共查询到20条相似文献,搜索用时 994 毫秒
1.
Majid M. Heravi Hamideh Alinejhad Khadijeh Bakhtiari Hossein A. Oskooie 《Molecular diversity》2010,14(4):621-626
Three-component one-pot synthesis of some novel 10-aryl-7,7-dimethyl-6,7,8,10-tetrahydro-9H-[1,3]-dioxolo[4,5-b]xanthen-9-ones, which have not been published before, and 12-aryl-9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones from condensation of 3,4-methylenedioxyphenol or β-naphthol, aldehydes and dimedone under solvent-free conditions at 120 °C is reported. 相似文献
2.
Ghasem Marandi Malek T. Maghsoodlou Nourallah Hazeri Sayyed M. Habibi-Khorassani Niloufar Akbarzadeh Torbati Faramarz Rostami-Charati Brian W. Skelton Mohamed Makha 《Molecular diversity》2011,15(1):197-201
Abstract
In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields. 相似文献3.
A practical strategy was developed for the preparation of highly substituted 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-dichloro-5-formylpyrimidine, primary amines, and aldehydes. The key step for this synthesis entails a cyclization
reaction involving an intramolecular amide addition to an iminium intermediate formed in situ from 4-amino-pyrimidine-5-carboxamide
2 and aldehydes to form the pyrimido[4,5-d]pyrimidine core with a strategically placed 5-Cl group for further derivatization. The utility of this methodology was demonstrated
through the preparation of a 27-membered library of representative 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones in moderate to good yields. 相似文献
4.
Bita Baghernejad Majid M. Heravi Hossein A. Oskooie Nargess Poormohammad Maliheh Khorshidi Yahia Sh. Beheshtiha 《Molecular diversity》2011,15(1):245-248
Abstract
A simple and efficient synthesis of N-cyclohexyl-benzofuran derivatives was achieved via a one-pot three-component reaction of cyclohexylisocyanide, an aromatic aldehydes, and phenols in DMF for 10 h with good yields. 相似文献5.
An efficient diastereoselective synthesis of 7-ethyl 5,6-dialkyl 7H-[1,3]thiazolo[2,3-b][1,3]oxazin-5,6, 7-tricarboxylates and 2-ethyl 3,4-dialkyl 2H-[1,3]oxazino [2,3-b][1,3]benzothiazole-2,3,4-tricarboxylates via reaction of thiazole and benzothiazole with dialkyl acetylenedicarboxylates
in the presence of ethyl pyruvate is described. 相似文献
6.
Ayoob Bazgir Somayeh Ahadi Ramin Ghahremanzadeh Hamid Reza Khavasi Peiman Mirzaei 《Ultrasonics sonochemistry》2010,17(2):447-452
A simple, facile, efficient and three-component procedure for the synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,6′(1′H)-diones by the reaction of 4-hydroxycumarin, isatins and 1H-pyrazol-5-amines in water under ultrasonic irradiation is reported. The advantages of this method are the use of an inexpensive and readily available catalyst, easy work-up, good yields, and the use of water as a solvent that is considered to be relatively environmentally benign. 相似文献
7.
I?aki Galve Raimon Puig de la Bellacasa David Sánchez-García Xavier Batllori Jordi Teixidó José I. Borrell 《Molecular diversity》2012,16(4):639-649
A practical protocol was developed for the synthesis of 2-arylamino substituted 4-amino-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones from ??,??-unsaturated esters, malononitrile, and an aryl substituted guanidine via the corresponding 3-aryl-3,4,5,6- tetrahydropyrido[2,3-d]pyrimidin-7(8H)-ones. Such compounds are formed upon treatment of 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles with an aryl substituted guanidine in 1,4-dioxane and are converted to the desired 4-aminopyridopyrimidines with NaOMe/MeOH through a Dimroth rearrangement. The overall yields of this three-step protocol are, generally speaking, higher than the multicomponent reaction, previously developed by our group, between an ??,??-unsaturated ester, malononitrile, and an aryl substituted guanidine. 相似文献
8.
Yavari I Sabbaghan M Porshamsian K Bagheri M Ali-Asgari S Hossaini Z 《Molecular diversity》2007,11(2):81-85
Reaction of 1-aryl-3-arylcarbonylthioureas with dialkyl acetylenedicarboxylates in CH2Cl2 at room temperature leads to alkyl 2-[2-(arylcarbonylimino)-3-aryl-4-oxo-1,3-thiazolan-5-ylidene]-acetates in good yields. 相似文献
9.
Convenient synthetic procedures for 1,2,3,6,7, 11b-hexahydro-4H-pyrimido[6, 1 -a] isoquinolin-4-thiones and 2,3,6,7,12,12b-hexahydro-1H-pyrimido[1′,6′:1,2]pyrido[3,4-b]indole-4-thiones have been developed. Structural factors which influence on a cascade cyclization process have been elucidated. 相似文献
10.
Yana I. Sakhno Svetlana V. Shishkina Oleg V. Shishkin Vladimir I. Musatov Elena V. Vashchenko Sergey M. Desenko Valentin A. Chebanov 《Molecular diversity》2010,14(3):523-531
Heterocyclization reactions of pyruvic acids, aromatic aldehydes and 5-amino-N-aryl-1H-pyrazole-4-carboxamides yielding four different types of final compounds are described. The reactions involving arylidenpyruvic
acids lead with high degree of selectivity to either 4,7-dihydropyrazolo[1,5-a]pyrimidine-5-carboxylic acids or 5-[(2-oxo-2,5-dihydrofuran-3-yl)amino]-1H-pyrazoles, depending on the catalyst type or temperature regime. The interactions based on arylpyruvic acids can take place
under kinetic or thermodynamic control producing 7-hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-7-carboxylic acids or 3-hydroxy-1-(1H-pyrazol-5-yl)-1,5-dihydro-2H-pyrrol-2-ones, respectively. 相似文献
11.
Ahmad Shaabani Fatemeh Hajishaabanha Hamid Mofakham Ali Maleki 《Molecular diversity》2010,14(1):179-182
In this study, a three-component one-pot synthesis of new 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles derived from 2-amino-1,1,3-tricyanopropene, salicylic aldehydes and secondary cyclic amines is reported.
The reaction is conducted in ethanol at ambient temperature in good-to-excellent yields. 相似文献
12.
Maxim A. Nechayev Nikolay Yu. Gorobets Alexander V. Borisov Sergiy M. Kovalenko Andrey A. Tolmachev 《Molecular diversity》2012,16(4):749-757
A facile method for the synthesis of substituted pyrrolo[2,3-c]pyridine-7-ones is developed that applies an acid-promoted intramolecular cyclization of 2-pyrrolecarboxylic acid amidoacetals as key step. The synthesis is easily scaled up to 1.5?mol quantity with no yield decrease. The alkylation/arylation reaction of the pyrrolo[2,3-c]pyridine-7-ones proceeds regioselectively giving N6-substituted derivatives. 相似文献
13.
Mohammad Reza Nabid Seyed Jamal Tabatabaei Rezaei Ramin Ghahremanzadeh Ayoob Bazgir 《Ultrasonics sonochemistry》2010,17(1):159-161
Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign. 相似文献
14.
Gouvêa DP Bareño VD Bosenbecker J Drawanz BB Neuenfeldt PD Siqueira GM Cunico W 《Ultrasonics sonochemistry》2012,19(6):1127-1131
The efficient multicomponent synthesis of thiazolidinones from the reaction of arenealdehydes, mercaptoacetic acid and 2-picolilamine or 2-aminopyridine under ultrasound irradiation are reported. The reaction with 2-aminopyridine needs a Lewis acid catalysis to afford the corresponding 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones. All novel compounds were identified and characterized by (1)H and (13)C NMR spectra. Applying the sonochemical methodology, two series of heterocyclic thiazolidinones were synthesized in good yields after short reaction times. 相似文献
15.
Elisabete M. S. Castanheira M. Solange D. Carvalho Daniel J. G. Soares Paulo J. G. Coutinho Ricardo C. Calhelha Maria-João R. P. Queiroz 《Journal of fluorescence》2011,21(3):911-922
Fluorescence properties of four new potential antitumoral compounds, 3-arylbenzothieno[2,3-c]pyran-1-ones, were studied in solution and in lipid membranes of dipalmitoyl phosphatidylcholine (DPPC), egg yolk phosphatidylcholine
(Egg-PC) and dioctadecyldimethylammonium bromide (DODAB). The 3-(4-methoxyphenyl)benzothieno[2,3-c]pyran-1-one (1c) exhibits the higher fluorescence quantum yields in all solvents studied. All compounds present a solvent sensitive emission,
with significant red shifts in polar solvents for the methoxylated compounds. The results point to an ICT character of the
excited state, more pronounced for compound 1c. Fluorescence (steady-state) anisotropy measurements of the compounds incorporated in liposomes of DPPC, DODAB and Egg-PC
indicate that all compounds have two different locations, one due to a deep penetration in the lipid membrane and another
corresponding to a more hydrated environment. In general, the methoxylated compounds prefer hydrated environments inside the
liposomes. The 3-(4-fluorophenyl)benzothieno[2,3-c]pyran-1-one (1a) clearly prefers a hydrated environment, with some molecules located at the outer part of the liposome interface. On the
contrary, the preferential location of 3-(2-fluorophenyl)benzothieno[2,3-c]pyran-1-one (1b) is in the region of lipid hydrophobic tails. Compounds with a planar geometry (1a and 1c) have higher mobility in the lipid membranes when phase transition occurs. 相似文献
16.
Xinying Zhang Dongfang Li Xuesen Fan Xia Wang Xiaoyan Li Guirong Qu Jianji Wang 《Molecular diversity》2010,14(1):159-167
The utilization of an ionic liquid, [bmim][BF4] as both reaction medium and promoter for a multi-component reaction of aldehyde (1) and 5-amino-3-methyl-1-phenylpyrazole (2) with Meldrum acid (3) or dimedone (5) is studied. From this reaction, pyrazolo[3,4-b]pyridinone (4) and pyrazolo[3,4-b]quinolinone (6) derivatives were prepared in high yields. This novel procedure showed such advantages as environmentally benign nature,
enhanced efficiency, simple operation process, and mild reaction conditions. As an application, the procedure was successfully
used in the preparation of a set of pyrimidine nucleoside–pyrazolo[3,4-b]pyridine and pyrazolo[3,4-b]quinolinone hybrids with potential biological activities. 相似文献
17.
A facile and efficient one-pot three-component procedure for synthesis of novel dispirooxindolecyclo[pyrrolo[1,2-c]thiazole-6,5′-thiazolidine] derivatives without any catalysts under ultrasonic condition has been developed. Combining with the advantages of sonochemistry, such as mild reaction conditions, good yield and short reaction times, we have made a progress on construction of novel disiproheterocyclic compounds via the 1,3-dipolar cycloaddition of azomethine ylides. Several experiments were especially carried out for investigating the acceleration mechanism of ultrasound on the cycloaddition. 相似文献
18.
An aqueous mediated novel synthesis of substituted 2′amino-4′benzoyl-2′-methyl spiro[indole 3,5′-[1,3]oxathiolane]-2(1H)-ones (2a–f) was carried out from the reaction of spiro [indole-3,2′-oxiranes] (1a–f) with thioacetamide in the presence of LiBr as catalyst. The reaction was carried out under both microwaves and sonication and results were also compared with conventional method. In general, improvement in rate and yields observed when reaction was carried out under sonication as compared to microwave irradiation and conventional method. 相似文献
19.
Summary Protonation of the reactive intermediates produced in the reaction between alkyl(aryl) isocyanides and dialkyl acetylenedicarboxylates
by indan-1,3-dione leads to vinylnitrilium cations, which undergo carbon centered Michael type addition with the conjugate
base of the CH-acid to produce functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans. 相似文献
20.
Aaron JJ Párkányi C Adenier A Potin C Zajíčková Z Martínez OR Svoboda J Pihera P Váchal P 《Journal of fluorescence》2011,21(6):2133-2141
The electronic absorption, fluorescence excitation and emission spectra, and fluorescence quantum yields of novel fused thienobenzofurans,
including thieno[3,2-b][1]benzofuran (1), [1]benzothieno[3,2-b]furan (2), and [1]benzothieno[3,2-b][1]benzofuran (3), were recorded in fourteen solvents of different polarities at room temperature. Compound 2 was not fluorescent. Experimental ground-state dipole moments of compounds 1–3 were measured in benzene at 298 K and compared with the corresponding theoretical dipole moment values. The solvent effects
on the electronic absorption and fluorescence spectra of these thienobenzofurans were quantitatively investigated by means
of solvatochromic correlations based on the Kawski-Chamma-Viallet and McRae equations. A weak negative solvatochromic behavior
was found for these compounds, showing that their dipole moments are slightly lower in the excited singlet-state than in the
ground-state. Kamlet-Abboud-Taft multiparameter relationships were also established for electronic absorption and fluorescence
wavenumbers, and fluorescence quantum yields in most solvents, demonstrating the occurrence of specific solute-solvent interactions. 相似文献