共查询到20条相似文献,搜索用时 11 毫秒
1.
E. M. Keshk A. A. Abu-Hashem M. M. Girges A. H. Abdel-Rahman F. A. Badria 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1577-1593
Benzo[1,2-b:5,4-b′]difuran-2-carbohydrazides 5a, b were reacted with aryl or alkyl isothiocyanates to give the corresponding thiosemicarbazides 6a–h. Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of benzo[1,2-b:5,4-b′]difuranyl-1,3,4-triazoles 7a–f. Desulfurization of thiosemicarbazides by mercuric oxide gave benzo[1,2-b:5,4-b′]difuranyl-1,3,4-oxadiazoles 8a–f. Treatment of thiosemicarbazides with ethyl bromoacetate or α-bromopropionic acid yielded benzo[1,2-b:5,4-b′]difuranyl-carbonyl-hydrazono-4-thiazolidinones 9a–f and 10a–f, respectively. Furthermore, the reaction of the thiosemicarbazides with phosphorus oxychloride gave benzo[1,2-b:5,4-b′]difuranyl-1,3,4-thiadiazoles 11a–f. Some compounds in this study were biologically evaluated for their ability to bind to DNA. 相似文献
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T. R. Hovsepian E. R. Dilanian A. P. Engoyan R. G. Melik-Ohanjanian 《Chemistry of Heterocyclic Compounds》2004,40(9):1194-1198
The cyclization of 4-substituted 1-arylacetyl- and 1-aryloxyacetylthiosemicarbazides and also the potassium salt of (4-bromophenoxy)acetodithiocarbazinic acid in the presence of base gives the novel 3-arylmethyl- and 3-aryloxymethyl-5-mercapto-1,2,4-triazoles and, in the presence of concentrated H2SO4, the novel 5-substituted 2-arylmethyl- and 2-aryloxymethyl-1,3,4-thiadiazoles. 相似文献
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E. R. Dilanyan T. R. Hovsepyan R. G. Melik-Ohanjanyan 《Chemistry of Heterocyclic Compounds》2008,44(11):1395-1397
New S-substituted 1,2,4-triazole and 1,3,4-thiadiazole derivatives have been prepared.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1712–1715, November, 2008. 相似文献
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S. M. Golovlyova Yu. A. Moskvichev E. M. Alov D. B. Kobylinsky V. V. Ermolaeva 《Chemistry of Heterocyclic Compounds》2001,37(9):1102-1106
A series of novel substituted 1,3,4-oxa(thia)diazoles and triazoline-3-thiones has been synthesized from thiosemicarbazides and nitriles of arylthio-, arylsulfonylacetic and -propionic acids. A mechanism is proposed for the preparation of 2-amino-5-substituted 1,3,4-thiadiazoles from carboxylic acids in polyphosphoric acid medium. 相似文献
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Data on the production methods and structure of triazole, tetrazole, dioxazole, oxadiazole, and thiadiazole aldoximes and
ketoximes and their derivatives are reviewed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 803–816, June, 2008. 相似文献
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M. E. Azab H. M. F. Madkour M. A. E. Ibraheem 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):1299-1313
Because of being a versatile synthon, the title compound 2 was utilized to construct different heterocyclic systems including pyrazol-4-carbonitrile 3, pyrazolone 4, triazole-5(4H)-thione 7, aminotriazole 9, oxadiazoles 10 and 12, thiazolidine 13, and oxatriazole 14. All new synthesized compounds were structurally confirmed by elemental analyses and spectroscopic data. 相似文献
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Data on the reactions of triazole, tetrazole, dioxazole, oxadiazole, and thiadiazole aldoximes, ketoximes, and amidoximes,
their synthesis, and the reactions of their derivatives are reviewed. The synthesis of new heterocycles based on the oximes
of five-membered heterocyclic compounds with three and four heteroatoms is examined separately. The principal results from
investigation of the biological activity of ethers of these oximes are also presented.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 963–990, July, 2008. 相似文献
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Nosrat O. Mahmoodi Fateme Ghanbari Pirbasti 《Phosphorus, sulfur, and silicon and the related elements》2016,191(6):811-843
Thiazoles are important heterocyclic compounds which have many biological activities and different applications such as useful ligands, in optical sensors, etc. A literature survey shows that there are different routes to thiazoles. One of the most frequently used synthetic approaches consists of a reaction between α-halocarbonyl compounds with a CSNH2 moiety. In this mini-review we have classified the contents based on the reagent or material providing the sulfur atom of the thiazole ring. Also, among many articles which have been devoted to thiazole syntheses here we presented some synthetic approaches published from 2012 to 2014. 相似文献
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将2-巯基-5-取代基-1,3,4-噻二唑经与β-氯苯丙酮取代、盐酸羟胺肟化和氯甲基噁二唑醚化,合成了6种3-(5-取代基-1,3,4-噻二唑-2-硫代基)-1-苯基丙酮-O-(5-苯基-1,3,4-噁二唑-2-甲基)肟醚化合物(4a~4f),用1H NMR、IR、MS和元素分析表征了其结构。 用MTT法测试了6种目标化合物对人黑色素瘤细胞株B16、人白血病细胞株HL60和人肝癌细胞株SMMC-7721的体外细胞毒活性。 测试结果表明,部分化合物对3种癌细胞具有潜在的体外生长抑制活性。 相似文献
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Wagnat W. Wardakhan Nahed N. E. El-Sayed 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):790-804
The thiosemicarbazide derivatives 3a and 3b were cyclized in the presence of concentrated sulfuric acid to give the 5-cyanomethyl-1,3,4-thiadiazole derivatives 4a and 4b , respectively. The latter products were used for many heterocyclic transformations to form coumarin, 1,3,4-thiadiazolo[4,5-a]pyridine, and 5-thiophenylthiophene. In addition, compound 3b underwent cyclization in NaOH (2 N) solution to give the 1,2,4-triazole derivative 16 . The reactivity of the latter product towards some chemical reagents was studied. The antimicrobial activities of the newly synthesized products were measured and showed high activities. 相似文献
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Coumarins are natural heterocycles that widely contribute to the design of various biologically active compounds. Fusing different aromatic heterocycles with coumarin at its 3,4-position is one of the interesting approaches to generating novel molecules with various biological activities. During our continuing interest in assembling information about fused five-membered aromatic heterocycles, and after having presented mono-hetero-atomic five-membered aromatic heterocycles in Part I. The current review Part II is intended to present an overview of the different synthetic routes to coumarin (benzopyrone)-fused five-membered aromatic heterocycles with multi-heteroatoms built on the pyrone ring, covering the literature from 1945 to 2021. 相似文献
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为了探索高效低毒、环境友好的新型杀菌剂,本文设计合成系列含有苯磺酰胺片段的1,2,4-三唑和噻二唑类化合物。所有目标化合物的结构由核磁共振波谱、质谱和元素分析确认。离体抑菌活性测试结果表明,部分化合物对7种常见植物病原真菌表现出不同的抑制作用,其中化合物10a、10g和10n对水稻恶苗病菌的抑制活性较高为48.6%,接近商品化杀菌剂嘧菌酯(52.9%)。以上结果可能为后续的分子设计提供依据。 相似文献
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The current work aims to design and synthesis a new series of isatin derivatives and greatly enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino (pyridine) methyl) indolin-2-one, 2-((oxoindoline) amino) benzoic acid, 3-(thiazolo-imino) indolinone, ethyl-2-((oxoindolin-3-ylidene)amino)-benzothiophene-3-carboxylate, 1-(oxoindoline)-benzo[4,5] thieno [2,3-d]pyrimidin-4(1H)-one, ethyl-2-(2-oxoindoline) hydrazine-1-carboxylate, N-(mercapto-oxo-pyrimidine)-2-(oxoindoline) hydrazine-1-carboxamide, N-(oxo-thiazolo[3,2-a] pyrimidine)-2-(oxoindolin-ylidene) hydrazine-carboxamide, 3-((amino-phenyl) amino)-3-hydroxy- indolinone, 3-((amino-phenyl) imino)-indolinone, 2-(2-((oxoindoline) amino) phenyl) isoindolinone, 2-(oxoindoline) hydrazine-carbothioamide, 5′-thioxospiro[indoline-3,3′-[1,2,4]triazolidin]-one, 5′-amino-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one and 3-((2-thioxo-imidazo[4,5-b]quinoxaline) imino) indolinone were synthesized from the starting material 1-(morpholino (pyridine) methyl) indoline-2,3-dione and evaluated for their in vitro cytotoxic activity against carcinogenic cells. The new chemical structures were evidenced using spectroscopy (IR, NMR and MS) and elemental analysis. The results show that compounds imidazo[4,5-b]quinoxaline-indolinone, thiazolopyrimidine-oxoindoline, pyrimidine-oxoindoline-hydrazine-carboxamide, spiro[indoline-3,2′-[1,3,4] thiadiazol]-one and spiro[indoline-3,3′-[1,2,4]triazolidin]-one have excellent anti-proliferative activities against different human cancer cell lines such as gastric carcinoma cells (MGC-803), breast adenocarcinoma cells (MCF-7), nasopharyngeal carcinoma cells (CNE2) and oral carcinoma cells (KB). 相似文献