Synthesis of N2-arylaminopyrimidine-5-carbonitrile derivatives via SNAr amination reaction

An efficient and high-yielding synthesis of N~2-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines and 2-methylthio-pyrimidine-5-carbonitriIe derivatives has been developed in the presence of cesium carbonate as basic reagent.This new protocol showed high chemical tolerance for a range of functional groups,and only the methylthio substituent on C2 of the pyrimidine ring was replaced with arylamine derivatives under the reaction conditions.     

Condensation of monoclonal antibodies with carboxylated liposomes carrying N4-oleoyl-ara C

Conclusion The condensation method, which is not limited in scale, is cheap and easily practicable. All components of the resulting complex are biodegradable and not toxic. Unreacted antibodies can be regained without losing their activity.Cell binding assays showed, that depending on the optimal concentration the antibody-prodrug-liposomes are bound 5–30 times better by the target cells BJAB and U937 than by the no target mouse cell line NS 1. It can not be excluded, however, that on a chemical condensation other antibody species might lose or change their activity or selectivity.

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Kopplung monoklonaler Antikörper mit carboxylierten Liposomen, die N⁴-Oleyl-ara C tragen

     

Regioselective N1- or N2-modification of benzotriazoles with iodonium salts in the presence of copper compounds

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Das polarographische Verhalten der Sulfonamide N1-(2-Thiazolyl)-sulfanilamid,N1- (3,4-Dimethylbenzoyl) -sulfanilamid und N1-(2-Pyridyl)-sulfanilamid

Ohne Zusammenfassung     

Permanganate oxidation of N6,N6,8-trisubstituted-2′,3′,5′- tri-o-acetyladenosines

Oxidation of 2′,5′ ,5′-tri-O-aaetyl derivatives of N⁶,N⁶-dialkyl- adenosines(3a-g) uifh KMnO₄ in 50% AcOH gave both the mono(5a-g) and didealkyl derivatives(6a-c); it uas conclusively proved that one and two methylene groups of the title nucleosides(2a-g) in the α position to the exocyclic nitrogen atom were simultaneously oxidized.     

Theoretical study of the N+2 molecular ion

The Equations of Motion method has been applied in the calculation of potential energy curves for the X²Σ⁺_g, A²Π_u and B²Σ⁺_u states of N⁺₂. Results are also reported for a new dissociative ²Σ⁺_g state. The theoretical curves are directly compared with the experimental ones as well as in terms of spectroscopic constants. The applicability of the Equations of Motion method to this type of problem is critically examined and discussed with regard to the choice of basis set, numerical effort and agreement with experiment.     

The transverse diffusion of mass-identified N+2 ions in nitrogen

A new apparatus suitable for the quantitative study of the transverse diffusion of mass identified ions is described. Measurements of the transverse diffusion of N⁺₂ in nitrogen are reported and comparison is made with other data.     

Amidrazones V. thermolysis of N1-benzyl-substituted amidrazone ylides

Thermolysis of 1,1-dimethyl-1-benzyl-2-(iminophenylmethyl)hydrazinium hydroxide inner salt gave dimethylamine, 2,4,6-triphenyl-s-triazine and 2,4,6-triphenyl-1,2-dihydro-s-triazine.     

Synthesis and spectroscopic characterization of P-doped Na4Si4

Na₄Si₄ is a Zintl salt composed of Na⁺ cations and tetrahedral anions and is a unique solid-state precursor to clathrate structures and nanomaterials. In order to provide opportunities for the synthesis of complex materials, phosphorus was explored as a possible substituent for silicon. Phosphorus doped sodium silicides Na₄Si_4−xP_x (x≤0.04) were prepared by reaction of Na with the mechanically alloyed Si_4−x:P_x (x=0.04, 0.08, 0.12) mixture in a sealed Nb tube at 650 °C for 3 days. Energy dispersive X-ray spectroscopy confirms the presence of P in all products. Powder X-ray diffraction patterns are consistent with the retention of the Na₄Si₄ crystal structure. As the amount of P increases, a new peak in the diffraction pattern that can be assigned to black phosphorus is apparent above the background. Raman and solid-state NMR provide information on phosphorus substitution in the Na₄Si₄ structure. Raman spectroscopy shows a shift of the most intense band assigned to the ν₁ (A₁) mode from 486.4 to 484.0 cm⁻¹ with increasing P, consistent with P replacement of Si. Differential nuclear spin-lattice relaxation for the Si sites determined via ²⁹Si solid-state NMR provides direct evidence for Si-P bonding in the (Si_1−xP_x)⁴⁻ tetrahedron. The ²³Na NMR shows additional Na…P interactions and the ³¹P NMR shows two P sites, consistent with P presence in both of the crystallographic sites in the (Si₄)⁴⁻ tetrahedron.     

Synthesis and thermochemistry of SrB2O4·4H2O and SrB2O4

Two pure strontium borates SrB₂O₄·4H₂O and SrB₂O₄ have been synthesized and characterized by means of chemical analysis and XRD, FT-IR, DTA-TG techniques. The molar enthalpies of solution of SrB₂O₄·4H₂O and SrB₂O₄ in 1 mol dm⁻³ HCl(aq) were measured to be −(9.92 ± 0.20) kJ mol⁻¹ and −(81.27 ± 0.30) kJ mol⁻¹, respectively. The molar enthalpy of solution of Sr(OH)₂·8H₂O in (HCl + H₃BO₃)(aq) were determined to be −(51.69 ± 0.15) kJ mol⁻¹. With the use of the enthalpy of solution of H₃BO₃ in 1 mol dm⁻³ HCl(aq), and the standard molar enthalpies of formation for Sr(OH)₂·8H₂O(s), H₃BO₃(s), and H₂O(l), the standard molar enthalpies of formation of −(3253.1 ± 1.7) kJ mol⁻¹ for SrB₂O₄·4H₂O, and of −(2038.4 ± 1.7) kJ mol⁻¹ for SrB₂O₄ were obtained.     

Kinetic energy dependence of the reactions of N+ and N2+ with molybdenum

Mass-selected beams of N⁺ and N₂⁺ in the energy range 5–50 eV react with molybdenum to produce a surface nitride. The relative reaction cross section for N⁺ reaction is higher than that of N₂⁺ in the range 5–25 eV and N₂⁺ exhibits a reaction threshold near 7 eV. The N₂⁺ threshold suggests collisional dissociation prior to reaction.     

Ni5P4/g-C3N4复合光催化剂的制备及光催化性能

使用尿素、 红磷和氯化镍为原料, 通过一种简单的焙烧方法合成了Ni₅P₄/g-C₃N₄光催化剂. 该催化剂形成的异质结可以降低界面电阻, 有效抑制光生电子-空穴对复合率. 以罗丹明B模拟污染物进行降解测试, 发现3NPC的反应速率常数最高, 几乎是g-C₃N₄的7倍, 并具有最高的光催化产氢能力, 制氢速率高达1013.88 μmol·g^-1·h^-1, 明显高于g-C₃N₄(664.38 μmol·g^-1·h^-1).     

Synthesis of the sulfones of leukotriene C4, D4, and E4

A simple one-step preparation of the sulfones of Leukotriene C₄, D₄ and E₄ has been developed by the direct oxidation of the parent compounds. An alternative synthesis of these sulfones has also been carried out by reduction of an acetylenic precursor.     

Synthesis and characterization of La4MnCu6S10

The new quaternary sulfide La₄MnCu₆S₁₀ has been synthesized by the reaction of La₂S₃, MnS, and CuS₂ at 1223 K. This compound crystallizes in a new structure type in space group of the triclinic system with one formula unit in a cell of dimensions at 153 K of a=6.6076(3) Å, b=7.3247(3) Å, c=8.7844(4) Å, α=83.457(1)°, β=74.398(1)°, γ=89.996(1)°, and V=406.61(3) Å³. The structure of La₄MnCu₆S₁₀ consists of a three-dimensional framework of interconnected LaS₇ monocapped trigonal prisms, MnS₆ octahedra, and CuS₄ tetrahedra. Band gaps of 2.49 eV in the [100] direction and 2.53 eV in the [001] direction have been derived from optical absorption measurements on a La₄MnCu₆S₁₀ single crystal.     

Ge4+、Sn4+掺杂尖晶石LiMn2O4的合成与电化学表征

使用Ge⁴⁺、Sn⁴⁺作为掺杂离子, 通过高温固相法制备四价阳离子掺杂改性的尖晶石LiMn₂O₄材料. X射线衍射(XRD)和扫描电子显微镜(SEM)分析表明, Ge⁴⁺离子取代尖晶石中Mn⁴⁺离子形成了LiMn_2-xGe_xO₄ (x=0.02,0.04, 0.06)固溶体; 而Sn⁴⁺离子则以SnO₂的形式存在于尖晶石LiMn₂O₄的颗粒表面. Ge⁴⁺离子掺入到尖晶石LiMn₂O₄材料中, 抑制了锂离子在尖晶石中的有序化排列, 提高了尖晶石LiMn₂O₄的结构稳定性; 而在尖晶石颗粒表面的SnO₂可以减少电解液中酸的含量, 抑制酸对LiMn₂O₄活性材料的侵蚀. 恒电流充放电测试表明, 两种离子改性后材料的容量保持率均有较大幅度的提升, 有利于促进尖晶石型LiMn₂O₄锂离子电池正极材料的商业化生产.     

KAIF4化合物的合成

KAIF₄ has been prepared by different procedures and product characterized by XRD and SEM methods.It is indicated that step by step reaction of solution synthesis in which pH = 4 and vaporized at 100℃ was the best procedure for preparing a high purity, thin and particle uniform product.     

Synthesis, structure, and magnetism of Tb4PdGa12 and Tb4PtGa12

Single crystals of Tb₄MGa₁₂ (M=Pd, Pt) have been synthesized. The isostructural compounds crystallize in the cubic space group , with Z=2 and lattice parameters: a=8.5940(5) and 8.5850(3) Å for Tb₄PdGa₁₂ and Tb₄PtGa₁₂, respectively. The crystal structure consists of corner-sharing MGa₆ octahedra and TbGa₃ cuboctahedra. Magnetic measurements suggest that Tb₄PdGa₁₂ is an antiferromagnetic metamagnet with a Néel temperature of 16 K, while the Pt analog orders at T_N=12 K.     

Li4Ti5O12-聚苯胺复合材料的合成与表征

以醋酸锂和钛酸四丁酯为原料，以乙醇为溶剂，采用溶胶-凝胶法制备Li₄Ti₅O₁₂;以苯胺、过硫酸铵为原料，以盐酸为溶剂，采用原位聚合法合成Li₄Ti₅O₁₂-聚苯胺复合材料。采用X-射线衍射、红外光谱和电化学测试等对复合材料进行了表征。结果表明，聚苯胺的加入明显提高了Li₄Ti₅O₁₂的电子导电性能，Li₄Ti₅O₁₂-PAn复合材料具有比Li₄Ti₅O₁₂更好的高倍率性能和循环稳定性。0.1C和2.0C放电时Li₄Ti₅O₁₂-PAn的放电容量达到了191.3和148.9 mAh·g^-1，经80次循环后二者平均每次循环容量衰减率分别为0.13%和0.61%。     

Laser-induced fluorescence in N2 and N+2 by multiple-photon excitation at 266 nm

The fluorescence transitions corresponding to the second positive system of N₂ (C³Π_u → B³Π_g) for Δv = 0, 1 and the first negative system of N⁺₂(B²Σ⁺_u → X²Σ⁺_g) for Δv = 0, 1, 2 have been observed following laser-induced mul excitation of N₂.