microcoil capabilities for MR microscopy by imaging Eremosphaera viridis cells with 18 μm isotropic resolution.     

A novel radio frequency coil for veterinary magnetic resonance imaging system

In this article,a novel designed radio frequency (RF) coil is designed and built for the imaging of puppies in a V-shape permanent magnetic resonance imaging (MRI) system.Two sets of Helmholtz coil pairs with a V-shape structure are used to improve the holding of an animal in the coil.The homogeneity and the sensitivity of the RF field in the coil are analysed by theoretical calculation.The size and the shape of the new coil are optimized and validated by simulation through using the finite element method (FEM).Good magnetic resonance (MR) images are achieved on a shepherd dog.