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1.
Alkenyl, aryl or allylic selenides smoothly couple with Grignard reagents in the presence of Ni(II)-phosphine complexes as catalysts to afford the corresponding unsaturated compounds in good yields. The reactivity order of coupling reaction with BuMgBr catalyzed by NiCl2 [Ph2PCH2CH2CH2PPh2] was found to be PhSeMe « PhCl > PhSMe by the competitive reactions. 相似文献
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Andrey V. Kachanov Oleg Yu. Slabko Olga V. Baranova Evgenia V. Shilova Vladimir A. Kaminskii 《Tetrahedron letters》2004,45(23):4461-4463
Triselenium dicyanide is formed by the interaction of malononitrile and selenium dioxide in dimethylsulfoxide or dimethylformamide. Addition of aromatic amines, indoles and some active methylene compounds to this reaction mixture gives the corresponding selenocyanates in one-pot. 相似文献
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Olefins including alkylidenecyclopropanes are readily prepared from the corresponding selenides by reaction of base on the corresponding selenonium salt. The reaction also applies to cyclopropylsulfides. 相似文献
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Jacques H. Poupaert Patrick Depreux Christopher R. McCurdy 《Monatshefte für Chemie / Chemical Monthly》2003,134(6):823-830
Summary. AlCl3-mediated chlorocarbonylation of a first arene by oxalyl chloride followed by in situ Friedel-Crafts acylation of a second electron-rich arene expeditiously provides, in a one-pot procedure, either symmetrical or unsymmetrical
benzophenones with yields ranging from 17–52%. Best results are obtained when the more activated substrate is used as the
second arene. Another advantage is that the resultant benzophenone precipitates from the reaction mixture allowing facile
workup.
Corresponding author. E-mail: Poupaert@cmfa.ucl.ac.be
Received October 4, 2002; accepted October 15, 2002
Published online March 6, 2003 相似文献
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《Tetrahedron: Asymmetry》2007,18(1):123-130
Herein, the reactivity of chlorodeoxypseudoephedrine hydrochlorides with oxo-, thio-, and selenocyanate nucleophiles is reported. 1,3-Heterazolidine-2-iminium or ammonium salts were obtained stereoselectively in most cases. The hard–soft nature of the calcogen atom determines the mechanistic pathway via an SN2 (X = O), aziridine intermediate (X = Se), or both (X = S). A simple method to synthesize stereoselectively the trans-isomer of 3,4-dimethyl-5-phenyl-oxazolidine-2-iminium chloride and the cis-isomer of 4-methyl-5-phenyl-oxazoline-2-ammonium chloride, was also found. In addition, heterazolidine-2-imines or amines were liberated from the corresponding salts [Cl− or XCN− (X = O, S, Se)] with aqueous NaOH. Finally, cis-3,4-dimethyl-5-phenyl-oxazolidine-2-iminium chloride, cis-4-methyl-5-phenyl-oxazoline-2-amine, and trans-4-methyl-5-phenyl-selenazoline-2-amine compounds were studied by X-ray diffraction. 相似文献
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Grignard reactions on methyl 4-methyl, 5-oxo, 5-phenyl (pX substituted) pentanoates 1-6 (X = H, Me, F, Cl, Br, OMe) produced mixtures of cis-(7-11) and trans-(12-16) tetrahydro 5,6 dimethyl-6-phenyl -2H-pyran-2-ones. They were isolated by HPLC and characterized by 1H and 13C techniques. The stereochemistry of Grignard reactions in THF with CH3MgCl was determined at 0° and 60°. 相似文献
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《Tetrahedron》1986,42(16):4577-4584
Vinyl halides react with MeSeLi in DMF to afford vinyl methyl selenides which are demethylated by the excess of the MeSeLi; the vinyl selenide anions thus obtained react with acetyl chloride to give vinyl acetyl selenides. This three steps one pot synthesis occurs with complete retention of configuration. The vinyl acetyl selenides are cleanly fragmented by electron transfer to the vinyl selenide anions; addition of iodine to the resulting solutions produced the divinyl diselenides with retention of configuration. The transformation of vinyl acetyl selenides into divinyl diselenides can also be induced by catalytic amounts of a solution of sodium in HMPA or of sodium methanethiolate. 相似文献
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Ruppa P. Kamalesh Babu Setharampattu S. Krishnamurthy Munirathinam Nethaji 《Heteroatom Chemistry》1991,2(4):477-485
Two new diphosphazane ligands, PriN(PPh2)(PO2C6H4) ( 1 ) and PriN{P(O2C6H4)}2 ( 3 ), have been synthesized and characterized by spectroscopic data. The structure of 1 has been confirmed by single crystal X-ray diffraction. Crystal data: Monoclinic, C2/c, Z = 16, a = 34.149(5) Å, b = 9.717(6) Å, c = 29.439(5) Å, β = 125.11(2)°, V = 7991 Å3, R = 0.058, Rw = 0.061. This compound shows two different P–N bond lengths (1.654 (4) and 1.743(4) Å) and a P–N–P angle of 120.7(2)°. Variable temperature 31P NMR measurements for 1 and 3 throw light on the nature of the conformers present in solution. 相似文献
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Jin‐Jun Wang Young Key Shim Gui‐Ji Jiang Kimiaki Imafuku 《Journal of heterocyclic chemistry》2004,41(1):29-35
From methyl pyropheophorbide‐a (MPPa) (1), methyl 2‐formylmethyl‐2‐devinyl‐9‐ethylenedioxy‐9‐deoxopyropheophorbide‐a (2) and methyl 3‐acetyl‐9‐ethylenedioxy‐2‐devinyl‐9‐deoxopyropheophorbide‐a (3) were prepared. The Grignard reactions of 2 and 3 were performed using cycloalkyl magnesium bromides to afford cycloalkyl‐substituted sec‐alcohol 4 and tert‐alcohols 9a‐c, respectively. By the deprotection of the ethylenedioxy group, these alcohols were respectively converted to exocyclic ketones 5 and 10a‐c, which were dehydrated to give chlorins 6 and 11a‐c having an alkenyl function at the 2‐position. On the other hand, the oxidation and deprotection of the alcohol 4 gave a diketo chlorin 8. 相似文献
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The interaction of o-nitro- and p-nitro-phenyl selenocyanate with aromatic thiols p-thiocresol, p-chlorothiophenol, 4-bromothiophenol, o-mercaptobenzoic acid and pentafluorothiophenol in non-aqueous media and under an atmosphere of dry nitrogen has been investigated. The main products are the diselenide or the selenenyl sulphide depending on the reactants. Hydrogen cyanide is given in all cases. The IR and Raman spectra of the diselenides and selenenyl sulphides are considered. 相似文献
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Appropriately substituted unsymmetrical diaryl carbonates react smoothly with primary amines to give the carbamates derived by nucleophilic displacement of the less electron rich aromatic substituent. Subsequent treatment of the carbamates with primary and secondary amines gives either symmetrical or unsymmetrical ureas in excellent yield and the overall process can be carried out as a “one pot” operation. Acetonitrile is the preferred solvent and addition of DBU facilitates the carbamate → urea transformation. 相似文献
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An efficient and transition metal-free method for the synthesis of aryl or alkyl difluoromethyl selenides (RSeCF2H) from the corresponding selenocyanates (RSeCN) and TMSCF2H/t-BuOK is described. The reaction performed in THF at 0?°C for 24?h or at room temperature for 6?h supplied a series of RSeCF2H in good to high yields. The successful preparation of difluoromethylselenolated sulfadimethoxine derivative and the scaled-up synthesis of 1-benzyl-5-((difluoromethyl)selanyl)indoline, as examples, suggested good practicability of this method. Advantages of the reaction include mild reaction conditions, good functional group tolerance, a wide range of substrates, and high efficiency. This protocol offered a number of novel difluoromethyl selenoethers, which would accelerate use of such compounds in the areas of life science. 相似文献