A further study of the substrate specificity in the reduction of 20-oxosteroids with a culture ofActinomyces roseochromogenus

Chemistry of Natural Compounds - A culture ofActinomyces roseochromogenus ATCC 3347 reduces 17-hydroxy- and 16α, 17α-epoxy-20-oxopregnenes to the corresponding 20α-alcohols, but is...     

Substrate specificity of microbiological conversions of steroids by means ofActinomyces albus ATCC 3006

Summary In a comparison of the substrate specificity of the action of a culture ofActinomyces albus 3006 and a cell-free preparation obtained from the mycelium ofA. albus 3006, it was found that the spectrum of the action of the steroid oxidoreductase ofA. albus is broader than the spectrum of the action of the culture. Some of the factors responsible for the difference in the specificity of the action of the culture of the microorganism and the enzyme preparation are examined.Khimiya Prirodnykh Soedinenii, Vol. 1, No. 2, pp. 100–107, 1965     

Stereodirectivity of the reduction of 20-oxosteroids by actinomycetes

Conclusions 1. It has been established that the reduction of the 20-oxo group of steroids to a 20-hydroxy group, previously described only for a few microorganisms, is carried out by many actinomycetes.2. A correlation has been found between the action of the actinomycetes studied on progesterone and the steric, directivity of the reduction of 17-hydroxyprogesterone by these cultures.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 3, pp. 145–149, 1969     

A study of the alkaloids ofSaussurea salsa andS. elegans

Conclusions 1. In the extraction ofS. salsa andS. elegans, the condensation of the neutral substances with ammonia takes place with the formation of products of a basic nature.2. FromS. elegans a new alkaloid elegantine C₂₃H₂₉O₅N has been obtained the saponification of which has given tyramine and a sesquiterpene lactone.Khimiya Prirodnykh Soedinenii, Vol. 4, No. 6, pp. 367–370, 1968     

A study of the alkaloids ofVeratrum lobelianum

Conclusions 1) At the beginning of vegetation, the total alkaloids in the epigeal part ofVeratrum lobelianum is 2.5% of the weight of the dry raw material, and at the end of vegetation, 0.036%.2) The new alkaloids veralosine, veralosinine, and veralosidine have been isolated from the epigeal part of the plant.3) On the basis of a study of chemical properties, IR, UV, NMR, and mass spectra, and also its conversion into tetrahydrosolasodine, structure and configuration I has been proposed as the most probable for veralosidine.Khimiya Prirodnykh Soedinenii, Vol. 6, No. 3, pp. 339–343, 1970     

A study of the alkaloids ofLeontice albertii

Conclusions 1. Thaspine, N-methylcytisine, anabasine, matrine, leontine, leontalbinine, and the new alkaloids d-sophoridine and albertidine have been isolated from the epigeal part ofL. Albertii Rgl.2. A new spatial structure has been proposed for sophoridine.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 5, pp. 409–412, 1969     

A study of the alkaloids ofCodonopsis clematidea

Conclusions From the epigeal part ofCodonopsis clematidea, the new alkaloid codonopsine has been isolated; its most probable structure is 1,4-dihydroxy-1,3-dimethyl-5-veratrylpyrrolidine.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 1, pp. 30–32, 1969     

Steroids LI. The transformation of a series of 20-oxosteroids by a culture of Bacillus megaterium VNIKhFI-1

Summary The substrate specificity of an intact culture ofBacillus megaterium in relation to steroids of the pregnane series with a dihydroxyacetone side chain and without it, and also with steroids containing a 16,17-epoxy ring, has been studied.It has been shown that a culture ofBac. megaterium performs the reduction of a 20-oxo to a 20-hydroxy group only in the case of ⁴-3-oxo-steroids containing a 16,17-epoxy ring.The necessity of a dihydroxyacetone side chain for the -reduction of a 20-oxo group has been established.S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry (VNIKhFI). Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 742–747, November–December, 1975.     

Mechanism of the reduction of the alkaloids ofHaplophyllum at a dropping mercury electrode

Summary 1. The furanoquinoline alkaloids skimmianine, haploperine, and -fagarine are reduced at a dropping mercury electrode in 0.1 N (C₂H₅)₄NI and (C₂H₅)₄NOH in 80% ethanol forming tetrahydro or hexahydro derivatives according to the potential of the electrode.2. Carbostyryl and N-methylcarbostyryl are reduced under the same conditions to the corresponding dihydro derivatives.3. The proposed mechanism for the electrode processes is confirmed by a comparison of the UV and IR spectra of the substances before and after their electrolysis at a controlled potential with the spectra of synthetic compounds.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 4, pp. 253–257, 1967     

A study of the alkaloids of plants of the genusStephania

Summary Four alkaloids have been isolated from the tubers ofStephania glabra (Roxb.) Miers. (synonymSt. rotunda Lour.) collected in the Democratic Republic of Vietnam:l-tetrahydropalmatine and three previously undescribed bases (A -C₁₉H₁₈O₂N, C - C₂₀H₂₅O₄N, and D -C₂₁H₂₅O₄N).Khimiya Prirodnykh Soedinenii, Vol. 1, No. 6, pp. 392–394, 1965.The substances in this paper are denoted by letters. The novelty of these substances has not been established, which contradicts the rules of this journal. The paper is printed as an exception (Editiorial Board).     

A chemical study ofPlectranthus glaucocalyx Maxim.

Summary A previously unknown crystalline substance C₂₀H₂₈O₄, calledplectrin, has been isolated from the leaves ofPlectranthus glaucocalyx Maxim., family Labiatae.Khimiya Prirodnykh Soedinenii, Vol. 1, No. 6, pp. 427–428, 1965