南中国海柳珊瑚网状软柳珊瑚Subergorgia reticulata中的多氧化甾醇

Two new polyoxygenated steroids, reticulatic acid （1） and reticulatin （2）, together with a known compound 3,22,25-trihydroxy-16-24,20-24-bisepoxy-3β,16β,20S,22R,24S-cholest-5-ene （3）, were isolated from the CH2Cl2/ EtOH extract of the South China Sea gorgonian coral Subergorgia reticulata. Their structures were established on the basis of extensive spectroscopic analysis. The absolute stereochemistry of compounds 2 and 3 was determined by the X-ray crystallographic analysis and the Mosher ester determination.     

Further Highly Oxygenated Guaiane Lactones from the South China Sea Gorgonian Menella sp.

Four new highly oxygenated guaiane lactones, 1‐epimenverin B ( 1 ), menverin F ( 2 ), 1‐deoxymenverin F ( 3 ), and menverin G ( 4 ), together with the two known related analogues menverins B ( 5 ) and C ( 6 ), were isolated from the South China Sea gorgonian Menella sp. Their structures and relative configuration were elucidated by analysis of spectroscopic data and by comparison with those of known related compounds.     

Polyhydroxylated Sterols from the South China Sea Gorgonian Verrucella umbraculum

Two new polyhydroxylated sterols, named verumbsteroids A and B ( 1 and 2 , resp.), along with seven known analog, 3 – 9 , were isolated from the gorgonian Verrucella umbraculum collected from the South China Sea. The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic investigations. The absolute configuration of 1 was determined by using modified Mosher method with the acetonide derivative of 1 . Compounds 1 and 3 – 5 were found to show cytotoxicities against five human tumor cell lines (HL‐60, K562, HeLa, A‐549, and HCT‐116) with the IC₅₀ values ranging from 2.76 to 9.62 μM .     

Polyhydroxylated Steroids from the South China Sea Gorgonian Anthogorgia sp.

Four new polyhydroxylated steroids, namely anthogorgsteroids A–D ( 1 – 4 ), were isolated from the South China Sea gorgonian Anthogorgia sp. The structures of these compounds were elucidated by detailed spectroscopic analyses and comparison with reported data.     

Two new eunicellin diterpenoids from the South China Sea gorgonian Muricella sibogae and their bioactivities

A systematic re-study on gorgonian Muricella sibogae from South China Sea yielded 10 eunicellin-based diterpenoids including two new ones, sibogins C and D (1 and 2). Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, IR and MS) and by comparison with data reported in literatures. All the isolates were tested for cytotoxic and antifouling activities. Compounds 3 and 5 showed significant antifouling activity against the green mussel Perna viridis, and especially 3 was suggested as a potent low-toxic antifouling agent with a large LC₅₀/EC₅₀ value of 18.6. This was the first report on the antifouling activity of the eunicellin-type diterpenoids against the green mussel.     

New Eunicellin Diterpenes and 9,10‐Secosteroids from the Gorgonian Muricella sibogae

Bioactivity‐guided isolation of the rare gorgonian Muricella sibogae (Nutting ) yielded the two new eunicellin diterpenes sibogin A and B ( 1 and 2 ), the three new 9,10‐secosteroids sibogol A–C ( 6 – 8 ), together with the three known eunicellin diterpenes 3 – 5 and the five known 9,10‐secosteroids 9 – 13 . Their structures were established by extensive spectral analysis (1D‐ and 2D‐NMR, IR, and MS). The cytotoxicity of the isolates 1 – 13 was evaluated in vitro against the selected tumor cell lines P388 and BEL‐7402. All the compounds showed only weak activity against P388 cell lines, with an inhibition rate ranging from 10 to 60% at a concentration of 50 μg/ml, whereas the were inactive against BEL‐7402 cell lines.     

南海针小月柳珊瑚化学成分的研究

南海针小月柳珊瑚化学成分的研究邓松之＊李凤英彭胜石饶志刚吴厚铭徐竞辉（中国科学院广州化学研究所广州５１０６５０）（中国科学院上海有机化学研究所上海）关键词柳珊瑚，化学成分，提取分离，结构１９９６－１２－１６收稿，１９９７－０６－１０修回中国科学院“八...     

New Steroids and a New Alkaloid from the Gorgonian Isis minorbrachyblasta: Structures,Cytotoxicity, and Antilarval Activity

Two new polyoxygenated steroids, (1α,3β,7α,11α,12β)‐gorgost‐5‐ene‐1,3,7,11,12‐pentol 12‐acetate ( 1 ) and 11‐O‐acetyl‐22‐epihippuristanol ( 2 ), and a new alkaloid, 2,3,5,6,11,11b‐hexahydro‐2‐hydroxy‐1H‐indolizino[8,7‐b]indole‐2‐carboxylic acid ( 3 ), together with three known compounds, 22‐epihippuristanol ( 4 ), hippuristanol ( 5 ), and tryptamine ( 6 ), were isolated from the EtOH/CH₂Cl₂ extracts of the South China Sea gorgonian Isis minorbrachyblasta. The structures of the new compounds were determined by spectroscopic methods. Compound 1 showed weak cytotoxicity against A549, HONE1, and HeLa cancer cell lines and strong antilarval activity towards Bugula neritina larvae with an EC₅₀ value of 5.8 μg/ml. Compound 5 showed moderate cytotoxicity against A549, HONE1, and HeLa cell lines, and the epimer mixture 4 / 5 (weight ratio 3 : 2) exhibited potent cytotoxicity against A549 and HONE1 cell lines with IC₅₀ values of 4.2 and 4.8 μg/ml, which indicated that epimers 4 and 5 might have a synergistic effect on their cytotoxicity against A549 and HONE1 cell lines.     

New C27 Steroidal Bisdesmosides from the Fresh Stems of Dracaena cambodiana

Two new steroidal bisdesmosides, cambodracanosides A and B ( 1 and 2 , resp.), were isolated from the fresh stems of Dracaena cambodiana, together with seven known glycosides. The structures of the new saponins were elucidated on the basis of detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and acidic hydrolysis.     

New Secondary Metabolites from Allium victorialis

Allumines A and B ( 1 and 2 , resp.), two new steroidal alkaloids, and a new cyclopentene derivative, 3 , were isolated from the CHCl₃‐soluble fraction of the whole plant of Allium victorialis. Their structures were elucidated by spectroscopic techniques, including 1D‐ and 2D‐NMR spectroscopy.     

Philinopsides A and B,Two New Sulfated Triterpene Glycosides from the Sea Cucumber Pentacta quadrangularis

Two new sulfated triterpene glycosides, philinopsides A ( 1 ) and B ( 2 ), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were established by extensive spectral analysis (2D‐NMR and MS) and chemical evidence. Philinopside A ( 1 ) and B ( 2 ) showed significant cytotoxicity (ED₅₀ 0.75–3.50 μg/ml) against ten tumor cell lines. Compound 1 also significantly inhibited the proliferation, migration, and tube formation of human microvascular endothelial cells.     

Two New Triterpenoids from the Stems of Schisandra bicolor

Two new triterpenoids, schisanbilactones A and B ( 1 and 2 , resp.), and a new natural product, 1‐chloro‐3‐phenylhex‐5‐en‐3‐ol ( 3 ), as well as a known triterpenoid, kadsulactone A ( 4 ), were isolated from the stems of Schisandra bicolor. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

Three New Isoflavonoids from the Aerial Parts of Ammopiptanthus mongolicus

Three new isoflavonoids, namely (±)‐ammopiptanine A ( 1 ), ammopiptanine B ( 2 ), ammopiptanoside A ( 3 ), together with 13 known compounds, were isolated from the aerial parts of Ammopiptanthus mongolicus. Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with those of related model compounds. The isoflavonoids described, except formononetin, wistin, daidzein, and calycosin, were isolated from this plant for the first time.     

Two New Glycosides from the Roots of Ranunculus ternatus

Two new glycosides named as ternatoside A 1 and ternatoside B 2 were isolated from the roots of Ranunculus ternatus, the structures were determined by 1D and 2D NMR, ESI-MS techniques, and chemical methods.     

Intercedenol A and B, Two New Triterpenoids from the Sea Cucumber Mensamaria intercedens

Two new triterpenoids named intercedenol A and B were isolated from the acid hydrolysate of the crude glycoside fraction. The structures were elucidated by ESI-MS and NMR spectrum.     

Two New Bis‐alkaloids from the Aerial Part of Piper flaviflorum

Two new bis‐alkaloids, flavifloramides A ( 1 ) and B ( 2 ), as well as two known alkaloids, N‐trans‐feruloyltyramine ( 3 ) and paprazine ( 4 ), were isolated from the aerial part of Piper flaviflorum. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.     

Two New Steroidal Saponins from the Processed Polygonatum kingianum

Two new spirostanol saponins, kingianoside I ( 1 ) and kingianoside K ( 2 ), corresponding to (3β,23S,25R)‐23‐hydroxy‐12‐oxospirost‐5‐en‐3‐yl 4‐O‐β‐D ‐glucopyranosyl‐β‐D ‐galactopyranoside ( 1 ) and (3β,25R)‐7‐oxospirost‐5‐en‐3‐yl α‐L ‐arabinofuranosyl‐(1→4)‐[6‐deoxy‐α‐L ‐mannopyranosyl‐(1→2)]‐β‐D ‐glucopyranoside ( 2 ), along with 13 known compounds, daucosterol, (25R)‐kingianoside G, (25RS)‐kingianoside A, pratioside D₁, (25RS)‐pratioside D₁, (25S)‐kingianoside C, kingianoside C, ginsenoside Rb₁, saponins Tb and Pb, dioscin, gracillin, and saponin Pa, were isolated from the processed rhizomes of Polygonatum kingianum. The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and chemical methods. Compound 2 contains a novel unusual spirostanol saponin aglycone. Ginsenoside Rb₁ and saponin Tb were isolated for the first time from the genus Polygonatum. The 13 known compounds were detected for the first time in the processed Polygonatum kingianum.     

Two New Sesquiterpenes from the Marine Fungus Eutypella scoparia FS26 from the South China Sea

A new monocyclofarnesane‐type sesquiterpene, 3,7,10‐trihydroxy‐6,11‐cyclofarnes‐1‐ene ( 1 ), and a new acorane‐type sesquiterpene, 8‐(hydroxymethyl)‐1‐(2‐hydroxy‐1‐methylethyl)‐4‐methylspiro[4.5]dec‐8‐en‐7‐ol ( 2 ), were isolated from the culture of Eutypella scoparia FS26 from the South China Sea, along with three known terpenes, 3 – 5 . The structures of these compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1 – 5 were evaluated for their cytotoxic activities against the SF‐268, MCF‐7, and NCI‐H460 tumor cell lines.     

Two New Iridoid Esters from the Root and Rhizome of Valeriana jatamansi Jones

Two new iridoid esters, named valerjatadoids A and B ( 1 and 2 , resp.), together with three known iridoid esters, jatamanin O ( 3 ), jatamanvaltrate P ( 4 ), and jatamanvaltrate Q ( 5 ), have been isolated from the root and rhizome of Valeriana jatamansi Jones . The structures of the two new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.