A hyperbolic free boundary problem modeling tumor growth: Asymptotic behavior

In this paper we study a free boundary problem modeling the growth of radially symmetric tumors with two populations of cells: proliferating cells and quiescent cells. The densities of these cells satisfy a system of nonlinear first order hyperbolic equations in the tumor, and the tumor's surface is a free boundary . The nutrient concentration satisfies a diffusion equation, and satisfies an integro-differential equation. It is known that this problem has a unique stationary solution with . We prove that (i) if , then , and (ii) the stationary solution is linearly asymptotically stable.

     

One-phase parabolic free boundary problem in a convex ring

This paper studies a free boundary problem for the heat equation in a convex ring. It is proved that the considered problem has unique solution under some conditions on the initial data.     

Global classical solution of quasi-stationary Stefan free boundary problem

We consider an one-phase quasi-stationary Stefan problem (Hele–Shaw problem) in multidimensional case. Under some reasonable conditions we prove that the problem has a classical solution globally in time. The method can be used in two-phase problem as well. We also discuss asymptotic behavior of solution as t→+∞. The method developed here can be extended to a general class of free boundary problems.     

On a free boundary problem in ground freezing

We consider a boundary value problem describing the stationary flow of a non‐Newtonian fluid through the frozen ground, with a free interface between the liquid and the solid phases. We prove the existence of at least one weak solution of the problem. Copyright © 2000 John Wiley & Sons, Ltd.     

一个早期肿瘤生长模型的数学分析

研究了乳腺癌的早期生长模型（DCIS）,它为耦合了抛物方程、椭圆方程的自由边界问题,运用椭圆型方程的变分理论、抛物方程的L^p理论和压缩映照原理,证明了这个问题局部解的存在惟一性,然后用延拓方法得到了整体解的存在惟一性。     

A free boundary problem for a class of nonlinear nonautonomous size-structured population model

In this paper, we study a free boundary problem for a class of nonlinear nonautonomous size-structured population model. Using the comparison principle and upper–lower solution methods, we establish the existence of the solution for such kind of a model.     

A free boundary problem arising from DCIS mathematical model

Ductal carcinoma in situ – a special cancer – is confined within the breast ductal only. We derive the mathematical ductal carcinoma in situ model in a form of a nonlinear parabolic equation with initial, boundary, and free boundary conditions. Existence, uniqueness, and stability of problem are proved. Algorithm and illustrative examples are included to demonstrate the validity and applicability of the technique in this paper. Copyright © 2016 John Wiley & Sons, Ltd.     

Almost minimizers of the one-phase free boundary problem

Abstract

We consider almost minimizers to the one-phase energy functional and we prove their optimal Lipschitz regularity and partial regularity of their free boundary. These results were recently obtained by David and Toro, and David, Engelstein, and Toro. Our proofs provide a different method based on a non-infinitesimal notion of viscosity solutions that we introduced.     

一种肿瘤生长自由边界问题整体解的存在唯一性

研究了一种肿瘤生长模型中自由边界问题,该肿瘤生长模型异于其它此类模型之处就在于采用了新的方式来描述繁衍细胞和休眠细胞的运动．运用抛物型方程的Lp理论和不动点原理,证明了该模型存在唯一的整体解．     

Uniqueness of solution to a free boundary problem from combustion

We investigate the uniqueness and agreement between different kinds of solutions for a free boundary problem in heat propagation that in classical terms is formulated as follows: to find a continuous function defined in a domain and such that

0\}. \end{displaymath}">

We also assume that the interior boundary of the positivity set, \nobreak 0\}$">, so-called free boundary, is a regular hypersurface on which the following conditions are satisfied:

Here denotes outward unit spatial normal to the free boundary. In addition, initial data are specified, as well as either Dirichlet or Neumann data on the parabolic boundary of . This problem arises in combustion theory as a limit situation in the propagation of premixed flames (high activation energy limit).

The problem admits classical solutions only for good data and for small times. Several generalized concepts of solution have been proposed, among them the concepts of limit solution and viscosity solution. We investigate conditions under which the three concepts agree and produce a unique solution.

     

一个关于肿瘤治疗的自由边界问题的数学分析

§1Introduction Avarietyofpartialdifferentialequationmodelsfortumorgrowthortherapyhave beendevelopedinthelastthreedecades[see2,3,16-18,21-26].Mostofthosemodelsare informoffreeboundaryproblems,andareverydiversified.Rigorousmathematical analysisofsuchfreeboundaryproblemshasdrawngreatinterest,andmanyinteresting resultshavebeenestablished[4-15].Inthispaperwedealwithamathematicalmodeldescribingtumorchemotherapy.In thismodelthetumorisviewedasdenselypacked,radially-symmetricsphereofradiusR(t)contain…     

Solving a free boundary problem with nonconstant coefficients

The present article is concerned with the numerical solution of a free boundary problem for an elliptic state equation with nonconstant coefficients. We maximize the Dirichlet energy functional over all domains of fixed volume. The domain under consideration is represented by a level set function, which is driven by the objective's shape gradient. The state is computed by the finite element method where the underlying triangulation is constructed by means of a marching cubes algorithm. We show that the combination of these tools lead to an efficient solver for general shape optimization problems.     

On the asymptotic free boundary for the American put option problem

In practical work with American put options, it is important to be able to know when to exercise the option, and when not to do so. In computer simulation based on the standard theory of geometric Brownian motion for simulating stock price movements, this problem is fairly easy to handle for options with a short lifespan, by analyzing binomial trees. It is considerably more challenging to make the decision for American put options with long lifespan. In order to provide a satisfactory analysis, we look at the corresponding free boundary problem, and show that the free boundary—which is the curve that separates the two decisions, to exercise or not to—has an asymptotic expansion, where the coefficient of the main term is expressed as an integral in terms of the free boundary. This raises the perspective that one could use numerical simulation to approximate the integral and thus get an effective way to make correct decisions for long life options.     

A free boundary problem related to thermal insulation

We study a free boundary problem arising from the theory of thermal insulation. The outstanding feature of this set optimization problem is that the boundary of the set being optimized is not a level surface of a harmonic function, but rather a hypersurface along which a harmonic function satisfies a Robin condition. We show that minimal sets exist, satisfy uniform density estimates, and, under some geometric conditions, have “locally flat” boundaries.     

Global fast and slow solutions of a localized problem with free boundary

In this paper,we consider a localized problem with free boundary for the heat equation in higher space dimensions and heterogeneous environment.For simplicity,we assume that the environment and solution are radially symmetric.First,by using the contraction mapping theorem,we prove that the local solution exists and is unique.Then,some sufficient conditions are given under which the solution will blow up in finite time.Our results indicate that the blowup occurs if the initial data are sufficiently large.Finally,the long time behavior of the global solution is discussed.It is shown that the global fast solution does exist if the initial data are sufficiently small,while the global slow solution is possible if the initial data are suitably large.     

Enhanced Euler's method to a free boundary porous media flow problem

We study an ODE‐based iterative method, the residual velocity method, for steady state free boundary problems. The convergence analysis of the method, as well as the numerical implementation based on Euler's method were provided by Donaldson and Wetton (J Appl Math 71 (2006), 877–897). In this article, we develop an enhanced Euler's method which is nearly as simple as the modified Euler's method but can achieve a rapid convergence rate similar to the fourth‐order Runge‐Kutta method. Numerical results are also provided to verify the validity of our method. © 2011 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2012