The survival of tert-butyldimethylsilyl group of silyl enol ethers in the reaction with dimethyl(methylene)ammonium iodide. Regioselective synthesis of tert-butyldimethylsilyl enol ethers containing an amino group.

$\text{t}$-butyldimethylsilyl enol ethers containing an amino group were obtained in good yields (70–90%) by the reaction of $\text{t}$-butyldimethylsilyl enol ethers with dimethyl(methylene)ammonium iodide (the Eschenmoser salt).     

Synthesis of β=iodo-t-butyl and methyl ethers from the reaction of alkenes with t-butyl and methyl hypoiodites

$\text{t}$-Butyl or methyl hypoiodite, generated from potassium t-butoxide or sodium methoxide and iodine monochloride, react with olefins via a bridged iodonium ion intermediate giving the $\text{trans}$-vicinal iodo -$\text{t}$-butyl or -methyl ethers.     

Synthesis of di-t-alkylamines

Di-$\text{t}$-alkylamines can be synthesized efficiently by a three-step process: (1) oxidation of a $\text{t}$-alkylamine to a $\text{t}$-alkylnitroso compound with peracetic acid in ethyl acetate (2) conversion of the $\text{t}$-alkylnitroso compound to a tri-$\text{t}$-alkylhydroxylamine by successive trapping of two $\text{t}$-butyl radicals and (3) sodium naphthalide reduction to the di-$\text{t}$-alkylamine.     

Activation of methylenetriphenylphosphorane by reaction with t-butyl- or sec-butyllithium

Experimental details are provided to support a previous report that α-methylenetriphenylphosphorane ($\text{1}$) may be activated for reaction with unreactive substrates such as epoxides and hindered ketones by α-metallation to $\text{2}$.     

Synthesis of N-benzoyl-L-daunosamine from D-threonine

The synthesis of N-benzoyl-$\text{L}$-daunosamine (14) from the C₄$\text{threo}$ aldehyde (2b), prepared from $\text{D}$-threonine, through the intermediacy of the C₇ adduct (7a) is reported     

Solvent effects on the nitrogen hyperfine splitting constant of the t-butyl-t-butoxy nitroxyl radical

A decrease in nitrogen hyperfine splitting constant (N-hfsc) with increasing solvent polarity is reported for $\text{t}$-butyl $\text{t}$-butoxy nitroxyl radical produced by trapping $\text{t}$-butoxyl radical with 2-methyl-2-nitrosopropane.     

Preparation of tert-butyldimethylsilyl (tbdms) enol ethers using potassium hydride in the presence of tbdms chloride

TBDMS enol ethers can be readily prepared regio- and stereoselectively under equilibrating conditions in high yield by adding potassium hydride to a THF solution of ketone with TBDMS chloride $\text{in situ}$.     

New fluoride ion-catalyzed reaction of f-alkylacetylenes with silyl enol ethers. An efficient route to f-alkyl-substituted propargylic alcohols and α-hydroxy ketones

Treatment of $\text{F}$-alkylacetylenes, generated $\text{in}$$\text{situ}$ from 1$\text{H}$-$\text{F}$-1- alkenephosphonates, with silyl enol ethers in the presence of a catalytic amount of tetrabutylammonium fluoride gives good yields of $\text{F}$-alkyl-substituted propargyl alcohols or 4-(1$\text{H}$-$\text{F}$-alkylidene)-1,3-dioxolane derivatives, the latter being converted to tie corresponding α-hydroxy ketones.     

Conformation,in solution,of c-4-t-butyl-1-phenyl-r-1-(N-piperidyl)cyclohexane hydrochloride. The conformational energy of t-butyl

Although the hydrochloride of $\text{c}$-4-$\text{t}$-butyl-1-phenyl-$\text{c}$-1-(N-piperidyl)cyclohexane crystallizes in the conformation with axial $\text{t}$-butyl, it exists as an almost equimolar mixture of the two chair conformers in CD₂ Cl₂ solution. The position of equilibrium allows one to calculate ΔG°_{$\text{t}$-Bu} as ?4.9 kcal/mol.     

Stereocontrolled (E,Z and erythro, threo) synthesis of ⊙-hydroxyallylic sulphides

All four isomers of substituted 3-alkylthio-4-hydroxybutenes have been synthesised: both the geometry of the double bond and the relative stereochemistry of the two chiral centres are controlled.     

The ipso-nitration of p-cresol

The nitration of $\text{p}$-cresol by nitric acid in aqueous sulphuric acid involves ~40% $\text{ipso}$-substitution at C^Me. The 4-methyl-4-nitrocyclohexa-2,5-dien-1-one (I) formed undergoes an acid-catalysed rearrangement to 4-methyl-2-nitrophenol.     

Advanced sedex (sensitive detector of exothermic processes)

The instrument described is suitable for the investigation of the thermal behaviour of substances and reaction mixtures under production conformable conditions; this is made possible by the sophisticated design of the sample chamber: easy stirring of the samples, measuring under any gas atmosphere and while bubbling gas through the sample, choice of the sample container and visual observation during the measurement. The control device allows the choice of one of three operational modes: constant temperature, linear increase in temperature, and adiabatic control; this permits the application of the SEDEX apparatus for a variety of methods including dynamic scanning, isoperibolic measurements, and (quasi) adiabatic studies.