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Lin Yu Yong‐Qiang Ma Guo‐Cang Wang Hai‐Bin Song Hong‐Geng Wang Jin‐Shan Li Jing‐Rong Cui Rui‐Qing Wang 《应用有机金属化学》2004,18(4):187-190
A series of triarylbismuth(V) di(N‐p‐toluenesulfonyl)aminoacetates with the formula (4‐CH3C6H4SO2NHCH2CO2)2BiAr3 (Ar?C6H5, 4‐CH3C6H4, 4‐ClC6H4, 4‐BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of (4‐CH3C6H4SO2NHCH2CO2)2Bi(C6H4Cl‐4)3 was determined and shows the bismuth to exist in a distorted trigonal bipyramidal geometry. Four human neoplastic cell lines (HL‐60, PC‐3MIE8, BGC‐823 and MDA‐MB‐435) were used to screen these compounds. The results indicate that these compounds at 10 μM show cytotoxicity. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
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《Acta Crystallographica. Section C, Structural Chemistry》2018,74(2):146-151
The mechanisms of interaction of inorganic complexes with DNA are important in the design and development of new metal‐based drug molecules. The limitations of cis‐platin have encouraged the design and development of new metal‐based target‐specific anticancer drugs having reduced side effects. The complex cis‐dichloridobis(1,2,5‐thiadiazolo[3,4‐f][1,10]phenanthroline‐κ2N1,N10)copper(II), [CuCl2(C12H6N4S)2], has been synthesized and characterized. The complex crystallizes in the monoclinic space group C2/c. The covalent binding of the complex with DNA was studied by absorption spectroscopy. The anticancer activity of the complex on the Human Lung Carcinoma (A549) cell line was investigated by MTT assay. The complex exhibits higher toxicity than cis‐platin and induces an apoptotic mode of cell death. 相似文献
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Sinyashin O. G. Gorshunov I. Yu. Milukov V. A. Batyeva E. S. Litvinov I. A. Kataeva O. N. Ginzburg A. G. Sokolov V. I. 《Russian Chemical Bulletin》1994,43(6):1054-1057
Cp(CO)2Mn · THF reacts in THF with thiosters of phosphorus acid, P(SR)3, to give new complexes Cp(CO)2MnP(SR)3 in which the manganese atom is coordinated to the phosphorus atom. The X-ray crystal structure of compounds with R = Pri and Ph was established. The metal atom has a coordination enviroment of the three-legged piano stool type. The bond angles OC-Mn-CO and OC-Mn-P are 90.6–95.9(4)°. Bond distances are: Mn-P 2.188(2) and 2.171(2) E, P-S 2.097(3)-2.137(3) E.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1116–1119, June, 1994.This work was carried out with financial support from the Russian Foundation for Basic Research (Project No.93-03-5830). 相似文献
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The salt [(CH3)4N]2[Sb6O4(NCS)12] is the first identified thiocyanato-oxy-antimonate(III) complex. Reported are details of the synthesis, relevant infrared data and its x-ray structure. The compound crystallizes in the triclinic space group P1 with Z = 2 (C10H12N7O2S6Sb3) and unit cell dimensions a = 11.314(6), b = 12.846(3), c = 8.679(2) Å; α = 91.93(3)°, β = 90.31(3)° and γ = 99.13(3)°. It contains centrosymmetric [Sb6O4(NCS)12]2? anions packed with isolated tetramethyl-ammonium cations. The fundamental structural element of the anion is provided by the fusion of three SbOSbO rings forming a zig-zag portion of a ribbon, only slightly pleated. Peculiar is the unequivalence of the six thiocyanate ligands, though all primarily N-bonded to antimony atoms. Three thiocyanates are terminal while other three are asymmetrically N-bridging between two centers; two of this latter type are also interconnecting the anions via Sb???S contacts. There are three different antimony environments, the primary bonding at Sb being to one nitrogen and three oxygens, to one oxygen and three nitrogens and to two atoms of each type. 相似文献
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以3-氨基吡嗪-2-羧酸为配体合成了一个钴的单核配合物Co(3-apac)2(H2O)2(1)(3-apac:3 -氨基吡嗪-2-羧酸),并利用元素分析、红外光谱、单晶X-射线衍射以及热重分析对配合物(1)进行了表征.晶体学数据:单斜晶系,C2/c空间群,a=7.8881 (11)(A),b=12.7560(18)(A... 相似文献
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《Journal of Coordination Chemistry》2012,65(18):3174-3187
Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl2(L)] (2), [BuSnCl2(L)] (3), [Me2SnCl(L)] (4), and [Ph2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies. The molecular structure of 5 was also determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and the central tin(IV) atom is six-coordinate in distorted octahedral geometry. The ligand (1) and complexes were screened for their in vitro antibacterial activities. The cytotoxic activities of 1–5 were tested against A2780 and A2780/Cp8 cancer cell lines. The compounds have better antibacterial activities than the free ligand; 2–5 are more potent cytotoxic agents than 1, while the diphenyltin(IV) 5 is more active with IC50 values of 0.05 and 0.54?µmol?L?1 against A2780 and A2780/Cp8 cell lines, respectively. 相似文献
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Run‐Chang Liu Yong‐Qiang Ma Lin Yu Jin‐Shan Li Jing‐Rong Cui Rui‐Qing Wang 《应用有机金属化学》2003,17(9):662-668
A series of arylantimony ferrocenecarboxylates with the formula (C5H5FeC5H4CO2)nSbAr(5?n) (n = 1, 2; Ar = C6H5, 4‐CH3C6H4, 3‐CH3C6H4, 2‐CH3C6H4, 4‐ClC6H4, 4‐FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H4CO2)2Sb(4‐CH3C6H4)3 and C5H5FeC5H4CO2SbPh4 were determined by X‐ray diffraction. Four human neoplastic cell lines (HL‐60, Bel‐7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 µM show certain in vitro antitumor activities. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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Greta Balan Olga Burduniuc Irina Usataia Vasilii Graur Yurii Chumakov Peter Petrenko Valentin Gudumac Aurelian Gulea Elena Pahontu 《应用有机金属化学》2020,34(3):e5423
New zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL)2]I2 (1) , [Cu (HL)Cl2] (2) , [Cu (HL)Br2] (3) , [Cu (HL)(H2O)2](ClO4)2 (4) , [Ni (HL)2]I2·H2O (5) , [Co(L)2]Cl (6) , [Co(L)2]NO3 (7) , [Co(L)2]I·[Co(L)2](I3) (8) were obtained with 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone ( HL ). The isothiosemicarbazone ligand was characterized by NMR (1H and 13C), IR spectroscopy and X-ray diffraction. All the complexes were characterized by elemental analysis, IR, UV–Vis, ESI-MS spectroscopy, molar conductivity, magnetic susceptibility measurements. X-ray diffraction analysis on the monocrystal and powder elucidated the structure of the complexes 1 , 5 , 7 and 8 . The ligand and the complexes were tested for their antioxidant and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans. Also, the antiproliferative properties of these compounds on human leukemia HL-60, human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cells and normal MDCK cells have been investigated. The nickel complex 5 and cobalt complexes 6 , 7 showed promising antiproliferative activity and low toxicity. 相似文献
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M. A. Salam Mahbubul Alam Sohug Sarker Mohammed M. Rahman 《Journal of Coordination Chemistry》2018,71(10):1593-1605
Three new diorganotin(IV) complexes, [Me2Sn(BDET] (2), [Bu2Sn(BDET)] (3), and [Ph2Sn(BDET)] (4), were synthesized by reacting R2SnCl2 (R = Me, Bu, and Ph) with 5-bromo-2-hydroxybenzaldehyde-N(4)-ethylthiosemicarbazone [H2BDET, (1)] in the presence of KOH in absolute methanol. The newly synthesized complexes were characterized by elemental analysis, molar conductivity, UV–vis, FT-IR, 1H, 13C, and 119Sn NMR spectroscopies. The molecular structure of 4 was confirmed by X-ray crystallography. X-ray crystallography revealed that the doubly deprotonated O,N,S-tridentate thiosemicarbazone coordinates to tin(IV), resulting in a distorted trigonal bipyramidal geometry. Their 1H, 13C, and 119Sn NMR spectra support a five-coordinate tin(IV) in solution for all complexes, in accord with the solid-state X-ray structure determined for 4. Compounds 1–4 were evaluated for their antibacterial activities against Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli, and Salmonella typhi. The results exhibited that 2–4 were active with comparable potency compared to the standard drug. Antibacterial studies also indicated that the complexes have potential for biological evaluation. 相似文献
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在乙醇钠存在下三苯基氯化锡或三苄基氯化锡水解得羟化三苯基锡 (1)或 (双三苄基锡 )氧化物 (2 )。其结构经元素分析、IR和1HNMR表征 ,X 射线单晶衍射测定了其晶体结构。 1为正交晶系 ,空间群P2 1/n,a =0 .830 0 0 (19)nm ,b =1.0 36 5 (2 )nm ,c =1.80 2 6 (4 )nm ,β =95 .4 72 (7)°,Z =4 ,V =1.5 5 0 7(6 )nm3 ,Dc=1.5 72g·cm -3 ,μ=1.6 4 0mm -1,F(0 0 0 ) =72 8,R1=0 .0 30 9,WR2 =0 .0 70 6 ,中心锡原子为五配位的三角双锥构型 ,且通过配位氧原子连成无限链状。 2为正交菱面体晶系 ,空间群R3 ,a =b =c =0 .96 36 (3)nm ,α =β =γ =84 .0 85 (3)° ,Z =1,V =0 .8812 (4 )nm3 ,Dc=1.5 0 8g·cm -3 ,μ =1.4 4 8mm -1,F(0 0 0 ) =4 0 2 ,R1=0 .0 36 0 ,WR2 =0 .0 5 4 2 ,由两个中心锡原子组成一个结构单元的四配位线性聚合体。 相似文献
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A Waugh type polyoxometalate H12[MnMo9O32(KO)6] has been synthesized and characterized by single crystal X-ray diffraction, IR, XRD and TG. The compound was crystallized
in the trigonal system, space group R3 with a = 15.5380(6) nm, b = 15.5380(6) nm, c = 12.3777(5) nm, α = 90°, β = 90°, γ = 120°, V = 2587.98(18) nm3, Z = 3, R
1 = 0.0134, θR
2 = 0.0308. The catalytic activity of the title compound for the dehydration of cyclohexanol was determined. The conversion
of C6H11OH reached 69.56% and the selectivity of C6H10 was 96% when the amount of catalyst, temperature range and reaction time were 6.59%, 170°C–180°C, 30 min, respectively.
Translated from Chinese Journal of Applied Chemistry, 2006, 23(9): 1000–1005 (in Chinese) 相似文献
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《Journal of Coordination Chemistry》2012,65(9):1546-1554
Nickel complex formulated as Ni(L)2 (L = monodeprotonated ligand corresponding to 2-acetylpyridine N(4)-methylthiosemicarbazone, HL) has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The complex consists of discrete monomeric molecules with octahedral nickel(II) with two anionic 2-acetylpyridine N(4)-methylthiosemicarbazones as NNS tridentate ligands coordinated to nickel via the pyridine nitrogen, azomethine nitrogen, and sulfur. Hydrogen bonds link the different components to stabilize the crystal structure. Biological studies, carried out in vitro against bacteria, fungi, and the K562 leukemic cell line have shown that the free ligand and complex show distinct differences in biological activity. 相似文献
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用三苯基氯化锡与1,5-戊二酸二钠以2:1摩尔比反应,合成了1,5-戊二酸 双(三苯基锡)酯,并进行了红外光谱、核磁共振氢谱及质谱表征。X射线单晶衍 射表明,该化合物属正交晶系,空间群C222(1),晶胞参数:a=1.5075(5)nm, b=4.8021(17)nm,c=2.8944(9)nm,α=90°,β=90°,γ=90°,V=20.953(12) nm^3,Z=8,Dc=1.316g/cm^3,μ=1.226mm^-1,F(000)=8280,R1=0.0546,wR2=0. 1182。晶体结构中存在5种化学环境不同的三角双锥构型的锡原子,由于配体中两 个羧基在不同方向的交联作用,使化合物呈现三维骨架结构,并且在骨架结构中存 在沿a轴和c轴方向伸展的规则的大环直孔道。 相似文献
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Afshin Saadat Patrick McArdle 《Phosphorus, sulfur, and silicon and the related elements》2016,191(10):1313-1317
The reaction of 2,4-bis (4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson’s reagent) with phenylethylamine produced [H3NCH2CH2C6H5]+ [(C6H5CH2CH2NH)(p C6H4OMe)PS2]? (1). Furthermore, reaction of 1 with NiCl2 in dry methanol led to the novel complex 2. The compounds were characterized by 1H and 31P NMR, IR spectroscopy, and elemental analysis. A single crystal X-ray structure of complex 2 showed that the nickel complex is square planar. The complex formed a supramolecular structure via intermolecular S1…H7B and O1…H2N2 hydrogen bonds. The X-ray crystallography of complex showed [R22](18) and R44(18) motifs in the monomers were connected to each other via S1…H7B, O1…H2N2 hydrogen bonds with donor–acceptor distance of 2.89 and 2.51 Å, respectively. The new compounds were additionally tested in view of their antibacterial properties. 相似文献