共查询到20条相似文献,搜索用时 15 毫秒
1.
《中国化学快报》2006,(11)
A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively. 相似文献
2.
A New Disulfated Triterpene Glycoside from the Sea Cucumber Mensamaria intercedens Lampert 总被引:1,自引:0,他引:1
ZhengRongZOU YangHuaYI QiangZhiXU HouMingWU HouWenLIN 《中国化学快报》2003,14(6):585-587
A new disulfated triterpene glycoside named intercedenside B was isolated from the sea cucumber Memsamaria intercedens Lampert.The structure was deduced from the spectral data. 相似文献
3.
Le Hoang Vien Le Thi Hanh Tran Thi Hong Thanh Nguyen Van Nam Nguyen Hoai 《Natural product research》2020,34(8):1061-1067
AbstractFrom the MeOH extract of the Vietnamese sea cucumber Holothuria edulis, eight triterpene glycosides (1–8), including one new compound namely holothurin A5 (1), were isolated by using various chromatographic separations. Their structures were established by spectroscopic experiments including 1D, 2D NMR and HR-ESI-MS. Holothurin A5 (1) has a hydroperoxy group at C-25. To the best of our knowledge, this is the first report of this group in triterpene saponins obtained from sea cucumbers to date. In addition, the in vitro cytotoxicity against five human cancer cell lines (HepG2, KB, LNCaP, MCF7 and SK-Mel2) of all isolated compounds was also evaluated using SRB assays. 相似文献
4.
Hua Han Yang Hua Yi Ling Li Xiao Hua Wang Bao Shu Liu Peng Sun Min Xiang Pan Research Center for Marine Drugs School of Pharmacy Second Military Medical University Shanghai China 《中国化学快报》2007,18(2):161-164
A new triterpene glycoside, leucospilotaside A, along with a known saponin, isolated from sea cucumber Holothuria leucospilota, and its structure was elucidated as 3β-O-[4-O-sodiumsulfate-β-D-quinovopyranosyl-(1→2)-β-D-xylopyranosyl]-holosta-22-ketone-9-en-17α,25α-diol (1) by extensive spectroscopic analysis and chemical methods. Leucospilotaside A (1) has a ketone carbonyl group (22) in the aglycon side chain. 相似文献
5.
Yang‐Hua Yi Qiang‐Zhi Xu Ling Li Shi‐Long Zhang Hou‐Ming Wu Jian Ding Yun‐Guang Tong Wen‐Fu Tan Mei‐Hong Li Fang Tian Jiu‐Hong Wu Chih‐Chuang Liaw KennethF. Bastow Kuo‐Hsiung Lee 《Helvetica chimica acta》2006,89(1):54-63
Two new sulfated triterpene glycosides, philinopsides A ( 1 ) and B ( 2 ), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were established by extensive spectral analysis (2D‐NMR and MS) and chemical evidence. Philinopside A ( 1 ) and B ( 2 ) showed significant cytotoxicity (ED50 0.75–3.50 μg/ml) against ten tumor cell lines. Compound 1 also significantly inhibited the proliferation, migration, and tube formation of human microvascular endothelial cells. 相似文献
6.
Liang ZHOU Jun Shan YANG? Guang Zhong TU Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing Beijing Institute of Microchemistry Research Beijing 《中国化学快报》2005,16(8)
Souliea vaginata (Maxim.) Franch. (Ranunculaceae) is widely distributed in the southwest and northwest of China. It possesses anti-inflammatory analgesic functions as a well-known Chinese folk medicine. Its rhizomes or the whole plant are used to treat conjunctivitis, stomatitis, pharyngitis, enteritis, and diarrhea1. Previously, we have reported the isolation and structural elucidation of suolieasides A-C from the ethanol extract of the rhizomes of this plant2. In our further investigation… 相似文献
7.
Liang ZHOU Jun Shan YANG Guang Zhong TU 《中国化学快报》2005,16(8):1047-1049
A new cycloartane triterpene glycoside was isolated from the rhizome of Souliea vaginata. Its structure was established as 12-deacetyloxy-15α-hydroxy-23-epi-26-deoxyactein by spectroscopic and chemical methods. 相似文献
8.
A new triterpene glycoside, leueospilotaside C, along with two known saponin, was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea, and its structure was elucidated as 3-O-{4'-O-sodiumsulfate-β-D-xylopyranosyl }-holosta-22,25-epoxy-9-ene-3β, 12a, 17a-triol (1) by extensive spectroscopic analysis and chemical methods. The glycosides have the same triterpene aglycone, but differ in the oligosaccharide moieties. 相似文献
9.
A new triterpene glycoside, pomolic acid 3-O-6″-methyl-β-D-glucuronopyranosyl-(1→3)-α-L-arabino- pyranoside, and a new flavonol glycoside, quercetin 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside together with three known triterpene saponins and two flavonol glycosides, were isolated from the leaves of Ilex cornuta. Their structures were established on the basis of spectroscopic analysis. 相似文献
10.
Markhabo M. Makhmudova Markus Bacher Gokhan Zengin Thomas Rosenau Fadia S. Youssef Diena M. Almasri Sameh S. Elhady Nilufar Z. Mamadalieva 《Molecules (Basel, Switzerland)》2022,27(24)
A new triterpene glycoside, silviridoside, was isolated from the aerial parts of Silene viridiflora (Caryophyllaceae) using different chromatographic techniques. The structure of silviridoside was comprehensively elucidated as 3-O-β-D-galacturonopyranosyl-quillaic acid 28-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-fucopyranosyl ester by one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). Silviridoside showed promising antioxidant activity in different antioxidant assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) (2.32 mg TE/g), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (1.24 mg TE/g), cupric-reducing antioxidant capacity (CUPRAC) (9.59 mg TE/g), ferric-reducing antioxidant power (FRAP) (5.13 mg TE/g), phosphomolybdenum (PHD) (0.28 mmol TE/g), and metal-chelating (MCA) (6.62 mg EDTA/g) assays. It exhibited a good inhibitory potential on acetylcholinesterase (AChE) (2.52 mg GALAE/g), butyrylcholinesterase (BChE) (7.16 mg GALAE/g), α-amylase (0.19 mmol ACAE/g), α-glucosidase (1.21 mmol ACAE/g), and tyrosinase (38.83 mg KAE/g). An in silico evaluation of the pharmacodynamic, pharmacokinetic, and toxicity properties of silviridoside showed that the new compound exhibited reasonable pharmacodynamic and pharmacokinetic properties without any mutagenic effect, but slight toxicity. Thus, it could be concluded that silviridoside could act as a promising lead drug for pharmaceutical and nutraceutical developments to combat oxidative stress and various disorders, but a future optimization is necessary. 相似文献
11.
YouHengGAO QuanXiMEI HuiFeiWU YuanMingDIAO XinShengPENG RuiFangZHANG 《中国化学快报》2005,16(7):925-927
A new labdane-type diterpene glycoside 1 , chlorophytoside A, had been isolated from Chlorophytum laxum R.Br. The structure had been elucidated as (10S)-6α-hydroxylabda-8,13-dien-15,16-olide 3R-O-β-D-glucopyranoside on the basis of chemical and spectroscopic data. 相似文献
12.
Enas E. Eltamany Usama Ramadan Abdelmohsen Dina M. Hal Amany K. Ibrahim Hashim A. Hassanean Reda F. A. Abdelhameed Tarek A. Temraz Dina Hajjar Arwa A. Makki Omnia Magdy Hendawy Asmaa M. AboulMagd Khayrya A. Youssif Gerhard Bringmann Safwat A. Ahmed 《Molecules (Basel, Switzerland)》2021,26(6)
Chemical investigation of the methanolic extract of the Red Sea cucumber Holothuria spinifera led to the isolation of a new cerebroside, holospiniferoside (1), together with thymidine (2), methyl-α-d-glucopyranoside (3), a new triacylglycerol (4), and cholesterol (5). Their chemical structures were established by NMR and mass spectrometric analysis, including gas chromatography–mass spectrometry (GC–MS) and high-resolution mass spectrometry (HRMS). All the isolated compounds are reported in this species for the first time. Moreover, compound 1 exhibited promising in vitro antiproliferative effect on the human breast cancer cell line (MCF-7) with IC50 of 20.6 µM compared to the IC50 of 15.3 µM for the drug cisplatin. To predict the possible mechanism underlying the cytotoxicity of compound 1, a docking study was performed to elucidate its binding interactions with the active site of the protein Mdm2–p53. Compound 1 displayed an apoptotic activity via strong interaction with the active site of the target protein. This study highlights the importance of marine natural products in the design of new anticancer agents. 相似文献
13.
ThefamilyMeliaceaeiswellknownforitslimonoidcomponentspossessinginsectantifeedantactivityandthosehighlyoxygenatedtriterpenesrelatedtotirucallol(euphanetypeskeleton)','.MeliaazedarachisaplantofthefamilyMeliaceae,distributedwidelyinChina'.Inordertofindnewlimonoidwithstronginsectantifeedantactivityandalsointerestinghighlyoxygenatedtriterpenes,westudiedsystematicallythechemicalcomponentsofMeliaazedarach.Inthispaper,wereportthestructureelucidationofanewtriterpene,namedazedarachicacid.Azedarachicac… 相似文献
14.
Yue LIU Jing QU Shi Shan YU Jing LIU You Cai HU 《中国化学快报》2006,17(12):1569-1572
Cynanchum forrestii Schlechter (Asclepiadaceae) is widely distributed in Yunnan, Xizang, Gansu, Sichuan, Guizhou Provinces, etc. in China and its roots have been used as an antifebrile, diuretic and analgetic in China1. In the previous investigation, we i… 相似文献
15.
Alexandra S. Silchenko Sergey A. Avilov Pelageya V. Andrijaschenko Roman S. Popov Ekaterina A. Chingizova Boris B. Grebnev Anton B. Rasin Vladimir I. Kalinin 《Molecules (Basel, Switzerland)》2022,27(21)
Five new triterpene (4,4,14-trimethylsterol) di-, tri- and tetrasulfated pentaosides, chilensosides A (1), A1 (2), B (3), C (4), and D (5) were isolated from the Far-Eastern sea cucumber Paracaudina chilensis. The structures were established on the basis of extensive analysis of 1D and 2D NMR spectra and confirmed by HR-ESI-MS data. The structural variability of the glycosides concerned the pentasaccharide chains. Their architecture was characterized by the upper semi-chain consisting of three sugar units and the bottom semi-chain of two sugars. Carbohydrate chains of compounds 2–5 differed in the quantity and positions of sulfate groups. The interesting structural features of the glycosides were: the presence of two sulfate groups at C-4 and C-6 of the same glucose residue in the upper semi-chain of 1, 2, 4, and 5 and the sulfation at C-3 of terminal glucose residue in the bottom semi-chain of 4 that makes its further elongation impossible. Chilensoside D (5) was the sixth tetrasulfated glycoside found in sea cucumbers. The architecture of the sugar chains of chilensosides A–D (1–5), the positions of sulfation, the quantity of sulfate groups, as well as the aglycone structures, demonstrate their similarity to the glycosides of the representatives of the order Dendrochirotida, confirming the phylogenetic closeness of the orders Molpadida and Dendrochirotida. The cytotoxic activities of the compounds 1–5 against human erythrocytes and some cancer cell lines are presented. Disulfated chilensosides A1 (2) and B (3) and trisulfated chilensoside C (4) showed significant cytotoxic activity against human cancer cells. 相似文献
16.
In the previous papers"', we have reported some chemical constituents fromClerodendrum serratum var. amplerghlium Moldenke. A continuation of our studies onthe same plant led to the isolation of a new phenylpropanoid, serratumoside A (l), whichis reported in this paper.Serratumoside A (l) with three known phenylpropanoid glycosides identified asacteoside', mwtinoside' and myricoside', respectively, were isolated from the Cserratum. Compound I was isolated as a brown amorphous powder, laly … 相似文献
17.
Guo‐Quan Sun Ling Li Yang‐Hua Yi Wei‐Hua Yuan Bao‐Shu Liu Yi‐Yi Weng Shi‐Long Zhang Peng Sun Zeng‐Lei Wang 《Helvetica chimica acta》2008,91(8):1453-1460
Two new lanostane‐type nonsulfated pentasaccharide triterpene glycosides, 17‐dehydroxyholothurinoside A ( 1 ) and griseaside A ( 2 ), were isolated from the sea cucumber Holothuria grisea. Their structures were elucidated by spectroscopic methods, including 2D‐NMR and MS experiments, as well as chemical evidence. Compounds 1 and 2 possess the same pentasaccharide moieties but differ slightly in their side chains of the holostane‐type triterpene aglycone. The structures of the two new glycosides were established as (3β,12α)‐22,25‐epoxy‐3‐{(O‐β‐D ‐glucopyranosyl‐(1→4)‐O‐[O‐3‐O‐methyl‐β‐D ‐glucopyranosyl‐(1→3)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐6‐deoxy‐β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐xylopyranosyl)oxy}‐12,20‐dihydroxylanost‐9(11)‐en‐18‐oic acid γ‐lactone ( 1 ) and (3β,12α)‐3‐{(O‐β‐D ‐glucopyranosyl‐(1→4)‐O‐[O‐3‐O‐methyl‐β‐D ‐glucopyranosyl‐(1→3)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐6‐deoxy‐β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐xylopyranosyl)oxy}‐12,20,22‐trihydroxylanost‐9(11)‐en‐18‐oic acid γ‐lactone ( 2 ). The 17‐dehydroxyholothurinoside A ( 1 ) and griseaside A ( 2 ) exhibited significant cytotoxicity against HL‐60, BEL‐7402, Molt‐4, and A‐549 cancer cell lines. 相似文献
18.
WeiCHEN YueMaoSHEN JianChuXU 《中国化学快报》2003,14(4):385-388
Dissectol A,a novel monoterpene glycoside was isolated from the methanol part of the 95% EtOH extract of Incarvillea dissecfoliola and its structure was determined by 1D and 2D NMR data. 相似文献
19.
A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7'-bi(1,8-dihydroxy-3-methyl-9,10-anthraquinonyl) 1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques including 2D-NMR and chemical methods. 相似文献
20.
A new flavanone (2S)-5, 7, 2',5'-tetrahydroxy-flavanone 1 together with a new flavanone glycoside (2S)-5, 7, 2',5'-tetrahydroxy-flavanone 7-O-β-D-glucopyranoside 2, were isolated from the dry roots of Scutellaria baicalensis. Their structures were elucidated on the basis of spectroscopic data. 相似文献