Alkaloids from the root barks of Goniothalamus cheliensis

（3S）-2-Oxo-5,12-dimethoxy-3-hydroxy-3-methylbenz[f]indoline （1）, a new benzoxindole alkaloid, along with two known alkaloids, was isolated from the root barks of Goniothalamus cheliensis Hu. The structure was elucidated by spectroscopic evidences, and the absolute configuration was determined by CD spectrum.     

Three New Styrylpyroncs from Goniothalamus leiocarpus

Goniolhalamusleiocarpus(Annonaceaefamily)isatropicalplantdistributedinsouthofYunnanprovinceofChina.Wehaveisolatedanewstyrylpypyrone--leiocarpinAlfromthestembarksofGoniothalamusleiocarpusandfourknownannonaceousacetogenins'fromtheseedsofthesameplant.Inthispaper,wereportedthreenewstyrylpyrones,named7epi-goniodioll,IeiocarpinB2andleiocarpinC3respectively.Theywereisolatedfromtheethanolicextractofstembarksoftheplantbyrepeatedlychromatographyofsilicacolumns.Theirstructureswereelucidatedbymeansofs…     

Two New Compounds from Goniothalamus Cheliensis Hu

Goniothalamus cheliensis Hu (Annonaceace) is a small tree or shrub in Yunnan Province, southwest of China. Acetogenins, styryllactones and alkaloids1-3 from the genus were reported in the previous literature and many of them showed strong cytotoxic activities against a number of human cancer cell lines4. The titled plant has been the subject of our investigation due to the impressive cytotoxicity of its organic extract against mouse lymphocytic leukemia cells in preliminary pharmacological s…     

Two New Styryllactones from Goniothalamus cheliensis

Two new styryllactones,iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone,were isolated from the roots of Goniothalamus cheliensis.Their structure were elucidated on the basis of spectroscopic and chemical evidences.     

Leiocyclocin A and B, Two Cyclopeptides from Goniothalamus leiocarpus

Ongoing phytochemical studies on Goniothalamus species have led to the isolation of a number of annonaceous acetogenins and unusual new styryllactones which were found to possess significant cytotoxic activities against several hunan tumour cell lines1,2. Firstly, cyclopeptides were reported to be isolated from genus Goniothalamus in this paper.Goniothalamus leiocarpus is an evergreen tree which grows in the south of Yunnan, China. Four new anticancer styryllactones3,4 from the stem bark and…     

Two New Alkaloids from Flueggea virosa

Two new securinega‐type alkaloids and four known ones were isolated from the twigs and leaves of Flueggea virosa. The structures of the new compounds were elucidated by means of spectroscopic methods (UV, IR, HR‐ESI‐MS, and 1D‐ and 2D‐NMR), and the absolute configurations were assigned by CD spectra. The structures of the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature.     

A Styrylpyrone Dimer from the Bark of Goniothalamus leiocarpus

A dimer of styrylpyrone derivative, leiocarpin E(1), was isolated from the bark of Goniothalamus leiocarpus. Its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested.     

Two New Nitrone Alkaloids from Huperzia serrata

Two new nitrone alkaloids were isolated from the whole plant of Huperzia serrata (Thunb .) Trev . They are both phlegmarine‐type lycopodium alkaloids with a nitrone moiety. Their structures were elucidated on the basis of spectral evidences, and their configurations were established on the basis of optical rotation, CD, and NOESY‐NMR data.     

Two New Iridoid Alkaloids,Daphmacropodosidines A and B,from Daphniphyllum macropodum

Two new iridoid alkaloids, daphmacropodosidines A ( 1 ) and B ( 2 ), together with two known ones, daphcalycinosidine B and caldaphnidine F, were isolated from the fruits of Daphniphyllum maropodum. Their structures were established by spectral methods, especially 2D NMR spectra (¹H,¹H‐COSY, HMQC, HMBC, and NOESY), as well as chemical means.     

Two New Norditerpenoid Alkaloids from Aconitum spicatum Stapf

Two new norditerpenoid alkaloids, spicatine A (1) and spicatine B (2) were isolated from the root of Aconitum spicatum. The new compounds were deduced on the basis of their spectral data (IR, HREIMS, EIMS, 1D, 2D-NMR). This is the first whole report on the isolation of diterpenoid alkaloids from the A.spicatum Stapf.     

Two new linear acetogenins from the fruits of Goniothalamus gracilipes

Two new linear acetogenins, gracilipin A (1) and methylsaccopetrin A (2) along with seven known compounds, saccopetrin A (3), 7,3′,4′-trimethylquercetin (4), rhamnazin (5), casticin (6), isokanugin (7), melisimplexin (8) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (9) were isolated from the fruits of Goniothalamus gracilipes Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds 1 and 3 showed cytotoxic activity against KB cell line with IC₅₀ values of 14.6 and 15.3 μM, respectively.     

Habaenines A and B,Two New Norditerpenoid Alkaloids from Aconitum habaense

Two new norditerpenoid alkaloids, habaenine A and B ( 1 and 2 ), together with two known compounds, were isolated from Aconitum habaense. The structures of the new compounds were elucidated on the basis of spectral analyses as (1α,6α,16β)‐8‐(acetyloxy)‐20‐ethyl‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐19‐oxoaconitan‐14‐yl 4‐methoxybenzoate ( 1 ) and (1α,6α,16β)‐8‐(acetyloxy)‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐aconitan‐14‐yl 4‐methoxybenzoate ( 2 ).     

Two New C20‐Diterpenoid Alkaloids from the Tibetan Medicinal Plant Aconitum naviculare Stapf

Two new C₂₀‐diterpenoid alkaloids named naviculine A ( 1 ) and naviculine B ( 2 ), were isolated from Aconitum naviculare Stapf . Their structures were established by spectral methods, especially 2D‐NMR spectra (¹H,¹H‐COSY, HMQC, HMBC, and NOESY) and DFT methods (at the B3LYP/6‐311++G(2d,p)//B3LYP/6‐31G(d) level), respectively. They were assayed for their anti‐HIV‐1 activity.     

Alkaloids from Ochrosia borbonica

Ten new monoterpenoid indole alkaloids, ochroborines A and B ( 1 and 2 , resp.), 10‐hydroxyisovallesiachotamine ( 3 ), 10‐hydroxyisositsirikine ( 4 ), 10,11‐dimethoxysitsirikine ( 5 ), 10‐methoxyapoyohimbine ( 6 ), 10‐hydroxyakuammidine ( 7 ), akuammidine 17‐O‐β‐D ‐glucoside ( 8 ), 15α‐hydroxyapparicine ( 9 ), and 15α‐hydroxy‐10‐methoxyapparicine ( 10 ), and 24 known alkaloids were isolated from leaves and twigs of Ochrosia borbonica J. F.Gmel . These structures were elucidated based on 1D‐ and 2D‐NMR, FT‐IR, UV, and MS data. 10‐Hydroxyisovallesiachotamine ( 3 ), ellipticine, and 10‐methoxyellipticine showed cytotoxic activities against five human cancer cell lines.     

Goniodilactone and gomoheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI₅₀S in the range of 1.29-4.56μg/mL.     

Palaeophytochemical Components from the Miocene‐Fossil Wood of Pinus Griffithii

Some Miocene‐fossil wood of Pinus griffithii preserved as lignified wood in brown coal was found in an open coalmine in Xundian of Yunnan Province, China. To explore its chemical components, here we show the palaeophytochemical investigation of this Pliocene‐fossil wood of P. armandii, resulting in the isolation of 11 compounds ( 1–11 ) including one new compound named 3,3‐dimethoxy‐24‐ethyl‐cholestan ( 1 ) by liquid column chromatography. Furthermore, sixteen volatiles were detected from this fossil wood by gas chromatography‐mass spectrometry (GC‐MS). These structures of 11 compounds were elucidated by analysis of their MS, 1D and 2D‐NMR spectra, and comparison with published data.     

New Diterpenoid Alkaloids from Delphinium Souliei Franch

Inourpreviouspapers'-',wehavereportedtheisolationandelucidationofaseriesofnewditerpenoidalkaloidsfromDelphinillnlsolllieiFranch.ContinuedphytochemcalinvestigationsontheconstituentsofthisplanthaveledtotheisolationoftwoothernewditerpenoidalkaloidssoulineE(l)andsoulineF(2).SoulineE(2.6mg)wasobtainedascolorlesscrystals,mpf77-78'C(fromethanol).[a]."8.0(c=0.05,CHCI;).itsmolecularformulaC,=H;,NO,wasderivedfromHkEIMS(M-f361.2613,cafe.361.2608).TheiHnmrspectrum(400MHz)exhibitedthefollowingsign…     

New Stephaoxocane Alkaloids from Stephania longa

Three new stephaoxocane‐type alkaloids, stephalonganines A–C ( 1 – 3 ), together with the known eletefine ( 4 ), were isolated from the whole plant of Stephania longa. Their structures were fully characterized spectroscopically, and the absolute configurations of the new alkaloids were assigned by comparison of their circular‐dichroism (CD) data with those of 1,2‐dihydrostephaoxocanine ( 5 ), in combination with 2D‐NMR experiments.