A New ent-Kaurane Diterpenoid from Isodon enanderianus

Isodon enanderianus (Hand. -Mazz.) H. W. Li, has been used in folk medicine as anti-inflammatory and detoxified agent1. The Isodon genus is known to be rich in ent-kaurane diterpenoids, a series of new ent-kaurane diterpenoids have been isolated from the dried leaves of I. enanderianus2-4. In order to find more biologically active substances, we have carefully investigated the chemical constituents of I. enanderianus collected in Shiping county of Yunnan province, and as a result, enanderi…     

A Novel Asymmetric ent-Kauranoid Dimer from Isodon enanderianus

ＩｎｔｒｏｄｕｃｔｉｏｎＩｓｏｄｏｎｅｎａｎｄｅｒｉａｎｕｓ (Ｈａｎｄ . Ｍａｚｚ .)Ｈ .Ｗ .Ｌｉ(Ｌａｂｉａｔａｅ) ,ｗｉｄｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎｔｈｅｓｏｕｔｈｅｒｎｐａｒｔｓｏｆＹｕｎｎａｎＰｒｏｖｉｎｃｅ ,ｈａｓｂｅｅｎｕｓｅｄｉｎＣｈｉｎｅｓｅｔｒａｄｉｔｉｏｎａｌｆｏｌｋｍｅｄｉｃｉｎｅａｓａｎｔｉ ｉｎｆｌａｍｍａｔｏｒｙａｎｄｄｅｔｏｘｉｆｉｅｄａｇｅｎｔ.1Ｐｒｅｖｉｏｕｓｐｈｙｔｏｃｈｅｍｉｃａｌｉｎｖｅｓｔｉｇａｔｉｏｎｈａｓｓｈｏｗｎｔｈｅｐｒｅｓ ｅｎｃｅｏｆａｓｅｒ…     

A New Flavone Glycoside from Epimedium koreanum

Epimedium koreanum is widely distributed throughout the east-northern part of China. As a Chinese herbal medicine, its aerial parts are used as tonics, aphrodisiacs and antirheumatics. Constituents of Epimedium koreanum have been reported as flavonoids, n…     

A Nove Asymmetric ent—Kauranoid Dimer from Isodon enanderianus

Further investigation on the aerial parts of Isodon enanderianus afforded a novel asymmetric ent-kauranoid dimer,enanderi-nanin J(1).The structure of the dimer was elucidated by means of spectroscopic methods (including 2D NMR tecniques ),Enanderinanin J was a dimer of xerophilusin A and probably formed by [4 2] cycloaddition.     

A Minor New Flavone from Scutellaria baicalensis Georgi

A new flavone,6,2′-dihydroxy-5,7,8,6′-tetramethoxyflavone,was isolated from the roots of Scutellaria baicalensis. Its structure was established on the basis of spectral evidences.     

Mahuangchiside, a New Flavone Glycoside from Chirita fimbrisepala

Chiritafimbrisepala Hand.-Mazz. (Gesneriaceae), commonly called "Mahuangchi" inChina, is distributed mainly in Southern China. As an anti-inflammatory Chinese folkmedicine. the root is used for the treatment of inflammations, such as hepatitis andgastroenteritis. The characteristic constituents of the family are flavonoids.Mahuangchiside I was obtained as yellow granular crystals (MeOH) from theextract of 90%EtOH, mp. 212-213"C. It is positive to Mg-HCI and Molish tests. TheUV absorp…     

Flavone glucosides from Artemisia juncea

A new flavone glucoside, 4′,5-dihydroxy-3′,5′,6-trimethoxyflavone-7-O-β-D-glucoside was obtained from aerial parts of Artemisia juncea, together with the known flavone eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of A. juncea showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl₃ fraction.     

A New Acylated Flavonoid from Anaphalis aureo-punctata

A new acylated flavonoid glycoside,3-O-kaempferol-3-O-acetyl-6-O-(p-coumaroyl)-β-D-glucopyranoside 1 was isolated from the whole plant of Anaphalis aureo-punetata.The structure was established by spectral methods.     

A New 6,7-Seco-Ent-Kaurane Diterpenoid from Isodon eriocalyx Var. laxiflora

Isodon eriocalyx var. laxiflora C. Y. Wu & H. W. Li, is a perennial herb naturally growing in the southern area of Yunnan province. In our continuing studies1 on its leaves collected from Xishuanbana prefecture, a new 6,7-seco-ent-kaurane diterpenoid, named laxiflorin E (1), together with two known 6,7-seco-ent-kaurane diterpenoids2, eriocalyxin A (2) and laxiflorin C (3), was isolated. Their structures were established by spectroscopic analysis. Compound 1, obtained as colorless rhombus…     

Two New Iridoid Glycosides from Caryopteris mongholica

The whole planl of Calyopteris mongholica Bunge was used in China as a herbalmedicine which relieves cold, cough and rheumatic pains'. In previous paper, ahypolactin-7-glucoside was reported from this plant'. In this paped, we wish to report theisolation and structure elucidation of two new iridoid glucosides, 8-acetyl-6'-O-tycoumaroyl)harpagide (la) and 6'-O-(P-coumaroyl) antirrinoside (2a) from the wholeplants of C mongholica Bunge.Compounds la and Za were isolated as an inseparable mixt…     

A new phenylethanoid glycoside from Isodon sculponeatus

A new phenylethanoid glycoside,seulponisidc(1) was isolated from the aerial parts of Isodon sculponeatus(Vaniot) Kudo, along with six known compounds martynoside(2),verbascoside(3),(+)-hydroxypinoresinol-8-O- β-D-glucoside(4),cedrusin(5), 7-megastigmene-3S,5R,6R,7E,9S-tetrol(6) and 4-oxo- β-ionol- β-D-glucopyranoside(7).Their chemical structures were elucidated from physieochemical data and by acidic hydrolysis.     

A New Flavonol Glycoside from Anaphalis sinica Hance

ＩｎｔｒｏｄｕｃｔｉｏｎＳｅｖｅｒａｌｐｌａｎｔｓｏｆｇｅｎｕｓＡｎａｐｈａｌｉｓ(Ｃｏｍｐｏｓｉｔａｅ)ｈａｖｅｂｅｅｎｐｈｙｔｏｃｈｅｍｉｃａｌｌｙｓｔｕｄｉｅｄ ,ｆｒｏｍｗｈｉｃｈｆｌａｖａｎｏｉｄｓ[1,2 ] ,ｈｅｌｉｐｙｒｏｎｅ[3] ,ｃｈｌｏｒｏａｃｅｔｙｌｅｎｉｃｃｏｍｐｏｕｎｄｓｗｉｔｈａｄｉｈｙｄｒｏｐｙｒａｎｏｒｆｕｒａｎｒｉｎｇ[4] ａｎｄｐｈｔｈａｌｉｄｅｓｈａｖｅｂｅｅｎｒｅｐｏｒｔｅｄ[5 ] .Ａ .ｓｉｎｉｃａＨａｎｃｅ ,ｄｉｓｔｒｉｂｕｔｅｄｉｎＣｈｉｎａａｎｄａｌｓｏｆｏｕｎｄ…     

A New Dihydroflavone Glycoside from Glycyrrhiza uralensis

A new dihydroflavone glycoside was isolated from the underground parts of Glycyrrhiza uralensis. Its structure was elucidated as 7-hydroxyl-4′-O-]3-D-(6″-O-α-hydroxylpropionyl) glucopyranosyl dihydroflavone by spectral methods.     

A new dihydrochalcone glycoside from the stems of Homalium stenophyllum

A new dihydrochalcone glycoside, phloretin-4-O-β-D-glucopyranoside (1), together with seven known flavonoids (2–8), were isolated from the stems of Homalium stenophyllum. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. The known compounds (2–8) were isolated from the genus Homalium for the first time. All compounds were evaluated for their antibacterial activities against six pathogenic bacteria in vitro.     

A New Bianthraqinonc Glycoside from Eremurus chinensis

Eremurus chinensis Fedtch has a wide distribution in the western part of China; it hasbeen used in Chinese folk medicine for the treatment of rheumatism and physicalweaknessl. Only few reports describe polysaccharides'-' rather than other chemicalconstituents from the genus Eremurus. We report here the isolation and structuralelucidation of a new bianthraquinone glycoside, 8-O- P -D-glucopyranosyl-2,7'-hi(l,8dihydroxy-3-methyl-9,10-anthraqu 1 from E. chinensis.The EtOAc soluble fraction ob…     

A New Flavone from the Roots of Uvaria macrophylla

Uvaria macrophylla is an evergreen tree of the family annonaceae, distributed in Hainan Province, China1. A new flavone, macrophyllol was isolated from the roots of Uvaria macrophylla. In this article we report the structure elucidation of 1.Macrophyllol 1 was isolated as yellow plate crystals, mp: 132-133(C, [(] +4.92 (c 0.06, MeOH). The HREIMS of 1 exhibited [M]+ at m/z 436.1504 corresponding to the molecular formula C25H24O7 (calc.436.1522). The IR spectrum of 1, showed the presenc…     

A New Phenylpropanoid Glycoside: Serratumoside A from Clerodendrum serratum

In the previous papers"', we have reported some chemical constituents fromClerodendrum serratum var. amplerghlium Moldenke. A continuation of our studies onthe same plant led to the isolation of a new phenylpropanoid, serratumoside A (l), whichis reported in this paper.Serratumoside A (l) with three known phenylpropanoid glycosides identified asacteoside', mwtinoside' and myricoside', respectively, were isolated from the Cserratum. Compound I was isolated as a brown amorphous powder, laly …     

A New Monoterpene Glycoside from Paeonia veitchii

The root cortex of Paeonia veitchii Lynch. is one of the most important crude drugs in Chinese traditional medicine. It is used as an analgesic, sedative, anti-inflammatory agent and a remedy for cardiovascular, extravasated blood1. The present paper deals with the structural elucidation of a new compound from this material. Compound 1, obtained as viscous oil, gave a quasi-molecular ion peak at m/z 521 [M-1]- in the negative FAB-MS, which was 42 amu greater than that of paeon…     

A new xanthone glycoside from Pyrrosia sheareri

A new xanthone glycoside, 3,5,7,8-tetramethoxyxanthone-1-O-β-D-glucopyranoside (1), along with five known compounds, mangiferin (2), kaempferol (3), quercetin (4), chlorogenic acid (5) and diploptene (6), was isolated from the whole plants of Pyrrosia sheareri (Bak.) Ching. The structure of compound 1 was established on the basis of extensive spectroscopic analyses and chemical methods.     

A New Bibenzyl Glycoside from Dendrobium moniliforme

A new bibenzyl glycoside has been isolated from the stems of Dendrobium moniliforme (L.) Sw.(Orchidaceas).Its structure has been identified on the basis of spectroscopic and chemical methods.