Analysis of correlated binary data under partially linear single-index logistic models

Clustered data arise commonly in practice and it is often of interest to estimate the mean response parameters as well as the association parameters. However, most research has been directed to address the mean response parameters with the association parameters relegated to a nuisance role. There is relatively little work concerning both the marginal and association structures, especially in the semiparametric framework. In this paper, our interest centers on the inference of both the marginal and association parameters. We develop a semiparametric method for clustered binary data and establish the theoretical results. The proposed methodology is investigated through various numerical studies.     

Prospective and retrospective analyses under logistic regression models

In logistic case-control studies, Prentice and Pyke (Biometrika 66 (1979) 403-411) showed that valid point estimators of the odds-ratio parameters and their standard errors may be obtained by fitting the prospective logistic regression model to case-control data. Wang and Carroll (Biometrika 80 (1993) 237-241; J. Statist. Plann. Inference 43 (1995) 331-340) generalized Prentice and Pyke's (Biometrika 66 (1979) 403-411) results to robust logistic case-control studies. In this paper, we extend the results of Prentice and Pyke (Biometrika 66 (1979) 403-411) and Wang and Carroll (Biometrika 80 (1993) 237-241; J. Statist. Plann. Inference 43 (1995) 331-340) to a class of statistics and a class of unbiased estimating equations. We present some results on simulation and on the analysis of two real datasets.     

Likelihood-based kernel estimation in semiparametric errors-in-covariables models with validation data

We present methods to handle error-in-variables models. Kernel-based likelihood score estimating equation methods are developed for estimating conditional density parameters. In particular, a semiparametric likelihood method is proposed for sufficiently using the information in the data. The asymptotic distribution theory is derived. Small sample simulations and a real data set are used to illustrate the proposed estimation methods.     

Strong convergence in nonparametric regression with truncated dependent data

In this paper we derive rates of uniform strong convergence for the kernel estimator of the regression function in a left-truncation model. It is assumed that the lifetime observations with multivariate covariates form a stationary α-mixing sequence. The estimation of the covariate’s density is considered as well. Under the assumption that the lifetime observations are bounded, we show that, by an appropriate choice of the bandwidth, both estimators of the covariate’s density and regression function attain the optimal strong convergence rate known from independent complete samples.     

Empirical likelihood inference in partially linear single-index models for longitudinal data

The empirical likelihood method is especially useful for constructing confidence intervals or regions of parameters of interest. Yet, the technique cannot be directly applied to partially linear single-index models for longitudinal data due to the within-subject correlation. In this paper, a bias-corrected block empirical likelihood (BCBEL) method is suggested to study the models by accounting for the within-subject correlation. BCBEL shares some desired features: unlike any normal approximation based method for confidence region, the estimation of parameters with the iterative algorithm is avoided and a consistent estimator of the asymptotic covariance matrix is not needed. Because of bias correction, the BCBEL ratio is asymptotically chi-squared, and hence it can be directly used to construct confidence regions of the parameters without any extra Monte Carlo approximation that is needed when bias correction is not applied. The proposed method can naturally be applied to deal with pure single-index models and partially linear models for longitudinal data. Some simulation studies are carried out and an example in epidemiology is given for illustration.     

Nonparametric regression function estimation with surrogate data and validation sampling

This paper develops estimation approaches for nonparametric regression analysis with surrogate data and validation sampling when response variables are measured with errors. Without assuming any error model structure between the true responses and the surrogate variables, a regression calibration kernel regression estimate is defined with the help of validation data. The proposed estimator is proved to be asymptotically normal and the convergence rate is also derived. A simulation study is conducted to compare the proposed estimators with the standard Nadaraya-Watson estimators with the true observations in the validation data set and the complete observations, respectively. The Nadaraya-Watson estimator with the complete observations can serve as a gold standard, even though it is practically unachievable because of the measurement errors.     

An empirical likelihood approach to data analysis under two-stage sampling designs

A new empirical likelihood approach is developed to analyze data from two-stage sampling designs, in which a primary sample of rough or proxy measures for the variables of interest and a validation subsample of exact information are available. The validation sample is assumed to be a simple random subsample from the primary one. The proposed empirical likelihood approach is capable of utilizing all the information from both the specific models and the two available samples flexibly. It maintains some nice features of the empirical likelihood method and improves the asymptotic efficiency of the existing inferential procedures. The asymptotic properties are derived for the new approach. Some numerical studies are carried out to assess the finite sample performance.     

Statistical inference for the index parameter in single-index models

In this paper, we are concerned with statistical inference for the index parameter in the single-index model . Based on the estimates obtained by the local linear method, we extend the generalized likelihood ratio test to the single-index model. We investigate the asymptotic behaviour of the proposed test and demonstrate that its limiting null distribution follows a χ²-distribution, with the scale constant and the number of degrees of freedom being independent of nuisance parameters or functions, which is called the Wilks phenomenon. A simulated example is used to illustrate the performance of the testing approach.     

Consistency of the generalized MLE of a joint distribution function with multivariate interval-censored data

Wong and Yu [Generalized MLE of a joint distribution function with multivariate interval-censored data, J. Multivariate Anal. 69 (1999) 155-166] discussed generalized maximum likelihood estimation of the joint distribution function of a multivariate random vector whose coordinates are subject to interval censoring. They established uniform consistency of the generalized MLE (GMLE) of the distribution function under the assumption that the random vector is independent of the censoring vector and that both of the vector distributions are discrete. We relax these assumptions and establish consistency results of the GMLE under a multivariate mixed case interval censorship model. van der Vaart and Wellner [Preservation theorems for Glivenko-Cantelli and uniform Glivenko-Cantelli class, in: E. Gine, D.M. Mason, J.A. Wellner (Eds.), High Dimensional Probability, vol. II, Birkhäuser, Boston, 2000, pp. 115-133] and Yu [Consistency of the generalized MLE with multivariate mixed case interval-censored data, Ph.D Dissertation, Binghamton University, 2000] independently proved strong consistency of the GMLE in the L₁(μ)-topology, where μ is a measure derived from the joint distribution of the censoring variables. We establish strong consistency of the GMLE in the topologies of weak convergence and pointwise convergence, and eventually uniform convergence under appropriate distributional assumptions and regularity conditions.     

Empirical likelihood for linear models under negatively associated errors

In this paper, we discuss the construction of the confidence intervals for the regression vector β in a linear model under negatively associated errors. It is shown that the blockwise empirical likelihood (EL) ratio statistic for β is asymptotically χ²-type distributed. The result is used to obtain an EL based confidence region for β.     

Thresholding projection estimators in functional linear models

We consider the problem of estimating the regression function in functional linear regression models by proposing a new type of projection estimators which combine dimension reduction and thresholding. The introduction of a threshold rule allows us to get consistency under broad assumptions as well as minimax rates of convergence under additional regularity hypotheses. We also consider the particular case of Sobolev spaces generated by the trigonometric basis which permits us to get easily mean squared error of prediction as well as estimators of the derivatives of the regression function. We prove that these estimators are minimax and rates of convergence are given for some particular cases.     

Probability density estimation for survival data with censoring indicators missing at random

In this paper, some nonparametric approaches of density function estimation are developed when censoring indicators are missing at random. A conditional mean score based estimator and a mean score estimator are suggested, respectively. The two estimators are proved to be asymptotically normal and uniformly strongly consistent. The bandwidth selection problem is also discussed. A simulation study is conducted to compare finite-sample behaviors of the proposed estimators.     

Confidence intervals for marginal parameters under fractional linear regression imputation for missing data

Item nonresponse occurs frequently in sample surveys and other applications. Imputation is commonly used to fill in the missing item values in a random sample {Y_i;i=1,…,n}. Fractional linear regression imputation, based on the model with independent zero mean errors ?_i, is used to create one or more imputed values in the data file for each missing item Y_i, where {X_i,i=1,…,n}, is observed completely. Asymptotic normality of the imputed estimators of the mean μ=E(Y), distribution function θ=F(y) for a given y, and qth quantile θ_q=F^-1(q),0<q<1 is established, assuming that Y is missing at random (MAR) given X. This result is used to obtain normal approximation (NA)-based confidence intervals on μ,θ and θ_q. In the case of θ_q, a Bahadur-type representation and Woodruff-type confidence intervals are also obtained. Empirical likelihood (EL) ratios are also obtained and shown to be asymptotically scaled variables. This result is used to obtain asymptotically correct EL-based confidence intervals on μ,θ and θ_q. Results of a simulation study on the finite sample performance of NA-based and EL-based confidence intervals are reported.     

Oracally efficient spline smoothing of nonlinear additive autoregression models with simultaneous confidence band

Under weak conditions of smoothness and mixing, we propose spline-backfitted spline (SBS) estimators of the component functions for a nonlinear additive autoregression model that is both computationally expedient for analyzing high dimensional large time series data, and theoretically reliable as the estimator is oracally efficient and comes with asymptotically simultaneous confidence band. Simulation evidence strongly corroborates with the asymptotic theory.     

Likelihood and conditional likelihood inference for generalized additive mixed models for clustered data

Lin and Zhang (J. Roy. Statist. Soc. Ser. B 61 (1999) 381) proposed the generalized additive mixed model (GAMM) as a framework for analysis of correlated data, where normally distributed random effects are used to account for correlation in the data, and proposed to use double penalized quasi-likelihood (DPQL) to estimate the nonparametric functions in the model and marginal likelihood to estimate the smoothing parameters and variance components simultaneously. However, the normal distributional assumption for the random effects may not be realistic in many applications, and it is unclear how violation of this assumption affects ensuing inferences for GAMMs. For a particular class of GAMMs, we propose a conditional estimation procedure built on a conditional likelihood for the response given a sufficient statistic for the random effect, treating the random effect as a nuisance parameter, which thus should be robust to its distribution. In extensive simulation studies, we assess performance of this estimator under a range of conditions and use it as a basis for comparison to DPQL to evaluate the impact of violation of the normality assumption. The procedure is illustrated with application to data from the Multicenter AIDS Cohort Study (MACS).     

Depth estimators and tests based on the likelihood principle with application to regression

We investigate depth notions for general models which are derived via the likelihood principle. We show that the so-called likelihood depth for regression in generalized linear models coincides with the regression depth of Rousseeuw and Hubert (J. Amer. Statist. Assoc. 94 (1999) 388) if the dependent observations are appropriately transformed. For deriving tests, the likelihood depth is extended to simplicial likelihood depth. The simplicial likelihood depth is always a U-statistic which is in some cases not degenerated. Since the U-statistic is degenerated in the most cases, we demonstrate that nevertheless the asymptotic distribution of the simplicial likelihood depth and thus asymptotic α-level tests for general types of hypotheses can be derived. The tests are distribution-free. We work out the method for linear and quadratic regression.     

Estimation in generalized linear models for functional data via penalized likelihood

We analyze in a regression setting the link between a scalar response and a functional predictor by means of a Functional Generalized Linear Model. We first give a theoretical framework and then discuss identifiability of the model. The functional coefficient of the model is estimated via penalized likelihood with spline approximation. The L² rate of convergence of this estimator is given under smoothness assumption on the functional coefficient. Heuristic arguments show how these rates may be improved for some particular frameworks.     

On a new multivariate two-sample test

In this paper we propose a new test for the multivariate two-sample problem. The test statistic is the difference of the sum of all the Euclidean interpoint distances between the random variables from the two different samples and one-half of the two corresponding sums of distances of the variables within the same sample. The asymptotic null distribution of the test statistic is derived using the projection method and shown to be the limit of the bootstrap distribution. A simulation study includes the comparison of univariate and multivariate normal distributions for location and dispersion alternatives. For normal location alternatives the new test is shown to have power similar to that of the t- and T²-Test.     

A generalized Hollander-Proschan type test for NBUE alternatives

In this note we develop a family of test statistics for testing exponentiality against NBUE alternatives. The asymptotic distribution of the test statistics is derived. The test statistics are shown to be asymptotically normal and consistent. This family of test statistics includes the test proposed by Hollander and Proschan (1975) as a special case. Efficiency studies have also been done.