Macrorhynines A and B,Two Novel Norditerpenoid Alkaloids from Aconitum macrorhynchum

Two novel norditerpenoid alkaloids, macrorhynines A and B ( 1 and 2 ), together with seven known compounds, were isolated from Aconitum macrorhynchum. The structures of the new compounds were elucidated as (1α,6α,14α)‐8‐acetoxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)aconitan‐14‐yl 4‐methoxybenzoate ( 1 ) and (1α,6α,14α)‐8‐acetoxy‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)aconitan‐14‐yl 4‐methoxybenzoate ( 2 ) on the basis of spectral analyses. The novel compounds were found to contain the rare C(19)?N, azomethine, group.     

Habaenines A and B,Two New Norditerpenoid Alkaloids from Aconitum habaense

Two new norditerpenoid alkaloids, habaenine A and B ( 1 and 2 ), together with two known compounds, were isolated from Aconitum habaense. The structures of the new compounds were elucidated on the basis of spectral analyses as (1α,6α,16β)‐8‐(acetyloxy)‐20‐ethyl‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐19‐oxoaconitan‐14‐yl 4‐methoxybenzoate ( 1 ) and (1α,6α,16β)‐8‐(acetyloxy)‐13‐hydroxy‐1,6,16‐trimethoxy‐4‐(methoxymethyl)‐aconitan‐14‐yl 4‐methoxybenzoate ( 2 ).     

Two New Norditerpenoid Alkaloids from Aconitum spicatum Stapf

Two new norditerpenoid alkaloids, spicatine A (1) and spicatine B (2) were isolated from the root of Aconitum spicatum. The new compounds were deduced on the basis of their spectral data (IR, HREIMS, EIMS, 1D, 2D-NMR). This is the first whole report on the isolation of diterpenoid alkaloids from the A.spicatum Stapf.     

Two New Alkaloids from the Roots of Aconitum sinomontanum Nakai

Two new alkaloids, ranaconidine (=20‐ethyl‐1α,14α,16β‐trimethoxyaconitane‐4,7,8,10‐tetrol; 1 ) and N‐(chloromethyl)taspine (=1‐[2‐(N‐(chloromethyl)‐N,N‐dimethylaminium)ethyl]‐3,8‐dimethoxybenzopyrano[5,4,3‐cde]benzopyran‐5,10‐dione; 2 ), together with two known compounds, i.e., benzethonium chloride ( 3 ) and ranaconine ( 4 ) were isolated from the roots of Aconitum sinomontanum Nakai . The structures of the compounds were elucidated on the basis of spectral evidences and in the comparison with previously published data.     

C19 and C20 Diterpene Alkaloids from Aconitum toxicum Rchb.

Acotoxinine ( 1 ), a new norditerpene alkaloid, was isolated from the roots of Aconitum toxicum Rchb ., together with the structurally related C₁₉ diterpene alkaloids neoline ( 2 ) and aconitine ( 3 ) and C₂₀ diterpene alkaloids songorine ( 4 ) and songoramine ( 5 ). The structures were elucidated by HR‐MS and advanced NMR methods, including ¹H‐NMR, JMOD, ¹H,¹H‐COSY, HSQC, and HMBC experiments. This is the first report of C₂₀ diterpenoid alkaloids in Aconitum toxicum.     

草乌中二萜类生物碱的电喷雾串联质谱研究

利用电喷雾质谱技术对传统中药草乌中的二萜类生物碱进行直接分析鉴定.通过实验数据并对比文献发现,草乌中含有单酯型、双酯型、三酯型和脂类等共4种类型生物碱,其中三酯型和脂类生物碱在草乌中为首次发现.由于这些生物碱的结构相似,在电喷雾串联质谱中碎裂方式相同,因此根据电喷雾串联质谱结果确定了这些生物碱的结构.     

Preparation of the N,19-seco Norditerpenoid Alkaloids from Norditerpenoid Alkaloid Yunaconitine

The synthesis of a new N,19-Seco norditerpenoid alkaloid 7 bearing nitro group from yunaconitine 1 as the starting material through a series of steps was described.     

Two New C20‐Diterpenoid Alkaloids from Aconitum carmichaelii

Two new C₂₀‐diterpenoid alkaloids, named aconicarchamines A and B ( 1 and 2 , resp.), were isolated from Aconitum carmichaelii. By UV, IR, MS, and 1D‐ and 2D‐NMR analyses, their structures were elucidated as 14,17‐dihydro‐14,17‐dihydroxyajabicine and 15‐O‐acetyllassiocarpine. Compound 1 is the third C₂₀‐diterpenoid alkaloid with the lycoctine skeleton bearing an exocyclic C‐atom at C(14).     

Three New C19‐Diterpenoid Alkaloids from Aconitum forrestii

A further study of the alkaloid constituents of Aconitum forrestii led to the isolation of three new C₁₉‐diterpenoid alkaloids, named 14‐acetoxy‐8‐O‐methylsachaconitine ( 1 ), 14‐acetoxyscaconine ( 2 ), and 8‐O‐ethylcammaconine ( 3 ). Their structures were determined by UV, IR, and MS, 1D‐ and 2D‐NMR analyses.     

Two New Norditerpenoid Alkaloids of Aconitum nagarum

Aconitum nagarum Stapf is mainly distributed in Yunnan province of China. Its roots can release pain and dispel dampness. They have been used as a folk medicine in China for the treatment of cold limbs in syncope, epigastric pain, vomiting and diarrhea1. The chemical constituents of this plant have been investigated1-4. For the further investigation, two new norditerpenoid alkaloids 13-hydroxyfranchetine 1 and 10- dehydroxyflavaconitine 2 were isolated from the ethanol extract of the roots o…     

Two New C20‐Diterpenoid Alkaloids from the Tibetan Medicinal Plant Aconitum naviculare Stapf

Two new C₂₀‐diterpenoid alkaloids named naviculine A ( 1 ) and naviculine B ( 2 ), were isolated from Aconitum naviculare Stapf . Their structures were established by spectral methods, especially 2D‐NMR spectra (¹H,¹H‐COSY, HMQC, HMBC, and NOESY) and DFT methods (at the B3LYP/6‐311++G(2d,p)//B3LYP/6‐31G(d) level), respectively. They were assayed for their anti‐HIV‐1 activity.     

Two New Norditerpenoid Alkaloids from Delphinium Souliei

DelphiniumsoulieiFranch,distributedintheSouthwestofGansuProvince,WestofSichuanProvince,andtheQinghaiProvinceofChina,isreportedtopossessantipyretic,antitoxic,antidysenteric,andantidiarrhealactivities.linthisstUdy,twonewditerpenoidalkaloidswereisolatedfromthewholeplantsofD.soulidi.TheirstructUreswereestablishedassoulineA(l)andsoulineB(2)onthebasisofspectraldata.SoulineA(l)wasisolatedascolorlesscrystals.Themolecularionpeakatm/z477.2678initsHREIMSrevealedthemolecularformulaC26H39NO7(cafe…     

直缘乌头中新的C19-二萜生物碱的结构研究

从直缘乌头（Aconitum transsectum Diels.）根中分离得到4个新的乌头碱型 C_(19)-二萜生物碱。由光谱法（IR, ~1H NMR, ~(13)C NMR, 2D-NMR, MS）确定其 结构为:8-O-乙基滇乌碱（8-O-ethylyunaconitine） (1)、去氮乙基查斯曼宁（N- deethyl chasmanine）(2)、直缘乌碱丁（transconitine D）(3)和直缘乌碱戊（ transconitine E）(4)。     

New Diterpenoid Alkaloids from Aconitum liangshanicum

One new C₁₉‐diterpenoid alkaloid, named liangshantine ( 1 ), and three new C₂₀‐diterpenoid alkaloids, liangshansines A–C ( 2 – 4 , resp.), as well as eight known compounds, were isolated from the roots of Aconitum liangshanicum. The structures of these new alkaloids were elucidated by spectroscopic methods.     

Norditerpenoid Alkaloids from the Roots of Aconitum hemsleyanum Pritz.var.Pengzhouense

In continuation of our studies on Aconitum hemsleyanum Pritz.var. pengzhouense, two new norditerpenoid alkaloids, pengshenines A(1) and B(2),have isolated from the roots of the plants and their strucures were elucidated by 1D-and 2D-NMR.     

Hemsleyaconitines F and G,Two Novel C19‐Diterpenoid Alkaloids Possessing a Unique Skeleton from Aconitum hemsleyanum

Hemsleyaconitines F and G ( 1 and 2 , resp.) were isolated from the EtOH extract of Aconitum hemsleyanum. Their structures were elucidated by extensive analyses of the IR, 1D‐ and 2D‐NMR, and MS data. The two C₁₉‐diterpenoid alkaloids 1 and 2 possess a novel skeleton, featuring a five‐membered D‐ring between C(9), C(13), C(14), C(15), and C(16), which is quite different from the previously isolated six‐membered D‐ring analogs.     

Piepunine,A Novel Bis‐diterpenoid Alkaloid from the Roots of Aconitum piepunense

Further investigation on the roots of Aconitum piepunense led to the isolation of a novel bis‐diterpenoid alkaloid designated as piepunine ( 1 ). Its structure was established by extensive interpretation of its 1D‐ and 2D‐NMR data, high‐resolution ESI‐MS, and IR spectra. Piepunine represents the first example of an atisine–denudatine‐type bis‐diterpenoid alkaloids.